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Two-dimensional materials for future information technology: status and prospects

Science China(Information Sciences) 2024年第6期67卷 1-147页

作者： Hao QIU Zhihao YU Tiange ZHAO Qi ZHANG Mingsheng XU Peifeng LI Taotao LI Wenzhong BAO Yang CHAI Shula chen Yiqi chen Hui-Ming chenG Daoxin DAI Zengfeng DI Zhuo DONG Xidong DUAN Yuhan FENG Yu FU jingshu GUO Pengwen GUO Yue HAO Jun HE Xiao HE Jingyi HU Weida HU Zehua HU Xinyue HUANG Ziyang HUANG Ali IMRAN Ziqiang KONG Jia LI Qian LI Weisheng LI Lei LIAO Bilu LIU Can LIU Chunsen LIU Guanyu LIU Kaihui LIU Liwei LIU Sheng LIU Yuan LIU Donglin LU Likuan MA Feng MIAO Zhenhua NI Jing NING Anlian PAN Tian-Ling REN Haowen SHU Litao SUN Yue SUN Quanyang TAO Zi-Ao TIAN Dong WANG Hao WANG Haomin WANG Jialong WANG Junyong WANG Wenhui WANG Xingjun WANG Yeliang WANG Yuwei WANG Zhenyu WANG Yao WE... School of Electronic Science and Engineering Nanjing University School of Integrated Circuits Interdisciplinary Research Center for Future Intelligent Chips (Chip-X)Nanjing University School of Integrated Circuit Science and Engineering Nanjing University of Posts and Telecommunications State Key Laboratory of Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of Sciences School of Physics and Key Lab of Quantum Materials and Devices of the Ministry of Education School of Electronic Science & EngineeringSoutheast University College of Integrated Circuits State Key Laboratory of Silicon and Advanced Semiconductor MaterialsZhejiang University Suzhou Laboratory State Key Laboratory of Integrated Chips and Systems School of MicroelectronicsFudan University Shaoxin Laboratory Department of Applied Physics The Hong Kong Polytechnic University Key Laboratory for Micro-Nano Physics and Technology of Hunan Province College of Materials Science and EngineeringHunan University College of Integrated Circuits Zhejiang University Shenzhen Geim Graphene Center Shenzhen Key Laboratory of Layered Materials for Value-Added ApplicationsTsinghua-Berkeley Shenzhen Institute & Institute of Materials ResearchTsinghua Shenzhen International Graduate SchoolTsinghua University State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZijingang CampusZhejiang University National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences CAS Key Laboratory of Nanophotonic Materials and Devices & Key Laboratory of Nanodevices and Applications i-LabSuzhou Institute of Nano-Tech and Nano-Bionics (SINANO)Chinese Academy of Sciences College of Chemistry and Chemical Engineering Hunan University Key Laboratory of Quantum State Construction and Manipulation (Ministry of Education) Department of PhysicsRenmin University of China School

Over the past 70 years, the semiconductor industry has undergone transformative changes,largely driven by the miniaturization of devices and the integration of innovative structures and materials. Two-dimensional(2D) materials like transition metal dichalcogenides(TMDs) and graphene are pivotal in overcoming the limitations of silicon-based technologies, offering innovative approaches in transistor design and functionality, enabling atomic-thin channel transistors and monolithic 3D integration. We review the important progress in the application of 2D materials in future information technology, focusing in particular on microelectronics and optoelectronics. We comprehensively summarize the key advancements across material production, characterization metrology, electronic devices, optoelectronic devices, and heterogeneous integration on silicon. A strategic roadmap and key challenges for the transition of 2D materials from basic research to industrial development are outlined. To facilitate such a transition, key technologies and tools dedicated to 2D materials must be developed to meet industrial standards, and the employment of AI in material growth, characterizations, and circuit design will be essential. It is time for academia to actively engage with industry to drive the next 10 years of 2D material research.

