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论晏几道词的“诗人句法”与“清壮顿挫”

中国韵文学刊 2024年第2期38卷 78-84页

作者：杨景龙安阳师范学院文学院河南安阳455000

晏几道是宋代词史上最重要的令词作家,在继承唐五代和宋初以来令词艺术优长的基础上,注意借助“诗人句法”和新兴的慢词长调的表现手法,抒写深挚饱满的离别相思之情和华屋山丘的身世悲凉之感,形成“清壮顿挫”的豪宕词风,收到了“动摇... 详细信息

晏几道是宋代词史上最重要的令词作家,在继承唐五代和宋初以来令词艺术优长的基础上,注意借助“诗人句法”和新兴的慢词长调的表现手法,抒写深挚饱满的离别相思之情和华屋山丘的身世悲凉之感,形成“清壮顿挫”的豪宕词风,收到了“动摇人心”的强烈艺术效果。晏几道对于令词作法颇具独创性的改造,赋予令词词体更高更强的艺术表现力。

关键词：晏几道诗人句法清壮顿挫令词艺术

氟基自组装超疏水涂层防冰霜及液滴接触特性研究

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材料保护 2024年第4期57卷 63-69页

作者：杨京龙邱超中国民航飞行学院航空工程学院四川广汉618307 中国空气动力研究与发展中心结冰与防除冰重点实验室四川绵阳621000

为了研究冷表面对超疏水涂层的防冰霜性能和液滴的撞击接触行为的影响,在碳纤维表面喷涂氟基自组装超疏水涂层,然后在半导体制冷台上对试样进行结霜、液滴结冰和液滴接触行为的可视化观测,分析超疏水涂层表面的结霜、液滴结冰以及液滴... 详细信息

为了研究冷表面对超疏水涂层的防冰霜性能和液滴的撞击接触行为的影响,在碳纤维表面喷涂氟基自组装超疏水涂层,然后在半导体制冷台上对试样进行结霜、液滴结冰和液滴接触行为的可视化观测,分析超疏水涂层表面的结霜、液滴结冰以及液滴的撞击接触行为随时间的变化规律。结果表明:在-5℃下,与普通表面不同,超疏水表面的凝结液滴没有发生冻结。在-10、-15℃下,超疏水表面的抑霜效果明显优于普通表面,结霜时间分别延迟了34 s和22 s;在-5、-10、-15℃下,超疏水表面上液滴的延迟结冰时间分别是普通表面的16倍、10倍、9倍;在不同温度下,液滴在撞击低温超疏水表面后,最大铺展直径相同,在-5、-10℃下液滴部分反弹,25℃下液滴在超疏水表面反弹了11次。

关键词：超疏水抑霜延迟结冰液滴碰撞

Routing and scheduling co-design for holistic software-defined deterministic network

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Fundamental Research 2024年第1期4卷 25-34页

作者： jinglong Zhang Fengyuan Zhu Zeming yang Cailian Chen Xiaohua Tian Xinping Guan School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

As a result of the growing complexity of industrial Internet applications,traditional hardware-based network designs are encountering challenges in terms of programmability and dynamic adaptability as they struggle to meet the real-time,high-reliability transmission requirements for the vast quantities of data generated in industrial *** paper proposes a holistic software-defined deterministic network(HSDDN)design *** solution uses a centralized controller to implement a comprehensive software definition,ranging from the network layer down to the physical *** the wireless access domain,we decouple the standard radio-frequency modules from baseband processing to realize a software-defined physical layer,which then allows us to adjust the data transmission cycles and tag the trigger rates to meet demand for low-power,high-concurrency *** the wired network domain,we integrate software-defined networking with time-sensitive networking and propose a coordinated design strategy to address routing and the deterministic scheduling *** define a set of constraints to ensure collaborative transmission of the periodic and aperiodic data *** guarantee load balancing across all paths and timeslots,we introduce the Jain’s fairness index as the optimization objective and then construct a nondeterministic polynomial-time(NP)-hard joint optimization ***,an algorithm called Tabu search for routing and scheduling with dual-stages(TSRS-DS)is *** experiments demonstrate the effectiveness of the proposed HSDDN architecture.

