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D2 Lymphadenectomy in Gastric Cancer Surgery

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Clinical oncology and cancer researeh 2009年第3期6卷 162-168页

作者： jingyu deng Han Liang Department of Gastric Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin Key Laboratory of Cancer Prevention and Therapy Tianjin 300060 China

Gastric cancer is one of the most common causesof cancer death worldwide. Surgery is the most widely utilizedtreatment for resectable gastric cancer. Evidence indicates thatlymph node involvement and depth of invasion of the primarytumor are the most important prognostic factors for gastriccancer patients. Therefore, lymph node clearance is deemed akey procedure in gastric cancer surgery for the prognostic valueto patients. Although the appropriate lymphadenectomy duringgastrectomy for cancer still remains controversial, extendedlymph node dissection (D2 lymphadenectomy) should berecommended in high volume hospitals.

关键词： gastric cancer lymphadenectomy lymph node metastasis prognosis.

Predictive values of multidetector-row computed tomography combined with serum tumor biomarkers in preoperative lymph node metastasis of gastric cancer

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Chinese Journal of Cancer Research 2019年第3期31卷 453-462页

作者： Huihui Bai jingyu deng Nannan Zhang Huifang Liu Wenting He Jinyuan Liu Han Liang Department of Gastric Cancer Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin’s Clinical Research Center for Cancer

Objective: Multidetector-row computed tomography(MDCT) and serum tumor biomarkers are commonly used to evaluate the preoperative lymph node metastasis and the clinical staging of gastric cancer(GC). This study intends to evaluate the clinical predictive value of MDCT and serum tumor biomarkers in lymph node metastasis of ***: The clinicopathologic data of 445 GC patients who underwent radical gastrectomy were retrospectively analyzed to evaluate the diagnostic value of MDCT and serum tumor biomarkers in lymph node metastatic staging of GC before ***: With the multinomial logistic regression analysis, the independent relative factors of lymph node metastasis of GC were identified as tumor size, depth of tumor invasion, vessel invasion, vascular embolus, and soft tissue invasion. The optimal critical value of the short diameter of lymph nodes detected by MDCT scanning for evaluation of preoperative lymph node metastasis was 6.0 mm, with 75.7% as predictive accuracy of lymph node metastasis compared to the postoperative pathological results of GC patients. In addition, the critical value of the short diameter of lymph nodes combined with serum tumor biomarkers [including carbohydrate antigen(CA)-724 and CA-199] could show an enhancement of predictive sensitivity of lymph node metastasis(up to 89.3%) before ***: MDCT combined with serum tumor biomarkers should be adopted to improve preoperative sensitivity and accuracy of lymph node metastasis for GC patients.

关键词： Gastric cancer MDCT serum tumor biomarkers preoperative

Validation of clinical significance of examined lymph node count for accurate prognostic evaluation of gastric cancer for the eighth edition of the American Joint Committee on Cancer(AJCC) TNM staging system

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Chinese Journal of Cancer Research 2018年第5期30卷 477-491页

作者： jingyu deng Jinyuan Liu Wei Wang Zhe Sun Zhenning Wang Zhiwei Zhou Huimian Xu Han Liang Department of Gastric Cancer Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center of Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Cancer for Cancer Department of Gastric and Pancreatic Surgery Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Surgical Oncology the First Affiliated Hospital of China Medical University

Objective： To validate the necessity of increasing the examined lymph node （ELN） count for enhancing the accuracy of prognostic evaluation of gastric cancer （GC） patients after curative gastrectomy in multiple medical centers of ***： The clinicopathological data of 7,620 patients who underwent the curative resection for GC between 2001 and 2011 were included to demonstrate whether the ELN count is indispensable for enhancing the accuracy of prognostic evaluation of GC patients after surgery. After a meticulous stratification by using the cut-point survival analysis, all included 7,620 patients were allocated into three groups as： less than 16 （〈16）, between 16 and 30 （16-30）, and more than 30 （〉30） ELNs. Survival differences among various subgroups of GC patients were analyzed to assess the impact of the ELN count on the stage migration in accordance with the overall survival （OS） of GC ***： Survival analyses revealed that the ELN count was positively correlated with the OS （P：0.001） and was an independent prognostic predictor （P〈0.01） of 7,620 GC patients. Stratum analysis showed that the accuracy of prognostic evaluation could be enhanced when the ELN count was no less than 16 （≥16） for node-negative patients and 〉30 for node-positive patients. Stage migrations were mainly detected in the various subgroups of patients with specific pN stages as follows： pN0 with 16-30 ELNs （pN016-30） and pN0 with 〉30 ELNs （pN0〉30）, pN0 with 〈16 ELNs （pN0〈16） and pNl〉30, pNl〈l6 and pN216_30, pNl：6_30 and pN2〉30, pN3a〈l6 and pN3b16-30, and pN3a〈16 and pN3 b〉30. These findings indicate that increasing the ELN count is a prerequisite to guarantee precisely prognostic evaluation of GC ***： The ELN count should be proposed to be 〉30 for acquiring the accurate prognostic evaluadort for GC patients, especially for node-positive patients.

