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闭合复位装置复位交锁髓内钉固定治疗股骨干骨折的临床疗效

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中国中医骨伤科杂志 2021年第2期29卷 49-52页

作者：彭昌贵李日旺陈景昆吴小杭方鸣罗鹰袁志坤包国庆广东东莞市石碣医院骨科广东东莞523290

目的:探讨股骨干三维闭合复位装置复位交锁髓内钉固定治疗股骨干骨折的临床疗效。方法:2015年6月至2019年5月采用三维骨折复位装置闭合复位股骨干骨折交锁髓内钉固定38例,术中在骨折远端置入1枚Schanz螺钉,连接复位装置操控进行骨折复位... 详细信息

目的:探讨股骨干三维闭合复位装置复位交锁髓内钉固定治疗股骨干骨折的临床疗效。方法:2015年6月至2019年5月采用三维骨折复位装置闭合复位股骨干骨折交锁髓内钉固定38例,术中在骨折远端置入1枚Schanz螺钉,连接复位装置操控进行骨折复位,导针通过骨折远端后按常规交锁髓内钉固定操作。结果:38例患者均闭合复位成功并顺利置入交锁髓内钉,手术时间平均为92 min(60~150 min),术中X线透视时间平均为20.5 s(10~30 s),术中出血量平均为120.5 mL(50~150 mL),术中骨折闭合复位时间平均18 min(10~25 min)。35例骨折愈合(优33例,良2例);2例是近2个月手术,复查发现有明显骨痂;1例是术后1个月,仍在随访中。结论:三维骨折复位装置在股骨干骨折闭合复位中能有效复位骨折,操作简单,使用方便,并且医护人员能在骨折复位过程中离开手术间,减少透视的辐射。

关键词：股骨干骨折复位装置复位交锁髓内钉骨折固定术

Single-cell Transcriptomic Analysis Reveals the Cellular Heterogeneity of Mesenchymal Stem Cells

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Genomics, Proteomics & Bioinformatics 2022年第1期20卷 70-86页

作者： chen Zhang Xueshuai Han jingkun Liu Lei chen Ying Lei Kunying chen Jia Si Tian-yi Wang Hui Zhou Xiaoyun Zhao Xiaohui Zhang Yihua An Yueying Li Qian-Fei Wang CAS Key Laboratory of Genomic and Precision Medicine Collaborative Innovation Center of Genetics and DevelopmentBeijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Medical Experimental Center Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266035China Qingdao Key Lab of Mitochondrial Medicine Qingdao 266035China International Department Liangxiang CampusBeijing University of Chinese MedicineBeijing 102401China Yihua Biotechnology Co. Ltd.Beijing 100041China Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Department of Functional Neurosurgery Third Medical CenterGeneral Hospital of Chinese PLABeijing 100039China

Ex vivo-expanded mesenchymal stem cells(MSCs)have been demonstrated to be a heterogeneous mixture of cells exhibiting varying proliferative,multipotential,and immunomodulatory ***,the exact characteristics of MSCs remain largely *** singlecell RNA sequencing of 61,296 MSCs derived from bone marrow and Wharton’s jelly,we revealed five distinct *** developmental trajectory of these five MSC subpopulations was mapped,revealing a differentiation path from stem-like active proliferative cells(APCs)to multipotent progenitor cells,followed by branching into two paths:1)unipotent preadipocytes or 2)bipotent prechondro-osteoblasts that were subsequently differentiated into unipotent *** stem-like APCs,expressing the perivascular mesodermal progenitor markers CSPG4/MCAM/NES,uniquely exhibited strong proliferation and stemness ***,the prechondrocyte subpopulation specifically expressed immunomodulatory genes and was able to suppress activated CD3^(+T) cell proliferation in vitro,supporting the role of this population in *** summary,our analysis mapped the heterogeneous subpopulations of MSCs and identified two subpopulations with potential functions in self-renewal and *** findings advance the definition of MSCs by identifying the specific functions of their heterogeneous cellular composition,allowing for more specific and effective MSC application through the purification of their functional subpopulations.

