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银基催化剂调控及其甲醛催化氧化性能研究

大连理工大学学报 2025年第1期65卷 17-22页

作者：黄彬曲振平大连理工大学环境学院辽宁大连116024

银基催化剂具有较好的氧化能力,在环境催化领域具有良好的应用前景.采用等体积浸渍法制备银基催化剂,考察了助剂种类、预处理气氛和温度、载体孔道结构等制备工艺条件对银基催化剂上甲醛(HCHO)催化氧化性能的影响.实验结果表明,在6%的Ag... 详细信息

银基催化剂具有较好的氧化能力,在环境催化领域具有良好的应用前景.采用等体积浸渍法制备银基催化剂,考察了助剂种类、预处理气氛和温度、载体孔道结构等制备工艺条件对银基催化剂上甲醛(HCHO)催化氧化性能的影响.实验结果表明,在6%的Ag/SBA-15催化剂中添加3%的Fe助剂能显著提高催化剂的HCHO催化氧化性能,先后采用O_(2)和H_(2)处理有助于提高催化剂活性,载体孔道结构对HCHO催化氧化活性影响较小,采用共浸渍法制备的银基催化剂的性能优于两步浸渍法制备的催化剂的性能.其中采用共浸渍法制备的AgFe/SBA-15催化剂,在O_(2)(600℃)和H_(2)(400℃)先后处理后,表现出良好的HCHO催化氧化性能,在75℃时可将HCHO完全转化为CO_(2)和H_(2)O.

关键词：甲醛催化氧化银基催化剂制备工艺条件

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

Segmentation of Hematoxylin-Eosin stained breast cancer histopathological images based on pixel-wise SVM classifier

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Science China(Information Sciences) 2015年第9期58卷 56-68页

作者： qu AiPing CHEN JiaMei WANG LinWei YUAN jingping YANG Fang XIANG QingMing MASKEY Ninu YANG GuiFang LIU Juan LI Yan State Key Laboratory of Software Engineering School of Computer Wuhan University Center of High Performance Computing Huaihua University Department of Oncology Zhongnan Hospital of Wuhan University Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center Department of Pathology Zhongnan Hospital of Wuhan University

Hematoxylin-Eosin(HE) staining is the routine diagnostic method for breast cancer(BC), and large amounts of HE stained histopathological images are available for analysis. It is emergent to develop computational methods to efficiently and objectively analyze these images, with the aim of providing potentially better diagnostic and prognostic information for BC. This work focuses on analyzing our in-house HE stained histopathological images of breast cancer tissues. Since tumor nests(TNs) and stroma morphological characteristics can reflect the biological behaviors of breast invasive ductal carcinoma(IDC), accurate segmentation of TNs and the stroma is the first step towards the subsequent quantitative analysis. We first propose a method based on the pixel-wise support vector machine(SVM) classifier for segmenting TNs and the stroma, then extract four morphological characters related to the TNs from the images and investigate their relationships with the patients’ 8-year disease free survival(8-DFS). The evaluation result shows that the classification based segmentation method is able to distinguish between TNs and stroma with 87.1% accuracy and 80.2% precision,suggesting that the proposed method is promising in segmenting HE stained IDC histopathological images. The Kaplan-Meier survival curves show that three morphological characters(number of TNs, total perimeter, and average area of TNs) in the images have statistical correlations with 8-DFS of the patients, illustrating that the segmented images can help to identify new morphological factors in IDC TNs for the prediction of BC prognosis.

关键词： breast cancer histopathology images segmentation image analysis support vector machine survival analysis

余庆县农村供水工程水资源保护问题及对策探讨

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水利技术监督 2025年第1期 136-138,199页

作者：屈艳贵州省遵义市余庆县水务局贵州遵义564400

随着农村供水工程建设的推进,水资源污染问题仍严重威胁农村供水工程的可持续发展,为分析当前建设中存在的问题并提出有效对策,以贵州省余庆县作为案例,通过实地调研分析了该县农村供水工程建设中存在的问题。研究发现,余庆县农村供水... 详细信息

随着农村供水工程建设的推进,水资源污染问题仍严重威胁农村供水工程的可持续发展,为分析当前建设中存在的问题并提出有效对策,以贵州省余庆县作为案例,通过实地调研分析了该县农村供水工程建设中存在的问题。研究发现,余庆县农村供水工程在监管体系、资金设备保障、水资源管理意识等方面存在不同程度的薄弱环节和不足,根据问题提出了一系列对策措施,对保障水资源的可持续利用具有重要参考价值。

