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Chinese Journal of Chemistry 2024年第1期42卷 43-47页

作者： Li Wang Renwei Xiao jingyuan song Long-Sheng Zheng Qiwei Lang Gen-Qiang Chen Xumu Zhang Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis Department of Chemistryand Medi-PingshanSouthern University of Science and TechnologyShenzhenGuangdong 518000China Academy for Advanced Interdisciplinary Studies Southern Universityof Science and TechnologyShenzhenGuangdong 518000China Chemistry and Chemical Engineering Guangdong Laboratory ShantouGuangdong 515031China

Transition metal-catalyzed asymmetric transfer hydrogenation has been proven to be a powerful approach for the synthesis of chiral ***,a highly efficient and enantioselective transfer hydrogenation of dibenzoheptaheterocyclic ketones catalyzed by an arene-tethered TsDPEN-based Rh(ll)catalyst has been successfully developed,and a variety of dibenzoheptaheterocyclic ketones were reduced by a 1/1 mixture of formic acid and DBU(1,8-diazabicyclo[5.4.0]undec-7-ene)with high yields and *** this method,the asymmetric reduction of 7,8-difluorodibenzo[b,e]thiepin-11(6H)-one has been realized,providing the key intermediate of baloxavir marboxil with>99% yield and>99% ee at a substrate/catalyst molar ratio of 1000.

关键词： Asymmetric transfer hydrogenation Baloxavir Chiral alcohol Enantioselectivity Heterocyclic diaryl ketone Rhodium(Ⅱ)

Crocus genome reveals the evolutionary origin of crocin biosynthesis

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1878-1891页

作者： Zhichao Xu Shanshan Chen Yalin Wang Ya Tian Xiaotong Wang Tianyi Xin Zishan Li Xin Hua Shengnan Tan Wei Sun Xiangdong Pu Hui Yao Ranran Gao jingyuan song Key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People's Republic of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China State Key Laboratory of Basis and New Drug Development of Natural and Nuclear Drugs Engineering Research Center of Chinese Medicine ResourceMinistry of EducationBeijing 100193China College of Life Science Northeast Forestry UniversityHarbin 150040China Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine China Academy of Chinese Medical SciencesInstitute of Chinese Materia MedicaBeijing 100700China Analysis and Testing Center of Northeast Forestry University Harbin 150040China School of Pharmacy Anhui Medical UniversityInflammation and Immune Mediated Diseases Laboratory of Anhui ProvinceHefei 230032China

Crocus sativus (saffron) is a globally autumn-flowering plant, and its stigmas are the most expensive spice and valuable herb medicine. Crocus specialized metabolites, crocins, are biosynthesized in distant species, Gardenia (eudicot) and Crocus (monocot), and the evolution of crocin biosynthesis remains poorly understood. With the chromosome-level Crocus genome assembly, we revealed that two rounds of lineage-specific whole genome triplication occurred, contributing important roles in the production of carotenoids and apocarotenoids. According to the kingdom-wide identification, phylogenetic analysis, and functional assays of carotenoid cleavage dioxygenases (CCDs), we deduced that the duplication, site positive selection, and neofunctionalization of Crocus-specific CCD2 from CCD1 members are responsible for the crocin biosynthesis. In addition, site mutation of CsCCD2 revealed the key amino acids, including I143, L146, R161, E181, T259, and S292 related to the catalytic activity of zeaxanthin cleavage. Our study provides important insights into the origin and evolution of plant specialized metabolites, which are derived by duplication events of biosynthetic genes.

关键词： Crocus sativus WGT Crocin biosynthesis Carotenoids Apocarotenoids CCDs

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深度学习偏振图像融合研究现状

红外技术 2024年第2期46卷 119-128页

作者：段锦张昊宋靖远刘举长春理工大学电子信息工程学院吉林长春130022

偏振图像融合旨在通过光谱信息和偏振信息的结合改善图像整体质量,在图像增强、空间遥感、目标识别和军事国防等领域具有广泛应用。本文在回顾基于多尺度变换、稀疏表示和伪彩色等传统融合方法基础上,重点介绍基于深度学习的偏振图像融... 详细信息

