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A double crosslinking MXene/cellulose nanofiber layered film for improving mechanical properties and stable electromagnetic interference shielding performance

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Journal of Materials Science & Technology 2022年第34期129卷 127-134页

作者： Shilu Luo Tiantian Xiang jingwen dong Fengmei Su Youxin Ji Chuntai Liu Yuezhan Feng Key Laboratory of Materials Processing and Mold Ministry of Education National Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002China

With the discovery of the two-dimensional(2D) MXene, it shows a great application potential in the field of electromagnetic interference(EMI) shielding, but the mechanical brittleness and easy oxidation of MXene limit its wide application. For this reason, a double crosslinking strategy is provided to solve the above problems in a nacre-like “brick-mortar” layered MXene/cellulose nanofiber(MXene/CNF) film.Typically, the film was firstly suffered by dopamine modification, then was further reinforced by secondary Ca^(2+)bridging, so as to obtain excellent mechanical properties and antioxidative EMI shielding performance. Comparing with the single crosslinking, the double crosslinking strategy reveals a higher efficiency in improving the mechanical property. The mechanical strength and toughness of the double crosslinking MXene/CNF film can increase to 142.2 MPa and 9.48 MJ/m^(3), respectively. More importantly, while achieving good mechanical properties, the MXene composite film still holds a very stable EMI shielding performance of more than 44.6 dB when suffering from the oxidation treatment of hightemperature annealing, showing excellent anti-oxidation ability and environment tolerance. Therefore,this work provides a universal but effective double crosslinking strategy to solve the mechanical brittleness and easy oxidation of MXene-based composites, thus showing a huge potential in flexible EMI shielding applications.

关键词： Ti_(2)C_(3)T_(x)MXene Layered structure Double crosslinking Mechanical properties EMI shielding performance

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Reversing the PAI-1-induced fibrotic immune exclusion of solid tumor by multivalent CXCR4 antagonistic nano-permeator

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药学学报:英文版 2023年第7期13卷 3106-3120页

作者： jingwen dong Chenfei Zhu Ying Huang Quanhao Li Jing Li Zheng Wang Yixin Wang Zhanwei Zhou Minjie Sun NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients State Key Laboratory of Natural MedicinesDepartment of PharmaceuticsChina Pharmaceutical UniversityNanjing 210009China

Fibrosis is one of the key factors that lead to the immune exclusion of solid tumors.Although degradation of fiber is a promising strategy,its application was still bottlenecked by the side effects of causing metastasis,resulting in the failure of immunotherapy.Here,we developed an antimetastatic polymer(HPA)for the delivery of chemo-drug and antifibrotic siPAI-1 to form the nano-permeator.Nano-permeator shrank after protonation and deeply penetrated into the tumor core to down-regulate the expression of PAI-1 for antifibrosis,and further promoted the sustained infiltration and activation of T cells for killing tumor cells.Moreover,metastasis after fiber elimination was prevented by multivalent CXCR4 antagonistic HPA to reduce the attraction of CXCL12 secreted by distant organs.The administration of stroma-alleviated immunotherapy increased the infiltration of CD8+T cells to 52.5%in tumor tissues,inhibiting nearly 90%metastasis by HPA in distant organs.The nano-permeator reveals the mechanism and correlation between antifibrosis and antimetastasis and was believed to be the optimizing immunotherapy for solid fibrotic tumors.

关键词： Immune exclusion PAI-1 Fibrosis Deep penetration AMD3100 CXCR4/CXCL12 Metastasis Immunotherapy

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基于生态系统服务价值的阿勒泰地区生态补偿区域空间选择与策略

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环境工程技术学报 2024年第1期14卷 308-317页

作者：董靖雯王承武新疆农业大学公共管理学院

生态补偿可有效缓解区域经济发展与生态保护之间的矛盾。基于2010—2020年阿勒泰地区土地利用数据,运用当量因子法计算研究区的生态系统服务价值(ESV)并进行时空变化分析,引用修正后生态补偿优先级指数对阿勒泰地区6县1市进行生态补偿... 详细信息

生态补偿可有效缓解区域经济发展与生态保护之间的矛盾。基于2010—2020年阿勒泰地区土地利用数据,运用当量因子法计算研究区的生态系统服务价值(ESV)并进行时空变化分析,引用修正后生态补偿优先级指数对阿勒泰地区6县1市进行生态补偿区域空间选择,并计算生态补偿额度。结果表明:2010—2020年阿勒泰地区草地、耕地、水域、建设用地面积增加,林地与未利用地面积减少。2010—2020年总ESV呈现降增交替的波动变化,整体减少0.85%,林地ESV降幅最大,单项功能价值量占比最高的为调节服务。阿勒泰地区生态补偿理论总额度为60.05亿元,修正后生态补偿(补偿额占总额比例)优先顺序依次为青河县(21.60%)>布尔津县(18.33%)>吉木乃县(10.46%)>哈巴河县(11.43%)>阿勒泰市(10.99%)>富蕴县(14.12%)>福海县(13.07%)。基于研究结果,从发挥政府作用、健全法律体系、拓宽资金渠道、创新补偿方式及规范补偿方与受偿方等方面提出完善阿勒泰地区生态补偿的策略。

