检索结果-南通市图书馆

Acta Pharmaceutica Sinica B 2016年第6期6卷 568-575页

作者： Wenzhi Yang Xue Qiao Kai Li jingran fan Tao Bo De-an Guo Min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences Agilent Technologies

To differentiate traditional Chinese medicines(TCM) derived from congeneric species in TCM compound preparations is usually challenging. The roots of Panax ginseng(PG), Panax quinquefolium(PQ) and Panax notoginseng(PN) are used as popular TCM. They contain similar triterpenoid saponins(ginsenosides) as the major bioactive constituents. Thus far, only a few chemical markers have been discovered to differentiate these three species. Herein we present a multiple marker detection approach to effectively differentiate the three Panax species, and to identify them in compound preparations. Firstly, 85 batches of crude drug samples(including 32 PG, 30 PQ, and 23 PN) were analyzed by monitoring 40 major ginsenosides in the extracted ion chromatograms(EICs) using a validated LC–MS fingerprinting method. Secondly, the samples were clustered into different groups by pattern recognition chemometric approaches using PLS-DA and OPLS-DA models, and17 diagnostic chemical markers were discovered. Aside from the previously known Rf and p-F11, ginsenoside Rs1 could be a new marker to differentiate PG from PQ. Finally, the above multiple chemical markers were used to identify the Panax species in 60 batches of TCM compound preparations.

关键词： Panax species Ginsenoside LC–MS fingerprinting Chemical marker TCM compound preparation

Chemical constituents of the aerial parts of Glycyrrhiza uralensis and their inhibitory activities against PTP1B andα-glucosidase

在线全文

学校读者我要写书评

暂无评论

Journal of Chinese Pharmaceutical Sciences 2020年第5期29卷 305-313页

作者： jingran fan Zeyuan Dong Yi Kuang Yanxia Zhou Xue Qiao Min Ye School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China

In the present study,a total of 11 compounds were isolated from the aerial parts of Glycyrrhiza uralensis,including two new compounds,glycyuralin Q(1)and glycyuralin R(2),and nine known compounds,including licoriphenone(3),orobol(4),trifoliol(5),7,2′,4′-trihydroxy-5-methoxy-3-arylcoumarin(6),11-hydroxy-9(Z),12(Z)-octadecadienoic acid(7),11-hydroxy-9(E),12(E)-octadecadienoic acid(8),licoricone(9),glycyrin(10),and 2′-hydroxyformononetin(11).Structures of the new compounds were identified by 1 D,2 D NMR and HR-MS data *** 1,2 and 10 showed potent inhibitory activities against PTP1 B,with IC50 values of 1.43,4.71 and 3.79μM,*** 2,4 and 10 inhibitedα-glucosidase with IC50 values of 13.61,11.13 and 17.48μM,respectively.

关键词： The aerial parts PTP1B α-Glucosidase Glycyrrhiza uralensis

Study on Cleaner Production Subsidies, Income Distribution Imbalance and Carbon Emissions Permit Reallocation Mechanism

在线全文

学校读者我要写书评

暂无评论

China Finance and Economic Review 2022年第4期11卷 66-88页

作者： Qingquan fan jingran Liu Jingda Wang The School of Finance and Taxation Capital University of Economics and Business Beijing China

The allocation mechanism for carbon emissions permit(CEP)is an institutional guarantee for advancing the development of China’s unified carbon trading *** initial allocation of carbon quotas fails to solve new inequalities stemming from subsidizing cleaner *** paper constructs a theoretical framework that describes China’s progressive decline in carbon intensity,calculates the equilibrium solution on the neoclassical saddle point path using the shooting method,and studies the income distribution imbalance caused by cleaner production subsidies and the reallocation mechanism of carbon emissions permit The main conclusion is that the incremental cleaner production subsidy policy meets the goal of maximizing welfare on the saddle point path,but it may lead to over-investment in the clean sector,thus causing the income distribution imbalance among *** research suggests that the amount of carbon emissions permit acquired by the clean sector should be higher than the actual emissions in the trading market and that,as the cleaner support increases,the share of carbon emissions permit acquired by the sector should be constantly increased through reallocation *** helps achieve the Pareto improvement in all parties’economic benefi ts.

