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Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)

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Signal Transduction and Targeted Therapy 2024年第2期9卷 766-781页

作者： Lei Zhang Jiabing Chen Xiaoying Yang Chuangpeng Shen Jiawen Huang Dong Zhang Naihua Liu Chaonan Liu Yadi Zhong Yingjian Chen Kaijia Tang jingyi guo Tianqi Cui Siwei Duan Jiayu Li Shangyi Huang Huafeng Pan Huabing Zhang Xiaoqiang Tang Yongsheng Chang Yong Gao State Key Laboratory of Traditional Chinese Medicine Syndrome Science and Technology Innovation CenterGuangzhou University of Chinese MedicineGuangzhouChina Key Laboratory of Immune Microenvironment and Disease(Ministry of Education) Tianjin Key Laboratory of Cellular Homeostasis and DiseaseDepartment of Physiology and PathophysiologyTianjin Medical UniversityTianjinChina Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogen Biology and ImmunologyJiangsu International Laboratory of Immunity and MetabolismXuzhou Medical UniversityXuzhouChina Department of Endocrinology The First Clinical CollegeGuangzhou University of Chinese MedicineGuangdongChina The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine ShenzhenChina Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor Nanjing University of Chinese MedicineNanjingChina Department of Biochemistry and Molecular Biology Metabolic Disease Research CenterSchool of Basic MedicineAnhui Medical UniversityHefeiChina Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengduChina

A lasting imbalance between fatty acid synthesis and consumption leads to non-alcoholic fatty liver disease(NAFLD),coupled with hepatitis and insulin resistance.Yet the details of the underlying mechanisms are not fully understood.Here,we unraveled that the expression of the transcription factor Zbtb18 is markedly decreased in the livers of both patients and murine models of NAFLD.Hepatic Zbtb18 knockout promoted NAFLD features like impaired energy expenditure and fatty acid oxidation(FAO),and induced insulin resistance.Conversely,hepatic Zbtb18 overexpression alleviated hepato-steatosis,insulin resistance,and hyperglycemia in mice fed on a high-fat diet(HFD)or in diabetic mice.Notably,in vitro and in vivo mechanistic studies revealed that Zbtb18 transcriptional activation of Farnesoid X receptor(FXR)mediated FAO and Clathrin Heavy Chain(CLTC)protein hinders NLRP3 inflammasome activity.This key mechanism by which hepatocyte’s Zbtb18 expression alleviates NAFLD and consequent liver fibrosis was further verified by FXR’s deletion and forced expression in mice and cultured mouse primary hepatocytes(MPHs).Moreover,CLTC deletion significantly abrogated the hepatic Zbtb18 overexpression-driven inhibition of NLRP3 inflammasome activity in macrophages.Altogether,Zbtb18 transcriptionally activates the FXR-mediated FAO and CLTC expression,which inhibits NLRP3 inflammasome’s activity alleviating inflammatory stress and insulin resistance,representing an attractive remedy for hepatic steatosis and fibrosis.

关键词： hepatic Hepatic impaired

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Seismic performance evaluation of water supply pipes installed in a full-scale RC frame structure based on a shaking table test

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 163-178页

作者： Wu Houli guo Endong Wang jingyi Dai Xin Dai Chenxi Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin 150080China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementHarbin 150080China

As an important part of nonstructural components,the seismic response of indoor water supply pipes deserves much attention.This paper presents shaking table test research on water supply pipes installed in a full-scale reinforced concrete(RC)frame structure.Different material pipes and different methods for penetrating the reinforced concrete floors are combined to evaluate the difference in seismic performance.Floor response spectra and pipe acceleration amplification factors based on test data are discussed and compared with code provisions.A seismic fragility study of displacement demand is conducted based on numerical simulation.The acceleration response and displacement response of different combinations are compared.The results show that the combination of different pipe materials and different passing-through methods can cause obvious differences in the seismic response of indoor riser pipes.