关键词： Deterministic networking Software-defined networking Software-defined physical layer Time-sensitive networking Backscatter communication Routing and scheduling co-design

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Envt cells in vivo

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Virologica Sinica 2023年第2期38卷 285-295页

作者： Hanyu Pan Xinyi yang Jing Wang Huitong Liang Zhengtao Jiang Lin Zhao Yanan Wang Zhiming Liang Xiaoting Shen Qinru Lin Yue Liang jinglong yang Panpan Lu Yuqi Zhu Min Li Pengfei Wang Jianqing Xu Hongzhou Lu Huanzhang Zhu State Key Laboratory of Genetic Engineering And Key Laboratory of Medical Molecular Virology of Ministry of Education/HealthSchool of Life SciencesFudan UniversityShanghai200438China Shanghai Institute of Infectious Disease and Biosecurity School of Life SciencesFudan UniversityShanghai200438China Department of Infectious Disease Key Laboratory of Medical Molecular Virology of Ministry of Education/HealthSchool of Basic Medical Sciences and Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Scientific Research Center Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Department of Infectious Diseases and Immunology Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Department of Infectious Diseases and Nursing Research Institution National Clinical Research Center for Infectious DiseasesThe Third People's Hospital of ShenzhenShenzhen518112China

HIV-specific chimeric antigen receptor(CAR)T-cells have been developed to target HIV-1 infected CD4t T-cells that express HIV Env ***,T cell exhaustion and the patient-specific autologous paradigm of CAR-T cell hurdled clinical ***,we created HIV-specific CAR-T cells using human peripheral blood mononuclear cells and a 3BNC117-E27(3BE)CAR construct that enabled the expression of programmed cell death protein(PD-1)-blocking scFv E27 and the single-chain variable fragment of the HIV-1-specific broadly neutralizing antibody 3BNC117 to target native HIV *** with T cells expressing 3BNC117-CAR alone,3BE CAR-T cells showed greater cytotoxic activity against HIV Envt cells with stronger proliferation capability,higher killing efficiency,and enhanced cytokine secretion in the presence of HIV Env-expressing ***,we manufactured TCR-deficient 3BE CAR-T cells through gene editing and demonstrated that these CAR-T cells could effectively kill HIV Env^(+) cells in vivo without the occurrence of severe graft-versus-host disease(GvHD)in NSG *** data suggest that we have provided a feasible approach to the generation of“off-theshelf”anti-HIV CAR-T cells in combination with PD-1 checkpoint blockade immunotherapy,which can be a powerful therapeutic candidate for the functional cure of HIV.

关键词： Anti-HIV CAR-T PD-1 blocking TCR disruption Cellular immunotherapy

High speed laser cladding as a new approach to prepare ultra-high temperature ceramic coatings

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Journal of Advanced Ceramics 2024年第2期13卷 143-154页

作者： Qiyao Deng Pengfei He Chuan Sun yang Li Yue Xing Yujie Wang jinglong Li Xiubing Liang Xin Wang Yujie Zhou Yujun Cai National-Local Joint Engineering Laboratory of Intelligent Manufacturing Oriented Automobile Die&Mould Tianjin University of Technology and EducationTianjin 300222China Defense Innovation Institute Academy of Military ScienceBeijing 100071China School of mechanical engineering Tianjin University of Technology and EducationTianjin 300222China Scientific and Technological Innovation Center Beijing 100012China

Ultra-high temperature ceramic(UHTC)coatings are used to protect the hot-end components of hypervelocity aerocrafts from thermal *** study provides a new approach to fabricate UHTC coatings with high speed laser cladding(HSLC)technology,and places more emphasis on investigating the formation mechanism,phase compositions,and mechanical properties of HSLC-UHTC *** show that a well-bonded interface between the coating and the tantalum alloy substrate can be *** coating is mainly composed of(Zr,Ta)C ceramic solid solution phase with a content of higher than 90% by volume and Ta(W)metal solid solution *** a relatively high powder feeding rate,the ZrC ceramic phase appears in the coating while a dense ZrC UHTC top layer with a thickness of up to~50μm is successfully *** for the mechanical properties of the HSLC coatings,the fracture toughness of the coating decreases with the increase of powder feeding *** increase of carbide solid solution phase can significantly improve the high temperature microhardness(552.7±1.8 HV0.5@1000℃).The innovative design of HSLC ZrC-based coatings on refractory alloys accomplishes continuous transitions on microstructure and properties from the substrate to the UHTC top layer,which is a very promising candidate scheme for thermal protection coating.

