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The overexpression of Rps14 in Lgr5+progenitor cells promotes hair cell regeneration in the postnatal mouse cochlea

Engineered Regeneration 2023年第3期4卷 328-336页

作者： jingru ai Pei Jiang Jingyuan Huang Hairong Xiao Yanqin Lin Mingchen Dai Yintao Wang Yuan Zhang Mengyao Tian Renjie Chai Shasha Zhang State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologyAdvanced Institute for Life and HealthJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096China Department of Otolaryngology Head and Neck Surgery Affiliated Drum Tower Hospital of Nanjing University Medical SchoolJiangsu Provincial Key Medical Discipline(Laboratory)NanjingChina Research Institute of Otolaryngology NanjingChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduChina Institute for Stem Cell and Regeneration Chinese Academy of ScienceBeijingChina Beijing Key Laboratory of Neural Regeneration and Repair Capital Medical UniversityBeijing 100069China

Sensory hair cells(HCs)in the cochlea cannot regenerate spontaneously in adult mammals after being damaged by external or genetic ***,several genes and signaling pathways are reported to induce cochlear HC regeneration at the early neonatal ***14 encodes a ribosomal protein that is involved in the regulation of cell differentiation and proliferation in ***,its roles in the cochlea have not been reported in ***,we specifically overexpressed Rps14 in Lgr5+progenitor cells in the newborn mouse cochlea and found that Rps14 conditional overexpression(cOE)mice had significantly increased the ectopic HCs,including inner and outer *** further explored the source of these ectopic HCs and found no EdU+supporting cells observed in the Rps14 cOE *** lineage tracing results,on the other hand,revealed that Rps14 cOE mice had significantly more tdTomato+HCs in their cochleae than control *** results indicated that regenerated HCs by cOE of Rps14 are most likely derived from inducing the direct trans-differentiation of Lgr5+progenitor cells into ***,real-time qPCR results suggested that the transcription factor genes Atoh1 and Gfi1,which are important in regulating HC differentiation,were upregulated in the cochlear basilar membrane of Rps14 cOE *** summary,this study provides in vivo evidence that,in the postnatal mouse cochlea,Rps14 is a potential gene that can promote the spontaneous trans-differentiation of Lgr5+progenitor cells into *** gene may one day be exploited as a therapeutic target for treating hearing loss.

关键词： Rps14 Lgr5+progenitor cells Ectopic hair cells Regeneration Proliferation Trans-differentiation

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SIZE EFFECTS OF ELASTIC MODULUS OF FCC METALS BASED ON THE CAUCHY-BORN RULE AND NANOPLATE MODELS

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Acta Mechanica Solida Sinica 2014年第2期27卷 111-121页

作者： Jianyun Liu jingru Song Yueguang Wei State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences

In the present research, a simple quasi-continuum model, the Cauchy-Born rule model, is used to investigate the size effects of elastic modulus for fcc metals. By considering a nanoplate model and calculating the strain energy for the nano-sized plate under tension and bending, the relationship between the elastic modulus and the plate thickness is found. Size effects of the elastic modulus are displayed by the relative differences of the elastic modulus between the nano-sized plate sample and the bulk sample. By comparing the present results with those of others, the effectiveness of the Cauchy-Born rule model in studying the size effects of material properties are shown.

关键词： quasi-continuum method Cauchy-Born rule size effect elastic modulus fcc-metal

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Anaerobic oxidation of methane coupled to sulfate reduction: Consortium characteristics and application in co-removal of H_2S and methane

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Journal of Environmental Sciences 2019年第2期31卷 238-248页

作者： Lin Li Song Xue jingru Xi State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of Sciences National Engineering Laboratory for VOCs Pollution Control Material & Technology University of Chinese Academy of Sciences State Key Laboratory of Applied Microbiology Southern China Guangdong Institute of MicrobiologyGuangdong Academy of Sciences

Anaerobic sludge from a sewage treatment plant was used to acclimatize microbial colonies capable of anaerobic oxidation of methane(AOM) coupled to sulfate reduction. Clone libraries and fluorescence in situ hybridization were used to investigate the microbial ***-reducing bacteria(SRB)(e.g., Desulfotomaculum arcticum and Desulfobulbus propionicus)and anaerobic methanotrophic archaea(ANME)(e.g., Methanosaeta sp. and Methanolinea sp.)coexisted in the enrichment. The archaeal and bacterial cells were randomly or evenly distributed throughout the consortia. Accompanied by sulfate reduction, methane was oxidized anaerobically by the consortia of methane-oxidizing archaea and SRB. Moreover, CH_4 and SO_4^(2-) were consumed by methanotrophs and sulfate reducers with CO_2 and H_2S as products. The H_3CSH produced by methanotrophy was an intermediate product during the process. The methanotrophic enrichment was inoculated in a down-flow biofilter for the treatment of methane and H_2S from a landfill site. On average, 93.33% of H_2S and 10.71% of methane was successfully reduced in the biofilter. This study tries to provide effective method for the synergistic treatment of waste gas containing sulfur compounds and CH_4.

