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Analysis on the distinguishing features of traditional Chinese therapeutics and related statistical issues

Frontiers of Medicine 2011年第2期5卷 203-207页

作者： jingqing hu Jie Qiao Deying Kang Baoyan Liu Center for Clinical Evaluation Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Department of Clinical Epidemiology West China HospitalSichuan UniversityChengdu 610041China China Academy of Chinese Medical Sciences Beijing 100700China

Traditional Chinese medicine(TCM)is one of the rarely existing ancient traditional medicines that hold systematic theories as well as preventative and therapeutic methods for diseases in *** the 1950s,such research methods as mathematics,statistics,and data mining(DM)have been gradually introduced to TCM studies,making it more ***,the distinct features of TCM theories and diagnostic-model have constantly challenged the methodology of *** paper introduces the following scientific features of traditional Chinese therapeutics:1)its goal is to balance the functions and conditions of human body;2)it emphasizes on holism and individualization;3)it stresses the longitudinal regulation and evaluation mode,which is a circle of syndrome diagnosis,treatment and evaluation;4)the interventions of TCM are abundant,compound and natural;and 5)humanistic thought is *** statistical problems are raised based on these ***,complex statistical methods that can analyze subjective indexes and latent variables,multidimensional and multistage data,non-equilibrium designed studies,and longitudinal data are ***,comprehensive evaluation on multiple-target mechanism has been brought in by combination ***,there is a need to analyze how humanity and related cultural factors may influence the effect of ***,promoting implemented studies of statistics as well as carrying out the TCM scientific propositions have become the common expectations of both TCM and modern medicine.

关键词： traditional Chinese therapeutics feature statistic

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Influencing factors on efficacy of summer acupoint application treatment for allergic rhinitis:a retrospective study

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Journal of Traditional Chinese Medicine 2012年第3期32卷 377-381页

作者： Jin Peng Xiaqiu Wu jingqing hu Yigong Fang Mingjie Zi Baoyan Liu Institute of Basic Research in ClinicalMedicine China Academy of Chinese Medical Sciences Beijing 100700 China Baoyan Liu China Academy of Chinese Medical Sciences Beijing 100700 China Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences Beijing100700 China Xiyuan Hospital China Academy of ChineseMedical Sciences Beijing 100700 China

OBJECTIVE:Allergic rhinitis(AR) is a common health *** acupoint application treatment(SAAT) is reported to effectively treat and prevent AR from seasonal *** the present study,we aimed to evaluate its effects,especially on the course of AR,through a retrospective ***:A cross-sectional multicenter study was performed based on patients treated between 2008 and 2009 in 13 clinical centers in China.A total of 1058 outpatients aged ≥2 years with documented AR and ≥1 year SAAT were eligible for enrollment.A case report form(CRF) was completed by both patient and *** CRF was designed to collect data on the patient's history of SAAT,AR condition,and self-reported health *** outcomes(dependent variables) were incidence and intensity of AR and concomitant medications *** were analyzed with ordinal logistic regression(OLR).RESULTS:Treatment course and seasonal pattern of AR were related to all dependent variables *** controlling for sample bias and confounding factors,the findings suggested that a 3-year treatment course had better efficacy(OR/incidence of AR:2.57,95%CI:1.76-3.76;OR/intensity of AR:2.17,95%CI:1.50-3.17;OR/concomitant medications:2.20,95% CI:1.50-3.23) compared with a 2-year or less treatment ***:The results showed that:1)the length of treatment course was positively associated with the efficacy of SAAT(the longer the treatment course,the better the efficacy);and 2)SAAT was more efficacious in treating seasonal AR than non-seasonal AR.

关键词： Acupoint sticking therapy Allergic rhinitis Cross-sectional studies Traditional Chinese Medicine

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Thinking and practice of accelerating transformation of traditional Chinese medicine from experience medicine to evidence-based medicine

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Frontiers of Medicine 2011年第2期5卷 163-170页

作者： Baoyan Liu Yanhong Zhang jingqing hu Liyun He Xuezhong Zhou China Academy of Chinese Medical Sciences Beijing 100700China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Guang'anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China School of Computer and Information Technology Beijing Jiaotong UniversityBeijing 100044China

The gradual development of Chinese medicine is based on constant accumulation and summary of experience in clinical practice,but without the benefit of undergoing the experimental medicine *** Chinese medicine has formed a systematic and unique theory system through thousands of years,with the development of evidence-based medicine,the bondage of the research methods of experience medicine to Chinese medicine is *** rapid transition and transformation from experience medicine to evidence-based medicine have become important content in the development of Chinese *** to the features of Chinese medicine,we propose the research idea of“taking two ways simultaneously,”which is the study both in the ideal condition and in the real *** and constructing the theoretical basis and methodology of clinical research in the real world,and building the stage for research technique is key to the effective clinical research of Chinese *** by gradually maturing and completing the clinical research methods of the real world could we realize“taking two ways simultaneously”and complementing each other,continuously produce scientific and reliable evidence of Chinese medicine,as well as transform and develop Chinese medicine from experience medicine to evidence-based medicine.

