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All-van der Waals stacking ferroelectric field-effect transistor based on In2Se3 for high-density memory

Science China(Information Sciences) 2023年第8期66卷 203-210页

作者： Xiaojie WANG Zeyang FENG jingwei cai Hao TONG Xiangshui MIAO Wuhan National Laboratory for Optoelectronics School of Optical and Electronic InformationHuazhong University of Science and Technology Hubei Yangtze Memory Laboratories

High-density integration of ferroelectric field-effect transistors(Fe FETs) is hindered by factors such as interfacial states, short-channel effects, and ferroelectricity degradation in ultrathin films. Accordingly, the introduction of two-dimensional(2D) materials could effectively solve these problems. However,most current studies focus on the replacement of Si-based channels with 2D channels. Little progress has been made in addressing issues caused by bulk-phase ferroelectric gate layers, such as the unavoidable rough interfaces and the fading of ferroelectricity in ultrathin films. Herein, the 2D ferroelectric material In2Se3is introduced as the gate dielectric. Combined with 2D insulating h-BN and 2D channel Mo S2, an all-van der Waals(vd W) stacking Fe FET is fabricated to provide a straight solution for the abovementioned issues.First, the robust ferroelectric phase of In2Se3is verified in an ultrathin film case and a high-temperature case, which is outstanding among recently reported 2D ferroelectrics. Second, device-level out-of-plane ferroelectric polarization switching is achieved in the cross-structure device. Based on these results, In2Se3is adopted as the ferroelectric gate dielectric to fabricate all-vd W stacking Fe FETs. The subsequent transistor performance measurement on the fabricated Fe FETs indicates that the ferroelectric polarization of the In2Se3layer plays a dominating role in forming a counterclockwise hysteresis loop. Further pulse response measurements manifest the feasibility of nonvolatile channel conductance tuning of these devices with a proper pulse design. Our findings suggest that In2Se3is a suitable 2D ferroelectric gate material and that all-vd W stacking Fe FETs based on 2D ferroelectrics are promising in the application of high-density memory.

关键词： high-density memory ferroelectric field-effecttransistors two-dimensional ferroelectrics van der Waals In$_{2}$Se$_{3}$

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Repeated laparoscopic liver resection using ICG fluorescent imaging for recurrent liver cancer

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第1期5卷 19-24页

作者： Zheyong Li jingwei cai Junhao Zheng Xiao Liang Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China

Objective:Liver cancer is very common in China,with cumulative five-year tumor recurrence rate after a microscopically margin-negative resection of hepatocellular carcinoma up to 70%.Postoperative recurrent hepatocellular carcinoma presents a challenge for surgeons because of the complexity of postoperative adhesion and the difficulty in of recognizing recurrent lesions.This study aims to introduce a method using an indocyanine green(ICG)fluorescent imaging technique to do repeated laparoscopic liver resection.Method:Patients received repeated laparoscopic liver resection using ICG fluorescent imaging between January 2017 and December 2019 in the Department of General Surgery of Sir Run Run Shaw Hospital were analyzed retrospectively.Basic information,intraoperative information,complications,and followup time were collected and analyzed.Results:Totally,35 patients with a median age of 59 years(ranged 38-82 years)were included.All of the patients received minimally invasive surgery.One case was performed robotically,and only two cases were converted to open surgery due to severe adhesion.The median operating time was 174 minutes,and the median blood loss during surgery was 100 mL.The median hospital stay after surgery was 5 days,with a range of 3e55 days.In total,32(91.4%)patients showed staining by ICG fluorescent imaging,and lesions were visible on fluorescent camera.The median follow-up time was 19.7 months,with a range of 1e40.2 months.The median relapse-free survival time was 18.5 months.Conclusion:Repeated laparoscopic liver resection using ICG fluorescent imaging is a safe and promising approach in the treatment of recurrent liver tumors in selected patients.

关键词： Recurrence Liver cancer Laparoscopic hepatectomy Fluorescent imaging

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Three-dimensional heterogeneous electro-Fenton system with reduced graphene oxide based particle electrode for Acyclovir removal

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Chinese Chemical Letters 2024年第1期35卷 424-430页

作者： Nan cai Ge Bai Ting Zhang Yongqian Lei Pengran Guo Zhiliang Chen jingwei Xu Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology Guangdong Provincial Engineering Research Center for Online Monitoring of Water PollutionInstitute of AnalysisGuangdong Academy of Sciences(China National Analytical CenterGuangzhou)Guangzhou 510070China College of Petrochemical Engineering Lanzhou University of TechnologyLanzhou 730000China Guangdong Engineering Technology Research Center of Heavy Metal Pollution Control and Restoration in Farmland Soil South China Institute of Environmental SciencesMEEGuangzhou 510535China

