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Full sexual maturity-cycle exposure to environmentally relevant concentrations of 17β-estradiol decreases reproductive capacity of zebrafish

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Journal of Environmental Sciences 2024年第3期137卷 580-592页

作者： Yongkang Zhang Yuanjun Jiang qian Sun Meng Li Sheng Chen jingyu Liang Chunsheng Liu College of Fisheries Huazhong Agricultural UniversityWuhan 430070China School of Environmental Studies China University of GeosciencesWuhan 430074China

17β-Estradiol(E2)has been widely detected in natural water and treatment with E2 induces potential endocrine disrupting effects in fish.However,effects on fish fecundity and steroid system after treatment with environmentally relevant concentrations of E2 for the full sexual maturation cycle remain unclear.In this study,zebrafish were treatment with 0,10 or100 ng/L E2 from embryo to adult stage,and effects on gonadal development and differentiation,steroid hormone levels,transcription of genes associated with the hypothalamic-pituitary-gonadal-liver(HPG)axis in adults and fertilization rate of offspring were assessed.The results showed that treatment with E2 lead to increased number of feminization in zebrafish.In females,E2 decreased cumulative amount of spawning and inhibited the maturation of oocyte.In males,E2 inhibited the maturation and motility of sperm,as well as decreased the movement speed of sperm.These adverse effects on sperm might be responsible for the reduced fertilization observed in offspring.In addition,treatment with E2 changed the levels of steroid hormones in zebrafish gonad and altered the transcriptional levels of genes associated with HPG axis,which is responsible for the regulation of germ cells maturation and gonadal development in zebrafish.Overall,these results suggested that treatment with environmentally relevant concentrations of E2 for the full sexual maturity cycle resulted in adverse effects on reproduction in zebrafish.

关键词： Environmental estrogen Zebrafish Fecundity Gonadal development Endocrine disruption

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Wearable and interactive multicolored photochromic fiber display

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Light(Science & Applications) 2024年第3期13卷 454-465页

作者： Pan Li Yuwei Wang Xiaoxian He Yuyang Cui jingyu Ouyang Ju Ouyang Zicheng He Jiayu Hu Xiaojuan Liu Hang Wei Yu Wang Xiaoling Lu qian Ji Xinyuan Cai Li Liu Chong Hou Ning Zhou Shaowu Pan Xiangru Wang Huamin Zhou Cheng-Wei Qiu Yan-Qing Lu Guangming Tao State Key Laboratory of Material Processing and Die&Mould Technology School of Materials Science and Engineering and Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Vascular Aging(HUST) Ministry of EducationWuhan 430030China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore National Laboratory of Solid State Microstructures Key Laboratory of Intelligent Optical Sensing and ManipulationCollege of Engineering and Applied Sciencesand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China School of Performing Arts Wuhan Conservatory of MusicWuhan 430060China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Architecture and Urban Planning Huazhong University of Science and TechnologyWuhan 430074China School of Fashion Beijing Institute of Fashion TechnologyBeijing 100029China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Tongji Medical College Huazhong University of Science and TechnologyWuhan 430074China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China

Endowing flexible and adaptable fiber devices with light-emitting capabilities has the potential to revolutionize the current design philosophy of intelligent,wearable interactive devices.However,significant challenges remain in developing fiber devices when it comes to achieving uniform and customizable light effects while utilizing lightweight hardware.Here,we introduce a mass-produced,wearable,and interactive photochromic fiber that provides uniform multicolored light control.We designed independent waveguides inside the fiber to maintain total internal reflection of light as it traverses the fiber.The impact of excessive light leakage on the overall illuminance can be reduced by utilizing the saturable absorption effect of fluorescent materials to ensure light emission uniformity along the transmission direction.In addition,we coupled various fluorescent composite materials inside the fiber to achieve artificially controllable spectral radiation of multiple color systems in a single fiber.We prepared fibers on mass-produced kilometer-long using the thermal drawing method.The fibers can be directly integrated into daily wearable devices or clothing in various patterns and combined with other signal input components to control and display patterns as needed.This work provides a new perspective and inspiration to the existing field of fiber display interaction,paving the way for future human–machine integration.

