检索结果-南通市图书馆

Flexible incidence angle scanning surface plasmon resonance microscopy for morphology detection with enhanced contrast

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photonics Research 2024年第6期12卷 1213-1221页

作者： LINGKE WANG jingyu MI SHUQI WANG WENRUI LI JU TANG JIAWEI zhang JIWEI zhang JIANLIN ZHAO Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi’an 710129China

Surface plasmon resonance microscopy(SPRM)has been massively applied for near-field optical measurement,sensing,and imaging because of its high detection sensitivity,nondestructive,noninvasive,wide-field,and label-free imaging ***,the transverse propagation characteristic of the surface plasmon wave generated during surface plasmon resonance(SPR)leads to notable“tail”patterns in the SPR image,which severely deteriorates the image ***,we propose an incidence angle scanning method in SPRM to obtain a resonance angle image with exceptional contrast that significantly mitigates the adverse effects of“tail”*** resonance angle image provides the complete morphology of the analyzed samples and enables two-dimensional quantification,which is incapable in conventional *** effectiveness of the method was experimentally verified using photoresist square samples with different sizes and two-dimensional materials with various geometric *** edges of samples were fully reconstructed and a maximum fivefold increase in the image contrast has been *** method offers a convenient way to enhance the SPRM imaging capabilities with low cost and stable performance,which greatly expands the applications of SPRM in label-free detection,imaging,and quantification.

关键词： angle resonance surface

基于改进ISM和MICMAC方法集成的高铁行车事故因素分析

在线全文

学校读者我要写书评

暂无评论

综合运输 2024年第3期46卷 43-50页

作者：陈家旭张景昱刘佩颜珊珊王铭铭中国铁道科学研究院集团有限公司北京100081

为探究高铁行车事故致因因素之间关联关系及层级结构,针对高铁行车历史事故数据,结合决策实验室分析法(DEMATEL)改进解释结构模型(ISM),构建了高铁路行车事故致因多层递阶结构模型,并集成了交叉影响矩阵相乘分类法(MICMAC),深入研究高... 详细信息

为探究高铁行车事故致因因素之间关联关系及层级结构,针对高铁行车历史事故数据,结合决策实验室分析法(DEMATEL)改进解释结构模型(ISM),构建了高铁路行车事故致因多层递阶结构模型,并集成了交叉影响矩阵相乘分类法(MICMAC),深入研究高铁行车事故致因因素间的复杂关联关系以及对事故的影响程度。研究结果表明:18项高铁行车事故致因因素间存在明显的层级结构和关联关系,设备性能不良或故障、安全防护失效和异物侵限是高铁行车事故的直接影响因素,养护维修不到位、专业技能水平差以及应急处置失效等是中间因素,规章制度不完善、监督管理不严是行车事故发生的根本因素。针对不同致因因素采取多元化改进管控措施,从而在根源上预防和控制事故发生。

关键词：高铁行车事故致因因素解释结构模型交叉影响矩阵相乘分类法

Cobalt-Catalyzed Switchable[4+1]and[4+1+1]Spirocyclization of Aromatic Amides with 2-Diazo-1H-indene-1,3(2H)-dione:Access to Spiro Indene-2,1'-isoindolinones and Spiro Isochroman-3,1'-isoindolinones

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第4期42卷 363-369页

作者： Bin Li Mengmeng Xie jingyu Li Nana Shen Xinying zhang Xuesen Fan State Key Laboratory of Antiviral Drugs Pingyuan LaboratoryKey Laboratory of Green Chemical Media and ReactionsKey Laboratory for Yellow River and Huai River Water Environmental Pollution ControlMinistry of EducationSchool of EnvironmentSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan453007 China

Herein,we report a condition-controlled divergent synthesis of spiro indene-2,1'-isoindolinones and spiro isochroman-3,1'-isoindolinones through cobalt-catalyzed formal[4+1]and[4+1+1]spirocyclization of aromatic amides with 2-diazo-1H-indene-1,3(2H)-*** the reaction is carried out under air in ethyl acetate,spiro indene-2,1'-isoindolinones are formed through Co(II)-catalyzed C—H/N—H[4+1]*** the reaction is run under O2 in CH3CN,on the other hand,spiro isochroman-3,1'-isoindolinones are generated through Baeyer-Villiger oxidation of the in situ formed spiro indene-2,1'-isoindolinones with O2 as a cheaper and environmental-friendly oxygen *** general,these protocols have advantages such as using non-precious and earth-abundant metal catalyst,no extra additive,high efficiency and regioselectivity.A gram-scale synthesis and the removal of the directing group further highlight its utility.