偏振图像融合旨在通过光谱信息和偏振信息的结合改善图像整体质量,在图像增强、空间遥感、目标识别和军事国防等领域具有广泛应用。本文在回顾基于多尺度变换、稀疏表示和伪彩色等传统融合方法基础上,重点介绍基于深度学习的偏振图像融合方法研究现状。首先阐述基于卷积神经网络和生成对抗网络的偏振图像融合研究进展,然后给出在目标检测、语义分割、图像去雾和三维重建领域的相关应用,同时整理公开的高质量偏振图像数据集,最后对未来研究进行展望。

关键词：偏振图像图像融合深度学习

限流孔板在飞机空调管道的噪声分析及优化设计

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机械科学与技术 2024年第1期43卷 180-186页

作者：赵海宇周强宋经远王青山中南大学高性能复杂制造国家重点实验室长沙410083 中国航发沈阳发动机研究所沈阳110015

为分析限流孔板在飞机空调管道系统中的噪声特性以及对限流孔板进行降噪优化设计,本文首先运用CFD方法对含限流孔板的直管进行稳态流场数值计算,探究气流流经限流孔板的流动状态;然后基于大涡模拟法和FW-H方程,对管道进行瞬态流场以及... 详细信息

为分析限流孔板在飞机空调管道系统中的噪声特性以及对限流孔板进行降噪优化设计,本文首先运用CFD方法对含限流孔板的直管进行稳态流场数值计算,探究气流流经限流孔板的流动状态;然后基于大涡模拟法和FW-H方程,对管道进行瞬态流场以及声场计算,分析限流孔板在飞机驾驶舱监测点的流致噪声特性;最后,对比分析不同通流孔径的限流孔板对驾驶舱监测点噪声的影响规律,从而提出较优的限流孔板低噪声结构设计形式。研究结果表明:增大通流孔径可提高降噪效果,但压降性能降低,限流孔板降噪需结合其压降性能综合考虑。

关键词：限流孔板 CFD方法噪声特性优化设计

一种仿生蜻蜓式垂直起降喷管的流动特性分析及优化设计

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空气动力学学报 2024年第5期42卷 45-52页

作者：赵海宇宋经远胡双卫钟锐王青山中南大学机电工程学院长沙410083 中国航发沈阳发动机研究所沈阳110015

为提高飞行器排气系统的隐身性及机动性,提出了一种仿生蜻蜓式垂直起降喷管,并对不同模式下喷管的流动特性及流道优化进行研究。首先运用CFD方法分别对常规巡航、S形隐身以及垂直起降模式下的蜻蜓式垂直起降喷管进行流场数值仿真,探究... 详细信息

为提高飞行器排气系统的隐身性及机动性,提出了一种仿生蜻蜓式垂直起降喷管,并对不同模式下喷管的流动特性及流道优化进行研究。首先运用CFD方法分别对常规巡航、S形隐身以及垂直起降模式下的蜻蜓式垂直起降喷管进行流场数值仿真,探究该喷管的流动特性;然后在此基础上,分别研究喷管各舱段间相对转角对S形隐身模式及垂直起降模式下喷管气动特性的影响规律,得出相应模式下气动性能较优的蜻蜓式垂直起降喷管。研究结果表明:相同条件下,常规巡航模式下喷管气动性能较优;各舱段相对转角对喷管气动性能有较大影响,其中转角θ_(1)、θ_(2)、θ_(3)分别为-34°、12°、22°的S形隐身模式喷管以及θ_(1)、θ_(2)、θ_(3)分别为35°、30°、30°的垂直起降模式喷管的综合气动性能较优。

关键词：排气系统垂直起降喷管 CFD方法气动性能流道优化

Genomic survey of bZIP transcription factor genes related to tanshinone biosynthesis in Salvia miltiorrhiza

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Acta Pharmaceutica Sinica B 2018年第2期8卷 295-305页

作者： Yu Zhang Zhichao Xu Aijia Ji Hongmei Luo jingyuan song Key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People's Republic of China Institute of Medicinal Plant Development Peking Union Medical College & Chinese Academy of Medical Sciences