关键词： Chinese medicine experience medicine evidence-based medicine real world

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Clinical phenotype network： the underlying mechanism for perso- nalized diagnosis and treatment of traditional Chinese medicine

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Frontiers of Medicine 2014年第3期8卷 337-346页

作者： Xuezhong Zhou Yubing Li Yonghong Peng jingqing hu Runshun Zhang Liyun He Yinghui Wang Lijie Jiang Shiyan Yan Peng Li Qi Xie Baoyan Liu School of Computer and Information Technology and Beijing Key Lab of Traffic Data Analysis and Mining Beijing Jiaotong University Beijing 100044 China China Academy of Chinese Medical Sciences Beijing 100700 China School of Engineering and lnformatics University of Bradford BD7 IDP UK Institute of Basic Theory of Traditional Chinese Medicine China Academy of Chinese Medical Sciences Beijing 100700 China Guang 'anmen Hospital China Academy of Chinese Medical Sciences Beijing 100053 China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Beijing 100700 China

Traditional Chinese medicine （TCM） investigates the clinical diagnosis and treatment regularities in a typical schema of personalized medicine, which means that individualized patients with same diseases would obtain distinct diagnosis and optimal treatment from different TCM physicians. This principle has been recognized and adhered by TCM clinical practitioners for thousands of years. However, the underlying mechanisms of TCM personalized medicine are not fully investigated so far and remained unknown. This paper discusses framework of TCM personalized medicine in classic literatures and in real-world clinical settings, and investigates the underlying mechanisms of TCM personalized medicine from the perspectives of network medicine. Based on 246 well-designed outpatient records on insomnia, by evaluating the personal biases of manifestation observation and preferences of herb prescriptions, we noted significant similarities between each herb prescriptions and symptom similarities between each encounters. To investigate the underlying mechanisms of TCM personalized medicine, we constructed a clinical phenotype network （CPN）, in which the clinical phenotype entities like symptoms and diagnoses are presented as nodes and the correlation between these entities as links. This CPN is used to investigate the promiscuous boundary of syndromes and the co-occurrence of symptoms. The small-world topological characteristics are noted in the CPN with high clustering structures, which provide insight on the rationality of TCM personalized diagnosis and treatment. The investigation on this network would help us to gain understanding on the underlying mechanism of TCM personalized medicine and would propose a new perspective for the refinement of the TCM individualized clinical skills.

关键词： personalized medicine complex network clinical phenotype network traditional Chinese medicine

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“热结血脉”概论

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世界科学技术-中医药现代化 2019年第10期21卷 2005-2008页

作者：胡镜清中国中医科学院中医基础理论研究所

“热结血脉”是近年来我们一直思考并探索的诸多疾病的共性病机假说。它是指热邪与瘀血等有形之物在血脉中郁结难解,互为因果,继发积热、生毒、结癥、伤脉的不良循环过程。其主要病机是“热邪”与血脉中的“瘀血痰湿”等有形之物相互搏... 详细信息

“热结血脉”是近年来我们一直思考并探索的诸多疾病的共性病机假说。它是指热邪与瘀血等有形之物在血脉中郁结难解,互为因果,继发积热、生毒、结癥、伤脉的不良循环过程。其主要病机是“热邪”与血脉中的“瘀血痰湿”等有形之物相互搏结,病位在“血脉”。总以清热解毒、活血凉血、散结养脉为治法,有助于临床疗效。

关键词：热结血脉病机理论

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痰瘀互结证新论

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中国中医基础医学杂志 2023年第1期29卷 12-13,115页

作者：胡镜清中国中医科学院中医基础理论研究所北京100700 中国中医药科技发展中心北京100075

自20世纪90年代诊断标准面世以来,痰瘀互结证受到越来越多的关注,渐至成为诊治疑难杂症的临床法门和理论研究热点。本文在全面梳理痰瘀互结证研究成果的基础上,系统性总结并新修订了痰瘀互结证的概念、病因病机、临床表现、分期分型和... 详细信息

自20世纪90年代诊断标准面世以来,痰瘀互结证受到越来越多的关注,渐至成为诊治疑难杂症的临床法门和理论研究热点。本文在全面梳理痰瘀互结证研究成果的基础上,系统性总结并新修订了痰瘀互结证的概念、病因病机、临床表现、分期分型和治疗原则,提出“痰瘀兼化”的病机变化主线,早期、中期、晚期分期与虚寒型、湿热型和混合型分型的新认识,以及治疗中强调痰瘀同治和注重祛湿、温阳、清热、补虚等综合运用。试图通过这样的集成总结和深化阐释,推动对痰瘀互结证科学内涵的研究,推动应用痰瘀互结证相关理论进一步提高疑难病的临床诊治水平。