关键词： two-dimensional (2D) materials information technology production technology standardization of characterization microelectronicdevices optoelectronic devices multi-functional integration

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Improved transport properties and mechanism in recessed-gate InAlN/GaN HEMTs using a self-limited surface restoration method

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Science China(Information Sciences) 2022年第10期65卷 285-292页

作者： Siyu LIU Xiaohua MA Jiejie ZHU Minhan MI jingshu GUO Jielong LIU Yilin chen Qing ZHU Ling YANG Yue HAO Key Laboratory of Wide Bandgap Semiconductor Technology School of Microelectronics Xidian University School of Advanced Materials and Nanotechnology Xidian University

The etching process of high-performance recessed-gate In Al N/Ga N high-electron mobility transistors(HEMTs) has been actively researched. This paper proposes a post-etching self-limited surface restoration method that effectively suppresses the etching damage, enhancing the transport properties of recessed-gate In Al N/Ga N HEMTs. We fabricated planar-gate devices, inductively coupled plasma(ICP)-etched devices, and post-etching-treated(PET) devices. The damage caused by the ICP etching process severely deteriorated the transport properties of the devices. However, the post-etching process effectively inhibited the etching damage and improved the device transport properties. Through temperature-dependent tests and a simulation, the change in the peak transconductance was compared among different devices. The temperature-dependent optical phonon scattering and impurity-dependent remote charge scattering mechanisms were analyzed. The results confirmed that the etching damage significantly affected the channel electron scattering mechanism. The field-effect mobility showed a linear relationship with temperature, and the optical phonon scattering model illustrated that the field-effect mobility decreased with increasing temperature. The etching damage caused a decrease in the field-effect mobility from 1075.5 to 699.1 cm~2/V·s,which increased the fitting error between this empirical line and the optical phonon scattering fitting curve from 0.086 to 0.948, similar to the remote charge scattering fitting curve. The combined error range is from 0.896 to 0.054.

关键词： GaN InAlN/GaN HEMTs etching damage scattering mechanism

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Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis

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Acta Pharmaceutica Sinica B 2023年第2期13卷 577-597页

作者： Yujun Zhou jingshu Tang Jiaqi Lan Yong Zhang Hongyue Wang Qiuyu chen Yuying Kang Yang Sun Xinhong Feng Lei Wu Hongtao Jin Shizhong chen Ying Peng State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Department of Natural Medicines School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Neurology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China New Drug Safety Evaluation Center Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China NMPA Key Laboratory for Safety Research and Evaluation of Innovative Drug Beijing 100050China

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease affecting both upper and lower motor neurons(MNs)with large unmet medical *** pathological mechanisms are considered to contribute to the progression of ALS,including neuronal oxidative stress and mitochondrial ***(HNK)has been reported to exert therapeutic effects in several neurologic disease models including ischemia stroke,Alzheimer’s disease and Parkinson’s *** we found that honokiol also exhibited protective effects in ALS disease models both in vitro and in *** improved the viability of NSC-34 motor neuron-like cells that expressed the mutant G93A SOD1 proteins(SOD1-G93A cells for short).Mechanistical studies revealed that honokiol alleviated cellular oxidative stress by enhancing glutathione(GSH)synthesis and activating the nuclear factor erythroid 2-related factor 2(NRF2)-antioxidant response element(ARE)***,honokiol improved both mitochondrial function and morphology via fine-tuning mitochondrial dynamics in SOD1-G93A ***,honokiol extended the lifespan of the SOD1-G93A transgenic mice and improved the motor *** improvement of antioxidant capacity and mitochondrial function was further confirmed in the spinal cord and gastrocnemius muscle in ***,honokiol showed promising preclinical potential as a multiple target drug for ALS treatment.