关键词： fiber interactive colored

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冠状动脉扩张研究现状

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中国循环杂志 2024年第6期39卷 614-619页

作者：李东瑞金晶玉佟倩吉林大学第一医院心内科吉林130000

冠状动脉扩张现象通常是在冠状动脉造影过程中被偶然发现,其作为一种较为罕见的冠状动脉表型,引起了许多研究者的兴趣。目前尽管有较多关于冠状动脉扩张的研究,但对于其病因和治疗方案仍有较大的争议。本文总结了近年来的冠状动脉扩张... 详细信息

冠状动脉扩张现象通常是在冠状动脉造影过程中被偶然发现,其作为一种较为罕见的冠状动脉表型,引起了许多研究者的兴趣。目前尽管有较多关于冠状动脉扩张的研究,但对于其病因和治疗方案仍有较大的争议。本文总结了近年来的冠状动脉扩张相关研究,从多方面阐述了冠状动脉扩张的研究进展,以期为后续研究提供支持和帮助。

关键词：冠状动脉扩张冠心病经皮冠状动脉介入治疗心绞痛

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Enhanced CO catalytic oxidation by Sr reconstruction on the surface of LaxSr1-xCoO3-δ

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Science Bulletin 2017年第9期62卷 658-664页

作者： Xiyang Wang Keke Huang jingyu qian Yingge Cong Chengda Ge Shouhua Feng State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry filin University Changchun 130012 China State Key Laboratory of Supramolecular Structure and Materials College of Chemistry filin University Changchun 130012 China

Surface electronic structure of solid materials plays a critical role in heterogeneous catalysis. However,surface chemical composition of the perovskite oxides is usually dominated by segregated A-site cations and the amount of oxygen vacancies is relatively low, which seriously restricts their catalytic oxidation property. Here, we prepare perovskite La_xSr_(1-x)CoO_(3-δ)(x = 0.3, 0.5, 0.7) with different Sr doping amount and experiment results show that perovskite LSCO with higher content of surface Sr possesses more oxygen vacancies and better catalytic activity. On this basis, we develop a new experimental strategy to create more surface oxygen vacancies to promote their CO catalytic activity. In this method, we use high active hydrogen atoms(BH^(4-)) as reductant to realize surface in-situ chemical composite modification of La_xSr_(1-x)CoO_(3-δ)(x = 0.3, 0.5, 0.7), which causes their surface reconstruction(surface Sr enrichment).The regulation mainly focuses on the atomic layer level without damaging their bulk phase structure.Different from traditional high temperature annealing under reducing atmosphere, this method is high-efficiency, green and controllable. Furthermore, we study the surface reconstruction process and demonstrated that it is atomic layer engineering on the surface of La_xSr_(1-x)CoO_(3-δ)(x = 0.3, 0.5, 0.7) by X-ray photoelectron spectroscopy(XPS) and X-ray absorption fine structure(XAFS). Our experiment results also show that these samples treated by this method exhibit superior activity for CO oxidation compared with original samples.

关键词： Surface reconstruction KBH4 Perovskite oxides Oxygen vacancies CO oxidation

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基于细菌双组分系统的生物传感器的研究进展

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合成生物学 2024年第1期5卷 38-52页

作者：赵静宇张健祁庆生王倩山东大学国家糖工程技术研究中心微生物技术国家重点实验室山东青岛266237

细菌双组分系统能够感知和响应细胞内外的物理、化学和生物刺激,通过耦合传感和调节机制从而引起一系列的细胞反应,是一个普遍存在的信号转导通路家族。当前越来越多的合成生物学家已开始利用双组分系统的特异属性来工程化设计微生物传... 详细信息

细菌双组分系统能够感知和响应细胞内外的物理、化学和生物刺激,通过耦合传感和调节机制从而引起一系列的细胞反应,是一个普遍存在的信号转导通路家族。当前越来越多的合成生物学家已开始利用双组分系统的特异属性来工程化设计微生物传感系统,并应用于光遗传学、材料科学、肠道微生物组工程、生物炼制和土壤改良等领域。本综述重点介绍了开发基于双组分系统的生物传感器的最新研究进展以及在各个领域中的潜在应用。同时探讨了如何运用新的工程方法提高双组分系统传感器性能的可靠性,包括遗传重构、DNA结合结构域交换、检测阈值调节和磷酸化串扰隔离,以及如何根据特定应用的要求定制双组分系统信号特性。在未来,研究者可以将这些方法与大规模的基因合成、高通量筛选相结合,以加速和帮助发现更多未确定特征输入的双组分系统,并开发新的对广泛的刺激做出反应的基因编码生物传感器,拓展双组分生物传感器在不同领域的应用。