关键词： Mesenchymal stem cell Single-cell RNA sequencing Heterogeneity Lineage trajectory Immune regulation

Technoeconomically competitive four-terminal perovskite/graphenesilicon tandem solar cells with over 20% efficiency

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Journal of Energy Chemistry 2021年第12期30卷 477-483,I0011页

作者： Pengjie Hang jingkun Cong Ge Li Lijian Zuo chenxia Kan Biao Li Jiangsheng Xie Yuxin Yao Ying Wang Hongzheng chen Deren Yang Xuegong Yu State Key Laboratory of Silicon Materials and School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027ZhejiangChina State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027ZhejiangChina

Perovskite/Silicon(PS) tandem solar cells have attracted much interest over recent years. However, the most popular crystalline silicon solar cells utilized in tandems require complicated fabrication processes mainly including texturization, diffusion, passivation and metallization, which takes up much cost in photovoltaic market. Here, we report a facile graphene/silicon(Gr/Si) solar cell featuring of lowtemperature( 200 °C) processing and an efficiency of 13.56%. For reducing the heat dissipation loss of high energy photon, the perovskite solar cell(PSC) with a wide band gap of 1.76 e V was adopted as the top cell for the tandem. To reduce the loss of parasitic absorption in hole transport layers(HTLs),thickness of Spiro-OMe TAD is re-optimized by compromising the efficiency and the optical transmittance of the devices. As a result, the semitransparent top perovskite solar cell yields a highest efficiency of13.35%. Furthermore, we firstly achieved a low-temperature-processed four-terminal(4-T) perovskite/graphene-silicon(PGS) heterojunction tandem solar cell with the efficiency of 20.37%. The levelized cost of electricity(LCOE) of PGS 4-T modules were estimated to a competitive price, exhibiting much greater potential for practical application compared to that of PS 4-T modules.

关键词： Perovskite/graphene-silicon tandem sola cells Low temperature Transmittance Technoeconomic competitiveness

Manipulating Nonsequential Double Ionization of Argon Atoms via Orthogonal Two-Color Field

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Chinese Physics Letters 2022年第9期39卷 10-16页

作者： Yingbin Li Lingling Qin Aihua Liu Ke Zhang Qingbin Tang Chunyang Zhai jingkun Xu Shi chen Benhai Yu Jing chen College of Physics and Electronic Engineering Xinyang Normal UniversityXinyang 464000China Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China School of Physics and Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Center for Applied Physics and Technology HEDPSand School of PhysicsPeking UniversityBeijing 100871China Institute of Applied Physics and Computational Mathematics Beijing 100088China Shenzhen Key Laboratory of Ultraintense Laser and Advanced Material Technology Center for Advanced Material Diagnostic Technologyand College of Engineering PhysicsShenzhen Technology UniversityShenzhen 518118China State Key Laboratory of Transient Optics and Photonics Chinese Academy of SciencesXi’an 710119China

Using a three-dimensional classical ensemble model,we investigate the dependence of relative frequency and relative initial phase for nonsequential double ionization(NSDI)of atoms driven by orthogonal two-color(OTC)*** findings reveal that the NSDI probability is clearly dependent on the relative initial phase of OTC fields at different relative *** inversion analysis results indicate that adjusting the relative frequency of OTC fields helps control returning probability and flight time of the first ***,manipulating the relative frequency at the same relative initial phases can vary the revisit time of the recolliding electron,leading that the emission direction of Ar^(2+)ions is explicitly dependent on the relative frequency.

关键词： initial ensemble finding

Food resources of the Khog Gzung site on the Tibetan Plateau revealed by sedimentary ancient DNA

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Science China Earth Sciences 2023年第4期66卷 840-851页

作者： Zhengquan GU Yu GAO Yiru WANG Jishuai YANG jingkun RAN Xiaoyan YANG Wangdue SHARGAN Mikkel W.PEDERSEN Guilian SHENG Yucheng WANG Fahu chen Group of Alpine Paleoecology and Human Adaptation(ALPHA) State Key Laboratory of Tibetan Plateau Earth SystemEnvironment and Resources(TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China School of History Nanjing UniversityNanjing 210008China Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Tibetan Institute for the Preservation of Cultural Relics Lhasa 850008China Lundbeck Foundation GeoGenetics Centre Globe InstituteUniversity of Copenhagen1350 CopenhagenDenmark State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430078China Department of Zoology University of CambridgeCambridgeCB23EJUK