关键词： Anaerobic methane oxidation Sulphate reduction Microbial population 13C isotope-labelling Potential pathway Landfill gas

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Low/distortion on Exterior Surface of Auto Body and Its Correction Method

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Chinese Journal of Mechanical Engineering 2012年第2期25卷 299-305页

作者： HU Ping BAO jingru ZHAO Kunmin School of Automotive Engineering Dalian University of TechnologyDalian 116024China

Surface low/distortion is one of the most challenging surface deflections that have a great effect on the exterior appearance of *** studies on surface distortion/deflection have focused on evaluation and visualization techniques,the research work on correction or prevention of surface low/distortion is limited,and there is no perfect surface low/distortion corrective method that can satisfy the needs of the engineering.A B-spline based geometry morphing algorithm is proposed and then a new program based on UG-NX platform is developed to modify the die face in the surface low/distortion *** verify this developed system,the experimental dies that can replicate the surface low/distortion phenomenon successfully is put to *** geometric variables are introduced to describe the basic geometry of typical depression features of automotive outer *** experimental dies are then designed to reflect various combinations of these geometric *** stamping experiments are conducted on cold rolled grade 5（CR5） sheet steel and various static measurements,such as oil-stoning,laser scanner,etc,are performed to measure and record the surface low/*** approaches including good bearing,holds in blank and die face morphing that aim to correct low/distortions are tried out and surface low/distortions are observed in the specimen with reverse draw depth of 10 *** measurement results show that die morphing is a practical and effective method to correct the surface low/*** correction method proposed can be used to minimize the occurrence of surface low/distortion in die manufacturing,which has certain reference significance to the correction of surface low/distortion.

关键词： sheet metal forming surface low/distortion surface deflection corrective method morphing algorithm

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Synthesis and Properties of Porous Organic Polymers from a Rigid Macrocyclic Building Block

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Chinese Journal of Chemistry 2013年第5期31卷 577-581页

作者： jingru Song Zhitang Huang Qiyu Zheng Beijing National Laboratory for Molecular Science CAS Key Laboratory of Molecular Recognition and Function Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

Two rigid macrocyclic CTV-based porous organic polymers, Click-POP-1 and Click-POP-2, have been synthe- sized by Click reaction of a cyclotriveratrylene analogue with alkyne groups and aromatic azides in one pot. FTIR, solid 13C NMR and elemental analysis confirmed the formation of the polymers. Both of them possess high thermo-stability which is up to 410 and 900 ℃, respectively, and moderate hydrogen storage properties with 0.46 wt% at 77 K. Their nitrogen uptake showed type-I isotherm with BET surface areas up to 342 and 317 m2·g ^-1.

关键词： cyclotriveratrylene porous organic polymer hydrogen uptake click reaction amorphous

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Hierarchical structure observation and nanoindentation size effect characterization for a limnetic shell

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Acta Mechanica Sinica 2015年第3期31卷 364-372页

作者： jingru Song Cuncai Fan Hansong Ma Yueguang Wei LNM Institute of Mechanics Chinese Academy of Sciences

In the present research, hierarchical structure observation and mechanical property characterization for a type of biomaterial are carried out. The investigated bioma- terial is Hyriopsis cumingii, a typical limnetic shell, which consists of two different structural layers, a prismatic ＂pillar＂ structure and a nacreous ＂brick and mortar＂ structure. The prismatic layer looks like a ＂pillar forest＂ with variationsection pillars sized on the order of several tens of microns. The nacreous material looks like a ＂brick wall＂ with bricks sized on the order of several microns. Both pillars and bricks are composed of nanoparticles. The mechanical properties of the hierarchical biomaterial are measured by using the nanoindentation test. Hardness and modulus are measured for both the nacre layer and the prismatic layer, respectively. The nanoindentation size effects for the hierarchical structural materials are investigated experimentally. The results show that the prismatic nanostructured material has a higher stiffness and hardness than the nacre nanostructured material. In addition, the nanoindentation size effects for the hierarchical structural materials are described theoretically, by using the trans-scale mechanics theory considering both strain gradient effect and the surface/interface effect. The modeling results are consistent with experimental ones.