关键词：合成生物学双组分系统细胞生物传感器代谢工程光遗传学细菌诊断

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Surface doping manipulation of the insulating ground states in Ta_(2)Pd_(3)Te_(5) and Ta_(2)Ni_(3)Te_(5)

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Chinese Physics B 2024年第6期33卷 88-93页

作者：江北姚静宇闫大禹郭照芃屈歌星邓修同黄耀波丁洪石友国王志俊钱天 Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Tsung-Dao Lee Institute New Cornerstone Science Laboratoryand School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 201210China Hefei National Laboratory Hefei 230088China

Manipulating emergent quantum phenomena is a key issue for understanding the underlying physics and contributing to possible applications.Here we study the evolution of insulating ground states of Ta_(2)Pu_(3)Te_(5) and Ta_(2)Ni_(3)Te_(5) under in-situ surface potassium deposition via angle-resolved photoemission spectroscopy.Our results confirm the excitonic insulator character of Ta_(2)d_(3)Te_(5).Upon surface doping,the size of its global gap decreases obviously.After a deposition time of more than 7 min,the potassium atoms induce a metal-insulator phase transition and make the system recover to a normal state.In contrast,our results show that the isostructural compound Ta_(2)Ni_(3)Te_(5) is a conventional insulator.The size of its global gap decreases upon surface doping,but persists positive throughout the doping process.Our results not only confirm the excitonic origin of the band gap in Ta_(2)Pd_(3)Te_(5),but also offer an effective method for designing functional quantum devices in the future.

关键词： excitonic insulator metal–insulator phase transition surface doping angle-resolved photoemission spectroscopy

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A cyanostilbene-based molecule with aggregation-induced emission properties: amplified spontaneous emission, protonation effect and electroluminescence

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Science China Chemistry 2019年第2期62卷 212-219页

作者： Yujie Dong Suqian Ma Xiaoyu Zhang jingyu qian Nianyong Zhu Bin Xu Cheuk-Lam Ho Wenjing Tian Wai-Yeung Wong Institute of Molecular Functional Materials and Department of Chemistry Hong Kong Baptist University State Key Laboratory Breeding Base of Green Chemistry Synthesis Technology College of Chemical Engineering Zhejiang University of Technology State Key Laboratory of Supramolecular Structure and Materials Jilin University Department of Applied Biology & Chemical Technology The Hong Kong Polytechnic University

A terpyridine-substituted cyanostilbene derivative(Z)-2-(4′-([2,2′:6′,2″-terpyridin]-4′-yl)-[1,1′-biphenyl]-4-yl)-3-phenylacrylonitrile(CNSTPy) was synthesized and characterized. The compound exhibits remarkable aggregation-induced emission phenomenon and its single crystal shows a blue emission with fluorescent efficiency as high as 45%. Based on its aggregation state behavior, multiple applications towards exploring its lasing, fluorescence switching and electroluminescence properties were realized. Amplified spontaneous emission(ASE) was observed from the crystal and verified by the variable pump strip method, with a threshold value of ～1.5 m J cm^(-2). The protonation/deprotonation processes accompanied by the formation of different molecular aggregation structure result in the distinct blue and yellow emissions. Additionally, the molecule also shows a moderate electroluminescence performance.

关键词： aggregation-induced emission cyanostilbene amplified spontaneous emission protonation effect

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三聚氰胺聚磷酸盐/焦磷酸哌嗪协同阻燃热塑性动态硫化橡胶

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塑料工业 2024年第3期52卷 124-129,137页

作者：宫芳芳陶雪王靖宇刘秀钱立军北京工商大学化学与材料工程学院北京100048 中国轻工业先进阻燃剂工程技术研究中心北京100048 石油和化工行业高分子材料无卤阻燃剂工程实验室北京100048 中核战略规划研究总院北京100048

研究了三聚氰胺聚磷酸盐/焦磷酸哌嗪(MPP/PAPP)膨胀体系影响热塑性动态硫化橡胶(TPV)阻燃和力学性能的量效关系,揭示了MPP/PAPP的协同阻燃和增强增韧作用。结果表明,总添加质量分数恒定为30%,MPP/PAPP以质量比3∶7共混TPV时,MPP和PAPP... 详细信息

