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Dendrobium species regulate energy homeostasis in neurodegenerative diseases: a review

Food Science and Human Wellness 2023年第6期12卷 2151-2174页

作者： Feixuan wang Jingqiong Wan Yangzhen Liao Shangyu Liu Yuan Wei Zhen Ouyang School of Pharmacy Jiangsu UniversityZhenjiang 212013China Nanjing Institute of Product Quality Inspection Nanjing 210019China School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013China

Brain energy homeostasis is a vital physiological function in maintaining a balanced internal metabolic environment.The impairment of energy homeostasis is recognized as a key pathophysiological basis for brain metabolic disorders and related neurodegenerative diseases.Dendrobium species(‘Shihu’in Chinese)such as D.officinale,D.huoshanense,D.nobile,D.chrysanthum,D.loddigesii,D.moniliforme,D.gratiosissimum,D.candidum and D.caulis are widely used as traditional Chinese medicines/nutraceuticals to control and treat neurodegenerative disorders.These dietary herbs and their derived compounds possess a variety of biological properties,such as suppression of oxidative stress and neuroinflammation,regulation of energy homeostasis mainly through improving brain mitochondria function,insulin signaling and lipid metabolism.Furthermore,they reduce neurotoxicity,alleviate brain injury and neuropathy,and prevent neurodegenerative conditions including stroke,Alzheimer’s disease,Parkinson’s disease,and Huntington’s disease in humans and/or rodents.Moreover,the nutraceuticals from Dendrobium species promote gut health and aid digestion,which appear to be associated with beneficial effects on brain energy homeostasis.Based on the above-mentioned health benefits associated with Dendrobium species,this work reviews their nutraceutical role in neurodegenerative disorders and further suggests the need to elucidate mechanisms of the underlying molecular actions.

关键词： Dendrobium species Nutraceutical role Energy homeostasis Neurodegenerative diseases

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TIR enzymatic functions:signaling molecules and receptor mechanisms

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aBIOTECH 2023年第2期4卷 172-175页

作者： Li wan National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai200032China

The evolutionarily conserved Toll/Interleukin-1 Receptor(TIR)domains across kingdoms of prokaryotes,plants,and animals play critical roles in innate immunity.Recent studies have revealed the enzymatic functions of TIRs,the structural bases of TIRs as holoenzymes,and the identity of TIR-generated small signaling molecules and their receptors,which significantly advanced our understanding on TIR-mediated immune signaling pathways.We reviewed the most up-to-date findings in TIR enzymatic functions from the perspectives of signaling molecules and receptor mechanisms.

关键词： NLR immune receptors TIR domains Signaling molecules Cell death

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金蝉花的本草考证

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中国野生植物资源 2022年第5期41卷 76-85页

作者：周兆永廖天月万晶琼杜文敏姜慧魏渊杨滨欧阳臻江苏大学药学院江苏镇江212013 江苏大学食品与生物工程学院江苏镇江212013 中国中医科学院中药研究所北京100700

通过查阅历代本草、医籍及近现代相关文献资料,对金蝉花药材的名称、基原、产地、品质评价、采收加工炮制及性味功效进行了综合考证,以期为金蝉花药材的深入研究与合理开发利用提供理论依据。

关键词：金蝉花本草考证基原产地品质评价炮制性味功效

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Protecting People from Tobacco Smoke in China: Current Status and Challenges

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China CDC weekly 2022年第21期4卷 460-464页

作者： Xia wan Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijingChina

Over the past two years,many people have encountered difficulties because of the advent of coronavirus disease 2019(COVID-19).The COVID-19 pandemic has unleashed many concerns,such as social isolation and loneliness,drastic changes to lifestyles,uncertainty for the future,and financial pressure.Some people reported smoking more than usual to reduce stress or loneliness(1),which made more people vulnerable to be exposed to second-hand tobacco smoke(SHS).As we know there is no safe level of exposure to SHS,and even brief exposure can cause harm(2).Under this circumstance,it is quite meaningful to reiterate the topic of protecting people from the harms of SHS.

关键词： smoke meaningful exposure

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Light people:Prof.Evelyn Hu's adventure:from semiconductors to quantum-from industry to academia

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光:科学与应用(英文版) 2023年第8期12卷 1459-1466页

作者： Yating wan Chenzi Guo Integrated Photonics lab King Abdullah University of Science and TechnologyThuwalMakkah ProvinceSaudi Arabia Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina

Editorial As part of our Light People series,we are delighted to have invited Prof.Evelyn Hu,a highly accomplished scientist from Harvard University,to share with us her personal journey.Prof.Hu's remarkable contributions in both academia and industry have taken her from industry giants to academia's most prestigious institutions,traversing various research frontiers that have played a critical role in the ongoing digital revolution.Through this interview,we aim to offer the Light community valuable insights into nanophotonics,quantum engineering,and Prof.Hu's research methodology and life philosophy,while also celebrating her outstanding achievements as a female role model.Ultimately,our goal is to inspire more women to pursue careers in this important and rapidly expanding field,which has a profound impact on all sectors of society.The following is a summary of an interview with Professor Evelyn Hu,available in the Supplementary Information.

