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Research 2024年第2期2023卷 691-702页

作者： Zhongjie Li Chao Yang Qin Zhang Geng Chen jingyuan xu Yan Peng Hengyu Guo School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444P.R.China Institute of Artificial Intelligence Shanghai UniversityShanghai 200444P.R.China National Engineering Research Center of Turbo-Generator Vibration School of Energy and EnvironmentSoutheast UniversityNanjing 210096P.R.China institute of Microstructure Technology Karlsruhe Institute of TechnologyKarlsruhe 76344Germany Shanghai Artificial Intelligence Laboratory Shanghai 200444P.R.China Department of Applied Physics Chongqing UniversityChongqing 400044P.R.China

The influence of a mechanical structure's volume increment on the volume power density (VPD) of triboelectric nanogenerators (TENGs) is often neglected when considering surface charge density and surface power density. This paper aims to address this gap by introducing a standardized VPD metric for a more comprehensive evaluation of TENG performance. The study specifically focuses on 2 frequency-up mechanisms, namely, the integration of planetary gears (PG-TENG) and the implementation of a double-cantilever structure (DC-TENG), to investigate their impact on VPD. The study reveals that the PG-TENG achieves the highest volume average power density, measuring at 0.92 W/m^(3). This value surpasses the DC-TENG by 1.26 times and the counterpart TENG by a magnitude of 69.9 times. Additionally, the PG-TENG demonstrates superior average power output. These findings introduce a new approach for enhancing TENGs by incorporating frequency-up mechanisms, and highlight the importance of VPD as a key performance metric for evaluating TENGs.

关键词： increment neglected considering

EXPONENTIAL STABILITY OF A REPARABLE MULTI-STATE DEVICE

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Journal of Systems Science & Complexity 2007年第3期20卷 437-443页

作者： Weiwei HU Houbao xu jingyuan YU Guangtian ZHU Beijing Institute of Information and Control Beijing 100037 China. Department of Mathematics Beijing Institute of Technology Beijing 100081 China. Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China.

The exponential stability of a multi-state device is discussed in this paper. We present that the Co-semigroup generated by the system operator is quasi-compact and irreducible. It is known that 0 is a simple eigenvalue of the system operator. In combination with this, we obtain that the time-dependent solution exponentially converges to the steady-state solution, which is the positive eigenfuction corresponding to the simple eigenvalue O.

关键词： C0-semigroup exponential stability irreducibility quasi-compact.

Target-triggered hairpin-free chain-branching growth of DNA dendrimers for contrast-enhanced imaging in living cells by avoiding signal dispersion

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Chinese Chemical Letters 2022年第2期33卷 773-777页

作者： Jiaqi Deng jingyuan xu Minzhi Ouyang Zhen Zou Yanli Lei Junbin Li Zhihe Qing Ronghua Yang Hunan Provincial Key Laboratory of Cytochemistry School of Chemistry and Food EngineeringChangsha University of Science and TechnologyChangsha 410114China Laboratory of Chemical Biology&Traditional Chinese Medicine Research Ministry of EducationCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China Department Ultrasound Diagnosis The Second Xiangya HospitalCentral South UniversityChangsha 410011China

The development of amplification strategies is one of the central challenges for detection of lowabundance targets. One-to-many(1:M) amplification strategies in which one target lights many signal probes, has improved the detection sensitivity in bulk solution, but with discounted contrast in cell imaging, because the lighted probes are dissociative and dispersible. In this work, a one-to-large(1:L) signaling mechanism, in which the lighted probes were orderly connected to each other, was conceptually proposed to enhance the contrast in cell imaging by avoiding signal dispersion in amplification. Accordingly,target-triggered hairpin-free chain-branching assembly(HFCBA) holds great potential to implement the1:L mechanism, but using it in cell imaging has yet to be demonstrated. As a proof of concept, a group of probes were first programmed to implement mi RNA-21-triggered HFCBA. After transfection of probes,gradually-growing signal flares in cells were monitored along with the growth of DNA dendrimers;and the in situ fluorescence accumulation in HFCBA resulted in highly-enhanced contrast to the surrounding by avoiding signal dispersion in amplification. The contrast-enhanced imaging with signal amplification is significant for biological analysis and molecular medicine. We expect the 1:L mechanism will provide a new thought for high-performance imaging of biomarkers in cells.