研究了三聚氰胺聚磷酸盐/焦磷酸哌嗪(MPP/PAPP)膨胀体系影响热塑性动态硫化橡胶(TPV)阻燃和力学性能的量效关系,揭示了MPP/PAPP的协同阻燃和增强增韧作用。结果表明,总添加质量分数恒定为30%,MPP/PAPP以质量比3∶7共混TPV时,MPP和PAPP的协同阻燃作用最佳。相比于单独添加MPP或者PAPP,9MPP/21PAPP/TPV复合材料拥有更高的极限氧指数(25.7%)、垂直燃烧级别(V-0)和最低的热释放速率峰值(149.9 kW/m^(2))。热重分析表明,9MPP/21PAPP/TPV样品中,MPP/PAPP间的协同作用能够大幅降低TPV基体在高温阶段的降解速率,提升残炭率,表现出优异的协同阻燃作用。在拉伸性能测试中,MPP/PAPP复配使用时,9MPP/21PAPP/TPV的拉伸强度和断裂伸长率均高于对照样品30MPP/TPV和30PAPP/TPV。

关键词：热塑性动态硫化橡胶三聚氰胺聚磷酸盐焦磷酸哌嗪协同阻燃拉伸性能

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宏基因组二代测序在实体器官移植感染防控中的应用

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器官移植 2024年第2期15卷 289-296页

作者：满霖李小杉王文静钱婷熊敏杨航陈静瑜吴波南京医科大学无锡医学中心无锡市人民医院南京医科大学附属无锡人民医院肺移植中心江苏无锡214023 南通大学附属江阴医院重症医学科

器官移植已成为多种终末期疾病的有效治疗手段,但器官移植受者术后需长期服用免疫抑制药,导致免疫功能低下,使得细菌、病毒和真菌感染的发生率相对较高。以病原学培养、免疫学检测和聚合酶链反应为代表的传统微生物检测方法被广泛用于... 详细信息

器官移植已成为多种终末期疾病的有效治疗手段,但器官移植受者术后需长期服用免疫抑制药,导致免疫功能低下,使得细菌、病毒和真菌感染的发生率相对较高。以病原学培养、免疫学检测和聚合酶链反应为代表的传统微生物检测方法被广泛用于感染检测,但存在耗时长、需预先假定病原体等问题。宏基因组二代测序由于具有病原体检出率高、对病原谱检测全面的优点,近年来被广泛应用于器官移植领域的感染防控。本文就宏基因组二代测序技术在实体器官移植感染防控上的应用现状进行综述,以期对移植相关感染的诊断和治疗提供参考。

关键词：器官移植宏基因组二代测序免疫抑制肺部感染供者来源性感染感染防控病原学检测聚合酶链反应(PCR)

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基于液相色谱-质谱的视神经炎患者血清代谢组学初步分析

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中华检验医学杂志 2024年第2期47卷 147-151页

作者：罗保斌钱婧雨崔世磊何小魁张晓红刘向祎首都医科大学附属北京同仁医院检验科北京100730 首都医科大学附属北京同仁医院神经内科北京100730

目的分析视神经炎患者血清特征性代谢物。方法病例对照研究。收集2021年1月至2022年1月北京同仁医院神经内科确诊的视神经炎患者血清样本,同时收集性别、年龄匹配的健康体检者血清样本作为对照组。其中,视神经炎组9例,女性5例,男性4例,... 详细信息

目的分析视神经炎患者血清特征性代谢物。方法病例对照研究。收集2021年1月至2022年1月北京同仁医院神经内科确诊的视神经炎患者血清样本,同时收集性别、年龄匹配的健康体检者血清样本作为对照组。其中,视神经炎组9例,女性5例,男性4例,年龄(35.8±12.9)岁,对照组9例,女性5例,男性4例,年龄(32.6±8.6)岁。采用液相色谱质谱技术分析视神经炎患者、健康人群血清中的代谢物。选择主成分分析(PCA)及正交偏最小二乘法分析(OPLS-DA)的多元统计分析方法,采用OPLS-DA模型的变量投影重要性(VIP)值并结合t检验的P值筛选差异代谢物。结果鉴定出37种特征代谢物,VIP>1且P<0.05的差异代谢物共有4种,3种为磷脂类物质,分别为LysoPC(P-16∶0)、LysoPC(16∶0)、LysoPC(P-18∶0),1种为苏氨酸,4种代谢物含量均下调,4种代谢物受试者工作曲线下面积分别为0.951、0.889、0.963和0.944。结论基于代谢组学分析,视神经炎患者血清中的一些代谢物发生了变化,可为视神经炎血清标志物的筛选提供实验基础。

关键词：视神经炎代谢生物标志物液质色谱-质谱法

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