关键词： Amyotrophic lateral sclerosis Glutathione Honokiol Mitochondrial biogenesis Mitochondrial dynamics NRF2 Oxidative stress SOD1-G93A

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Structural diversification of bioactive bibenzyls through modular co-culture leading to the discovery of a novel neuroprotective agent

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1771-1785页

作者： Yuyu Liu Xinnan Li Songyang Sui jingshu Tang Dawei chen Yuying Kang Kebo Xie Jimei Liu Jiaqi Lan Lei Wu Ridao chen Ying Peng Jungui Dai State Key Laboratory of Bioactive Substance and Function of Natural Medicines CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugsand NHC Key Laboratory of Biosynthesis of Natural ProductsInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Bibenzyls,a kind of important plant polyphenols,have attracted growing attention for their broad and remarkable pharmacological ***,due to the low abundance in nature,uncontrollable and environmentally unfriendly chemical synthesis processes,these compounds are not readily ***,one high-yield bibenzyl backbone-producing Escherichia coli strain was constructed by using a highly active and substrate-promiscuous bibenzyl synthase identified from Dendrobium officinale in combination with starter and extender biosynthetic *** types of efficiently postmodifying modular strains were engineered by employing methyltransferases,prenyltransferase,and glycosyltransferase with high activity and substrate tolerance together with their corresponding donor biosynthetic *** different bibenzyl derivatives were tandemly and/or divergently synthesized by co-culture engineering in various combination ***,a prenylated bibenzyl derivative(12)was found to be an antioxidant that exhibited potent neuroprotective activity in the cellular and rat models of ischemia ***-seq,quantitative RT-PCR,and Western-blot analysis demonstrated that 12 could up-regulate the expression level of an apoptosis-inducing factor,mitochondria associated 3(Aifm3),suggesting that Aifm3 might be a new target in ischemic stroke *** study provides a flexible plug-and-play strategy for the easy-to-implement synthesis of structurally diverse bibenzyls through a modular co-culture engineering pipeline for drug discovery.

关键词： Bibenzyls Modular co-culture engineering Promiscuous enzymes Neuroprotective agent Aifm3 Dendrobium officinale

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LF精炼炉钢包回转台驱动系统设计与分析

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工业加热 2024年第2期53卷 1-3,8页

作者：刘璨王婧姝石晛张姝羽刘帅李晨陈星王辉刘雨中钢集团鞍山热能研究院有限公司辽宁鞍山114044 通用技术集团沈阳机床中捷友谊厂辽宁沈阳110000

LF炉是整个钢铁精炼工艺过程中最为重要的设备,具有脱硫、脱氧,微调钢水成分的作用,对提高钢水品质具有重要作用;是每个钢企生产优钢特钢的必备设备。现有LF精炼炉主要结构型式分为双车式、回转台式以及电极旋转式。回转台式LF炉其特点... 详细信息

LF炉是整个钢铁精炼工艺过程中最为重要的设备,具有脱硫、脱氧,微调钢水成分的作用,对提高钢水品质具有重要作用;是每个钢企生产优钢特钢的必备设备。现有LF精炼炉主要结构型式分为双车式、回转台式以及电极旋转式。回转台式LF炉其特点是利用回转台的自转将钢水从等待工位转运钢水至冶炼工位进行冶炼;回转台式LF炉具有占地面积小,使用安全可靠,维护保养工作量小,效率高等优势。回转台作为LF精炼炉的重要组成设备,对整个精炼炉安全运行有着重要的作用;而回转台的平稳运行又取决于驱动装置设计的可靠性。针对回转台的驱动装置设计进行分析。通过对回转台驱动系统基础数据的计算、电机和减速机的选型,提出一个安全、可靠的设计方案,以便其他设计者进行参考。

关键词： LF钢包精炼炉回转台驱动装置设计分析

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安宁疗护相关症状的中医干预指导意见

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中华老年医学杂志 2024年第7期43卷 785-796页