关键词：农村供水工程水资源保护可持续利用

基于应急疏散的滨海地下交通枢纽空间精细化分区研究

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灾害学 2025年第1期40卷 227-234页

作者：瞿扬李彦潼张赫王睿天津大学建筑学院天津300072

暴雨和洪涝对滨海城市的地下空间构成严重威胁,应急疏散效率在受灾场景中至关重要。研究表明空间分区能有效提高疏散效率。目前传统分区方法依赖单一的最短路径方法,无法兼顾安全与高效。该文基于安全性评估提出了一种精细化分区方法。... 详细信息

暴雨和洪涝对滨海城市的地下空间构成严重威胁,应急疏散效率在受灾场景中至关重要。研究表明空间分区能有效提高疏散效率。目前传统分区方法依赖单一的最短路径方法,无法兼顾安全与高效。该文基于安全性评估提出了一种精细化分区方法。首先以应急疏散为目的,对地下空间按功能划分;其次考虑到灾害风险性、人员聚集性和设施高效性三个维度的影响因素,并构建安全性分区评价体系;最后综合上述因素,构建精细化分区划定体系。文章以深圳红树湾地铁站为案例,验证了新方法在保障疏散安全的同时,提升了疏散效率,为地下交通枢纽的防灾规划提供了理论支持。

关键词：地下交通枢纽空间应急疏散安全性分区精细化分区

Research progress of novel adsorption processes in water purification: A review

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Journal of Environmental Sciences 2008年第1期20卷 1-13页

作者： qu Jiuhui State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

As an effective, efficient, and economic approach for water purification, adsorbents and adsorption processes have been widely studied and applied in different aspects for a long time. In the recent years, a lot of novel adsorption processes have been developed for enhancing the efficiency of removing the organic and inorganic contaminants from water. This article reviews some new adsorbents and advanced adsorption methods that specialize in their compositions, structures, functions, and characteristics used in water treatment. The review emphasizes adsorption/catalytic oxidation process, adsorption/catalytic reduction process, adsorption coupled with redox process, biomimetic sorbent and its sorption behaviors of POPs, and modified adsorbents and their water purification efficiency.

关键词： adsorbents adsorption pollutants water purification

circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

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Science China Life Sciences 2025年

作者： Dan Wang Sicheng Zuo Junshang Ge Hongke qu Jie Wu Na Yi Lei Shi Yumin Wang Yongzhen Mo Chunmei Fan Yi He Pan Chen Ming Zhou Bo Xiang Wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. In this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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Time-Periodic Solutions to quasilinear Hyperbolic Systems on General Networks

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 41-72页

作者： Peng qu School of Mathematical Sciences Fudan UniversityShanghai 200433China

For quasilinear hyperbolic systems on general networks with time-periodic boundary-interface conditions with a dissipative structure,the existence and stability of the time-periodic classical solutions are discussed.

关键词： Time-periodic solution quasilinear hyperbolic system General net-work Classical solution Asymptotic stability

营养支持干预在老年慢性阻塞性肺疾病合并营养不良患者中的应用效果及对营养状态的影响

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中国医学创新 2025年第1期22卷 73-77页

作者：瞿伶利广州市第一人民医院老年综合内科广东广州510000

目的:探讨营养支持干预在老年慢性阻塞性肺疾病(COPD)合并营养不良患者中的应用效果及对营养状态的影响。方法:选择2023年4月—2024年2月广州市第一人民医院老年综合内科收治的老年COPD合并营养不良患者148例,以信封法分为两组,各74例... 详细信息

目的:探讨营养支持干预在老年慢性阻塞性肺疾病(COPD)合并营养不良患者中的应用效果及对营养状态的影响。方法:选择2023年4月—2024年2月广州市第一人民医院老年综合内科收治的老年COPD合并营养不良患者148例,以信封法分为两组,各74例。对照组采用常规方法护理,观察组联合营养支持干预,两组均完成4周护理。比较两组肺功能、运动耐力、营养状态、依从性及满意度。结果:两组干预后肺功能与运动耐力均提高,观察组第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)占预计值百分比(FEV_(1)%pred)均高于对照组,6分钟步行试验(6MWT)距离长于对照组(P<0.05);两组干预后营养状态均改善,观察组血红蛋白(Hb)、白蛋白(ALB)、前白蛋白(PAB)均高于对照组,上臂肌围(MAMC)、三头肌皮褶厚度(TSF)及握力(HGS)均大于对照组(P<0.05);观察组依从性高和满意度高的比例均高于对照组(P<0.05)。结论:营养支持干预应用于老年COPD合并营养不良患者中,能提高患者肺功能和运动耐力,改善营养状态,提升依从性和满意度。

关键词：营养支持干预老年慢性阻塞性肺疾病营养状态运动耐力肺功能依从性满意度