关键词： carbon emissions permit carbon trading market cleaner production subsidies reallocation mechanism

Double dividend of carbon intensity:environmental-quality improvement and sustainable economic growth

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Population,Resources and Environment 2015年第3期13卷 187-197页

作者： Qingquan fan Xianhua Zhou jingran Liu School of Economics and Management Tsinghua University Department of Non-life Actuarial Science China Institute for Actuarial ScienceCentral University of Finance and Economics School of Foreign Languages Civil Aviation University of China

This paper established an equilibrium model including representative household,government,and eight industries,and two different environmental policy tools such as carbon intensity and carbon cap were added into the *** paper points out that the carbon intensity policy imposed on major high-emission industries achieved double dividend of environmentalquality improvement and sustainable economic growth under the condition of proper constraint *** result supports the environmental Porter *** paper finds out that the double dividend is due to the fact that environmental governance policy leads to the rising price of resources and demand of labors,resulting in an effective redistribution of production factors among industries and sustainable economic ***,this paper estimates the marginal effect of economic structure on carbon emission and carbon intensity and provides targeted suggestions.

关键词： carbon intensity industrial structure economic growth environmental quality

A Topology-Matching Spike Protein-Capping Tetrahedral DNA Nanocrown for SARS-CoV-2 Neutralization

在线全文

学校读者我要写书评

暂无评论

CCS Chemistry 2023年第6期5卷 1372-1385页

作者： jingran Chen Shuxin Xu Qing Ye Hang Chi Ying Li Mei Wu Baochao fan Zhanchen Guo Cheng-Feng Qin Bin Li Zhen Liu State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023 State Key Laboratory of Pathogen and Biosecurity Department of VirologyBeijing Institute of Microbiology and EpidemiologyAMMSBeijing 100071 Institute of Veterinary Research Jiangsu Academy of Agricultural SciencesNanjing 210014

The constantly mutating severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)poses great risk of efficacy loss to the present neutralizing ***,it is urgently needed to develop versatile strategies that enable rapid design and engineering of potent neutralizing therapeutics for newly emerging ***,we present an unprecedented DNA nanocrown that can topologically match and multivalently bind the S-trimer of SARS-CoV-2 and thereby inhibit its infection to host cells.A neutralizing aptamer binding the N-terminal domain(NTD)supersite of the S protein was first screened and *** was further elaborately engineered onto the best fitting tetrahedral DNA nanostructure to form a spike protein-capping nanocrown,which can effectively block not only wild-type(WT)SARS-CoV-2 pseudovirus,but also several important mutants including D614G,N501Y,andΔ69–***,it can evidently diminish the RNA copies of authentic WT SARS-CoV-2 in host cells by 4.6 orders of ***,utilizing the aptamer selection method and the dedicated engineering route,our topology-matching DNA framework provides a versatile platform for SARS-CoV-2 inhibition and has the potential to be facilely expanded to newly emerging variants and other fatal coronaviruses.

关键词： aptamer topology-matching DNA framework SARS-CoV-2 neutralization therapy N-terminal domain supersite

Functional principle of the synergistic effect of co-loaded Co-Pi and FeOOH on Fe2O3 photoanodes for photoelectrochemical water oxidation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Catalysis 2020年第11期41卷 1761-1771页

作者： jingran Xiao Longlong fan Zhongliang Huang Jun Zhong Feigang Zhao Kaiji Xu Shu-Feng Zhou Guowu Zhan College of Chemical Engineering Huaqiao UniversityXiamen 361021FujianChina