关键词：痰瘀互结病机分期临床表现治创治法

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证候疗效评价关键科学问题刍议

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世界科学技术-中医药现代化 2012年第1期14卷 1242-1245页

作者：胡镜清中国中医科学院广安门医院北京100053

证候目前已作为中医药临床疗效评价的关键指标之一,症状与体征量化后的中医证候记分近些年来已广泛用于评价中医药干预效果。但因其存在所测量的结局层面定位不清、诊断与评价属性混淆、证候动态变化测量困难等关键科学问题未能解决而... 详细信息

证候目前已作为中医药临床疗效评价的关键指标之一,症状与体征量化后的中医证候记分近些年来已广泛用于评价中医药干预效果。但因其存在所测量的结局层面定位不清、诊断与评价属性混淆、证候动态变化测量困难等关键科学问题未能解决而备受争议。着力研究并逐渐解决这些关键科学问题,是挖掘证候疗效评价的科学内涵,彰显中医药特色优势的基本前提。

关键词：证候疗效评价

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中医学中“虚”“损”“衰”辨析

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中医杂志 2020年第4期61卷 289-293页

作者：张敏胡镜清中国中医科学院中医基础理论研究所北京市100700

通过对"虚""损""衰"本义辨析,从"虚""损""衰"的病证与治法进行文献梳理。"虚"为虚弱、不足之义,虚证的治疗应明辨气血阴阳脏腑之所属,以补为主。"损"为减少、损害之义,"积虚成损"是虚损性疾病形成的渐进演变的病理过程,"损"必伴有脏腑... 详细信息

通过对"虚""损""衰"本义辨析,从"虚""损""衰"的病证与治法进行文献梳理。"虚"为虚弱、不足之义,虚证的治疗应明辨气血阴阳脏腑之所属,以补为主。"损"为减少、损害之义,"积虚成损"是虚损性疾病形成的渐进演变的病理过程,"损"必伴有脏腑组织的损伤,应以"益""调""缓"的方法治疗,不同于单纯的补法。"衰"为衰弱、衰老之义,虚衰较虚程度更深,进一步可发展为邪盛正衰的亡脱证;另外,老年疾病的发生往往与衰老相关,延缓衰老的治疗则以补益五脏为主,重在补肾,兼以化痰祛瘀。

关键词：虚证虚损衰老补肾化痰祛瘀

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从病机角度浅析《黄帝内经》审机论治的疾病诊疗体系

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中医杂志 2020年第17期61卷 1488-1492页

作者：佟旭胡镜清中国中医科学院中医基础理论研究所北京市100700

从病机角度着眼,解析《黄帝内经》审机论治的疾病诊疗体系。凡欲诊病,先察病机,审察病机处于《黄帝内经》疾病诊疗中的核心;掌握住病机就掌握了疾病的本质和治疗的关键,面对临床复杂多变的病情局面,能够起到执简驭繁的作用。此外,《黄... 详细信息

从病机角度着眼,解析《黄帝内经》审机论治的疾病诊疗体系。凡欲诊病,先察病机,审察病机处于《黄帝内经》疾病诊疗中的核心;掌握住病机就掌握了疾病的本质和治疗的关键,面对临床复杂多变的病情局面,能够起到执简驭繁的作用。此外,《黄帝内经》对临证审机论治亦有重要的方法学启示,知晓其常、把握其变是审机论治的指导思想;求责"有、无、虚、实"是临证审察病机的思维范式;多维综合、全局遍历是审察病机的执行方法。最后,以"心痛"为典型案例,分析和呈现《黄帝内经》以病机为核心对"心痛"一证进行诊断治疗的全过程。

关键词：病机黄帝内经审机论治

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中医药科研机构评价研究

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世界科学技术-中医药现代化 2018年第7期20卷 1083-1090页

作者：申力胡镜清中国中医科学院中医基础理论研究所北京100700

完善的科研评价体系的建立有助于高效地促进科学研究发展、科技成果转化,形成良性竞争科研环境,从而推动科技事业的不断进步。科研机构评价是科研评价体系的重要部分部分,本文通过文献分析,并以国家重点实验室和国家中医临床研究基地督... 详细信息

完善的科研评价体系的建立有助于高效地促进科学研究发展、科技成果转化,形成良性竞争科研环境,从而推动科技事业的不断进步。科研机构评价是科研评价体系的重要部分部分,本文通过文献分析,并以国家重点实验室和国家中医临床研究基地督查评价指标体系为例,为中医药科研机构的评价研究提供借鉴。

关键词：中医药评价科研机构

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