关键词： Stomach neoplasm lymph node metastasis prognosis

基于网络药理学方法及分子对接技术探究清热祛湿汤治疗膝骨关节炎作用机制

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新中医 2024年第1期56卷 212-220页

作者：黄嘉煜刘渊伍明贵田凯平邓景宇农战广西中医药大学广西南宁530001

目的:采用网络药理学方法及分子对接技术研究清热祛湿汤治疗膝骨关节炎的作用机制。方法:通过中药系统药理学数据库与分析平台(TCMSP)数据库检索清热祛湿汤药物成分靶点;通过TTD、Genecards、OMIM数据库检索膝骨关节炎靶点;制作韦恩图... 详细信息

目的:采用网络药理学方法及分子对接技术研究清热祛湿汤治疗膝骨关节炎的作用机制。方法:通过中药系统药理学数据库与分析平台(TCMSP)数据库检索清热祛湿汤药物成分靶点;通过TTD、Genecards、OMIM数据库检索膝骨关节炎靶点;制作韦恩图获取药物-疾病交集靶点;通过Cytoscape3.9.0软件绘制药物有效成分-疾病-共同靶点网络图;利用String数据库构建蛋白相互作用(PPI)网络;使用R语言软件对交集靶点进行基因本体(GO)富集分析和京都基因与基因组百科全书(KEGG)富集分析;使用AutoDockTools1.5.6等软件对药物主要有效成分与疾病核心靶蛋白进行分子对接验证。结果:清热祛湿汤的有效成分为槲皮素、木犀草素等;PPI网络构建获得的核心靶蛋白是蛋白激酶B抗体(AKT1)、纤溶酶原激活物抑制物1(SERPINE1)等;GO富集分析获得1902条GO条目;KEGG富集分析获得105条信号通路;将5种药物有效成分与5种核心靶蛋白进行分子对接,均具有较好的结合活性。结论:清热祛湿汤治疗膝骨关节炎具有多成分、多靶点、多途径的特点,具体通过发挥调控炎症反应、软骨基质降解、软骨细胞的凋亡和增殖等作用,延缓膝骨关节炎的进展。

关键词：膝骨关节炎清热祛湿汤网络药理学分子对接作用靶点信号通路

Prognostic impact of D2-plus lymphadenectomy and optimal extent of lymphadenectomy in advanced gastric antral carcinoma: Propensity score matching analysis

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Chinese Journal of Cancer Research 2020年第1期32卷 51-61页

作者： Weilin Sun jingyu deng Nannan Zhang Huifang Liu Jinyuan Liu Pengfei Gu Yingxin Du Zizhen Wu Wenting He Pengliang Wang Han Liang Department of Gastrointestinal Cancer Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center of CancerKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China Affiliated Cancer Hospital&Institution of Guangzhou Medical University Guangzhou 510095China