关键词： high speed laser cladding(HSLC) ultra-high temperature ceramic(UHTC) thermal protection coating microstructure mechanical properties

Evolution of microstructure and properties of a novel Ni-based superalloy during stress relief annealing

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1876-1889页

作者： Lei Jia Heng Cui Shufeng yang Shaomin Lü Xingfei Xie jinglong Qu Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Beijing GAONA Materials&Technology Co. Ltd.Beijing 100081China High-Temperature Materials Institute Central Iron and Steel Research InstituteBeijing 100081China

We discussed the decrease in residual stress,precipitation evolution,and mechanical properties of GH4151 alloy in different annealing temperatures,which were studied by the scanning electron microscope(SEM),high-resolution transmission electron microscopy(HRTEM),and electron backscatter diffraction(EBSD).The findings reveal that annealing processing has a significant impact on diminishing residual *** the annealing temperature rose from 950 to 1150℃,the majority of the residual stresses were relieved from 60.1 MPa down to 10.9 ***,the stress relaxation mechanism transitioned from being mainly controlled by dislocation slip to a combination of dislocation slip and grain boundary ***,the annealing treatment promotes the decomposition of the Laves,accompanied by the precipitation ofμ-(Mo_(6)Co_(7))starting at 950℃ and reaching a maximum value at 1050℃.The tensile strength and plasticity of the annealing alloy at 1150℃ reached the maximum(1394 MPa,56.1%)which was 131%,200%fold than those of the as-cast alloy(1060 MPa,26.6%),but the oxidation process in the alloy was accelerated at 1150℃.The enhancement in durability and flexibility is primarily due to the dissolution of the brittle phase,along with the shape and dispersal of theγ′phase.

关键词： GH4151 alloy annealing treatment residual stress precipitation evolution strength mechanical properties

Comparative Study of 3D-Printed Porous Titanium Alloy with Rod Designs of Three Different Geometric Structures for Orthopaedic Implantation

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 54-66页

作者： Jiaxin Li Haozhang Zhong Bojun Cao Zhaoyang Ran Jia Tan Liang Deng Yongqiang Hao jinglong Yan Department of Orthopedics The Second Affiliated Hospital of Harbin Medical UniversityHarbin150001China Shanghai Engineering Research Center of Innovative Orthopaedic Instruments and Personalized Medicine Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Institute of Materials Modification and Modeling Shanghai Jiao Tong UniversityShanghai200240China

Porous titanium alloy is currently widely used in clinical treatment of orthopaedic diseases for its lower elastic modulus and ability to integrate with bone *** the micro-level,cells can respond to different geometries,and at the macro-level,the geometric design of implants will also affect the biological function of *** this study,three kinds of porous scaffolds with square,triangular and circle rod shapes were designed and 3D *** study observed the proliferation and differentiation of MC3T3-E1 cells during surface culture of the three types of *** also evaluated the characteristics of the three scaffolds by means of compression tests and scanning electron microscopy to provide a reference for the design of porous titanium alloy implants for clinical *** trends of cell proliferation and gene expression between the three types of scaffolds were observed after treatment with two *** results show that the square rod porous scaffolds have the best proliferative and osteogenic activities,and these findings may be due to differences in piezo-type mechanosensitive ion channel component 1(Piezo1)and Yes-associated protein(YAP)expression caused by the macro-geometric topography.

关键词： Porous titanium scaffolds Geometric morphology Cell proliferation Structural design

Decabromodiphenyl ether induces the chromosome association disorders of spermatocytes and deformation failures of spermatids in mice

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Journal of Environmental Sciences 2024年第4期138卷 531-542页

作者： jinglong Xue Xiangyang Li Yafei Chi Leqiang Gao Yue Zhang Yan Wang Moxuan Zhao Jialiu Wei Zhixiong Shi Xianqing Zhou Department of Toxicology and Hygienic Chemistry School of Public HealthCapital Medical UniversityBeijing 100069China Beijing Key Laboratory of Environmental Toxicology Capital Medical UniversityBeijing 100069China Laboratory Animal Center Capital Medical UniversityBeijing 100069China Key Laboratory of Cardiovascular Epidemiology&Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