关键词： Spiro indene-2,1'-isoindolinones Spiro isochroman-3,1'-isoindolinones 3d Transition metals Cobalt-catalyzed C-H Activation Switchable[4+1]and[4+1+1]spirocyclization Aromatic amides 2-Diazo-1H-indene-1,3(2H)-dione

Full sexual maturity-cycle exposure to environmentally relevant concentrations of 17β-estradiol decreases reproductive capacity of zebrafish

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第3期137卷 580-592页

作者： Yongkang zhang Yuanjun Jiang Qian Sun Meng Li Sheng Chen jingyu Liang Chunsheng Liu College of Fisheries Huazhong Agricultural UniversityWuhan 430070China School of Environmental Studies China University of GeosciencesWuhan 430074China

17β-Estradiol(E2)has been widely detected in natural water and treatment with E2 induces potential endocrine disrupting effects in ***,effects on fish fecundity and steroid system after treatment with environmentally relevant concentrations of E2 for the full sexual maturation cycle remain *** this study,zebrafish were treatment with 0,10 or100 ng/L E2 from embryo to adult stage,and effects on gonadal development and differentiation,steroid hormone levels,transcription of genes associated with the hypothalamic-pituitary-gonadal-liver(HPG)axis in adults and fertilization rate of offspring were *** results showed that treatment with E2 lead to increased number of feminization in *** females,E2 decreased cumulative amount of spawning and inhibited the maturation of *** males,E2 inhibited the maturation and motility of sperm,as well as decreased the movement speed of *** adverse effects on sperm might be responsible for the reduced fertilization observed in *** addition,treatment with E2 changed the levels of steroid hormones in zebrafish gonad and altered the transcriptional levels of genes associated with HPG axis,which is responsible for the regulation of germ cells maturation and gonadal development in ***,these results suggested that treatment with environmentally relevant concentrations of E2 for the full sexual maturity cycle resulted in adverse effects on reproduction in zebrafish.

关键词： Environmental estrogen Zebrafish Fecundity Gonadal development Endocrine disruption

Full-Stokes metasurface polarimetry requiring only a single measurement

在线全文

学校读者我要写书评

暂无评论

Photonics Research 2024年第3期12卷 514-521页

作者： CHENGLONG ZHENG HUI LI jingyu LIU MENGGUANG WANG HUAPING ZANG YAN zhang JIANQUAN YAO Key Laboratory of Material Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Key Laboratory of Opto-Electronics Information Technology(Tianjin University) Ministry of EducationSchool of Precision Instruments and Opto-Electronics EngineeringTianjin UniversityTianjin 300072China Beijing Key Laboratory for Metamaterials and Devices Key Laboratory of Terahertz OptoelectronicsMinistry of Educationand Beijing Advanced Innovation Center for Imaging TechnologyDepartment of PhysicsCapital Normal UniversityBeijing 100048China State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China

Polarization is crucial in various fields such as imaging,sensing,and substance detection.A compact,fast,and accurate polarization detection device is vital for these ***,we demonstrate a multifocus metalens for terahertz polarization detection that requires only a single measurement to obtain complete polarization parameters and reconstruct the polarization state of the incident *** individual subarrays of this metalens convert each of the six polarized components into the same polarization,which in turn links the Stokes parameters to these six *** incident linear polarizations and elliptical polarizations are characterized by Stokes parameters and polarization *** and experimental results show that the scheme can accurately detect the incident polarization with a single *** proposed metasurface polarimetry may find applications in the fields of real-time terahertz detection and integrated optics.

