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Bipolar membrane electrodialysis integrated with in-situ CO_(2)absorption for simulated seawater concentrate utilization,carbon storage and production of sodium carbonate

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Journal of Environmental Sciences 2024年第8期142卷 21-32页

作者： jingtao Bi Tianyi chen Yue Xie Ruochen Shen Bin Li Mengmeng Sun Xiaofu Guo Yingying Zhao School of Chemical Engineering and Technology Hebei University of TechnologyTianjin 300401China Engineering Research Center of Seawater Utilization Technology of Ministry of Education School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300401China Hebei Collaborative Innovation Center of Modern Marine Chemical Technology Tianjin 300401China Tianjin Key Laboratory of Chemical Process Safety Tianjin 300130China Shandong Technology Innovation Center of Seawater and Brine Efficient Utilization Weifang 262737China

In the context of carbon capture,utilization,and storage,the high-value utilization of carbon storage presents a significant challenge.To address this challenge,this study employed the bipolar membrane electrodialysis integrated with carbon utilization technology to prepare Na_(2)CO_(3)products using simulated seawater concentrate,achieving simultaneous saline wastewater utilization,carbon storage and high-value production of Na_(2)CO_(3).The effects of various factors,including concentration of simulated seawater concentrate,current density,CO_(2)aeration rate,and circulating flow rate of alkali chamber,on the quality of Na_(2)CO_(3)product,carbon sequestration rate,and energy consumption were investigated.Under the optimal condition,the CO_(3)^(2-)concentration in the alkaline chamber reached a maximum of 0.817 mol/L with 98 mol%purity.The resulting carbon fixation rate was 70.50%,with energy consumption for carbon sequestration and product production of 5.7 k Whr/m^(3)CO_(2)and1237.8 k Whr/ton Na_(2)CO_(3),respectively.This coupling design provides a triple-win outcome promoting waste reduction and efficient utilization of resources.

关键词： Bipolar membrane electrodialysis(BMED) Carbon capture Utilization and storage(CCUS) Seawater concentrate Sodium carbonate

Response Mechanisms to Flooding Stress in Mulberry Revealed by Multi-Omics Analysis

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Phyton-International Journal of Experimental Botany 2024年第2期93卷 227-245页

作者： jingtao Hu Wenjing chen Yanyan Duan Yingjing Ru Wenqing Cao Pingwei Xiang chengzhi Huang Li Zhang Jingsheng chen Liping Gan College of Biology and Food Engineering Chongqing Three Gorges UniversityChongqing404100China Chongqing Three Gorges Academy of Agricultural Sciences Chongqing Three Gorges UniversityChongqing404155China

Abiotic stress,including flooding,seriously affects the normal growth and development of plants.Mulberry(Morus alba),a species known for its flood resistance,is cultivated worldwide for economic purposes.The transcriptomic analysis has identified numerous differentially expressed genes(DEGs)involved in submergence tolerance in mulberry plants.However,a comprehensive analyses of metabolite types and changes under flooding stress in mulberry remain unreported.A non-targeted metabolomic analysis utilizing liquid chromatographytandem mass spectrometry(LC-MS/MS)was conducted to further investigate the effects of flooding stress on mulberry.A total of 1,169 metabolites were identified,with 331 differentially accumulated metabolites(DAMs)exhibiting up-regulation in response to flooding stress and 314 displaying down-regulation.Pathway enrichment analysis identified significant modifications in many metabolic pathways due to flooding stress,including amino acid biosynthesis and metabolism and flavonoid biosynthesis.DAMs and DEGs are significantly enriched in the Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways for amino acid,phenylpropanoid and flavonoid synthesis.Furthermore,metabolites such as methyl jasmonate,sucrose,and D-mannose 6-phosphate accumulated in mulberry leaves post-flooding stress.Therefore,genes and metabolites associated with these KEGG pathways are likely to exert a significant influence on mulberry flood tolerance.This study makes a substantial contribution to the comprehension of the underlying mechanisms implicated in the adaptation of mulberry plants to submergence.

关键词： Mulberry flooding stress flavonoid biosynthesis phenylpropanoid biosynthesis

Transcriptional control of mature ILC3 function and plasticity: not just RORγt

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Cellular & Molecular Immunology 2022年第2期19卷 142-144页

作者： Xinping Lv Shan Zhu Jing Wu jingtao chen Institute of Translational Medicine The First Hospital of Jilin UniversityChangchunChina

Transcription factors are vital and indispensable for innate lymphoid cell(ILC)subset development and lineage-specific functions as well as the diversity and plasticity of ILCs[1].ILC3s,including lymphoid tissue inducer(LTi)-like ILC3s and natural cytotoxicity receptor(NCR)+ILC3s,are commonly defined by the expression of the transcription factor retinoic acid receptor-related orphan receptor(ROR)yt[2,3]and coexpress some ILC-associated transcription factors,such as ILC2-expressing RORa and ILC1-defined T-bet.However,the combined role of multiple transcrip-tion factors in ILC diversity and plasticity remains unclear.