The establishment of multi-component catalytic systems on Fe2O3 photoanodes presents considerable potential for significantly enhancing the performance of photoelectrochemical water splitting systems. In this study, we hydrothermally synthesized a Fe2O3 photoanode. In addition, d-Fe OOH synthesized via dip-coating and hydrothermally prepared h-FeOOH were used as cocatalysts and their synergistic combinations with cobalt phosphate(Co-Pi) were investigated. The synergy between h-FeOOH and Co-Pi was remarkable, whereas that between d-Fe OOH and Co-Pi was negligible. For example, the onset potentials of the Co-Pi/h-FeOOH and Co-Pi/d-FeOOH dual catalysts, were cathodically shifted by 270 and 170 m V, respectively. Moreover, the photocurrent density of the Co-Pi/h-FeOOH/Fe2O3 anode was significantly higher than that of the Co-Pi/d-FeOOH/Fe2O3 one. The synergistic effect of Co-Pi and h-FeOOH could be attributed to the significantly inhibited recombination of surface charges owing to the formation of a p-n junction between β-FeOOH and Fe2O3 and the large contact area between the granular h-FeOOH and Co-Pi. However, the thin amorphous FeOOH layer of the Co-Pi/d-FeOOH/Fe2O3 anode acted as a hole-transfer medium, and weakly promoted the kinetics of the charge transfer process.

关键词： Fe2O3 Synergistic effect Onset potential Photoanode Water splitting

在线全文

学校读者我要写书评

暂无评论

植物嫁接砧穗愈合机制研究进展

浙江农林大学学报 2018年第3期35卷 552-561页

作者：刘婧冉杜长霞樊怀福浙江农林大学浙江省农产品品质改良技术研究重点实验室浙江杭州311300 浙江农林大学农业与食品科学学院浙江杭州311300

植物嫁接砧穗愈合是指同种或异种植物的细胞、组织或器官互相影响与作用,结合成一个完整有机体的过程,受砧穗自身和外界等多种因素的调节和控制,是植物学领域的研究热点。嫁接可使植物的产量及品质得到提升,并有助于植物更好地适应环境... 详细信息

植物嫁接砧穗愈合是指同种或异种植物的细胞、组织或器官互相影响与作用,结合成一个完整有机体的过程,受砧穗自身和外界等多种因素的调节和控制,是植物学领域的研究热点。嫁接可使植物的产量及品质得到提升,并有助于植物更好地适应环境。了解植物嫁接砧穗愈合机制对提高嫁接成活率和嫁接技术在生产中的应用具有重要的意义。就当前植物嫁接砧穗愈合的形态学进程、生理生化机制、分子调控及影响因素等方面的研究进展进行了综述,并对未来研究方向进行了展望。

关键词：植物学嫁接砧穗愈合机制综述

Confined Growth of MOFs via Transformation from Cu2O

在线全文

学校读者我要写书评

暂无评论

Confined Growth of MOFs via Transformation from Cu2O

中国化学会第十届全国无机化学学术会议

作者： Longlong fan Zhongliang Huang Feigang Zhao jingran Xiao Shu-Feng Zhou Guowu Zhan College of Chemical Engineering Huaqiao University

Metal-organic frameworks (MOFs),coordinated by metal ions/cluster and multidentate organic linkers in highly regular networks,have emerged as an exciting material in nanotechnology. Tremendous efforts have been paid so far on the architectural synthesis of MOF crystals with controllable size,morphology,and topology due to their versatile applications,which has become a burgeoning topic in chemistry and materials science. Confined MOF crystals inside a cavity (e.g.,confined space within a shell/channel) own fascinating properties and tunable functionalities,similar to the confined nanoparticles. For instance,the MOFs in isolated environments are largely different from the flat structures,which are expected to show interesting properties on the molecular packing,orientation,reactivity, being critically important for the catalysis applications of *** concept is summarized in Figure 1,each CuO@m SiO can be viewed as isolated nanoreactors for the synthesis of MOFs,in which the diffusion rate of ligand from bulk solution to the interior of the mesoporous silica,and the decomposition rate of the CuO to release copper ions are two most decisive factors on the formation of HKUST-1 within the mesoporous silica ***,by proper manipulation of synthetic parameters,we can control the shapes of the MOFs within the confined *** to the mesoporous nature of m SiO shell,the confined MOFs are fully accessible for the guest molecules.