作者：常婧舒陈扬宋芊林磊韩丹阳刘宇宁李晔北京市安宁疗护指导中心国家老年医学中心北京医院中医科、国家老年医学中心、中国医学科学院老年医学研究院北京100730 中国中医科学院广安门医院肿瘤科北京100053 中国中医科学院西苑医院综合内科北京100091 北京医院针灸科、国家老年医学中心、中国医学科学院老年医学研究院北京100730 北京市鼓楼中医医院肿瘤科北京100075 北京市回民医院回医药研究所北京100054 不详

安宁疗护既体现出新时代的生命观,也有着丰厚的中国传统文化底蕴。安宁疗护的目标是减少患者痛苦,维护患者尊严,帮助患者平静离世。中医药防治疾病有简、便、廉、验的特点,其更擅于从整体入手,通过辨证论治舒缓和解除全身病痛,提高临终... 详细信息

安宁疗护既体现出新时代的生命观,也有着丰厚的中国传统文化底蕴。安宁疗护的目标是减少患者痛苦,维护患者尊严,帮助患者平静离世。中医药防治疾病有简、便、廉、验的特点,其更擅于从整体入手,通过辨证论治舒缓和解除全身病痛,提高临终患者生活质量。为了给安宁疗护从业人员提供基本的中医临床实践方案,由国家老年医学中心、北京市安宁疗护指导中心组织相关专业专家学者,聚焦疾病或衰老终末期的常见症状,收集行之有效的中医特色疗法与技术,经过反复讨论及专家审阅修正,最终形成了本指导意见,供安宁疗护从业人员或中医临床工作者以及相关研究人员参考使用。

关键词：临终医护临终关怀中医安宁疗护指导意见

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Establishment of an indicator framework for global One Health Intrinsic Drivers index based on the grounded theory and fuzzy analytical hierarchy-entropy weight method

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Infectious Diseases of Poverty 2022年第6期11卷 97-98页

作者： Jiaxin Feng Zhaoyu Guo Lin Ai jingshu Liu Xiaoxi Zhang Chunli Cao Jing Xu Shang Xia Xiao‑Nong Zhou Jin chen Shizhu Li National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre 不详

Background:One Health has become a global consensus to deal with complex health ***,the pro‑gress of One Health implementation in many countries is still relatively slow,and there is a lack of systematic evalua‑tion *** purpose of this study was to establish an indicator framework for global One Health Intrinsic Drivers index(GOH-IDI)to evaluate human,animal and environmental health development process ***:First,82 studies were deeply analyzed by a grounded theory(GT)method,including open coding,axial coding,and selective coding,to establish a three-level indicator framework,which was composed of three selective codes,19 axial codes,and 79 open ***,through semi-structured interviews with 28 health-related experts,the indicators were further integrated and simplifed according to the inclusion criteria of the ***,the fuzzy analytical hierarchy process combined with the entropy weight method was used to assign weights to the indi‑cators,thus,forming the evaluation indicator framework of human,animal and environmental health development ***:An indicator framework for GOH-IDI was formed consisting of three selective codes,15 axial codes and 61 open *** were six axial codes for“Human Health”,of which“Infectious Diseases”had the highest weight(19.76%)and“Injuries and Violence”had the lowest weight(11.72%).There were four axial codes for“Animal Health”,of which“Animal Epidemic Disease”had the highest weight(39.28%)and“Animal Nutritional Status”had the low‑est weight(11.59%).Five axial codes were set under“Environmental Health”,among which,“Air Quality and Climate Change”had the highest weight(22.63%)and“Hazardous Chemicals”had the lowest weight(17.82%).Conclusions:An indicator framework for GOH-IDI was established in this *** framework were universal,balanced,and scientifc,which hopefully to be a tool for evaluation of the joint development of human,animal and environmental health in diferent reg

关键词： Global One Health Intrinsic drivers index Indicator Grounded theory Fuzzy analytical hierarchy process Entropy weight method

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钢结构装配式产品加工工序碳排放研究

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工业建筑 2024年第8期54卷 140-148页

作者：张相勇陈华周李任戈李毅陈振明李静姝曹洪涛林波荣周浩黄祖坚中建科工集团有限公司北京100089 中建钢构工程有限公司广东深圳518118 清华大学建筑学院北京100084 华南理工大学亚热带建筑与城市科学全国重点实验室广州510640