The environmental presence of decabromodiphenyl ether(BDE-209),which is toxic to the male reproductive system,is *** current study investigated its mechanism of toxicity in *** results showed,that BDE-209 induced DNA damage,decreased the expression of the promoter of meiosis spermatogenesis-and oogenesis-specific basic helix-loop-helix 1(Sohlh1),meiosis related-factors Lethal(3)malignant brain tumor like 2(L3MBTL2),PIWI-like protein 2(MILI),Cyclin-dependent kinase 2(CDK2),Cyclin A,synaptonemal complex protein 1(SYCP1)and synaptonemal complex protein 3(SYCP3),and caused spermatogenic cell apoptosis,resulting in a decrease in sperm quantity and ***,BDE-209 downregulated the levels of anaphase-promoting complex/cyclosome(APC/C),increased the expression of PIWI-like protein 1(MIWI)in the cytoplasm of elongating spermatids,and decreased the nuclear levels of RING finger protein 8(RNF8),ubiquitinated(ub)-H2A/ub-H2B,and Protamine 1(PRM1)/Protamine 2(PRM2),while increasing H2A/H2B nuclear levels in *** reproductive toxicity was persistent for 50 days following the withdrawal of BDE-209 *** results suggested that BDE-209 inhibits the initiation of meiosis by decreasing the expression of ***,the reduced expression of L3MBTL2 inhibited the formation of chromosomal synaptonemal complexes by depressing the expression of meiosis regulators affecting the meiotic progression and also inhibited histone ubiquitination preventing the replacement of histones by protamines,by preventing RNF8 from entering nuclei,which affected the evolution of spermatids into mature sperm.

关键词： BDE-209 Meiosis L3MBTL2 Sperm RNF8 Histone ubiquitination

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基于双向循环插补的大地电磁脉冲类噪声处理

煤田地质与勘探 2024年第8期52卷 198-212页

作者：杨凯刘诚李含贺景龙中国地质调查局西安矿产资源调查中心陕西西安710100 中国地质调查局金矿勘查技术创新中心陕西西安710100 中国地质大学(武汉)地球物理与空间信息学院湖北武汉430074

【目的】大地电磁测深是一种通过观测天然电磁场获取地下电性结构的勘探方法,较易受到噪声干扰。脉冲类噪声是大地电磁工作中的常见噪声,其幅值高、频带宽,会对数据质量产生较大影响。【方法】为了压制脉冲类噪声,以插补思想为基础,提... 详细信息

【目的】大地电磁测深是一种通过观测天然电磁场获取地下电性结构的勘探方法,较易受到噪声干扰。脉冲类噪声是大地电磁工作中的常见噪声,其幅值高、频带宽,会对数据质量产生较大影响。【方法】为了压制脉冲类噪声,以插补思想为基础,提出了基于时间序列双向循环插补模型(Bidirectional recurrent imputation for time series,BRITS)的大地电磁脉冲类噪声处理方法。首先,将噪声干扰段删除,此时大地电磁时间序列可视为待插补的缺失序列,而后利用该缺失序列构建训练集,对BRITS模型进行插补训练,训练完成后对缺失序列进行插补,即可得到去噪结果。通过仿真及实测含噪声数据处理,并与经验模态分解(Empirical mode decomposition,EMD)阈值方法进行了对比。【结果和结论】结果表明:BRITS方法对仿真噪声数据处理后与原始数据的归一化互相关系数可达0.999以上,信噪比可达29 dB以上,EMD阈值方法处理前后相关系数为0.778,信噪比为3.09 dB;在实测数据处理中,BRITS方法有效恢复了噪声干扰数据,相比EMD阈值方法,其阻抗奈奎斯特图更接近天然大地电磁信号特征。通过不同训练样本试验得出:对4分量大地电磁数据而言,数据中至少需包含两道正常分量,单个含噪分量中噪声占比不大于20%,且噪声连续干扰长度不超过10个采样点,此时,BRITS方法去噪后数据的相关系数在0.96以上,可以保证一定的去噪精度。

关键词：大地电磁噪声处理脉冲类噪声时间序列插补双向循环插补