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Combinatorial analysis of transcription and metabolism reveals the regulatory network associated with antioxidant substances in waxy corn

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Food Quality and Safety 2022年第4期6卷 638-650页

作者： Jianhong Ke Rui Wang Bangqian Song jinglun du Xiaojiao Li Ningning Song Zhirong Cai Rongli Chen Honghua Yi Xiangyin Lu Chen Jiang Zhengguo Li Baowen Huang Maize Research Institute of Chongqing Academy of Agricultural Sciences ChongqingChina Key Laboratory of Plant Hormones and Development Regulation of Chongqing School of Life SciencesChongqing UniversityChongqingChina

Maize is an essential source of nutrition for humans and animals and is rich in various metabolites that determine its *** maize varieties show significant differences in metabolite *** kinds of waxy maize parental materials,S181 and 49B,created by the Chongqing Academy of Agricultural Sciences,are widely grown in China.S181 shows higher starch and sugar contents than *** study generated metabolic profiles to assess the differences between the two varieties.A total of 674 metabolites that were significantly differentially expressed between the two varieties were identified by gas chromatography and untargeted metabolomics *** metabolites were associated with 21 categories,including antioxidant ***,6415 differentially expressed genes(DEGs)were identified by ***,these DEGs comprised starch and sugar synthesis pathway genes and 72 different transcription factor *** these,six families that were reported to play an essential role in plant antioxidant action accounted for 39.2%of the transcription factor *** the Kyoto Encyclopedia of Genes and Genomes(KEGG)classification,the DEGs were mainly involved in amino acid biosynthesis,glycolysis/glucose metabolism,and the synthetic and metabolic pathways of antioxidant active ***,the correlation analysis of transcriptome and metabolomics identified five key transcription factors(ZmbHLH172,ZmNAC44,ZmNAC-like18,ZmS1FA2,ZmERF172),one ubiquitin ligase gene(ZmE25A)and one sucrose synthase gene(ZmSS1).They likely contribute to the quality traits of waxy corn through involvement in the metabolic regulatory network of antioxidant ***,our results provide new insights into maize quality-related antioxidant metabolite networks and have potential applications for waxy corn breeding.

关键词： Maize quality antioxidants widely targeted metabolomics transcriptomics weighted correlation network analysis

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Enantio-divergent C–H borylation with two different ligands from a single chiral source

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Science China Chemistry 2025年第1期68卷 226-232页

作者： Rongrong du Senmiao Xu State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of Education Hangzhou Normal University University of Chinese Academy of Sciences

Reported here is an iridium-catalyzed enantio-divergent C（sp3）–H borylation of α-gem-dimethyl groups of trifluoromethyl ketone-derived hydrazones to construct a series of acyclic all-carbon quaternary stereocenters with a high level of chiral induction. Two different chiral bidentate boryl ligands from a common chiral source not only can switch the enantioselectivity but also are complementary in terms of the substrate scope.

关键词： asymmetric catalysis C–H borylation all-carbon quaternary stereocenters synthetic methods

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From text to image:challenges in integrating vision into ChatGPT for medical image interpretation

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Neural Regeneration Research 2025年第2期20卷 487-488页

作者： Shunsuke Koga Wei du Department of Pathology and Laboratory Medicine Hospital of the University of PennsylvaniaPhiladelphiaPAUSA

Large language models(LLMs),such as ChatGPT developed by OpenAI,represent a significant advancement in artificial intelligence(AI),designed to understand,generate,and interpret human language by analyzing extensive text *** potential integration into clinical settings offers a promising avenue that could transform clinical diagnosis and decision-making processes in the future(Thirunavukarasu et al.,2023).This article aims to provide an in-depth analysis of LLMs’current and potential impact on clinical *** ability to generate differential diagnosis lists underscores their potential as invaluable tools in medical practice and education(Hirosawa et al.,2023;Koga et al.,2023).

关键词： image diagnosis text

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时效处理对新型耐热钢组织及力学性能的影响

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钢铁 2024年第7期59卷 130-138页

作者：杜京伦杨苏冰丁恒楠王资兴刘天罗锐江苏大学材料科学与工程学院江苏镇江212013 江苏大学农业工程学院江苏镇江212013 江苏省产业技术研究院先进金属材料及应用技术研究所江苏常熟215506

新型含铝奥氏体耐热钢(AFA)在650~700℃温度范围内,具有组织稳定、高温性能优异以及制备成本较低等优点而成为超超临界火电机组的候选材料。为了系统阐明新型含铝奥氏体耐热钢在700℃下的第二相短时析出行为及与力学性能的关系,采用时... 详细信息