关键词： RORγt lymphoid plasticity

Group 3 innate lymphoid cells: intestinal patrolling guardians bullied by T cells

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Cellular & Molecular Immunology 2023年第2期20卷 115-116页

作者： Xinping Lv Shan Zhu Jing Wu jingtao chen Cancer Center First Hospital of Jilin UniversityChangchun130021JilinChina Laboratory for Tumor Immunology First Hospital of Jilin UniversityChangchun130061JilinChina

Since the discovery of group 3 innate lymphoid cells(ILC3s),many studies have reported that,in addition to T cells,ILC3s also play an indispensable role in intestinal immune surveillance,host defense,and homeostasis[1].Although both ILC3s and T cells regulate intestinal inflammation through the secretion of interleukin(IL)-22,differences in the behaviors of these two cell types,especially the dynamic shift and mechanism of ILC3 regulation between normal and inflammatory states,remain unclear.A recent paper by Jarade et al.[2]published in Nature Immunology reported that intestinal ILC3s under basal conditions are immotile and arrested in the presence of T cells.Furthermore,the environmental T cells,the microbiota,and the chemokine CCL25 jointly shape ILC3 patrolling behavior and their effector function of maintaining intestinal barrier integrity via IL-22.These findings facilitate the study of ILC biodynamics and ILC immune regulation and the search for therapeutic strategies for gastrointestinal diseases.

关键词： lymphoid jointly guard

Transcriptional divergence between cDC1s and cDC2s: an AP1–IRF composite element-dependent program

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Cellular & Molecular Immunology 2021年第7期18卷 1618-1619页

作者： Shan Zhu Chao Niu jingtao chen Key Laboratory of Organ Regeneration&Transplantation of the Ministry of Education The First Hospital of Jilin UniversityChangchun130061PR China Department of Cancer Center The First Hospital of Jilin UniversityChangchun130021PR China

Conventional dendritic cells(cDCs)are categorized into two main subsets,cDC1 and cDC2,distinguished by their differential expression of cell surface markers,and the development of these two cDC subsets is dependent on interferon regulatory factor 8(IRF8)and IRF4,respectively.1 Kim et al.2 recently reported that cDC1 can be distinguished from cDC2 based on an AP1–IRF composite element(AICE)-dependent gene program.IRF8 at a high concentration engages AICEs at enhancer regions to direct a program toward establishing the cDC1 identity.These findings provide a molecular basis to explain the distinct transcriptional signatures of cDC1s and cDC2s.

关键词： al. interferon element

IL-25 blockade inhibits metastasis in breasl cancer

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Protein & Cell 2017年第3期8卷 191-201页

作者： Zhujun Jiang jingtao chen Xuemei Du Hang cheng Xiaohu Wang chen Dong Institute for Immunology and School of Medicine Tsinghua University Beijing 100084 China Institute of Translational Medicine The First Hospital Jilin University Chanqchun 130031 China Department of Pathology Beijing Shijitan Hospital of Capital Medical University Beijing 100038 China Department of Pediatrics The First Hospital Jilin University Changchun 130031 China

Metastasis is the leading cause of death in breast cancer patients. However, the mechanisms underlying metasta- sis are not well understood and there is no effective treatment in the clinic. Here, we demonstrate that in MMTV- PyMT, a highly malignant spontaneous breast tumor model, IL-25 （also called IL-17E） was expressed by tumor- infiltrating CD4＋ T cells and macrophages. An IL-25 neu- tralization antibody, while not affecting primary tumor growth, substantially reduced lung metastasis. Inhibition of IL-25 resulted in decreased type 2 T cells and macro- phages in the primary tumor microenvironments, both reported to enhance breast tumor invasion and subse- quent metastasis to the lung. Taken together, our data suggest IL-25 blockade as a novel treatment for metastatic breast tumor.

关键词： IL-25 breast cancer metastasis MMTV-PyMT

酿酒酵母稳定整合位点鉴定及其在橘烯生物合成中的应用

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生物工程学报 2024年第6期40卷 1924-1934页

作者：陈东莹朱晁谊陈和锋周靖涛李爽华南理工大学生物科学与工程学院广东广州510006

橘烯(valencene)是一种带有柑橘香气的高值倍半萜类化合物,被广泛应用于食品、化妆品等行业,以及工业合成圆柚酮。本研究在酿酒酵母基因组中鉴定到了16个位于基因间区(intergenic region,IGR)的基因组位点,利用CRISPR-Cas9技术,将Ypet... 详细信息

