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Engineering 2024年第9期40卷 28-50页

作者： jingqi zeng Xiaobin Jia School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjing 211198China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

This paper introduces a systems theory-driven framework to integration artificial intelligence(AI)into traditional Chinese medicine(TCM)research,enhancing the understanding of TCM’s holistic material basis while adhering to evidence-based *** the System Function Decoding Model(SFDM),the research progresses through define,quantify,infer,and validate phases to systematically explore TCM’s material *** employs a dual analytical approach that combines top-down,systems theory-guided perspectives with bottom-up,elements-structure-function methodologies,provides comprehensive insights into TCM’s holistic material ***,the research examines AI’s role in quantitative assessment and predictive analysis of TCM’s material components,proposing two specific AIdriven technical *** interdisciplinary effort underscores AI’s potential to enhance our understanding of TCM’s holistic material basis and establishes a foundation for future research at the intersection of traditional wisdom and modern technology.

关键词： Artificial intelligence Systems theory Traditional Chinese medicine Material basis Bottom-up

基于加权基因共表达网络分析和分子对接探讨青娥丸治疗腰椎间盘突出症的作用机制

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中医学报 2024年第2期39卷 393-399页

作者：金晖葛殊玮彭广吴洁吴睿哲曾景奇王凡湖南中医药大学第二附属医院湖南长沙410005

目的:基于加权基因共表达网络分析和分子对接探讨青娥丸治疗腰椎间盘突出症(lumbar disc herniation,LDH)的作用机制。方法:通过GEO数据库获取LDH相关数据集GSE124272,采用R软件构建加权基因共表达网络;通过模块基因与性状的关联分析筛... 详细信息

目的:基于加权基因共表达网络分析和分子对接探讨青娥丸治疗腰椎间盘突出症(lumbar disc herniation,LDH)的作用机制。方法:通过GEO数据库获取LDH相关数据集GSE124272,采用R软件构建加权基因共表达网络;通过模块基因与性状的关联分析筛选关键模块,以及模块基因与表型数据的关联分析筛选重要基因。利用中药系统药理学数据库与分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)、中药分子机制生物信息学分析工具(Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine,BATMAN-TCM)数据库检索青娥丸的活性成分,基于Uniprot数据库筛选活性成分的作用靶点,采用Cytoscape软件构建“药物-活性成分-靶点”网络。通过DisGeNET、GeneCards数据库获取LDH疾病靶点,将其与模块基因、青娥丸靶点取交集,作为青娥丸治疗LDH的关键靶点;采用R软件进行基因本体(Gene Ontology,GO)、京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)富集分析;采用AutoDockTools软件进行分子对接验证。结果:GSE124272数据集共涉及5495个基因,blue模块(R=0.63,P=0.008)可能是LDH的关键模块,筛选得到310个重要基因。青娥丸活性成分65个,排名前5的活性成分是补骨脂素、鞣花酸、原人参二醇、异补骨脂素、槲皮素。青娥丸作用靶点997个,LDH疾病靶点1127个,与关键模块基因取交集得到5个关键靶点,包括丝裂原活化蛋白激酶14(mitogen activated protein kinase 14,MAPK14)、基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)、白细胞介素-1β(interleukin-1β,IL-1β)等。KEGG富集分析筛选得到125条通路,包括MAPK信号通路、破骨细胞分化、细胞凋亡等。分子对接显示,青娥丸关键成分与关键基因有较强的结合活性。结论:青娥丸可能通过补骨脂素、鞣花酸、原人参二醇等活性成分作用于MAPK14、MMP-9、IL-1β等关键靶点,调控MAPK信号通路、破骨细胞分化等通路从而发挥治疗LDH的作用。

关键词：腰椎间盘突出症青娥丸 GEO 加权基因共表达网络分子对接作用机制

温阳健骨封包联合八段锦在骨质疏松症患者中的应用

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中华现代护理杂志 2024年第3期30卷 388-392页

作者：高娟李海洋蒋谷芬曾景奇何碧瑜陈旭湖南中医药大学第二附属医院骨伤科长沙410005 中医药导报杂志社编辑部长沙410008 湖南中医药大学第二附属医院副院长办公室长沙410005 湖南中医药大学第二附属医院消化内分泌科长沙410005

目的探讨温阳健骨封包联合八段锦在骨质疏松症(OP)肾阳虚患者中的应用效果。方法采用便利抽样法,选取2021年1月—2022年5月湖南中医药大学第二附属医院骨伤科住院的100例原发性OP肾阳虚患者,随机分为常规组、封包组、八段锦组、联合组,... 详细信息