Objective: To investigate the prognostic impact of D2-plus lymphadenectomy including the posterior(No. 8 p,No. 12 b/p, No. 13, and No. 14 v), and para-aortic(No. 16 a2, and No. 16 b1) lymph nodes(LNs) in subtotal gastrectomy for advanced gastric antral ***: A total of 203 patients with advanced gastric cancer(GC) located in the antrum, who underwent R0 gastrectomy with D2 or D2-plus lymphadenectomy between January 2003 and December 2011 were *** score matching was used to reduce the strength of the confounding factors to accurately evaluate prognoses. The therapeutic value index(TVI) was calculate to evaluate the survival benefit of dissecting each LN ***: Of 102 patients with D2-plus lymphadenectomy, 21(20.59%) were pathologically identified as having LN metastases beyond the extent of D2 lymphadenectomy. After matching, the overall survival(OS) was significantly better in the D2-plus than the D2 group(P=0.030). In the multivariate survival analysis, D2-plus lymphadenectomy(hazard ratio, 0.516;P=0.006) was confirmed to significantly improve the survival rate. In the logistic regression analysis, p N stage [odds ratio(OR), 2.533;95% confidence interval(95% CI), 1.368-4.691;P=0.003] and extent of LNs metastasis(OR, 5.965;95% CI, 1.335-26.650;P=0.019) were identified as independent risk factors for LN metastases beyond the extent of D2 lymphadenectomy. The TVI of patient with metastasis to LNs station was 7.1(No. 8p), 5.7(No. 12p), 5.1(No. 13), and 7.1(both No. 16a2 and No. 16b1), ***: D2-plus lymphadenectomy may improve the prognoses of some patients with advanced GC located in the antrum, especially for No. 8p, No. 12b, No. 13, and No. 16.

关键词： Stomach neoplasm lymphadenectomy prognosis metastasis

Numerical analysis on the transport properties and residence time distribution of ribbon biomass particles in a riser reactor based on CFD-DEM approach

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Particuology 2024年第4期87卷 133-146页

作者： Haichao Zhao Conghui Gu Bingyang Xu Yuan Liu Mingpu Du Kaiyuan deng jingyu Zhu Iana Voronina Zhulin Yuan School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang212100China China Tobacco Jiangxi Industrial Co.Ltd. Nanchang330096China Institute of Mechanics and Power Engineering Ogarev Mordovia State UniversitySaransk430005Russia Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing210096China

A bended ribbon biomass particle model was developed to explore the dynamic transport properties inside a riser *** time distribution(RTD)of the particles was analyzed by using the Eulerian-Lagrange *** effects of sampling height,particle density,particle size and gas-to-solid mass ratio on RTD were *** coupled Computational Fluid Dynamics and Discrete Element Method(CFD-DEM)model was verified firstly by experimental data on pressure drop and residence time distribution density *** simulation results demonstrated that the ribbon biomass particles display a typical annular-core spatial distribution during *** RTD of particles exhibit an approximate single-peaked normal *** mean residence time(MRT)can reach up to 0.7 s when the particle density is 1200 kg/m^(3).Particle with higher density has longer mean residence *** flow patterns are closer to plug flow if particle length over 12 *** particle flow pattern is not sensitive to changes in particle density and size,while the gas-to-material mass ratio has a significant impact on it.

关键词： Riser Gas-solids two-phase flow Ribbon biomass particles Residence time distribution CFD-DEM

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淋巴结转移在胃癌临床研究中的现况

中国肿瘤临床 2013年第22期40卷 1370-1372页

作者：邓靖宇天津医科大学肿瘤医院胃部肿瘤科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津市300060

淋巴结转移被认为是胃癌进展中重要的扩散方式和疾病阶段,准确的淋巴结转移分期有助于临床实施胃癌患者预后的评估和治疗策略的制定。对于临床胃癌治疗而言,淋巴结转移相关研究中存在很多疑问尚未能明确。本文通过近年来国内外该专业领... 详细信息

淋巴结转移被认为是胃癌进展中重要的扩散方式和疾病阶段,准确的淋巴结转移分期有助于临床实施胃癌患者预后的评估和治疗策略的制定。对于临床胃癌治疗而言,淋巴结转移相关研究中存在很多疑问尚未能明确。本文通过近年来国内外该专业领域研究结果总结分析,对现阶段胃癌淋巴结转移研究近况作一综述。

关键词：淋巴结胃癌转移

GRK2-YAP signaling is implicated in pulmonary arterial hypertension development

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Chinese Medical Journal 2024年第7期137卷 846-858页

