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Improving Global Information System for Pandemic Response

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China Today 2020年第7期69卷 38-39页

作者： zhang jingwen the Northwestern Polytechnic University

CHINA’S State Council Information Office released a white paper titled“Fighting COVID-19:China in Action”in early *** white paper chronicles China’s all-hands-on-deck response to the public health emergency,showing what makes a responsible major country in the face of a *** country deserves credit for its efficiency in messaging the epidemic dynamics to its people as well as its timeliness and transparency in terms of information sharing with the international community because what it has done greatly helped both the domestic and global fights against the virus.

关键词： transparency white Global

Design,Synthesis and Biological Activities of Quinazoline Containing Sorafenib Analogs as Antitumor Agents

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Wuhan University Journal of Natural Sciences 2017年第3期22卷 239-246页

作者： zhang jingwen WANG Ningning XIE Xiaoxia YAN Chunhong FU Fenghua YAO Jianwen WANG Hongbo School of Pharmacy Yantai University Yantai 264005Shandong China GRU Cancer Center Georgia Regents University AugustaGA 30912 USA

A series of novel sorafenib derivatives containing quinazoline moiety were designed and synthesized. Their anti-proliferative activities against HCT116 and HCT115 cell lines were evaluated using MTT assay. Most of the synthesized compounds showed significant cytotoxicity against the selected cell lines. These cytotoxicities were consistent with their inhibitory activity against the phosphorylation of c-Raf, MEK1/2 and ERK1/2. Compound GD-09 also showed much stronger anti-tumor activity than that of sorafenib in vivo by B16 melanoma xenograft model test.

关键词： sorafenib analogs synthesis quinazoline antitumor agents

Mechanism　for　Phase　Conjugation　Reflections　of　Two　Mutually　Coherent　Beams　from　Potassium　Sodium　Strontium　Barium　Niobate

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Chinese Journal of Lasers 1996年第6期B5卷 526-534页

作者： zhang Liangmin zhang jingwen SHAO Zongshu MU Xiaodong CHEN Huanchu JIANG Minhua (National Laboratory of Crystal Materials, Shandong University, Jinan 250100, China) Shandong Univ Jinan China

ＭｅｃｈａｎｉｓｍｆｏｒＰｈａｓｅＣｏｎｊｕｇａｔｉｏｎＲｅｆｌｅｃｔｉｏｎｓｏｆＴｗｏＭｕｔｕａｌｌｙＣｏｈｅｒｅｎｔＢｅａｍｓｆｒｏｍＰｏｔａｓｓｉｕｍＳｏｄｉｕｍＳｔｒｏｎｔｉｕｍＢａｒｉｕｍＮｉｏｂａｔｅ￥Ｚ... 详细信息

ＭｅｃｈａｎｉｓｍｆｏｒＰｈａｓｅＣｏｎｊｕｇａｔｉｏｎＲｅｆｌｅｃｔｉｏｎｓｏｆＴｗｏＭｕｔｕａｌｌｙＣｏｈｅｒｅｎｔＢｅａｍｓｆｒｏｍＰｏｔａｓｓｉｕｍＳｏｄｉｕｍＳｔｒｏｎｔｉｕｍＢａｒｉｕｍＮｉｏｂａｔｅ￥ＺＨＡＮＧＬｉａｎｇｍｉｎ；ＺＨＡＮ...

关键词： photorefractive phase conjugation mutually pumped phase conjugntor

Restoring cellular calcium homeostasis to rescue ER stress by 1,2-bis(2-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid acetoxymethyl ester-loaded lipid-mPLGA hybrid-nanoparticles for acute kidney injury therapy

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Chinese Chemical Letters 2024年第3期35卷 337-345页

作者： jingwen zhang Jiahui Yan Yanan Wang Hong Liu Xueping Sun Yuchao Gu Liangmin Yu Changcheng Li Jun Wu Zhiyu He Frontiers Science Center for Deep Ocean Multispheres and Earth System and Key Laboratory of Marine Chemistry Theory and TechnologyMinistry of EducationOcean University of ChinaQingdao 266100China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China School of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China Sanya Oceanographic Institution Ocean University of ChinaQingdao 572024China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)NanshaGuangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong Kong 999077China