New pollutant pharmaceutical and personal care products(PPCPs),especially antiviral drugs,have received increasing attention not only due to their increase in usage after the outbreak of COVID-19 epidemics but also due to their adverse impacts on water ecological environment.Electro-Fenton technology is an effective method to remove PPCPs from water.Novel particle electrodes(MMT/rGO/Fe_(3)O_(4))were synthesized by depositing Fe3O4 nanoparticles on reduced graphene oxide modified montmorillonite and acted as catalysts to promote oxidation performance in a three-dimensional electro-Fenton(3D-EF)system.The electrodes combined the catalytic property of Fe3O4,hydrophilicity of montmorillonite and electrical conductivity of graphene oxides,and applied for the degradation of Acyclovir(ACV)with high efficiency and ease of operation.At optimal condition,the degradation rate of ACV reached 100%within 120 min,and the applicable pH range could be 3 to 11 in the 3D-EF system.The stability and reusability of MMT/rGO/Fe_(3)O_(4)particle electrodes were also studied,the removal rate of ACV remained at 92%after 10 cycles,which was just slightly lower than that of the first cycle.Potential degradation mechanisms were also proposed by methanol quenching tests and FT-ICR-MS.

关键词： Advanced oxidation Three-dimensional electro-Fenton Reduced graphene oxide Acyclovir(ACV) Degradation

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逆断层错动诱发铁路路基变形演化机制

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铁道建筑 2024年第6期64卷 17-23页

作者：梁经纬蔡德钩闫宏业尧俊凯中国铁道科学研究院研究生部北京100081 中国铁道科学研究院集团有限公司铁道建筑研究所北京100081

针对断裂带震间蠕滑及同震黏滑错动会导致穿越活动断裂带铁路路基出现不均匀变形与裂缝的问题,通过自主研发的多角度、速率可控的L形边界断层错动室内模型试验装置以及数值仿真计算,分析考虑岩土体黏聚力与抗拉强度损失的联合损伤因子,... 详细信息

针对断裂带震间蠕滑及同震黏滑错动会导致穿越活动断裂带铁路路基出现不均匀变形与裂缝的问题,通过自主研发的多角度、速率可控的L形边界断层错动室内模型试验装置以及数值仿真计算,分析考虑岩土体黏聚力与抗拉强度损失的联合损伤因子,揭示了不同断裂带倾角、不同断裂带与线路走向夹角情况下逆断层错动诱发路基及地基变形演化机制。结果表明:逆断层错动影响下,路基顶面竖向出现S形隆起,水平方向上路基整体呈现向断层固定盘方向的推覆变形;根据路基边坡变形特点,可将边坡划分为推覆变形区、推覆-鼓胀变形区、潜在不稳定区;逆断层错动下,断层错动盘上方破裂属张拉破裂,断层固定盘上方大面积破裂既由张拉变形所导致,也由剪切变形所导致,属拉-剪混合型破裂;对于地基深部静止区与楔形剪切区之间的弧形破裂,随着破裂逐渐向地表延伸,破裂性质逐渐由剪切破裂向拉-剪混合型破裂转化。

关键词：铁路路基演化机制模型试验数值模拟断层错动

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以学习为中心的教学范式改革研究——以金融工程专业高等数学教学为例

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科技风 2024年第18期 111-113页

作者：蔡井伟史新和金陵科技学院理学院江苏南京211169 金陵科技学院商学院江苏南京211169

在分析传统教学弊端的基础上指出以学习为中心的教学须解决的主要问题并给出了相应的对策。形成高等数学与金融工程专业的知识联动对学生学习进行双轮驱动的教学设想并以此提出符合高等数学实际的以学习为中心的教学范式。最后,阐述了... 详细信息

在分析传统教学弊端的基础上指出以学习为中心的教学须解决的主要问题并给出了相应的对策。形成高等数学与金融工程专业的知识联动对学生学习进行双轮驱动的教学设想并以此提出符合高等数学实际的以学习为中心的教学范式。最后,阐述了以学习为中心的高等数学教学范式在实践中的意义。

关键词：学习为中心范式改革高等数学教学实践意义

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Optimizing diabetic kidney disease animal models:Insights from a meta-analytic approach

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动物模型与实验医学(英文) 2023年第5期6卷 433-451页

作者： Fanghong Li Zhi Ma Yajie cai jingwei Zhou Runping Liu School of Chinese Materia Medica Beijing University of Chinese MedicineBeijingChina School of Life Sciences Beijing University of Chinese MedicineBeijingChina Department of Nephrology Dongzhimen HospitalThe First Affiliated Hospital of Beijing University of Chinese MedicineBeijingChina