关键词：生态系统服务价值生态补偿空间选择生态补偿额度阿勒泰地区

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论《米与盐的年代》中的他者化中国形象建构

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湖南科技大学学报（社会科学版） 2024年第3期27卷 51-57页

作者：叶冬邓婧雯湖南师范大学外国语学院湖南长沙410081

美国当代科幻作家金·斯坦利·罗宾森的长篇或然历史小说《米与盐的年代》呈现了后冷战时期西方所建构的中国形象,小说中折射出了西方学者在有关中国的知识领域、思维方式和话语机制等三个维度上固有的成见和刻板印象,其本质是欧美“东... 详细信息

美国当代科幻作家金·斯坦利·罗宾森的长篇或然历史小说《米与盐的年代》呈现了后冷战时期西方所建构的中国形象,小说中折射出了西方学者在有关中国的知识领域、思维方式和话语机制等三个维度上固有的成见和刻板印象,其本质是欧美“东方主义”视野下对中国形象的描绘和建构。针对欧美学者对中国文化误读这一现象,应以理性而审慎的批判意识去辨析和解读西方价值观下有关中国题材的作品,并建构起具有文化多样性和文明互鉴的平等互动的交流模式。

关键词：《米与盐的年代》中国形象东方主义

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Scaled-up synthesis of defect-rich layered double hydroxide monolayers without organic species for efficient oxygen evolution reaction

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Green Energy & Environment 2022年第5期7卷 975-982页

作者： Haoyuan Chi jingwen dong Tian Li Sha Bai Ling Tan Jikang Wang Tianyang Shen Guihao Liu Lihong Liu Luyi Sun Yufei Zhao Yu-Fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China College of Chemistry Key Laboratory of Theoretical&Computational Photochemistry of Ministry of EducationBeijing Normal UniversityBeijing100875China Polymer Program Institute of Materials Science and Department of Chemical&Biomolecular EngineeringUniversity of ConnecticutStorrsConnecticut06269USA Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing100029China

The scaled-up synthesis of organic-free monolayer nanomaterials is highly desirable,especially in obtaining green energy by electrocatalysis.In this study,a method for the scaled-up synthesis of the series of monolayer layered double hydroxides(LDHs)without the addition of organic solvents is reported via the separate nucleation and aging steps process.The resulting monolayer LDHs with the thicknesses of less than 1 nm showed a narrow thickness distribution.X-ray absorption fine-structure revealed that monolayer NiFe-LDH nanosheets have a number of oxygen and metal vacancies defects.As a practical application,monolayer NiFe-LDH nanosheets containing defects showed an enhanced electrocatalytic water oxidation activity compared with that of bulk NiFe-LDH.Density functional theory calculations uncovered that excellent catalytic activity is attributed to vacancies defects.The proposed method is an economical and universally applicable strategy for the scaled-up production of monolayer LDHs.

关键词： process synthesis monolayer

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Vertically Aligned Silicon Carbide Nanowires/Boron Nitride Cellulose Aerogel Networks Enhanced Thermal Conductivity and Electromagnetic Absorbing of Epoxy Composites

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Nano-Micro Letters 2022年第7期14卷 209-227页

作者： Duo Pan Gui Yang Hala MAbo-Dief jingwen dong Fengmei Su Chuntai Liu Yifan Li Ben Bin Xu Vignesh Murugadoss Nithesh Naik Salah MEl-Bahy Zeinhom MEl-Bahy Minan Huang Zhanhu Guo Key Laboratory of Materials Processing and Mold(Zhengzhou University) Ministry of EducationNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002People’s Republic of China Department of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle upon Tyne NE18STUK Integrated Composites Laboratory(ICL) Department of Chemical and Biomolecular EngineeringUniversity of TennesseeKnoxvilleTN 37996USA Advanced Materials Division Engineered Multifunctional Composites(EMC)Nanotech LLCKnoxvilleTN 37934USA College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Mechanical and Manufacturing Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnataka 576104India Department of Chemistry Turabah University CollegeTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Department of Chemistry Al-Azhar UniversityNasr CityCairo 11884Egypt