Tanshinones are a class of bioactive components in the traditional Chinese medicine Salvia miltiorrhiza, and their biosynthesis and regulation have been widely studied. Current studies show that basic leucine zipper(bZIP) proteins regulate plant secondary metabolism, growth and developmental processes. However, the b ZIP transcription factors involved in tanshinone biosynthesis are ***, we conducted the first genome-wide survey of the b ZIP gene family and analyzed the phylogeny,gene structure, additional conserved motifs and alternative splicing events in S. miltiorrhiza. A total of 70 Smb ZIP transcription factors were identified and categorized into 11 subgroups based on their phylogenetic relationships with those in Arabidopsis. Moreover, seventeen Smb ZIP genes underwent alternative splicing events. According to the transcriptomic data, the Smb ZIP genes that were highly expressed in the Danshen root and periderm were selected. Based on the prediction of b ZIP binding sites in the promoters and the co-expression analysis and co-induction patterns in response to Ag^+ treatment via quantitative real-time polymerase chain reaction(qRT-PCR), we concluded that Smb ZIP7 and Smb ZIP20 potentially participate in the regulation of tanshinone biosynthesis. These results provide a foundation for further functional characterization of the candidate Smb ZIP genes, which have the potential to increase tanshinone production.

关键词： bZIP genes Salvia miltiorrhiza Phylogenetic analysis Expression pattern analysis Tanshinone biosynthesis

Trends in herbgenomics

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Science China(Life Sciences) 2019年第3期62卷 288-308页

作者： Tianyi Xin Yu Zhang Xiangdong Pu Ranran Gao Zhichao Xu jingyuan song Key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People's Republic of China Institute of Medicinal Plant Development Peking Union Medical College & Chinese Academy of Medical Sciences Yunnan Branch Institute of Medicinal Plant Development Peking Union Medical College & Chinese Academy of Medical Sciences

From Shen Nong's Herbal Classic(Shennong Bencao Jing) to the Compendium of Materia Medica(Bencao Gangmu) and the first scientific Nobel Prize for the mainland of China, each milestone in the historical process of the development of traditional Chinese medicine(TCM) involves screening, testing and integrating. After thousands of years of inheritance and development,herbgenomics(bencaogenomics) has bridged the gap between TCM and international advanced omics studies, promoting the application of frontier technologies in TCM. It is a discipline that uncovers the genetic information and regulatory networks of herbs to clarify their molecular mechanism in the prevention and treatment of human diseases. The main theoretical system includes genomics, functional genomics, proteomics, transcriptomics, metabolomics, epigenomics, metagenomics, synthetic biology, pharmacogenomics of TCM, and bioinformatics, among other fields. Herbgenomics is mainly applicable to the study of medicinal model plants, genomic-assisted breeding, herbal synthetic biology, protection and utilization of gene resources, TCM quality evaluation and control, and TCM drug development. Such studies will accelerate the application of cutting-edge technologies, revitalize herbal research, and strongly promote the development and modernization of TCM.

关键词： herbgenomics(bencaogenomics) traditional Chinese medicine omics practical application

DNA barcoding in herbal medicine: Retrospective and prospective

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Journal of Pharmaceutical Analysis 2023年第5期13卷 431-441页

作者： Shilin Chen Xianmei Yin Jianping Han Wei Sun Hui Yao jingyuan song Xiwen Li Institute of Herbgenomics Chengdu University of Traditional Chinese MedicineChengdu611137China Key Laboratoryof Beijing for Identification and Safety Evaluation of Chinese Medicine Instituteof Chinese Materia MedicaChina Academyof Chinese Medical SciencesBeijing100700China State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengdu611137China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100193China

DNA barcoding has been widely used for herb identification in recent decades,enabling safety and innovation in the field of herbal *** this article,we summarize recent progress in DNA bar-coding for herbal medicine to provide ideas for the further development and application of this *** importantly,the standard DNA barcode has been extended in two ***,while conventional DNA barcodes have been widely promoted for their versatility in the identification of fresh or well-preserved samples,super-barcodes based on plastid genomes have rapidly developed and have shown advantages in species identification at low taxonomic ***,mini-barcodes are attractive because they perform better in cases of degraded DNA from herbal *** addition,some mo-lecular techniques,such as high-throughput sequencing and isothermal amplification,are combined with DNA barcodes for species identification,which has expanded the applications of herb identification based on DNA barcoding and brought about the post-DNA-barcoding ***,standard and high-species coverage DNA barcode reference libraries have been constructed to provide reference se-quences for species identification,which increases the accuracy and credibility of species discrimination based on DNA *** summary,DNA barcoding should play a key role in the quality control of traditional herbal medicine and in the international herb trade.

