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Review of construction methods for whole-cell computational models

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Systems Microbiology and Biomanufacturing 2022年第2期2卷 259-270页

作者： jingru zhou Xingcun Fan Lingfeng Cao Huijie Sun Jianye Xia XueFeng Yan State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China Tianjin Institute of Industrial Biotechnology Chinese Academy of ScienceTianjin 300308China Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationEast China University of Science and TechnologyShanghai 200237People’s Republic of China

The complex mechanisms of the internal operation of cellular functions have not been fully resolved and these functions are regulated by multiple effects,such as transcription regulation,signal transduction,and enzyme catalysis,forming complex interactive *** makes the construction of a whole-cell computational model,containing various complex cellular functions,very ***,biological models have played a significant role in the field of systems biology,such as guiding gene-target mining and studying cell metabolic ***,there is increasing research interest in the construction of whole-cell computational *** two classical languages of systems biology,this review expounds on the development and challenges of whole-cell computational modeling from the two classical methods of steady-state and dynamic ***,we propose a new approach for constructing whole-cell computational models.

关键词： Whole-cell computational model Systems biology Steady-state Dynamic modeling

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教育分层现象的民族心理学考察

西北民族研究 2014年第2期 195-202,176页

作者：周静茹兰州大学西北少数民族研究中心

作为一种重要的社会资源,教育通过其在社会中的不平等分布,影响个体社会流动,决定着群体在社会分层结构中的地位变化。在中国现代社会转型过程中,教育不公平所引发的教育分层现象在民族地区更加凸显。作为引发民族心理嬗变的诱因,教育... 详细信息

作为一种重要的社会资源,教育通过其在社会中的不平等分布,影响个体社会流动,决定着群体在社会分层结构中的地位变化。在中国现代社会转型过程中,教育不公平所引发的教育分层现象在民族地区更加凸显。作为引发民族心理嬗变的诱因,教育分层是民族关系发展的危险信号,必须深刻认识和及时有效解决。引导少数民族提高现代教育认同感,加强政府职责,通过制度安排与政策调整以增进教育公平,是民族地区持续发展与民族关系和谐稳定的有效途径。

关键词：宁夏教育分层民族心理应对措施

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警察职业教育案例教学方法探析

中国职业技术教育 2006年第4期22卷 46-47页

作者：周静茹广东司法警官职业学院广东广州510520

警察职业教育中引入案例教学方法，是培养学生能力的一种有效的途径，有助于学生分析和解决问题能力的提高。

关键词：职业教育警察案例教学探析

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改性活性炭负载高分子季铵盐的杀菌性能

化工学报 2012年第1期63卷 286-291页

作者：周静茹裴丽霞张立志华南理工大学化学与化工学院传热强化与过程节能教育部重点实验室广东广州510640

引言活性炭比表面积大、吸附性能好,广泛应用在空气污染防治和工业废水处理中,如大型通风系统的过滤器、肾透析病房的水处理系统[1-2]。然而,活性炭表面易繁殖细菌,使其本身也成了微生物的污染源,从而影响净化空气或水的效果[3]。

关键词：活性炭高分子季铵盐杀菌吸附

Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout

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Protein & Cell 2017年第6期8卷 467-470页

作者： Dong, Zheng Li, Yuan zhou, jingru Jiang, Shuai Wang, Yi Chen, Yulin Zhao, Dongbao Yang, Chengde Qian, Qiaoxia Ma, Yanyun He, Hongjun Ji, Hengdong Yang, Yajun Wang, Xiaofeng Xu, Xia Pang, Yafei Zou, Hejian Jin, Li Zhang, Feng Wang, Jiucun Fudan Univ Sch Life Sci Collaborat Innovat Ctr Genet & Dev State Key Lab Genet Engn Shanghai 200433 Peoples R China Changhai Hosp Div Rheumatol & Immunol Shanghai 200433 Peoples R China Shanghai Jiao Tong Univ Sch Med Ruijin Hosp Div Rheumatol Shanghai 200025 Peoples R China Taixing Peoples Hosp Div Rheumatol Taixing 225499 Peoples R China Taizhou Peoples Hosp Div Rheumatol Taizhou 225300 Peoples R China Fudan Taizhou Inst Hlth Sci Taizhou 225316 Peoples R China Fudan Univ Huashan Hosp Div Rheumatol Shanghai 200040 Peoples R China Fudan Univ Inst Rheumatol Immunol & Allergy Shanghai 200040 Peoples R China