关键词： field incident polar

基于快速康复理念的线上线下整体优化干预在伴肌少症老年全髋关节置换术患者中的应用效果

在线全文

学校读者我要写书评

暂无评论

转化医学杂志 2024年第1期13卷 82-88页

作者：杜晓松周美王威孟小娜才达张净宇唐山市第二医院康复科河北唐山063000 唐山市第二医院骨病科河北唐山063000 唐山市第二医院创伤科河北唐山063000 唐山市第二医院创伤研究所河北唐山063000

目的探讨基于快速康复理念的线上线下整体优化干预在伴肌少症老年全髋关节置换术(THA)患者中的应用效果。方法选取2021年4月—2023年4月收治的104例伴肌少症老年THA,根据干预方法不同分为对照组、观察组,各52例。对照组予以常规围手术... 详细信息

目的探讨基于快速康复理念的线上线下整体优化干预在伴肌少症老年全髋关节置换术(THA)患者中的应用效果。方法选取2021年4月—2023年4月收治的104例伴肌少症老年THA,根据干预方法不同分为对照组、观察组,各52例。对照组予以常规围手术期干预,在此基础上,观察组予以基于快速康复理念的线上线下整体优化干预。对比2组住院情况、不良事件发生率、依从性、视觉模拟评分法(VAS)、简易躯体执行能力测试量表(SPPB)、髋关节伤残和骨关节炎问卷(HOOS)、Harris髋关节功能及Barthel指数评分。结果观察组首次下床时间、首次排便时间、住院时间均短于对照组(P<0.01);观察组术后3 d、术后7 d VAS评分均低于对照组(P<0.05);观察组不良事件总发生率3.85%(2/52)低于对照组17.31%(9/52)(P<0.05);观察组总依从度96.15%(50/52)高于对照组78.85%(41/52)(P<0.01);术后1个月、3个月观察组SPPB、HOOS及Harris、Barthel指数评分均较对照组高(P<0.05)。结论基于快速康复理念的线上线下整体优化干预应用于伴肌少症老年THA患者中,可降低患者术后疼痛感,减少不良事件,提升依从性,促进髋关节及躯体功能好转,有助于患者预后恢复。

关键词：关节成形术,置换,髋肌少症老年快速康复理念简易躯体执行能力测试量表髋关节伤残和骨关节炎问卷疼痛日常生活活动

以快速康复理念为指导的整体优化康复训练对老年肌少症全髋关节置换患者康复效果的影响

在线全文

学校读者我要写书评

暂无评论

临床误诊误治 2024年第7期37卷 48-53页

目的探讨以快速康复理念为指导的整体优化康复训练对老年肌少症全髋关节置换患者康复效果的影响。方法选取2020年4月—2023年4月收治的老年肌少症全髋关节置换患者126例,按照随机数字表法分为研究组和常规组各63例。常规组给予常规干预... 详细信息

目的探讨以快速康复理念为指导的整体优化康复训练对老年肌少症全髋关节置换患者康复效果的影响。方法选取2020年4月—2023年4月收治的老年肌少症全髋关节置换患者126例,按照随机数字表法分为研究组和常规组各63例。常规组给予常规干预,研究组在常规组基础上给予基于快速康复理念制订的整体优化康复训练。比较2组康复指标、肺活量、优势手握力、简易躯体能力测试(SPPB)、髋关节功能[Harris髋关节功能评分量表(Harris)]、负性情绪、自我管理能力、日常生活能力[日常生活能力量表(ADL)]及视觉模拟评分法(VAS)评分。结果研究组下床活动、进食、肛门排气、住院时间短于常规组(P<0.01)。研究组术后1、6个月后肺活量、优势手握力、SPPB评分、Harris评分、自我管理能力评分高于常规组,负性情绪、ADL评分低于常规组(P<0.05,P<0.01)。出院当天、术后1个月,研究组VAS评分[(2.03±0.31)、(0.75±0.21)分]均低于常规组[(3.14±0.35)、(1.26±0.39)分](P<0.05,P<0.01)。结论以快速康复理念为指导的整体优化康复训练可促进老年肌少症全髋关节置换患者病情康复,改善术后优势手握力、肺功能,调节患者情绪状态,促进患者躯体功能、髋关节功能恢复,并提升患者自我管理能力及日常生活能力。