With the innovation of microelectronics technology, the heat dissipation problem inside the device will face a severe test. In this work, cellulose aerogel(CA) with highly enhanced thermal conductivity(TC) in vertical planes was successfully obtained by constructing a vertically aligned silicon carbide nanowires(SiC NWs)/boron nitride(BN) network via the ice template-assisted strategy. The unique network structure of SiC NWs connected to BN ensures that the TC of the composite in the vertical direction reaches 2.21 W m^(-1) K^(-1) at a low hybrid filler loading of 16.69 wt%, which was increased by 890% compared to pure epoxy(EP). In addition, relying on unique porous network structure of CA, EP-based composite also showed higher TC than other comparative samples in the horizontal direction. Meanwhile, the composite exhibits good electrically insulating with a volume electrical resistivity about 2.35 × 10^(11) Ω cm and displays excellent electromagnetic wave absorption performance with a minimum reflection loss of-21.5 dB and a wide effective absorption bandwidth(<-10 dB) from 8.8 to 11.6 GHz. Therefore, this work provides a new strategy for manufacturing polymer-based composites with excellent multifunctional performances in microelectronic packaging applications.

关键词： Epoxy Ice template Vertical alignment Thermal conductivity Multifunctionality

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基于功率动态分配与容量短期补偿的用户侧BESS复用策略

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电力系统自动化 2024年第7期48卷 225-234页

作者：张圣祺董静雯王逸林王晛张少华上海大学机电工程与自动化学院上海市200444 国网宁波市奉化区供电公司浙江省宁波市315000

用户侧电池储能系统(BESS)在维持新能源高渗透电网电力电量平衡中扮演着重要角色,其面向峰谷套利和调频的复用模式受到了广泛关注。但该模式下,BESS调度面临峰谷套利价格时变性和调频需求随机性的双重挑战。为更好地利用BESS资源,以最... 详细信息

用户侧电池储能系统(BESS)在维持新能源高渗透电网电力电量平衡中扮演着重要角色,其面向峰谷套利和调频的复用模式受到了广泛关注。但该模式下,BESS调度面临峰谷套利价格时变性和调频需求随机性的双重挑战。为更好地利用BESS资源,以最大化用户侧BESS日内收益为目标,提出了基于功率动态分配与容量短期补偿的用户侧BESS复用策略,并形成以套利功率、调差系数、容量补偿系数为核心参数的复用结果。仿真分析表明,通过动态功率分配,实现了BESS功率面向峰谷套利和调频的动态调整;通过容量短期补偿,实现了BESS对频率偏差信号的持续跟踪,并有效避免了容量越限的发生,BESS综合收益显著提升。

关键词：电池储能系统峰谷套利调频动态规划动态功率分配

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Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR

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Acta Pharmaceutica Sinica B 2021年第10期11卷 3134-3149页

作者： Xiaojia Liu Mingxiao Yin jingwen dong Genxiang Mao Wenjian Min Zean Kuang Peng Yang Lu Liu Na Zhang Hongbin Deng Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Zhejiang Provincial Key Lab of Geriatrics Department of GeriatricsZhejiang HospitalHangzhou 310013China State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization China Pharmaceutical UniversityNanjing 210009China Qingdao Women and Children’s Hospital Qingdao UniversityQingdao 266034China

Programmed cell death ligand 1(PD-L1)/programmed cell death protein 1(PD-1)cascade is an effective therapeutic target for immune checkpoint blockade(ICB)therapy.Targeting PD-L1/PD-1 axis by small-molecule drug is an attractive approach to enhance antitumor immunity.Using flow cytometry-based assay,we identify tubeimoside-1(TBM-1)as a promising antitumor immune modulator that negatively regulates PD-L1 level.TBM-1 disrupts PD-1/PD-L1 interaction and enhances the cytotoxicity of T cells toward cancer cells through decreasing the abundance of PD-L1.Furthermore,TBM-1 exerts its antitumor effect in mice bearing Lewis lung carcinoma(LLC)and B16 melanoma tumor xenograft via activating tumor-infiltrating T-cell immunity.Mechanistically,TBM-1 triggers PD-L1 lysosomal degradation in a TFEB-dependent,autophagy-independent pathway.TBM-1 selectively binds to the mammalian target of rapamycin(m TOR)kinase and suppresses the activation of m TORC1,leading to the nuclear translocation of TFEB and lysosome biogenesis.Moreover,the combination of TBM-1 and anti-CTLA-4 effectively enhances antitumor T-cell immunity and reduces immunosuppressive infiltration of myeloid-derived suppressor cells(MDSCs)and regulatory T(Treg)cells.Our findings reveal a previously unrecognized antitumor mechanism of TBM-1 and represent an alternative ICB therapeutic strategy to enhance the efficacy of cancer immunotherapy.