新型含铝奥氏体耐热钢(AFA)在650~700℃温度范围内,具有组织稳定、高温性能优异以及制备成本较低等优点而成为超超临界火电机组的候选材料。为了系统阐明新型含铝奥氏体耐热钢在700℃下的第二相短时析出行为及与力学性能的关系,采用时效热处理、第二相析出粗化模型和综合力学试验相结合的方法,分析了700℃短时(≤500 h)时效对新型含铝奥氏体耐热钢Fe-18.4Cr-31Ni-1Nb-2.9Al(质量分数,%)的微观结构和力学性能的影响。研究结果表明,Laves相和B2-Ni Al相尺寸会随着时效时间的延长而逐渐增大。当时效至20 h,Laves相开始沿晶界析出,随着时效时间的延长,其尺寸粗化并覆盖晶界。相比之下,100 h时B2-Ni Al相在晶内析出,并由短棒状长为针状。随着时效时间从100 h延长至500 h,Laves相和B2-Ni Al相的平均尺寸从449 nm增加到706.9 nm。用Lifshitz-Slyozov-Wanger(LSW)粗化模型理论定量分析Laves相和B2-Ni Al相粗化动力学和等温时效时间的关系。计算得析出相的粗化速率k为1.9258×10^(-27)m^(3)/s,表明Laves相和B2-Ni Al相的长大速率由溶质原子扩散所控制。基体中Laves相和B2-Ni Al相的析出导致硬度和高温拉伸性能的增强。0~500 h,硬度持续增加,而抗拉强度先增加后降低。这是由于在0~200 h,Laves相和弥散的B2-Ni Al相析出,而200~500 h,B2-Ni Al相长大,使得抗拉强度降低,而伸长率增加。与未时效状态的抗拉强度528 MPa,伸长率76%相比,500 h时效后,其抗拉强度增至579 MPa,伸长率为52%。

关键词：新型含铝奥氏体耐热钢时效析出相粗化速率力学性能

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Effect of a Carbon Fibre-steel Fibre-graphite Conductive Filler on the Electrothermal Properties of Cementitious Materials

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 141-151页

作者： FAN Yanan WEI Hong ZHENG Hongyong du Hongxiu Department of Architecture and Environmental Engineering Taiyuan UniversityTaiyuan 030032China College of Civil Engineering Taiyuan University of TechnologyTaiyuan 030032China

Carbon fibre,steel fibre and graphite were used as conductive fillers to prepare cementitious materials with excellent electrothermal *** electrically conductive cementitious materials with different volume dosages were analysed through compressive and flexural strength,electrochemical impedance spectroscopy and temperature rise *** equivalent circuit model was established to study the electrically conductive heat generation mechanism in the electrically conductive cementitious *** results indicate that the mechanical properties of cementitious composite materials with a ternary conductive phase are better than those of pristine cementitious materials because the fibrous filler improves their mechanical ***,the incorporation of graphite in the material reduces its *** fibrous and point-like conductive phase materials into the cementitious material enhances the overall conductive pathway and considerably reduces the electrical resistance of the cementitious material,enhancing its conductive *** volume ratios of carbon fibre,steel fibre and graphite that achieve an optimal complex doping in the cementitious material were 0.35%,0.6%and 6%,*** was determined using the mutation point of each circuit element parameter as the percolation *** addition,at a certain safety voltage,there is a uniform change between the internal and surface temperatures of the conductive cementitious material,and the heating effect in this materialis is considerably better than that in the pristine cementitious material.

关键词： cementitious composites conductive fillers electrothermal properties electrochemical impedance spectroscopy

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Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets

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Neural Regeneration Research 2025年第10期20卷 2787-2806页

作者： Qingcong Zheng du Wang Rongjie Lin Weihong Xu Department of Spinal Surgery the First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijingChina Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Regulated cell death is a form of cell death that is actively controlled by *** studies have shown that regulated cell death plays a key role after spinal cord *** and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal ***,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord *** injury triggers not only cell death but also cellular survival *** signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and ***,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord *** analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord ***,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.

关键词： autophagy cell death ferroptosis inflammation pathological mechanisms pyroptosis regulated cell death regulatory pathways spinal cord injury therapeutic targets

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The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao Lingyan Meng Kang du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

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促进大型综合交通枢纽片区活力策略研究

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建筑与文化 2016年第4期 240-241页

作者：王佐王英春杜京伦北京建筑大学

21世纪铁路交通不断完善和提速,高铁和地铁应运而生,大型综合交通枢纽(以下简称"枢纽")的建设和片区规划提上日程。如何利用商业、文化、娱乐等综合设施促进其区域活力,国内外实践值得我们总结其经验,本文进行针对性研究并提出策略。

关键词：大型综合交通枢纽片区活力

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精神分裂症纹状体神经影像学研究进展

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中华行为医学与脑科学杂志 2024年第4期33卷 374-378页

作者：李婉怡张荣荣申旭冉闫伟杜经纶谢世平南京医科大学第四临床医学院南京210029 南京医科大学附属脑科医院精神科南京210029

纹状体作为大脑核心区域,与大脑多个脑区构成复杂网络,参与多项功能如大脑信息整合、奖赏学习、运动等。不少研究表明,精神分裂症患者纹状体存在不同程度结构改变,另有相关研究发现,精神分裂症患者纹状体与其他脑区、默认网络、视觉网... 详细信息

纹状体作为大脑核心区域,与大脑多个脑区构成复杂网络,参与多项功能如大脑信息整合、奖赏学习、运动等。不少研究表明,精神分裂症患者纹状体存在不同程度结构改变,另有相关研究发现,精神分裂症患者纹状体与其他脑区、默认网络、视觉网络、奖赏网络等存在功能连接异常,而这些异常可能与精神分裂症的认知障碍、幻觉妄想、快感缺失等相关。本文主要介绍精神分裂症纹状体的结构及功能磁共振成像的最新研究进展,为更好理解精神分裂症患者神经生物学发病机制提供参考。

关键词：精神分裂症结构磁共振成像功能磁共振成像纹状体神经影像学

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Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang Liu Xiang Li Shen du Ming Gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

during the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

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