关键词： Cell imaging Amplification Signal dispersion Self-assembly DNA dendrimers

Thermoacoustic heat pump utilizing medium/low-grade heat sources for domestic building heating

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Energy and Built Environment 2024年第4期5卷 628-639页

作者： Yiwei Hu Kaiqi Luo Dan Zhao Zhanghua Wu Yupeng Yang Ercang Luo jingyuan xu Chinese Academy of Science Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryBeijing 100190China University of Chinese Academy Science Beijing 100049China Building Energy Research Center Tsinghua UniversityBeijing 100084China Department of Mechanical Engineering Faculty of EngineeringUniversity of CanterburyPrivate Bag 4800Christchurch 8041New Zealand Institute of Microstructure Technology Karlsruhe Institute of TechnologyKarlsruhe 76344Germany

Thermoacoustic heat pumps are a promising heating technology that utilizes medium/low-grade heat to reduce reliance on *** study proposes a single direct-coupled configuration for a thermoacoustic heat pump,aimed at minimizing system complexity and making it suitable for domestic *** investiga-tions were conducted under typical household heating conditions,including performance analysis,exergy loss evaluation,and axial distribution of key *** show that the proposed thermoacoustic heat pump achieves a heating capacity of 5.7 kW and a coefficient of performance of 1.4,with a heating temperature of 300℃and a heat-sink temperature of 55℃.A comparison with existing absorption heat pumps reveals favor-able adaptability for large temperature lift applications.A case study conducted in Finland over an annual cycle analyzes the economic and environmental performance of the system,identifying two distinct modes based on the driving heat source:medium temperature(≥250℃)and low temperature(<250℃),both of which exhibit favorable heating *** the thermoacoustic heat pump is driven by waste heat,energy savings of 20.1 MWh/year,emission reductions of 4143 kgCO_(2)/year,and total environmental cost savings of 1629€/year are *** results demonstrate the potential of the proposed thermoacoustic heat pump as a cost-effective and environmentally friendly option for domestic building heating using medium/low-grade heat sources.

关键词： Thermoacoustic heat pump Thermodynamics Heat pump Medium/low-grade heat Domestic heating

Progress and Prospects of Research on Climate Policy and Governance

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Innovation and Development Policy 2021年第2期 135-156页

作者： Chunkui Zhu Peishan Tong jingyuan xu School of International Relations and Public Affairs Fudan UniversityShanghai 200433China Shanghai Center for Innovation and Governance Fudan UniversityShanghai 200433China Institute for Global Public Policy Fudan UniversityShanghai 200433China

Research on climate policy and governance has rapidly evolved since the early 1990s,yet there is a lack of a systematic review,especially in quantitative methods,that provides an overall account of this interdisciplinary *** article provides a bibliometric analysis of 2487 SSCI journal articles published from 1990 to 2018 to characterize the intellectual landscape of climate policy and governance literature by visualizing the changes in researchers’collaboration and publications’cocitation and identifying the emerging research *** findings show that publications on this topic have surged since the Kyoto Protocol came into effect in *** studies,economics,and public administration are three major disciplines drawing high attention to this *** and research institutions from the United States,the United Kingdom,and Germany have maintained dominance over climate policy and governance ***,we identify three pressing topics for creating future research agendas,including adaptive capacity,technology and innovation,and urban *** technology innovation,local climate governance and the increasing political awareness will become future research trends.

关键词： climate policy and governance bibliometric analysis literature review research trends

The Effect of Partially Substituted Lupin, Soybean, and Navy Bean Flours on Wheat Bread Quality

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Food and Nutrition Sciences 2018年第7期9卷 840-854页

作者： Sean Liu Diejun Chen jingyuan xu National Center for Agricultural Utilization Research Agricultural Research Service US Department of Agriculture Peoria IL USA

Many edible legumes contain high amounts of proteins, fibers, minerals and vitamins. Their essential amino acid composition and concentration complements the amino acids in wheat and other cereals. In addition, breads fortified with protein rich legumes make the breads more palatable. In this study, we evaluated breads made from wheat flour partially substituted with soybean, navy bean, and lupin flours at 10%, 20%, and 30% levels. The physicochemical properties of breads were measured and compared with the control (made from 100% wheat flour). Statistical analysis was used to assess the significance of the differences. The breads fortified with soybean, lupin and navy bean flours showed remarkable springiness, similar to the breads made from wheat flour. However, the higher amount of substitution increased the firmness of the breads, probably due to the incorporation of additional fibers and proteins into the formulations. Compared to wheat bread, the volumes of 90:10 wheat-soybean, wheat-lupin, and wheat-navy bean breads decreased about 7%, 2%, and 10%, respectively. Higher substitution levels would result in a higher reduction in volume for all legumes tested. The volume reduction as a result of legume substitution appears to be navy bean flour > soybean flour > lupin flour. The inclusion of legumes in the bread formulations imparts a slightly darker crust color and crumb color with the exception of breads with the soybean flour substitution. Lupin appears to be the best substitution candidate among the legumes tested for fortified bread making. Lupin can be presented as a high-value protein source in developing marketable foods for health conscious consumers.