Early pathogenesis of ischemia-reperfusion(I/R)-induced acute kidney injury(AKI)is dominated by intracellular calcium overload,which induces oxidative stress,intracellular energy metabolism disorder,inflammatory activation,and a series of pathologic cascaded reactions that are closely intertwined with self-amplifying and interactive feedback loops,ultimately resulting in cell damage and kidney ***,most nanomedicines originate from the perspective of antioxidant stress,which can only quench existing reactive oxide species(ROS)but cannot prevent the continuous production of ROS,resulting in insufficient *** a safe and promising drug,BAPTA-AM is hydrolyzed into BAPTA by intracellular esterase upon entering cells,which can rapidly chelate with overloaded Ca^(2+),restoring intracellular calcium homeostasis,thus inhibiting ROS regeneration at the ***,we designed a KTP-targeting peptide-modified yolk-shell structure of liposome–poly(ethylene glycol)methyl ether-block-poly(L-lactide-co-glycolic)(mPLGA)hybrid nanoparticles(<100 nm),with the characteristics of high encapsulation rate,high colloid stability,facile modification,and prolonged blood circulation *** the BA/mPLGA@Lipo-KTP was targeted to the site of kidney injury,the cholesteryl hemisuccinate(CHEMS)in the phospholipid bilayer,as an acidic cholesterol ester,was protonated in the simulated inflammatory slightly acidic environment(pH 6.5),causing the liposomes to rupture and release the BA/mPLGA nanoparticles,which were then depolymerized by intracellular *** BAPTA-AM was diffused and hydrolyzed to produce BAPTA,which can rapidly cut off the malignant loop of calcium overload/ROS generation at its source,blocking the endoplasmic reticulum(ER)apoptosis pathway(ATF4–CHOP–Bax/Bcl-2,Casp-12–Casp-3)and the inflammatory pathway(TNF-α–NF-κB–IL-6 axes),thus alleviating pathological changes in kidney tissue,thereby inhibiting the expression of renal tubular marker kidney injury mole

关键词： BAPTA-AM Calcium overload Acid-responsive AKI ER stress

<i>N</i>-Order Fixed Point Theory for N-Order Generalized Meir-Keeler Type Contraction in Partially Ordered Metric Spaces

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Journal of Applied Mathematics and Physics 2019年第5期7卷 1174-1184页

作者： Shiyun Wang jingwen zhang Department of Science Shenyang Aerospace University Shenyang China

This paper concerns N-order fixed point theory in partially ordered metric spaces. For the sake of simplicity, we start our investigations with the tripled case. We define tripled generalized Meir-Keeler type contraction which extends the definition of [Bessem Samet, Coupled fixed point theorems for a generalized Meir-Keeler contraction in partially ordered metric spaces, Nonlinear Anal. 72 (2010), 4508-4517]. We then discuss the existence and uniqueness of tripled fixed point theorems in partially ordered metric spaces. For general cases, we generalized our results to the N-order case. The results will promote the study of N-order fixed point theory.

关键词： Tripled Fixed Point Meir-Keeler Type Contraction Partially Ordered Set N-Order Fixed Point

Lx2-32c,a novel semi-synthetic taxane,exerts antitumor activity against prostate cancer cells in vitro and in vivo

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Acta Pharmaceutica Sinica B 2017年第1期7卷 52-58页

作者： Guangyao Lv Dengjun Sun jingwen zhang Xiaoxia Xie Xiaoqiong Wu Weishuo Fang Jingwei Tian Chunhong Yan Hongbo Wang Fenghua Fu School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)Ministry of EducationYantai University Departments of Medical Oncology Affiliated Yuhuangding HospitalMedical College of Qingdao University The Military Affiliated General Hospital of Beijing PLA State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College GRU Cancer Center Georgia Regents University