Dear Editor Gout is usually characterized by recurrent flares of acute inflammatory arthritis and the crystallization of urate in tissues and joints （Dong et al., 2017）. The formation of monosodium urate crystals （MSU） is due to the elevated uric acid levels in the blood （Yang et al., 2016）. But only 10% of individuals with hyperuricemia develop gout, suggesting that certain people are at a higher risk of developing MSU crystals （Mer- riman and Dalbeth, 2011） or initiating of the acute inflamma- tory response than others.

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Safety and feasibility of low-dose fluorescein-guided resection of glioblastoma

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Safety and feasibility of low-dose fluorescein-guided resect...

Molecular detection and quantification of Xanthomonas albilineans in juice from symptomless sugarcane stalks using a real-time quantitative PCR assay

第十四届中国医师协会神经外科医师年会

作者： Cungang FAN Ruen LIU Yilin JIANG Guangyong WU Gang Wu Bo LIU jingru zhou Feng Jiao Department of Neurosurgery Peking University People’s Hospital

Background The extent of resection is an independent predictor of prognosis in patients with glioblastomas. Although fluorescein sodium may enhance intraoperative visualization of tumor margin and increase the extent of glioblastoma, the dose related anaphylactic reaction is still a major concern. In the present study, we used allergy skin testing to exclude the patients susceptible to anaphylaxis preoperatively, and then investigated the feasibility of low-dose fluorescein sodium to guide glioblastoma resection intraoperatively, thereby to improve the safety of fluorescein-guided glioma resection. Methods Patients with suspected glioblastoma based on brain MRI were subjected to allergy skin intradermal tests for fluorescein sodium preoperatively. Only those with negative allergy skin tests received intravenous injection of low dose fluorescein sodium（1-2 mg/kg） during microsurgical tumor resection under dedicated Yellow 560 filter. The degree of fluorescent staining was documented and the extent of resection was evaluated by MRI scan. Results One patient with positive allergy skin test was excluded from fluorescein sodium administration and no anaphylactic reaction was found during fluorescein sodium guided surgery in the patients who were negative for allergy skin tests. The low dose fluorescein sodium（1-2 mg/kg） could provide enough visualization of tumors with sufficient discrimination from surrounding normal brain tissue and improve the resection extent of glioblastoma. Conclusion Preoperative allergy skin test is a useful method to exclude the patients susceptible to anaphylaxis, together with intraoperative low dose fluorescein sodium administration, may facilitate glioblastoma resection by fluorescence guidance while avoid safety concern of dose-related anaphylaxis.

关键词： Fluorescein sodium glioblastoma glioma allergy skin test anaphylaxis Yellow 560

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Molecular detection and quantification of Xanthomonas albili...

中红外光谱吸收法在重整汽油性质快速检测中的应用

中国植物病理学会2021年学术年会

作者： SHI Yang ZHAO Jianying zhou jingru NTAMBO Mbuya Sylvain XU Pengyuan ROTT Philippe C. GAO Sanji National Engineering Research Center for Sugarcane Fujian Agriculture and Forestry University Département de phytotechnie Faculté des Sciences AgronomiquesUniversité de Lubumbashi CIRAD UMRPHIMF-34398 MontpellierFranceand PHIMPlant Health InstituteUniv MontpellierCIRADINRAEInstitut AgroIRD