关键词： Biomaterial Hierarchical structure - Mechan-ical property Nanoindentation size effect Trans-scalemechanics

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A novel nanoporous Mg-Li material for efficient hydrogen generation

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Journal of Magnesium and Alloys 2022年第11期10卷 3054-3063页

作者： jingru Liu Qingxi Yuan Wangxia Huang Xiping Song State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083PR China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese AcademyBeijing 100049PR China

Hydrogen generation material is a new kind of energy material that can supply hydrogen by reacting with water and is drawing more and more attention with the development of hydrogen economy. In this study, a novel nanoporous magnesium-lithium material prepared by a physical vapor deposition method exhibits an excellent hydrogen generation property. It generates hydrogen efficiently and quickly with saltwater, reaching a hydrogen generation amount of 962 mL g^(-1) and hydrogen generation rates of 60 mL g^(-1)min^(-1), 109 mL g^(-1)min^(-1),256 mL g^(-1)min^(-1) and 367 mL g^(-1)min^(-1) at 0 ℃, 25 ℃, 35 ℃ and 50 ℃, respectively. The nanoporous magnesium-lithium material is composed of a solid solution phase with a magnesium-lithium atomic ratio of 17:3. By synchrotron radiation analysis, the sizes of the nanopores are in the range of 100 nm ~ 600 nm with an average size of 280 nm, and the porosity is calculated to be ~42.4%. The improved hydrogen generation property is attributed to the nanoporous structure with a high specific surface area, and the addition of lithium element which acts as active sites in hydrogen generation process.

关键词： Nanoporous Mg-Li material Physical vapor deposition Hydrogen generation

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A Facile Strategy to Fabricate Polysaccharide-Based Magnetic Hydrogel Based on Enamine Bond

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Chinese Journal of Chemistry 2020年第11期38卷 1263-1268页

作者： Hongchen Liu jingru Yang Yunlei Yin Haisong Qi College of Textiles Zhongyuan University of TechnologyZhengzhouHenan 450007China State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhouGuangdong 510640China

of main observation and conclusion Magnetic hydrogels have found extensive applications in fields such as soft robotics,drug delivery and shape *** a facile method was fabricated to prepare polysaccharide-based magnetic *** chitosan-Fe3O4 ferrofluid was obtained by dispersing carboxyl groups modified Fe3O4 nanoparticles uniformly in chitosan ***,the magnetic polysaccharide hydrogel was obtained by simply mixing cellulose acetoacetate solution with chitosan-Fe3O4 *** structures and properties of the magnetic hydrogel were analyzed using Fourier-transform infrared spectroscopy,rheological recovery,responsiveness,and stability *** results indicated that magnetic polysaccharide hydrogel showed pH responsiveness and excellent self-healing properties,and the hydrogel manifested outstanding stability under physiological conditions(37℃)for 72 *** addition,the injectable polysaccharide-based hydrogel exhibited sensitive magnetic responsive and shape-shifting ability under an external magnetic ***,the strategy for the facile preparation of the magnetic polysaccharide-based hydrogel in this work could provide a benign and versatile method for achieving self-healing,responsive,injectable properties for the application in biomedical fields.

关键词： field. facile stability

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STABILITY ANALYSIS FOR THE LARGE-SCALE SYSTEMS WITH TIME-DELAY

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Journal of Systems Science & Complexity 2006年第4期19卷 558-565页

作者： jingru Qu Cunchen GAO Department of Mathematics Ocean University of China Qingdao 266071 China.

The stability analysis problems were put forward for the large-scale systems with time-delay by using the partial decomposition method. With the stability of the isolated subsystems without time- delay, some sufficient criterions for the asymptotical stability of the whole system were obtained by making a Lyapunov function with the Razumikhin condition and a Lyapunov functional for the retarded type and neutral type, respectively.

关键词： Large-scale time-delay system Lyapunov functional partial decomposition method Razumikhin-type theorem.

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Crack deflection occurs by constrained microcracking in nacre

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Acta Mechanica Sinica 2018年第1期34卷 143-150页

作者： jingru Song Cuncai Fan Hansong Ma Lihong Liang Yueguang Wei LNM Institute of Mechanics Chinese Academy of Sciences Department of Mechanics College of Engineering Peking University

For decades, nacre has inspired researchers because of its sophisticated hierarchical structure and remarkable mechanical properties, especially its extreme fracture toughness compared with that of its predominant constituent,CaCO3, in the form of aragonite. Crack deflection has been extensively reported and regarded as the principal toughening mechanism for nacre. In this paper, our attention is focused on crack evolution in nacre under a quasi-static state. We use the notched three-point bending test of dehydrated nacre in situ in a scanning electron microscope(SEM) to monitor the evolution of damage mechanisms ahead of the crack tip. The observations show that the crack deflection actually occurs by constrained microcracking. On the basis of our findings, a crack propagation model is proposed, which will contribute to uncovering the underlying mechanisms of nacre’s fracture toughness and its damage evolution. These investigations would be of great value to the design and synthesis of novel biomimetic materials.

关键词： Biological mineralized material Nacre Toughening mechanism Three-point bending test Crack deflection Microcracking

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