关键词： Bread Quality Lupin Navy Bean Rheology Soybean Wheat

On-Line Detection of Porosity in Gas Tungsten Arc Welding of Aluminum Alloy Based on Spectrum Features

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Journal of Shanghai Jiaotong university(Science) 2024年第2期29卷 339-348页

作者：蒋浩强陈善本许靖远 School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The real-time detection of porosity in welding process is an important problem to be solved in intelligent welding manufacturing.A new on-line detection method for porosity of aluminum alloy in robotic arc welding based on arc spectrum is proposed in this ***,k-shape and the improved k-means were used for the initial feature selection of the preprocessed arc spectrum to reduce the data ***,the secondary feature selection was carried out based on the importance of features to further reduce feature ***,the optimal sample label library was established by combining the final characteristic parameters and the X-ray pictures of ***,an on-line detection method of porosity in gas tungsten arc welding of aluminum alloy based on light gradient boosting machine(LightGBM)was *** with extreme gradient boosting(XGBoost)and categorical boosting(CatBoost),this method can achieve better detection *** new method proposed in this paper can be used to detect other welding defects,which is helpful to the development of intelligent welding technology.

关键词： porosity detection robotic arc welding arc spectrum

Design of Pt （Ⅳ） Prodrug by Targeting Epigenetic Alterations and Binding Human Serum Albumin for Drug Delivery

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Design of Pt （Ⅳ） Prodrug by Targeting Epigenetic Alterati...

Nucleolar-Targeting Platinum-based Agent Expresses Increased Toxicity and Overcomes Platinum Drug Resistance in Cancer Cells

第十届全国化学生物学学术会议

作者： Qian Chen Xin Qiao jingyuan xu Department of Chemical Biology and Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of PharmacyTianjin Medical University

Aberrant epigenetic alterations of tumor suppressor genes have been recognized as a driving force in cancer. Histone deacetylases（HDACs）, for example, are promising targets for cancer due to their crucial involvement in epigenetic and cellular signaling[1]. HDACs modulate the expression and functions of DNA repair proteins which remove DNA interstrand crosslinks（ICLs） and control the accessibility of chromatin. Manipulating ICL repair with HDAC inhibition can provide an effective strategy for ICL-inducers, such as platinum-based agents. Herein, we report an asymmetrical Pt（Ⅳ） prodrug PhB-Pt（Ⅳ）-18 C by combined HDAC inhibition, human serum albumin（HSA） binding, DNA cross-link-triggered apoptosis for synergistic chemotherapy and drug delivery. PhB-Pt（Ⅳ）-18 C effectively kills cisplatin-resistant human lung cancer cells with an up to 50-fold increase in growth inhibition compared with cisplatin. The presence of an octodecane tail can tune the cellular uptake and the cytotoxicity, and can allow binding with HSA for drug delivery. Additionally, PhB-Pt（Ⅳ）-18 C can inhibit expression of HDAC, arrest cell cycle, and induce apoptosis. These results demonstrate the combination strategy to be a valuable route for additional preclinical studies.

关键词： Epigenetics ICLs HDACs Prodrug Platinum(Ⅳ)

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Design of Pt（IV） Prodrug by Targeting Epigenetic Alterations and Binding Human Serum Albumin for Drug Delivery

第十届全国化学生物学学术会议

作者： Zhenlei Zhang Xin Qiao jingyuan xu Department of Chemical Biology and Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of PharmacyTianjin Medical University

The nucleolus, also known as ―ribosomal factory‖, is the subnuclear site of ribosome biogenesis. In particular, a hallmark of aggressive tumors is an increase in size and number of nucleoli, and selectively targeting nucleoli has been shown to be an effective strategy for cancer-specific therapy. To increase tumor selectivity and overcome drug resistance of clinically used platinum drugs, nucleolar targeting molecule was attached to platinum agent. The nucleolar-targeting monofunctional platinum agent（P1B1） is highly active in inhibiting proliferation of cisplatin-resistant human lung cancer cells with an up to 12-fold increase in growth inhibition compared with cisplatin, and P1B1 is less toxic than the parent nucleolar targeting molecules and cisplatin in MRC-5 human embryonic lung fibroblast cells. Immunoblotting assay and immunofluorescence staining results reveal that P1B1 can significantly inhibit expression of RNA polymerase I subunit RPA194 and nucleolar phosphoprotein nucleolin（NCL）, and subsequently can induce nucleolar stress, cell cycle arrest, and apoptosis. Our study highlights the importance of targeting cancer-specific nucleolar pathways as a novel strategy for overcoming platinum drug resistance.

关键词： Nucleolar-targeting Monofunctional platinum agent Platinum drug resistance

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Design of Pt（IV） Prodrug by Targeting Epigenetic Alteratio...