Diabetic kidney disease(DKD)is a prevalent complication of diabetes,often leading to end-stage renal disease.Animal models have been widely used to study the pathogenesis of DKD and evaluate potential therapies.However,current animal models often fail to fully capture the pathological characteristics of renal injury observed in clinical patients with DKD.Additionally,modeling DKD is often a time-consuming,costly,and labor-intensive process.The current review aims to summarize modeling strategies in the establishment of DKD animal models by utilizing meta-analysis related methods and to aid in the optimization of these models for future research.A total of 1215 articles were retrieved with the keywords of“diabetic kidney disease”and“animal experiment”in the past 10 years.Following screening,84 articles were selected for inclusion in the meta-analysis.Review manager 5.4.1 was employed to analyze the changes in blood glucose,glycosylated hemoglobin,total cholesterol,triglyceride,serum creatinine,blood urea nitrogen,and urinary albumin excretion rate in each model.Renal lesions shown in different models that were not suitable to be included in the metaanalysis were also extensively discussed.The above analysis suggested that combining various stimuli or introducing additional renal injuries to current models would be a promising avenue to overcome existing challenges and limitations.In conclusion,our review article provides an in-depth analysis of the limitations in current DKD animal models and proposes strategies for improving the accuracy and reliability of these models that will inspire future research efforts in the DKD research field.

关键词： animal model diabetic kidney diseases meta-analysis

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Platelet rich plasma-complexed hydrogel glue enhances skin wound healing in a diabetic rat model

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BIOCELL 2022年第5期46卷 1329-1338页

作者： YUNLONG ZHANG jingwei ZHANG YU ZHU BIN cai Department of Orthopedic Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200233China Department of Orthopedics Shanghai Fengxian District Central Hospital/Southern Medical University Affiliated Fengxian HospitalShanghai201400China

Diabetic patients often exhibit delayed or incomplete progress in the healing of acute wounds,owing to poor blood perfusion.Platelet-rich plasma(PRP)has attracted much attention as a means to improve wound healing,because it contains high growth factor concentrations.However,the burst-like release of PRP growth factors results in a short halflife of these therapeutic proteins,thus greatly limiting the therapeutic effect.In this study,we prepared PRP from human umbilical cord blood and developed an in situ photocrosslinkable PRP hydrogel glue(HNPRP)by adding a photoresponsive hyaluronic acid(HA-NB)into PRP.The HNPRP hydrogel allowed for controlled release of plateletderived growth factor-BB(PDGF-BB)and transforming growth factor-β(TGF-β)for up to 28 days.In vitro cell culture showed that HNPRP promoted migration of fibroblasts and keratinocytes as well as PRP and did not reveal the advantages of HNPRP.However,in a diabetic rat skin wound model,HNPRP treatment promoted faster wound closure.Furthermore,the HNPRP group,compared with the control,PRP and hydrogel only groups,showed significantly greater re-epithelialization and numbers of both newly formed and mature blood vessels.The HNPRP group also displayed higher collagen formation than did the control group.In conclusion,HNPRP enhances angiogenesis and skin regeneration and consequently achieves faster wound healing,thus extending its potential for clinical applications to treat diabetic skin wounds.

关键词： Platelet-rich plasma Wound healing Umbilical cord blood Hydrogel glue Angiogenesis

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Flexible electrochromic fiber with rapid color switching and high optical modulation

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Nano Research 2023年第4期16卷 5473-5479页

作者： Tianxue Zhu Jiaqing Xiong jingwei Chen Xinran Zhou Guofa cai Yuekun Lai Pooi See Lee National Engineering Laboratory for Modern Silk College of Textile and Clothing EngineeringSoochow UniversitySuzhou 215123China School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore College of Chemical Engineering Fuzhou UniversityFuzhou 350116China Qingyuan Innovation Laboratory Quanzhou 362801China Innovation Center for Textile Science and Technology Donghua UniversityShanghai 201620China