关键词： Herbal identification Super-barcode Mini-barcode Meta-barcoding Cutting-edgebarcoding

基于全基因组的栀子花香成分合成TPS基因系统分析

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植物科学学报 2024年第1期42卷 85-95页

作者：许文杰娄千陈启桢胡开治曹敏刘燕琴韩蓉蓉宋经元中国医学科学院北京协和医学院药用植物研究所国家中医药管理局中药资源保护重点研究室北京100193 重庆市药物种植研究所重庆408435

栀子(Gardenia jasminoides ***)花色洁白且香气怡人,不仅具有极高的观赏价值,还是重要天然香料来源。萜类是栀子花独特香气的主要组成成分,但合成该类挥发性产物的关键萜类合酶(TPS)尚未鉴定。本研究基于栀子高质量基因组,通过转录组... 详细信息

栀子(Gardenia jasminoides ***)花色洁白且香气怡人,不仅具有极高的观赏价值,还是重要天然香料来源。萜类是栀子花独特香气的主要组成成分,但合成该类挥发性产物的关键萜类合酶(TPS)尚未鉴定。本研究基于栀子高质量基因组,通过转录组数据、系统发育树和保守结构域分析等,全面挖掘栀子萜类花香成分合成相关的TPS基因。结果显示,栀子基因组共注释到44个GjTPS基因,不均匀分布于11条染色体,其中9个GjTPS参与串联复制事件。所有GjTPS被划分为5个亚家族,其中27个属于被子植物特有的TPS-a、TPS-b和TPS-g分支。结合栀子5个器官的转录组数据及实时荧光定量PCR分析,筛选出5个候选GjTPS基因,其在盛开期的花器官中特异高表达,且含有DDXXD和NSE/DTE活性基序。其中,GjTPS1、GjTPS2、GjTPS3和GjTPS27为TPS-b分支酶,推测为芳樟醇或罗勒烯等栀子主要花香成分合成酶,而TPS-a分支的GjTPS18可能是金合欢烯合酶。

关键词：栀子花香萜类合酶基因组转录组

Cloning and analysis of 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase genes HsHDR1 and HsHDR2 in Huperzia serrate

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Acta Pharmaceutica Sinica B 2015年第6期5卷 583-589页

作者： Haizhou Lv Xin Zhang Baosheng Liao Wanjing Liu Liu He jingyuan song Chao Sun Hongmei Luo Shilin Chen Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Chinese Materia Medica China Academy of Chinese Medicinal Sciences

We cloned and analyzed the two genes of the 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase(HDR) gene family from Huperzia *** two transcripts coding HDR,named Hs HDR1 and Hs HDR2,were discovered in the transcriptome dataset of *** and were cloned by reverse transcription-polymerase chain reaction(RT-PCR).The physicochemical properties,protein domains,protein secondary structure,and 3D structure of the putative Hs HDR1 and Hs HDR2 proteins were *** full-length c DNA of the Hs HDR1 gene contained 1431 bp encoding a putative protein with 476 amino acids,whereas the Hs HDR2 gene contained 1428 bp encoding a putative protein of 475 amino *** two proteins contained the conserved domain of 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase(PF02401),but without the transmembrane region and signal *** most abundant expression of Hs HDR1 and Hs HDR2 was detected in *** roots,followed by the stems and *** results provide a foundation for exploring the function of Hs HDR1 and Hs HDR2 in terpenoid and sterol biosynthesis in Huperziaceae plants.

关键词： 1-Hydroxy-2-methyl-2(E)-butenyl-4-diphosphate reductase Huperzia serrate Terpenoid Gene clone Bioinformatics analysis