关键词： confined growth MOFs Cu2O encapsulation galvanic replacement

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

企业研发风险与补贴政策优化研究

经济研究 2022年第5期57卷 192-208页

作者：何晴刘净然范庆泉首都经济贸易大学财政税务学院 100070

企业创新活动直接关系创新链和产业链对接的成效,是推进中国经济高质量发展的主动力。如何积极应对创新活动的不确定性风险,以激励企业加大研发投入力度,是政府研发补贴政策要解决的关键问题,无论在理论探索还是政策优化方面都极具研究... 详细信息

企业创新活动直接关系创新链和产业链对接的成效,是推进中国经济高质量发展的主动力。如何积极应对创新活动的不确定性风险,以激励企业加大研发投入力度,是政府研发补贴政策要解决的关键问题,无论在理论探索还是政策优化方面都极具研究价值。本文构建了一个包括政府补贴和企业研发投入的局部均衡模型,分析不同风险阶段政府补贴对企业研发行为的影响,厘清研发补贴政策产生激励作用和挤出效应的内在机制。基于2007—2019年中国上市公司数据,本文进一步对不同研发风险阶段政府补贴的政策效果差异进行评估。理论研究发现,在具有较高风险的研究阶段和较低风险的开发阶段,政府补贴对研发活动预期边际收益影响的变化方向不同,从而对企业研发投入产生了异质性影响。实证研究为这一理论观点提供了经验证据。政府对企业创新活动的补贴政策需要综合考虑研究阶段补贴的激励作用和开发阶段补贴的挤出效应,这为新一轮的研发补贴政策优化提供了理论依据与实践支撑。

关键词：创新活动研发风险激励作用挤出效应补贴政策优化

政府研发补贴的异质性与政策协同:基础研究的视角

在线全文

学校读者我要写书评

暂无评论

财政研究 2024年第7期 96-112页

作者：刘净然刘祎男范庆泉首都经济贸易大学经济学院首都经济贸易大学财政税务学院

健全科技领域的新型举国体制,发挥整个科技链条上政策组合的协同效应,是面向国家重大战略需求、突破关键技术瓶颈的核心问题。为此,本文构建了基础研究投入和企业研发决策的局部均衡模型,设计科技创新链条上的政策组合,探究政府研发补... 详细信息

健全科技领域的新型举国体制,发挥整个科技链条上政策组合的协同效应,是面向国家重大战略需求、突破关键技术瓶颈的核心问题。为此,本文构建了基础研究投入和企业研发决策的局部均衡模型,设计科技创新链条上的政策组合,探究政府研发补贴如何精准发力和提质增效。基于校企联合申请专利信息,识别出2014—2020年上市公司与高等学校形成的校企创新联合体,利用“双一流”高校建设作为基础研究投入变动的外生冲击,通过上市公司披露的政府补助明细构造政府研发补贴变量,评估基础研究投入变化对政府研发补贴政策效果的影响差异。理论研究发现,基础研究投入和政府研发补贴的政策组合能够产生更高的创新效能,基础研究投入对研发补贴政策效果具有正向的调节作用。实证结果支持了理论发现,并在科技成果转化率的不同情景下解释了政策组合的效能差异,这对于优化创新资源配置和提升政府研发补贴的政策效能具有重要价值,为尽早实现高水平科技自立自强提供了理论依据与实践路径。

关键词：基础研究调节作用研发补贴创新动力创新联合体