钢结构装配式建筑须在工厂预先制作构件,该阶段介于上游粗钢生产和下游建筑现场施工之间,目前缺乏相关碳排放基础性研究。现有研究多基于投入-产出法得出吨钢平均碳排放因子参数,忽视了不同产品之间的差异,且无法呈现碳排放来源。本研... 详细信息

钢结构装配式建筑须在工厂预先制作构件,该阶段介于上游粗钢生产和下游建筑现场施工之间,目前缺乏相关碳排放基础性研究。现有研究多基于投入-产出法得出吨钢平均碳排放因子参数,忽视了不同产品之间的差异,且无法呈现碳排放来源。本研究提出基于工序的钢结构装配式产品加工碳排放精细化计测方法,针对钢构件制作主要工序,在天津一家年产16万t钢构件加工工厂,选择代表性机器进行钢结构装配式产品制作阶段加工工序碳排放测试,获得各工序单位加工工作所产生的碳排放参数,并以线性函数拟合功能单元(FU)加工工作量和碳排放关系。分析表明:对于下料、组立、装配、矫正工序,当分别采用切面面积、构件长度、焊缝质量、构件长度作为FU时,所得拟合函数决定系数R2均大于0.9。

关键词：钢结构建筑钢构件预制功能单元耗电焊丝二氧化碳碳排放因子

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几种表面活性剂对大气颗粒物去除效果的比较

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科技创新与应用 2015年第16期5卷 76-76页

作者：陈静书战德胜杨翔宇侯亚恒长春师范大学化学学院吉林长春130032

文章以不同的表面活性剂吸收空气中的PM10和PM2.5。试验证实:空气经过表面活性剂吸收后其中大气颗粒物含量降低,对于PM 2.5和PM10吸收效果最好的活性剂是脂肪酸钠。在脂肪酸钠浓度为5%时,PM2.5和PM10的去除率分别可以达到30%和42%。

关键词：大气颗粒物雾霾表面活性剂

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MiRNA-3473b contributes to neuroinflammation following cerebral ischemia

MiRNA-3473b contributes to neuroinflammation following cereb...

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中国神经科学学会第十二届全国学术会议

作者： Jia JIA Xiaoyu WANG Shuangshuang chen jingshu NI Xuechu ZHEN Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-PsychiatricDiseases and College of Pharmaceutical Sciences Soochow University

Objective This study was designed to investigate the expression of mi R-3473 b following stroke, as well as its contribution to ischemic brain damage. Methods: Microglia were treated with LPS and conditioned medium collected from neurons subjected to oxygen-glucose deprivation（OGD）. Mouse cerebral ischemia model was established by the middle cerebral artery occlusion（MCAO）. Acute cerebral infarction was determined by TTC staining. q RT-PCR and western blot analysis were performed to examine the expression levels of mi R-3473 b and pro-inflammatory factors. Results（1） In vitro study demonstrated that mi R-3473 b was increased in activated BV2 cells, and pretreatment with mi R-3473 b antagomir reduced the m RNA and protein levels of proinflammatory factors i NOS, COX-2, TNF-α and IL-6 in BV2 cells activated by LPS and OGD-conditioned neuronal medium.（2） In vivo study showed that mi R-3473 b was upregulated in the leukocytes and brain in the mice after transient cerebral ischemia. Pretreatment with mi R-3473 b antagomir decreased brain levels of mi R-3473 b following MCAO, resulting in significant reduction of infarct volume in MCAO mice. Conclusion These findings suggest that mi R-3473 b inhibition lessened the ischemic brain injury through suppressing microglia activation. Manipulation of post-stroke mi R-3473 b levels is a potential therapeutic approach to mitigate stroke-induced brain injury.

关键词： MiR-3473b MCAO microglia neuroinflammation

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