目的探讨温阳健骨封包联合八段锦在骨质疏松症(OP)肾阳虚患者中的应用效果。方法采用便利抽样法,选取2021年1月—2022年5月湖南中医药大学第二附属医院骨伤科住院的100例原发性OP肾阳虚患者,随机分为常规组、封包组、八段锦组、联合组,每组25例,常规组为常规治疗,封包组在常规组基础上采取温阳健骨封包干预,八段锦组在常规组的基础上进行八段锦锻炼,联合组在常规组的基础上采取温阳健骨封包与八段锦联合措施,干预时间为12周。比较干预前后各组的临床疗效、中医症候积分、腰椎骨密度、生活质量量表(SF-36)评分、视觉模拟量表(VAS)评分。结果干预后,联合组的临床疗效优于常规组、八段锦组,VAS评分、中医症候积分低于其他3组,腰椎骨密度、SF-36评分高于其他3组,差异均有统计学意义(P<0.05)。结论温阳健骨封包联合简化八段锦对骨质疏松症肾阳虚患者具有良好的临床疗效,能改善骨质疏松患者腰腿痛症状及中医症候,增加患者腰椎骨密度,提高患者生活质量。

关键词：骨质疏松生活质量温阳健骨封包八段锦肾阳虚

Comparative Study on Different Methods for Prediction of Thermal Insulation Performance of Thermal Barrier Coating Used on Turbine Blades

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Journal of Thermal Science 2024年第1期33卷 172-189页

作者： ZHANG Zhixin zeng Wu ZHANG Xiaodong zeng Yuntao Advanced Gas Turbine Laboratory Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China Key Laboratory of Advanced Energy and Power Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China Innovation Academy for Light-duty Gas Turbine Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

As turbine inlet temperature gets higher and higher,thermal barrier coating(TBC) is more and more widely used in turbine *** turbine blades with TBC,it is of great significance to evaluate the temperature distribution of its substrate metal quickly and accurately,especially during the design *** different degrees of simplification such as whether to consider the change of the geometric size of the fluid domain by TBC and whether to consider the planar heat conduction in TBC,three different methods used in conjugate heat transfer(CHT) simulation to model the TBC of the turbine blades have been developed and widely used by ***,little research has been conducted to investigate the influence of the three methods on the temperature distribution of turbine *** fill this gap,three geometric models were *** are a solid conduction model with a substrate metal layer and a TBC layer,a transonic turbine vane with internal cooling and TBC,and a plate cylindrical film hole cooling model with *** methods were used in these geometric models and their differences were carefully analyzed and *** result shows that for the conduction model used in this paper,with the same TBC surface temperature distribution,the difference between the three methods is very small and can be *** a transonic turbine vane with internal cooling,regarding the local maximum temperature of the substrate-TBC interface,the largest difference between the method in which TBC is considered as a thermal resistance or a virtual layer of cells and the method in which three-dimensional heat conduction equation of TBC is solved occurs at the trailing *** difference near the leading edge is below *** employed to the film cooling model,the difference of the laterally averaged temperature of the substrate-TBC interface can be 8 K which is mainly due to the change of the length to diameter ratio of the film cooling hole by *** the substrate

关键词： turbine blade thermal barrier coating conjugate heat transfer film cooling hole

Nested Saturated Control of Uncertain Complex Cascade Systems Using Mixed Saturation Levels

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1163-1174页

作者： Meng Li Zhigang zeng Wuhan National Laboratory for Optoelectronics Wuhan 430074 School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074China School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074 Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Wuhan 430074China

This study addresses the problem of global asymptotic stability for uncertain complex cascade systems composed of multiple integrator systems and non-strict feedforward nonlinear systems. To tackle the complexity inherent in such structures, a novel nested saturated control design is proposed that incorporates both constant saturation levels and state-dependent saturation levels. Specifically, a modified differentiable saturation function is proposed to facilitate the saturation reduction analysis of the uncertain complex cascade systems under the presence of mixed saturation levels. In addition, the design of modified differentiable saturation function will help to construct a hierarchical global convergence strategy to improve the robustness of control design scheme. Through calculation of relevant inequalities, time derivative of boundary surface and simple Lyapunov function,saturation reduction analysis and convergence analysis are carried out, and then a set of explicit parameter conditions are provided to ensure global asymptotic stability in the closed-loop systems. Finally, a simplified system of the mechanical model is presented to validate the effectiveness of the proposed method.

关键词： method saturation differentiable

Aggregation-regulated bioreduction process of graphene oxide by Shewanella bacteria

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Chinese Journal of Chemical Engineering 2024年第5期69卷 56-62页

作者： Kaixin Han Yibo zeng Yinghua Lu Ping zeng Liang Shen Department of Chemical and Biochemical Engineering College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China Chinese Research Academy of Environmental Sciences Beijing 100012China

The bioreduction of graphene oxide(GO)using environmentally functional bacteria such as Shewanella represents a green approach to produce reduced graphene oxide(rGO).This process differs from the chemical reduction that involves instantaneous molecular *** bioreduction,the contact of bacterial cells and GO is considered the rate-limiting *** reveal how the bacteria-GO integration regulates rGO production,the comparative experiments of GO and three Shewanella strains were carried ***-transform infrared spectroscopy,X-ray photoelectron spectroscopy,Raman spectroscopy,and atomic force microscopy were used to characterize the reduction degree and the aggregation *** results showed that a spontaneous aggregation of GO and Shewanella into the condensed entity occurred within 36 h.A positive linear correlation was established,linking three indexes of the aggregation potential,the bacterial reduction ability,and the reduction degree(ID/IG)comprehensively.