Leaf scald,a bacterial disease caused by Xanthomonas albilineans(Ashby) Dowson,is a major limiting factor for sugarcane production *** identification and quantification of *** is a prerequisite for successful management of this disease.A very sensitive and robust qPCR assay was developed in this study for detection and quantification of *** using TaqMan probe and primers targeting a putative adenosine triphosphate-binding cassette(ABC) transporter gene(abc).The novel qPCR assay was highly specific to the 43 tested *** strains belonging to different pulsed-field gel electrophoresis(PFGE) *** detection thresholds were 100 copies/μL of plasmid DNA,100 fg/μL of bacterial genomic DNA,and 100 CFU/mL of bacterial suspension prepared from pure *** qPCR assay was 100 times more sensitive than a conventional PCR *** pathogen was detected by qPCR in 75.1%(410/546) symptomless stalk samples,whereas only28.4%(155/546) samples tested positive by conventional *** on qPCR data,population densities of *** in symptomless stalks of the same varieties differed between two sugarcane production areas in China,Beihai(Guangxi province) and Zhanjiang(Guangdong province).Nonsignificant correlation of *** populations was found between Beihai and *** newly developed qPCR assay proved to be highly sensitive and reliable for the detection and quantification of *** in sugarcane stalks.

关键词： Leaf scald molecular detection real-time quantitative PCR Saccharum spp. Xanthomonas albilineans

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石油化工技术与经济 2022年第3期38卷 41-44页

作者：周景茹中国石化上海石油化工股份有限公司质量管理中心上海200540

用中红外光谱吸收法对74个重整汽油样本进行检测,采用偏最小二乘法(PLS)对谱图进行处理,并选取合适的参数,得到优化后的重整汽油的研究法辛烷值、马达法辛烷值、馏程、烯烃和芳烃体积分数的校正模型,建立了快速检测重整汽油性质的中红... 详细信息

用中红外光谱吸收法对74个重整汽油样本进行检测,采用偏最小二乘法(PLS)对谱图进行处理,并选取合适的参数,得到优化后的重整汽油的研究法辛烷值、马达法辛烷值、馏程、烯烃和芳烃体积分数的校正模型,建立了快速检测重整汽油性质的中红外系统,用20个重整汽油样品分别对校正模型进行验证,验证值与参考方法预测值的偏差较小,说明建立的系统模型较好。

关键词：中红外光谱吸收法辛烷值馏程烯烃体积分数芳烃体积分数校正模型

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基于约束的基因组规模代谢网络模型构建方法研究进展

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生物工程学报 2021年第5期37卷 1526-1540页

作者：周静茹刘鹏夏建业庄英萍华东理工大学生物反应器工程国家重点实验室上海200237

基因组规模代谢网络模型(Genome-scale metabolic network model,GSMM)正成为细胞代谢特性研究的重要工具,经过多年发展相关理论方法取得了诸多进展。近年来,在基础GSMM模型基础上,通过整合基因组、转录组、蛋白组和热力学数据,实现基... 详细信息

基因组规模代谢网络模型(Genome-scale metabolic network model,GSMM)正成为细胞代谢特性研究的重要工具,经过多年发展相关理论方法取得了诸多进展。近年来,在基础GSMM模型基础上,通过整合基因组、转录组、蛋白组和热力学数据,实现基于各种约束的GSMM构建,在基因靶点识别、系统代谢工程、药物发现、人类疾病机理研究等多个方面取得了进一步的发展和理论突破。文中重点综述包括转录组约束、蛋白组约束、以及热力学约束条件在GSMM中的实施方法、相应方法的不足及应用限制等。最后介绍了如何综合运用转录、蛋白及热力学约束,实现GSMM的全整合模型及其细化,并对基于约束的GSMM构建及应用前景进行了展望。

关键词：基因组规模代谢网络模型多组学热力学数学建模约束方法