关键词： water supply pipe different materials shaking table test amplification factor seismic fragility

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Simultaneous enhanced ammonia and nitrate removal from secondary effluent in constructed wetlands using a new manganese-containing substrate

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 91-102页

作者： Zhihao Xian Jun Yan jingyi Dai Hao Wu Xin Zhang Wenbo Nie Fucheng guo Yi Chen Key Laboratory of the Three Gorges Reservoir Region’s Eco-Environment(Ministry of Education) Chongqing UniversityChongqing 400044China College of Environment and Ecology Chongqing UniversityChongqing 400044China

Constructed wetlands(CWs)are widely used to treat secondary effluent.However,simultaneously removing ammonia(NH_(4)^(+)-N)and nitrate(NO_(3)^(–)–N)is challenging because of insufficient oxygen and carbon sources.In this study,a novel composite material(MPCM)comprising MnO2 and polycaprolactone was developed as a substrate for CWs to enhance the synchronous removal of NH_(4)^(+)–N and NO_(3)^(–)–N.The CWs with a higher MPCM content(H-CW),lower MPCM content(LCW),and controlled CW(C-CW)exhibited average NH_(4)^(+)–N removal efficiencies of 75.69%,70.49%,and 52.40%,respectively.The 15N isotope tracking technique showed that NH_(4)^(+)–N removal was attributed to anaerobic ammonia oxidation mediated by MnO2 reduction(Mnammox),which accounted for 17.16%–27.24%of the NH_(4)^(+)–N removal in the composite material layers(0–20 cm)of the H-CW and L-CW.The richness of ammonia oxidizers in the upper layers(40–50 cm)of the HCW and L-CW further facilitated NH_(4)^(+)–N removal.Moreover,the average total nitrogen(TN)removal efficiencies of the H-CW and L-CW were 1.99 and 1.59 times that of C-CW,respectively,owing to enhanced denitrification by MPCM.Furthermore,N2O emissions were reduced by 81.31%and 70.83%in the H-CW and L-CW,respectively.This study provides an effective approach for improving nitrogen removal and reducing N2O emissions during the treatment of secondary effluent by CWs.

关键词： Constructed wetland Nitrogen removal Manganese redox Polycaprolactone Nitrous oxide

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Large-scale spatial data visualization method based on augmented reality

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虚拟现实与智能硬件（中英文） 2024年第2期6卷 132-147页

作者： Xiaoning QIAO Wenming XIE Xiaodong PENG Guangyun LI Dalin LI Yingyi guo jingyi REN Key Laboratory of Electronics and Information Technology for Space Systems National Space Science CenterChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Ordnance Science and Research Academy of China Beijing 100089China

Background A task assigned to space exploration satellites involves detecting the physical environment within a certain space.However,space detection data are complex and abstract.These data are not conducive for researchers'visual perceptions of the evolution and interaction of events in the space environment.Methods A time-series dynamic data sampling method for large-scale space was proposed for sample detection data in space and time,and the corresponding relationships between data location features and other attribute features were established.A tone-mapping method based on statistical histogram equalization was proposed and applied to the final attribute feature data.The visualization process is optimized for rendering by merging materials,reducing the number of patches,and performing other operations.Results The results of sampling,feature extraction,and uniform visualization of the detection data of complex types,long duration spans,and uneven spatial distributions were obtained.The real-time visualization of large-scale spatial structures using augmented reality devices,particularly low-performance devices,was also investigated.Conclusions The proposed visualization system can reconstruct the three-dimensional structure of a large-scale space,express the structure and changes in the spatial environment using augmented reality,and assist in intuitively discovering spatial environmental events and evolutionary rules.