Tubulin has been shown to be an effective target for the development of cytotoxic agents against prostate cancer. Previously, we reported that Lx2-32 c is an anti-tubulin agent with high binding affinity to tubulin. In this study, we investigated the potential of Lx2-32 c to act as an effective cytotoxic agent in the treatment of prostate cancer. MTT assays showed that Lx2-32 c was cytotoxic to all tested prostate cancer cell lines. The Lx2-32c-treated cells typically exhibited a rounded morphology associated with the onset of apoptosis, as evidenced by immunocytochemical staining. Human prostate cancer cell lines treated with Lx2-32 c arrest in the G2/M phase of the cell cycle and the treatment is associated with an increased ratio of cells in the sub-G0/G1 phase as determined by flow cytometry. Furthermore, expression of the cleaved form of poly(ADP-ribose) polymerase in prostate cancer cell lines treated with Lx2-32 c was shown by Western blotting assay. Xenograft implants of LNCa P and PC3-derived tumors in nude mice showed that Lx2-32 c treatment significant inhibited tumor growth with effects equivalent to those of docetaxel. These findings demonstrate the potential of Lx2-32 c as a candidate antitumor agent for the treatment of prostate cancer.

关键词： Lx2-32c Cephalomannine Prostate cancer Microtubule Cell cycle arrest Apoptosis

Very High Photorefractive Gain in Two-Beam Coupling with Thin Iron-Doped LiNbO_(3) Crystal

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Chinese Physics Letters 1993年第4期10卷 227-230页

作者： zhang jingwen SUN Wanjun BIAN Shaoping XU Kebin SUN Guangyao LI Minghua XU Yuheng Department of Applied Physics Harbin Institute of TechnologyHarbin 150006 Department of Applied Chemistry Harbin Institute of TechnologyHarbin 150006

The largest exponential gain coefficient(Γ=250 cm^(-1)),to our knowledge,is obtained in thin(d=0.20mm)iron-doped LiNbO_(3) *** dependence of two-beam coupling coefficients on beam crossing angle are measured and compared in two samples fabricated from the same material with different values of *** explanation based on light climbing effect is given.

关键词： crystal beam exponential

Parity,Timing and Level of Fertility:A Comparative Study on Mean Age at Childbearing in China,Japan and South Korea

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China Population and Development Studies 2017年第2期1卷 33-48页

作者： SONG Jian zhang jingwen Center for Population and Development Studies Renmin University of ChinaBeijingChina School of Sociology and Population Studies Renmin University of ChinaBeijingChina

Using fertility data from national surveys and population censuses for China,Japan and South Korea,this study analyzes the levels and trends of mean age at childbearing(MAC)in the three countries from 1990 to *** using the decomposition technique to isolate the effects of parity composition and childbearing schedule in each of the three countries,the article presents a quantitative examination of the factors that underlie dynamic changes and cross-national differences of *** indicate that the MAC of China experienced a decrease between 1990 and 1995,followed by sustained growth *** increase of MAC in China has been driven by the postponement of childbearing and changes in parity composition,with the former playing a larger *** mechanisms underlying the patterns since 2010 deserve special *** with Japan and South Korea,China has had relatively lower MAC during the last 25 years;the three countries demonstrate different patterns in terms of the roles of parity composition and birth *** accuracy of MAC in identifying the timing of period fertility and the policy implications of timing on upturning fertility level are discussed.

关键词： Mean age at childbearing Parity composition Fertility postponement Low fertility level Population of East Asia

Living together with children and elderly:the impact of family structure on the consumption of migrants and residents in urban China

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China Population and Development Studies 2018年第2期2卷 186-203页

作者： Yueping Song jingwen zhang Institute of Health Science Research Renmin University of ChinaBeijingChina School of Sociology and Population Studies Renmin University of ChinaBeijingChina

Using data from the first wave of the“China Family Dynamic Survey”conducted in 2014,this study compares the impact on consumption of the presence of children or elderly people in migrant households and to that in urban resident households,and then examines the extent to which lack of access to public services might explain the differences in consumption patterns that do *** results indicate that migrant households with infants and toddlers increase their consumption of healthcare services,while those with preschool children increase their consumption of educational *** households with elderly members significantly increase their consumption of healthcare *** comparison of migrant households with urban resident households shows that there are considerable differences between migrant households and urban resident households in terms of how educational and healthcare expenditures are affected by the presence of children and *** differences grow out of a huge gap in the accessibility of low-cost,subsidized public preschool education and government-funded health insurance programs.

关键词： Children Elderly Migrant households Urban resident households Consumption