关键词： PD-L1 Immune checkpoint blockade Transcription factor EB Lysosome mTOR

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Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5

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Acta Pharmaceutica Sinica B 2020年第12期10卷 2299-2312页

作者： Yang Liu Xiaojia Liu Na Zhang Mingxiao Yin jingwen dong Qingxuan Zeng Genxiang Mao Danqing Song Lu Liu Hongbin Deng Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Zhejiang Provincial Key Lab of Geriatrics Department of GeriatricsZhejiang HospitalHangzhou 310013China Qingdao Women and Children’s Hospital Qingdao UniversityQingdao 266034China

Programmed cell death-1(PD-1)/programmed cell death ligand-1(PD-L1)blocking therapy has become a major pillar of cancer immunotherapy.Compared with antibodies targeting,small-molecule checkpoint inhibitors which have favorable pharmacokinetics are urgently needed.Here we identified berberine(BBR),a proven anti-inflammation drug,as a negative regulator of PDL1 from a set of traditional Chinese medicine(TCM)chemical monomers.BBR enhanced the sensitivity of tumour cells to co-cultured T-cells by decreasing the level of PD-L1 in cancer cells.In addition,BBR exerted its antitumor effect in Lewis tumor xenograft mice through enhancing tumorinfiltrating T-cell immunity and attenuating the activation of immunosuppressive myeloid-derived suppressor cells(MDSCs)and regulatory T-cells(Tregs).BBR triggered PD-L1 degradation through ubiquitin(Ub)/proteasome-dependent pathway.Remarkably,BBR selectively bound to the glutamic acid76 of constitutive photomorphogenic-9 signalosome 5(CSN5)and inhibited PD-1/PD-L1 axis through its deubiquitination activity,resulting in ubiquitination and degradation of PD-L1.Our data reveals a previously unrecognized antitumor mechanism of BBR,suggesting BBR is small-molecule immune checkpoint inhibitor for cancer treatment.

关键词： PD-L1 Immune checkpoint blockade COP9 signalosome 5 Berberine PD-1/PD-L1 axis T-cell immunity

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Using bio-orthogonally catalyzed lethality strategy to generate mitochondria-targeting anti-tumor metallodrugs in vitro and in vivo

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National Science Review 2021年第9期8卷 50-59页

作者： Xuling Xue Chenggen Qian Qin Tao Yuanxin Dai Mengdi Lv jingwen dong Zhi Su Yong Qian Jing Zhao Hong-Ke Liu Zijian Guo College of Chemistry and Materials Science Jiangsu Key Laboratory of Biofunctional Materials Nanjing Normal University School of Pharmacy China Pharmaceutical University State Key Laboratory of Coordination Chemistry Chemistry and Biomedicine Innovation Center School of Chemistry and Chemical Engineering Nanjing University

Synthetic lethality was proposed nearly a century ago by geneticists and recently applied to develop precision anti-cancer therapies. To exploit the synthetic lethality concept in the design of chemical anti-cancer agents, we developed a bio-orthogonally catalyzed lethality (BCL) strategy to generate targeting anti-tumor metallodrugs both in vitro and in vivo. Metallodrug Ru-rhein was generated from two non-toxic species Ru-N3 and rhein-alkyne via exclusive endogenous copper-catalyzed azide alkyne cycloaddition(Cu AAC) reaction without the need of an external copper catalyst. The non-toxic species Ru-arene complex Ru-N3and rhein-alkyne were designed to perform this strategy, and the mitochondrial targeting product Ru-rhein was generated in high yield (>83%) and showed high anti-tumor efficacy in vitro. This BCL strategy achieved a remarkable tumor suppression effect on the tumor-bearing mice models. It is interesting that the combination of metal-arene complexes with rhein via Cu AAC reaction could transform two non-toxic species into a targeting anti-cancer metallodrug both in vitro and in vivo, while the product Ru-rhein was non-toxic towards normal cells. This is the first example that exclusive endogenous copper was used to generate metal-based anti-cancer drugs for cancer treatment. The anti-cancer mechanism of Ru-rhein was studied and autophagy was induced by increased reactive oxygen species and mitochondrial damage. The generality of this BCL strategy was also studied and it could be extended to other metal complexes such as Os-arene and Ir-arene complexes. Compared with the traditional methods for cancer treatment, this work presented a new approach to generating targeting metallodrugs in vivo via the BCL strategy from non-toxic species in metal-based chemotherapy.

关键词： metallodrug cancer therapy mitochondrial targeting bio-orthogonally catalyzed lethality bio-orthogonal reaction

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