关键词： Large-scale spatial data analysis Visual analysis technology Augmented reality 3D reconstruction Space environment

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Metabolic profiles and morphological characteristics of leaf tips among different sweet potato(Ipomoea batatas Lam.)varieties

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Journal of Integrative Agriculture 2024年第2期23卷 494-510页

作者： Wenqing Tan Xinbo guo Zhangying Wang Rong Zhang Chaochen Tang Bingzhi Jiang Ruixue Jia Yuanyuan Deng Shaohai Yang jingyi Chen Crops Research Institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Crop Genetic Improvement of Guangdong ProvinceGuangzhou 510640China School of Food Science and Engineering South China University of TechnologyGuangzhou 510640China Sericultural&Agri-Food Research Institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional FoodsMinistry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products ProcessingGuangzhou 510610China

Sweet potato leaf tips have high nutritional value,and exploring the differences in the metabolic profiles of leaf tips among different sweet potato varieties can provide information to improve their qualities.In this study,a UPLC-Q-Exactive Orbitrap/MS-based untargeted metabolomics method was used to evaluate the metabolites in leaf tips of 32 sweet potato varieties.Three varieties with distinct overall metabolic profiles(A01,A02,and A03),two varieties with distinct profiles of phenolic acids(A20 and A18),and three varieties with distinct profiles of flavonoids(A05,A12,and A16)were identified.In addition,a total of 163 and 29 differentially expressed metabolites correlated with the color and leaf shape of sweet potato leaf tips,respectively,were identified through morphological characterization.Group comparison analysis of the phenotypic traits and a metabolite-phenotypic trait correlation analysis indicated that the color differences of sweet potato leaf tips were markedly associated with flavonoids.Also,the level of polyphenols was correlated with the leaf shape of sweet potato leaf tips,with lobed leaf types having higher levels of polyphenols than the entire leaf types.The findings on the metabolic profiles and differentially expressed metabolites associated with the morphology of sweet potato leaf tips can provide useful information for breeding sweet potato varieties with higher nutritional value.

关键词： sweet potato leaf tips phenotypic traits metabolic profile differentially expressed metabolites polyphenols

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Multi-phase separation in mitochondrial nucleoids and eukaryotic nuclei

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Biophysics Reports 2023年第3期9卷 113-119页

作者： Qi Long Yanshuang Zhou jingyi guo Hao Wu Xingguo Liu CAS Key Laboratory of Regenerative Biology Joint School of Life Sciences The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan People's Hospital Guangzhou Medical University Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine China-New Zealand Joint Laboratory on Biomedicine and Health CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine Institute for Stem Cell and Regeneration Institute for Stem Cell and Regeneration Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Centre for Regenerative Medicine and Health Hong Kong Institute of Science & Innovation Chinese Academy of Sciences

In mammalian cells, besides nuclei, mitochondria are the only semi-autonomous organelles possessing own DNA organized in the form of nucleoids. While eukaryotic nuclear DNA compaction, chromatin compartmentalization and transcription are regulated by phase separation, our recent work proposed a model of mitochondrial nucleoid self-assembly and transcriptional regulation by multi-phase separation. Herein, we summarized the phase separation both in the nucleus and mitochondrial nucleoids,and did a comparison of the organization and activity regulating, which would provide new insight into the understanding of both architecture and genetics of nucleus and mitochondrial nucleoids.

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Innovations in metallurgical and materials processes:advancing liquid theory and honoring Prof.Han-jie guo's contributions to physical chemistry in metallurgy

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Journal of Iron and Steel Research(International) 2024年第1期31卷 1-2页

作者： Shuai Liu Jing guo Han-jie guo School of Artificial Intelligence Beijing Technology and Business UniversityBeijing100048China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China

Spanning three decades,Prof.Han-jie guo's research group has dedicated itself to exploring the fundamental theories and practical applications of physical chemistry within the realm of metallurgy.Operating under the a... 详细信息

关键词： chemistry liquid complexes

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Fucoxanthin improves serum lipids， liver metabolism and gut microbiota in hyperlipidemia mice

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Food Science and Human Wellness 2024年

作者： Yonghui Zhou jingyi Zhang Kun Xu Weihao Zhang Feng Chen Bin Liu Bingbing guo Faculty of Environment and Life Beijing University & Technology Shenzhen Key Laboratory of Marine Microbiome Engineering Institute for Carbon Neutrality Institute for Advanced Study Shenzhen University