关键词： Graphene oxide Reduced graphene oxide Bioreduction Aggregation Shewanella

Eigenvalues for the Clamped Plate Problem of L_(ν)^(2) Operator on Complete Riemannian Manifolds

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2223-2243页

作者： Ling Zhong zeng Jiangxi Provincial Center for Applied Mathematics&School of Mathematics and Statistics Jiangxi Normal UniversityNanchang 330022P.R.China

L_(ν) operator is an important extrinsic differential operator of divergence type and has profound geometric *** this paper,we consider the clamped plate problem of L_(ν)^(2)operator on a bounded domain of the complete Riemannian manifolds.A general formula of eigenvalues of L_(ν)^(2) operator is *** this general formula,we obtain some estimates for the eigenvalues with higher order on the complete Riemannian *** several fascinating applications,we discuss this eigenvalue problem on the complete translating solitons,minimal submanifolds on the Euclidean space,submanifolds on the unit sphere and projective *** particular,we get a universal inequality with respect to the L_(II) operator on the translating ***,it is very difficult to get universal inequalities for weighted Laplacian and even Laplacian on the complete Riemannian ***,this work can be viewed as a new contribution to universal estimate.

关键词： Mean curvature flows L_(ν)^(2)operator clamped plate problem eigenvalues Riemannian manifolds translating solitons

Electrochemical conversion of organic compounds and inorganic small molecules

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Science China Chemistry 2024年第10期67卷 3223-3246页

作者： Weimei zeng Youai Qiu Department of Chemistry Nankai UniversityTianjin 300071China

Electrochemical synthesis presents a facile and sustainable strategy to produce valuable *** review summarizes the most recent advances in electrosynthesizing value-added compounds with inorganic small ***“small molecules”refers to a broad spectrum of chemicals,we mainly focus on the electrochemical conversion of CO_(2),H_(2)O/D_(2)O,NH_(3)and SO_(2)until March *** review intends to compare the results and display general trends throughout the field,with an emphasis on the substrate scope and mechanical ***,we propose several techniques and protocols that can enable a more fundamental understanding of the electrochemical reaction involving inorganic small molecules and help drive this methodology toward commercialization.

关键词： electrochemical synthesis inorganic small molecule organic synthesis carbon dioxide water

Analysis of gravity wave activity during stratospheric sudden warmings in the northern hemisphere

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Earth and Planetary Physics 2024年第2期8卷 415-422页

作者： XuanYun zeng Guang Zhong School of Physics and Electronic Sciences Changsha University of Science and TechnologyChangsha 410000China Key Laboratory of Geospace Environment Chinese Academy of SciencesUniversity of Science&Technology of ChinaHefei 230026China

Due to the significant changes they bring to high latitude stratospheric temperature and wind,stratospheric sudden warmings(SSWs)can have an impact on the propagation and energy distribution of gravity waves(GWs).The variation characteristics of GWs during SSWs have always been an important *** temperature data from January to March in 2014−2016,provided by the Constellation Observing System for Meteorology,Ionosphere and Climate(COSMIC)mission,we have analyzed global GW activity at 15−40 km in the Northern Hemisphere during SSW *** the SSWs that we studied,the stratospheric temperature rose in one or two longitudinal regions in the Northern Hemisphere;the areas affected extended to the east of 90°*** these SSWs,the potential energy density(E_(p)of GWs expanded and covered a larger range of longitude and altitude,exhibiting an eastward and downward *** E_(p)usually increased,while partially filtered by the eastward zonal *** zonal winds weakened or turned westward,E_(p)began to *** SSWs,the E_(p)usually *** observations can serve as a reference for analyzing the interaction mechanism between SSWs and GWs in future work.

关键词： stratospheric sudden warming gravity wave wind filter

Equivariant Chern Classes of Orientable Toric Origami Manifolds

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Chinese Annals of Mathematics,Series B 2024年第2期45卷 221-234页

作者： Yueshan XIONG Haozhi zeng School of Mathematics and StatisticsHuazhong University of Science and Technology Wuhan 430074China

A toric origami manifold,introduced by Cannas da Silva,Guillemin and Pires,is a generalization of a toric symplectic *** a toric symplectic manifold,its equivariant Chern classes can be described in terms of the corresponding Delzant polytope and the stabilization of its tangent bundle splits as a direct sum of complex line *** in general a toric origami manifold is not simply connected,so the algebraic topology of a toric origami manifold is more difficult than a toric symplectic *** this paper they give an explicit formula of the equivariant Chern classes of an oriented toric origami manifold in terms of the corresponding origami ***,they prove the stabilization of the tangent bundle of an oriented toric origami manifold also splits as a direct sum of complex line bundles.

关键词： Equivariant Chern classes Toric origami manifolds Unitary structures Spin structures