关键词：肌少症关节成形术,置换,髋快速康复理念康复训练髋关节功能日常生活活动疼痛,手术后

血小板与淋巴细胞比值和乳酸脱氢酶与卡瑞利珠单抗治疗的晚期食管鳞癌患者预后的相关性研究

在线全文

学校读者我要写书评

暂无评论

中国临床实用医学 2024年第1期15卷 16-22页

作者：尚皓天王莉张建国杨永亮王秋露陈亚男张靖宇连云港市第二人民医院肿瘤科连云港222002

目的探究中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、全身免疫炎症指数(SII)、乳酸脱氢酶(LDH)指标与接受卡瑞利珠单抗免疫治疗的晚期食管鳞癌患者预后的相关性。方法本研究为回顾性队列研究,选取2020年7月至2022年6... 详细信息

目的探究中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、全身免疫炎症指数(SII)、乳酸脱氢酶(LDH)指标与接受卡瑞利珠单抗免疫治疗的晚期食管鳞癌患者预后的相关性。方法本研究为回顾性队列研究,选取2020年7月至2022年6月在连云港市第二人民医院肿瘤科收治的64例食管鳞癌患者,男12例,女52例,年龄68(63,74)岁,年龄范围为52~85岁。收集患者的一般资料和治疗前1周的外周血液指标,通过受试者操作特征曲线确定最佳截断值,采用Kaplan-Meier法进行生存分析,采用Cox比例风险模型对无进展生存期和总生存期分别进行单因素和多因素分析预后因素。结果NLR的曲线下面积为0.841,最佳截断值为4.6;PLR的曲线下面积为0.842,最佳截断值为194.5;SII的曲线下面积为0.792,最佳截断值是725.4;LDH的曲线下面积为0.731,最佳截断值为277.0 U/L。在Cox单因素分析中,LDH、NLR、SII与无进展生存期相关(P277.0 U/L有较长的无进展生存期,LDH≤277.0 U/L比LDH>277.0 U/L有较长的总生存期,PLR≤194.5比PLR>194.5有较长的总生存期。联合指标的曲线下面积(0.876)高于单一LDH曲线下面积(0.713)和单一PLR曲线下面积(0.842),表明LDH联合PLR的预测价值更高。结论LDH、PLR对晚期食管鳞癌患者接受卡瑞利珠单抗治疗预后有关,并且LDH联合PLR的预测价值高于单一指标,NLR、SII并未发现与预后有一定相关性。

关键词：预后晚期食管鳞癌卡瑞利珠单抗免疫治疗炎症指数血小板与淋巴细胞比值

在线全文

学校读者我要写书评

暂无评论

斑秃的氧化应激和潜在抗氧化疗法

皮肤科学通报 2024年第1期41卷 83-87页

作者：孙超宋冰张景瑜柴宝詹淑霞陈宏翔深圳市前海蛇口自贸区医院皮肤科(医学美容科) 广东深圳518000 中国科学院深圳先进技术研究院生物医学与健康工程研究所广东深圳518000 深圳大学附属第六医院广东深圳518052 华中科技大学协和深圳医院皮肤科广东深圳518052 华中科技大学同济医学院附属协和医院皮肤科湖北武汉430022

斑秃(alopecia areata,AA)是一种以非瘢痕性脱发为特征的自身免疫性皮肤病。尽管毛囊(HF)免疫豁免(IP)失效被认为是斑秃主要的驱动因素,但AA的确切发病机制仍不清楚。其他因素,如遗传倾向、过敏、微生物群和心理压力等,在AA的发生和发... 详细信息

斑秃(alopecia areata,AA)是一种以非瘢痕性脱发为特征的自身免疫性皮肤病。尽管毛囊(HF)免疫豁免(IP)失效被认为是斑秃主要的驱动因素,但AA的确切发病机制仍不清楚。其他因素,如遗传倾向、过敏、微生物群和心理压力等,在AA的发生和发展中也发挥着重要作用。氧化应激(oxidative stress,OS)是氧化和抗氧化防御系统之间的不平衡,在皮肤疾病中起着重要作用。本综述的目的是阐明OS在AA发病机制和诊断中的作用,并讨论相关生物标记物及潜在的抗氧化治疗方案。

关键词：斑秃氧化应激生物标志物自噬抗氧化