作者： Peng Ye Yunfei deng Yue Gu Pengfei Liu Jie Luo Jiangqin Pu jingyu Chen Yu Huang Nanping Wang Yong Ji Shaoliang Chen Division of Cardiovascular Molecular Laboratory Third Clinical CollegeNanjing Medical UniversityNanjingJiangsu 210006China Division of Cardiovascular Laboratory Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Division of Cardiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200080China Division of Pulmonary Surgery Wuxi People’s HospitalNanjing Medical UniversityWuxiJiangsu 300247China Institute of Vascular Medicine The Chinese University of Hong KongHongkong 999077China Health Science Center East China Normal UniversityShanghai 200241China School of Pharmacy Nanjing Medical UniversityNanjingJiangsu 210004China Division of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China

Background:Pulmonary arterial hypertension(PAH)is characterized by excessive proliferation of small pulmonary arterial vascular smooth muscle cells(PASMCs),endothelial dysfunction,and extracellular matrix remodeling.G protein-coupled receptor kinase 2(GRK2)plays an important role in the maintenance of vascular tone and blood ***,the role of GRK2 in the pathogenesis of PAH is ***:GRK2 levels were detected in lung tissues from healthy people and PAH patients.C57BL/6 mice,vascular smooth muscle cell-specific Grk2-knockout mice(Grk2^(∆SM22)),and littermate controls(Grk2^(flox/flox))were grouped into control and hypoxia mice(n=8).Pulmonary hypertension(PH)was induced by exposure to chronic hypoxia(10%)combined with injection of the SU5416(cHx/SU).The expression levels of GRK2 and Yes-associated protein(YAP)in pulmonary arteries and PASMCs were detected by Western blotting and immunofluorescence *** mRNA expression levels of Grk2 and Yes-associated protein(YAP)in PASMCs were quantified with real-time polymerase chain reaction(RT-PCR).Wound-healing assay,3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT)assay,and 5-Ethynyl-2′-deoxyuridine(EdU)staining were performed to evaluate the proliferation and migration of ***,the interaction among proteins was detected by immunoprecipitation ***:The expression levels of GRK2 were upregulated in the pulmonary arteries of patients with PAH and the lungs of PH ***,cHx/SU-induced PH was attenuated in Grk2^(∆SM22) mice compared with littermate *** amelioration of PH in Grk2^(∆SM22) mice was accompanied by reduced pulmonary vascular *** vitro study further confirmed that GRK2 knock-down significantly altered hypoxia-induced PASMCs proliferation and migration,whereas this effect was severely intensified by overexpression of *** also identified that GRK2 promoted YAP expression and nuclear translocation in PASMCs,resulting in excessive PA

关键词： Pulmonary arterial hypertension GRK2 YAP Pulmonary artery smooth muscle cell Hypoxia

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再谈淋巴结转移对胃癌预后评估的意义

中华胃肠外科杂志 2016年第2期19卷 157-164页

作者：邓靖宇梁寒天津医科大学肿瘤医院胃部肿瘤科国家肿瘤临床研究中心天津市肿瘤防治重点实验室 300060

淋巴结转移是胃癌疾病进展中最重要的事件之一，不仅能够反映疾病的近况，也有助于对患者预后作出准确的评估。尽管对于淋巴结转移的机制尚未完全明确，但已知其发生与肿瘤细胞的生物学特性改变为主的一系列事件明显相关，包括细胞增殖... 详细信息

淋巴结转移是胃癌疾病进展中最重要的事件之一，不仅能够反映疾病的近况，也有助于对患者预后作出准确的评估。尽管对于淋巴结转移的机制尚未完全明确，但已知其发生与肿瘤细胞的生物学特性改变为主的一系列事件明显相关，包括细胞增殖、侵袭、趋化运动以及淋巴引流途径的改变。在临床工作中，对淋巴结转移状态的准确评估能够明显影响胃癌的治疗选择和预后评估。淋巴结转移状态的准确评估方式一直存有争议，淋巴结转移数目被认为是目前评估胃癌预后最佳的指标，尽管淋巴结转移范围对于决定胃癌根治性术式的选择仍具有重要意义。微转移、孤立肿瘤细胞转移、跳跃性转移等特殊类型的淋巴结转移对于胃癌预后的影响仍有争议，但随着对这些转移机制研究的深入，将会证实其在临床中的应用价值。

关键词：胃肿瘤淋巴结转移预后