Fucoxanthin， a kind of exclusively algae-derived carotenoids， could reduce lipid content and regulate gut microbiota composition in obese mice， showing potential in preventing hyperlipidemia. This study aimed to illustrate fucoxanthin efficacy in modulating lipid metabolism in serum and liver of high-fat-induced hyperlipidemia mice， as well as investigate the underlying association with gut microbiota changes. Results showed that fucoxanthin significantly reduced body weight gain and body white fat of the mice. In the serum， total triglycerides (TG)， total cholesterol (TC) contents were significantly decreased and high-density-lipoprotein cholesterol levels was significantly upregulated. Moreover， fucoxanthin remarkedly prevented lipid accumulation in the liver. Especially， metabolomics results showed that lipids and lipid-like molecules were significantly downregulated compared with the control， indicating the advance of hepatic lipid metabolism. Bile acids profile in the liver was also greatly changed by fucoxanthin. Meanwhile， fucoxanthin remodeled gut microbiota composition and promoted the relative abundance of Desulfovibrio， Blautia and Clostridia genera. Finally， correlation analysis revealed that these gut microbiota changes were closely related with hepatic metabolites/metabolism and serum lipids. Altogether， this study showed great potential of fucoxanthin in improving serum lipids profile， hepatic lipids and bile acids metabolism of hyperlipidemia mice， which was associated with gut microbiota alteration.

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Light People:Prof.Eric Mazur speaks about ultrafast optics and education

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Light(Science & Applications) 2024年第3期13卷 402-406页

作者： Chenzi guo Yang Li Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina State Key Laboratory of Precision Measurement Technology and Instrument Department of Precision InstrumentTsinghua UniversityBeijingChina

Prof.Eric Mazur is a great influencer over and beyond the optics community.As a physicist,he is a pioneer of ultrafast optics and was one of the inventors of colliding-pulse mode-locked laser.As an educator,he not only gave talks to thousands,but also revolutionized teaching with his globally renowned methodology“Peer Instruction”.As a leader and entrepreneur,he co-founded several companies and was President of Optica(formerly the Optical Society)and currently is the Chair of the Optica Foundation.Here,Light:Science&Applications talked with Prof.Eric Mazur about his opinions on research,education and industry.The full interview video can be found in the Supplementary File.

关键词： optics education companies

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Emerging direct current triboelectric nanogenerator for high-entropy mechanical energy harvesting

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Science China(Technological Sciences) 2024年第5期67卷 1297-1316页

作者： CHEN Jie guo RuiLong guo HengYu College of Physics and Electronic Engineering Chongqing Normal UniversityChongqing 401331China Department of Applied Physics Chongqing UniversityChongqing 401331China

In the era of the Internet of Things(IoT),the provision of sustainable power to distributed,mobile,and low-power-consumption electronic devices is a critical challenge.To overcome this challenge,the triboelectric nanogenerator(TENG),a highly efficient high-entropy mechanical energy harvesting device,was developed in 2012.This device enables the direct conversion of irregular and low-frequency mechanical energy into pulsed alternating current(AC)signals.However,the incompatibility of most electronic devices with AC signals necessitates rectifier circuits or generators that deliver direct current(DC)signals.In recent years,DC-TENGs have undergone extensive development,achieving significant milestones in various application fields while also facing crucial challenges that require solutions.In this review,three categories of DC-TENG devices with distinct operating mechanisms are comprehensively explored:multiphase coupling,mechanical rectification,and air breakdown.Their typical structures and working mechanisms are thoroughly discussed,and specific output performance limitations,along with corresponding optimization strategies,are identified.Furthermore,the applications of DC-TENGs in various scenarios are summarized.Finally,the challenges faced by DC-TENGs and potential solutions are analyzed to guide further advancements in this technology.

关键词： TENG direct current working mechanisms output performance limitations optimization strategies

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