关键词： interview frontier industry

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Light People:Prof.John Bowers spoke about silicon photonics

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Light(Science & Applications) 2022年第12期11卷 2843-2848页

作者： Chenzi Guo Yating wan Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina Integrated Photonics lab King Abdullah University of Science and TechnologyThuwalMakkah

Editorial Silicon photonics is advancing rapidly with many scientific and engineering advances and many new applications for photonics.To highlight the topic,Light:Science&Applications invited John Bowers,director of the Institute for Energy Efficiency and distinguished professor from the University of California,Santa Barbara,to talk about the fundamentals and industries,and give a future perspective of silicon photonics.The below is summarized from the video interview of Prof.Bowers.The original interview can be accessed in Supplementary video.

关键词： Efficiency interview photonics

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Evaluating changes in business distribution within urban rail transit hubs in Beijing via Point of Interest (POI) data analysis (2008-2020)

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Frontiers of Architectural Research 2024年第2期13卷 305-318页

作者： Bo wan Dongyang wan Qiang Sheng School of Architecture and Design Beijing Jiaotong UniversityBeijing 100044China

This paper,set against the backdrop of expanding urban rail networks and dynamic urban development,focuses on the distribution and evolution of commercial Points of Interests(POIs)within the central urban rail transit areas of Beijing.The study examines data from four different years-2008,2013,2017,and 2020-to observe the temporal evolution of commercial entities.It identifies stable explanatory variables affecting the distribution and evolution of commercial POIs,which include rail transit accessibility,characteristics of the working and residential population distribution around stations,and the construction intensity in the vicinity of station areas.Through statistical analysis and model building,relatively stable linear regression equations were established,with R2 values generally maintained above 0.5(except for 2017).The study advances our understanding of the influence of rail transit on urban commercial spaces and how this influence shifts with temporal and urban developmental changes.It elucidates the correlation between changes in the number of businesses and spatial configuration,offering insights and information for urban planners and policy makers.This research also serves as a model for exploring the interplay between urban rail transit and commercial spaces in other major cities.

关键词： Urbanrail transit areas Spatial configuration Distributionand evolution of commercial POls

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Light People:Prof.Kei May Lau,newly elected US NAE member in Hong Kong,talks about future of photonics and women in science

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Light(Science & Applications) 2024年第4期13卷 602-608页

作者： Yating wan Chenzi Guo Electrical and Computer Engineering the ComputerElectrical and Mathematical Sciences and Engineering DivisionKing Abdullah University of Science and Technology23955-6900 ThuwalSaudi Arabia Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina

Editorial Photonics technology remains a driving force in today’s scientific landscape,marked by continuous innovation and crossdisciplinary relevance.In an enlighting conversation with Light:Science&Applications,Prof.Kei May Lau,a pioneer in photonics research,shares her deep insights on the evolution of technologies of LEDs,lasers,challenges of hetero-epitaxy,and the future of micro-LEDs and quantum dot lasers.Recently honored as a member of the US National Academy of Engineering(NAE)for her significant contributions to photonics and electronics using III-V semiconductors on silicon,Prof.Lau stands out as the sole Hong Kong scholar inducted into the NAE this year,joining 114 new and 21 international members.In this exclusive Light People interview,Prof.Lau shares her journey as a pioneering woman in engineering,her commitment to mentorship and academia,and her perspective on advancing female representation in science.The summary provided is distilled from Prof.Lau’s thoughtful responses during the interview.For a deeper exploration of Prof.Lau’s experiences and advice,the full interview is available in the Supplementary material.

关键词： interview lighting driving

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HPLC法测定石斛类药材中烟酸和烟酰胺的含量

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中国野生植物资源 2023年第4期42卷 23-27,38页

作者：王飞轩廖扬振廖天月万晶琼陈国霞朱南韩邦兴欧阳臻江苏大学药学院江苏镇江212013 南京市产品质量监督检验院江苏南京210019 江苏大学食品与生物工程学院江苏镇江212013 皖西学院生物与制药工程学院安徽六安237000

目的:建立同时测定石斛类药材中烟酸和烟酰胺含量的HPLC法。方法:采用Supersil AQ C-_(18)柱(4.6 mm×250 mm,5μm),0.1%庚烷磺酸钠溶液(含7%甲醇和2%异丙醇,pH至2.1±0.1)为流动相,流速为1.0 mL/min,检测波长为261 nm。结果:烟酸和烟... 详细信息

目的:建立同时测定石斛类药材中烟酸和烟酰胺含量的HPLC法。方法:采用Supersil AQ C-_(18)柱(4.6 mm×250 mm,5μm),0.1%庚烷磺酸钠溶液(含7%甲醇和2%异丙醇,pH至2.1±0.1)为流动相,流速为1.0 mL/min,检测波长为261 nm。结果:烟酸和烟酰胺分别在0.002~0.040 mg/mL(R^(2)=0.9995)、0.006~0.120 mg/mL(R^(2)=0.9995)浓度范围内线性关系良好,平均回收率为99.68%和99.14%,RSD为1.91%和1.74%。结论:不同种石斛类药材中烟酸与烟酰胺的含量有差异,铜皮石斛中烟酸含量最高,流苏石斛中烟酰胺含量最高。该研究建立的方法简便、准确、重复性好,为石斛药材的品质评价及开发研究提供科学依据。

关键词：石斛烟酸烟酰胺高效液相色谱法含量测定

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Unveiling the future of chemistry:the 2023 emerging investigator issue of Science China Chemistry

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Science China Chemistry 2023年第12期66卷 3323-3330页

作者： Li-Jun wan Institute of Chemistry Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

In the dynamic realm of scientific discovery,it is imperative to acknowledge and support the innovative perspectives and groundbreaking research emanating from the next generation of leaders in our field.To this end,S... 详细信息

关键词： breaking field chemistry

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