Though flexible electrochromic devices have shown huge potential application in the fields of safety warning,display and smart windows,limited attention was paid on preparing flexible electrochromic fiber because of the difficulty in fabricating the multilayer electrochromic device structure in one-dimensional form.In this study,a flexible electrochromic nylon fiber based on Ag nanowires(NWs)/PEDOT:PSS/WO3 nanoparticles(NPs)(PEDOT:PSS=poly(3,4-ethylenedioxythiophene):polystyrenesulfonic acid)is successfully fabricated,delivering rapid color switching(2.5 and 9 s for bleaching and coloration)and high optical modulation(65.5%at 633 nm),and sustainable to repeated mechanical deformations.Ag NWs,PEDOT:PSS and WO3 NPs were dip-coated on the nylon fiber,resulting in an electrochromic fiber electrode with stable fiber resistance of 50-100Ω/10 cm,which can withstand mechanical deformation against 300 times of bending cycles with bending radius of 0.5 cm,and sustain 30 times of tape-peeling.During the galvanostatic tests,the capacitance of the electrochromic electrode can maintain 70%of the initial value even after 5,000 times of charge-discharge cycles.Even in knotted shape,the fiber still shows excellent color contrast.This study provides a novel method to construct flexible electrochromic fiber and pave the way for the development of flexible optoelectronic devices,such as flexible and wearable displays.

关键词： flexible electrochromic fiber WO3 nanoparticle

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Surface modification of titanium substrate via combining photothermal therapy and quorum-sensing-inhibition strategy for improving osseointegration and treating biofilm-associated bacterial infection

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Bioactive Materials 2022年第12期7卷 228-241页

作者： jingwei Hu Yao Ding Bailong Tao Zhang Yuan Yulu Yang Kun Xu Xuan Li Peng liu Kaiyong cai Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing400044China Laboratory Research Center The First Affiliated Hospital of Chongqing Medical UniversityChongqing400016China Institute of Medical Research Northwestern Polytechnical UniversityXi’an710072China

Insufficient osseointegration and biofilm-associated bacterial infection are important challenges for clinical application of titanium(Ti)-based implants.Here,we constructed mesoporous polydopamine(MPDA)nanoparticles(NPs)loaded with luteolin(LUT,a quorum sensing inhibitor),which were further coated with the shell of calcium phosphate(CaP)to construct MPDA-LUT@CaP nanosystem.Then,MPDA-LUT@CaP NPs were immobilized on the surface of Ti implants.Under acidic environment of bacterial biofilm-infection,the CaP shell of MPDA-LUT@CaP NPs was rapidly degraded and released LUT,Ca^(2+)and PO_(4)^(3-)􀀀from the surface of Ti implant.LUT could effectively inhibit and disperse biofilm.Furthermore,under near-infrared irradiation(NIR),the thermotherapy induced by the photothermal conversion effect of MPDA destroyed the integrity of the bacterial membrane,and synergistically led to protein leakage and a decrease in ATP levels.Combined with photothermal therapy(PTT)and quorum-sensing-inhibition strategy,the surface-functionalized Ti substrate had an antibacterial rate of over 95.59%against Staphylococcus aureus and the elimination rate of the formed biofilm was as high as 90.3%,so as to achieve low temperature and efficient treatment of bacterial biofilm infection.More importantly,the modified Ti implant accelerated the growth of cell and the healing process of bone tissue due to the released Ca^(2+)and PO_(4)^(3-)􀀀.In summary,this work combined PTT with quorum-sensing-inhibition strategy provides a new idea for surface functionalization of implant for achieving effective antibacterial and osseointegration capabilities.

关键词： Titanium implant Biofilm infection Osseointegration Photothermal therapy Quorum sensing

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Optical experimental solution for the multiway number partitioning problem and its application to computing power scheduling

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中国科学:物理学、力学、天文学英文版 2023年第9期66卷 15-22页

作者： jingwei Wen Zhenming Wang Zhiguo Huang Dunbo cai Bingjie Jia Chongyu Cao Yin Ma Hai Wei Kai Wen Ling Qian China Mobile(Suzhou)Software Technology Company Limited Suzhou 215163China Beijing QBoson Quantum Technology Co. Ltd.Beijing 100015China

Quantum computing is an emerging technology that is expected to realize an exponential increase in computing power. Recently,its theoretical foundation and application scenarios have been extensively researched and explored. In this work, we propose efficient quantum algorithms suitable for solving computing power scheduling problems in the cloud-rendering domain, which can be viewed mathematically as a generalized form of a typical NP-complete problem, i.e., a multiway number partitioning problem.In our algorithm, the matching pattern between tasks and computing resources with the shortest completion time or optimal load balancing is encoded into the ground state of the Hamiltonian;it is then solved using the optical coherent Ising machine, a practical quantum computing device with at least 100 qubits. The experimental results show that the proposed quantum scheme can achieve significant acceleration and save 97% of the time required to solve combinatorial optimization problems compared with classical algorithms. This demonstrates the computational advantages of optical quantum devices in solving combinatorial optimization problems. Our algorithmic and experimental work will advance the utilization of quantum computers to solve specific NP problems and will broaden the range of possible applications.

关键词： quantum algorithm coherent Ising machine multiway number partitioning problem

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