橘烯(valencene)是一种带有柑橘香气的高值倍半萜类化合物,被广泛应用于食品、化妆品等行业,以及工业合成圆柚酮。本研究在酿酒酵母基因组中鉴定到了16个位于基因间区(intergenic region,IGR)的基因组位点,利用CRISPR-Cas9技术,将Ypet表达盒整合到不同的基因组位点,整合成功率高达87.50%,不同插入位点之间的表达差异达1.91倍。研究显示,位置效应在基因表达中相对稳定,基本不受启动子和报告基因变更的影响。之后筛选高效表达的元件组合PTDH3-TPRC1,在优选的整合位点迭代整合来自阿拉斯加黄扁柏(Callitropsis nootkatensis)橘烯合成酶(VSm),橘烯产量提升至254.67 mg/L。过表达多个拷贝的关键基因t HMG1-ERG20,橘烯的产量提高了93.49%。所得工程菌株L-13在3 L发酵罐中进行2阶段补料分批发酵能够生产橘烯9 530.18 mg/L,相较出发菌株提高了近100倍,展现了筛选出的基因组位点在橘烯生产优化过程中的潜力。

关键词：酿酒酵母位点效应 CRISPR-Cas9 橘烯生物合成

调谐质量阻尼器和非线性能量阱抑制内燃机闭环轴系扭转振动的比较研究

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力学学报 2024年第1期56卷 236-246页

作者：马凯杜敬涛刘杨陈曦明哈尔滨工程大学动力与能源工程学院振动噪声控制研究所哈尔滨150001 中国运载火箭技术研究院北京航天发射技术研究所北京100076

传统线性减振器在抑制内燃机轴系的扭转振动方面有着长期的应用,但较窄的减振带宽限制了其性能的发挥.考虑到内燃机闭环轴系的周期性激振力随转速的变化而变化,其在相对较宽的频率域内实现高效的减振十分必要.为了探究非线性能量阱(nonl... 详细信息

传统线性减振器在抑制内燃机轴系的扭转振动方面有着长期的应用,但较窄的减振带宽限制了其性能的发挥.考虑到内燃机闭环轴系的周期性激振力随转速的变化而变化,其在相对较宽的频率域内实现高效的减振十分必要.为了探究非线性能量阱(nonlinear energy sink,NES)替代调谐质量阻尼器(tuned mass damper,TMD)抑制曲轴扭转振动的可行性,文章将建立曲轴的多惯量非线性闭环自激耦合振荡模型,在此基础上,研究TMD和NES对闭环曲轴扭振减振的影响规律.分析过程综合考虑了轴系不同轴段位置的瞬态和稳态扭转振动.除此之外,定义了振动密度,性能领先效率和波动率3种函数综合考虑不同动力吸振器(dynamic vibration absorber,DVA)的性能优劣.讨论了NES和TMD在不同的设计参数下(变刚度、变阻尼和变位置排布)的减振效率和鲁棒性.结果表明,NES和TMD控制曲轴扭振时具有不同的刚度及阻尼失效区间.随着设计参数的变化,NES和TMD的减振性能交替领先,NES的综合性能领先了24.5%,TMD的综合性能领先了3.3%.同时,NES具有较高的阻尼依赖性(13.6%),TMD具有较高的刚度(3.6%)及位置依赖性(25.6%).

关键词：柴油机扭振减振非线性能量阱闭环轴系鲁棒性

Recent advances in the role of toll-like receptors and TLR agonists in immunotherapy for human glioma

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Protein & Cell 2014年第12期5卷 899-911页

作者： Shuanglin Deng Shan Zhu Yuan Qiao Yong-Jun Liu Wei chen Gang Zhao jingtao chen Institute of Translational Medicine the First Hospital Jilin University Changchun 130031 China Department of Neurosurgery the First Hospital Jilin University Changchun 130031 China Medlmmune Gaithersburg MD 20878 USA Department of Hematology-Oncology and BMT Department of Pediatrics University of Minnesota Medical School Minneapolis MN 55455 USA

Gliomas are extremely aggressive brain tumors with a very poor prognosis. One of the more promising strat- egies for the treatment of human gliomas is targeted immunotherapy where antigens that are unique to the tumors are exploited to generate vaccines. The approach, however, is complicated by the fact that human gliomas escape immune surveillance by creating an immune suppressed microenvironment. In order to oppose the glioma imposed immune suppression, mol- ecules and pathways involved in immune cell matura- tion, expansion, and migration are under intensive clinical investigation as adjuvant therapy. Toll-like receptors （TLRs） mediate many of these functions in immune cell types, and TLR agonists, thus, are currently primary candidate molecules to be used as important adjuvants in a variety of cancers. In animal models for glioma, TLR agonists have exhibited antitumor proper- ties by facilitating antigen presentation and stimulating innate and adaptive immunity. In clinical trials, several TLR agonists have achieved survival benefit, and many more trials are recruiting or ongoing. However, a second complicating factor is that TLRs are also expressed on cancer cells where they can participate instead in a variety of tumor promoting activities including cell growth, proliferation, invasion, migration, and even stem cell maintenance. TLR agonists can, therefore, possibly play dual roles in tumor biology. Here, how TLRs and TLR agonists function in glioma biology and in anti-gli- oma therapies is summarized in an effort to provide acurrent picture of the sophisticated relationship of gli- oma with the immune system and the implications for immunotherapy.

关键词： glioma toll-like receptor agonist centralnervous system immunotherapy