Traditional zooarchaeological and archaeobotanical methods based on morphological identification of the excavated faunal and floral remains have been broadly used in reconstructing ancient subsistence economies. However, the accuracy and reliability of these methods rely heavily on the preservation state of the remains. By sequencing the ancient DNA of plants,animals, and microorganisms preserved in sediment, sedimentary ancient DNA(sedaDNA) now offers a novel approach for reconstructing the taxa composition dated back to hundreds of thousands of years. Yet, its application in open-air archaeological sites is rarely reported. In this study, we attempted to apply sedaDNA shotgun metagenomics on the archaeological deposits of the Khog Gzung site(an open-air site dated to 3160–2954 cal yr BP) on the Tibetan Plateau, and then compared the reconstructed taxonomic composition to the unearthed remains. Results showed that most of the crops and domestic animals identified by the two approaches, such as barley(Hordeum vulgare) and sheep(Ovis aries), are in general consistent. Some species, such as foxtail millet(Setaria italica), however, were only detected by sedaDNA. In addition, a variety of microorganisms were also detected by the sedaDNA. The two approaches combined revealed diversified food resources at the Khog Gzung site, which included crops such as millet, barley and wheat, domestic animals such as sheep and cattle, and likely also wild animals from fishing and hunting. Our data proves that sedaDNA has a great potential in reconstructing the faunal and floral compositions from archaeological deposits, therefore laying the foundation for its border applications.

关键词： Tibetan Plateau Sedimentary ancient DNA Faunal remains Floral remains

Measurement of atmospheric nanoparticles:Bridging the gap between gas-phase molecules and larger particles

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Journal of Environmental Sciences 2023年第1期123卷 183-202页

作者： Chao Peng chenjuan Deng Ting Lei Jun Zheng Jun Zhao Dongbin Wang Zhijun Wu Lin Wang Yan chen Mingyuan Liu jingkun Jiang Anpei Ye Maofa Ge Weigang Wang State Key Laboratory for Structural Chemistry of Unstable and Stable Species Beijing National Laboratory for Molecular Sciences(BNLMS)CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China School of Environment Science and Engineering Nanjing University of Information Science&TechnologyNanjing 210044China School of Atmospheric Sciences Sun Yat-sen UniversityZhuhaiGuangdong 519082China State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention(LAP3) Department of Environmental Science&EngineeringFudan UniversityShanghai 200433China Key Laboratory for the Physics and Chemistry of Nanodevices Department of ElectronicsSchool of Electronics Engineering and Computer SciencePeking UniversityBeijing 100871China University of Chinese Academy of Sciences Beijing 100049China

Atmospheric nanoparticles are crucial components contributing to fine particulate matter(PM_(2.5)),and therefore have significant effects on visibility,climate,and human *** to the unique role of atmospheric nanoparticles during the evolution process from gas-phase molecules to larger particles,a number of sophisticated experimental techniques have been developed and employed for online monitoring and characterization of the physical and chemical properties of atmospheric nanoparticles,helping us to better understand the formation and growth of new *** this paper,we firstly review these state-of-the-art techniques for investigating the formation and growth of atmospheric nanoparticles(e.g.,the gas-phase precursor species,molecular clusters,physicochemical properties,and chemical composition).Secondly,we present findings from recent field studies on the formation and growth of atmospheric nanoparticles,utilizing several advanced ***-more,perspectives are proposed for technique development and improvements in measuring atmospheric nanoparticles.

关键词： Nanoparticle Measurement techniques Size distributions Physical properties Chemical composition

MgS+1．5％ZrS_2固体电解质硫浓差电池的实验研究

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金属学报 2005年第12期41卷 1285-1288页

作者：于景坤刘涛陈敏东北大学材料与冶金学院沈阳110004

以金属和升华硫为原料,利用温度梯度法合成硫化物;并用合成的MgS+1．5％ZRS2作为固体电解质,以Mo+MoS2 作为参比极研制了硫浓差电池．在1623 K利用该电池对碳饱和铁水(氧的活度α[O]≤ 2×10-6)中的硫含量进行了测定．进一步优化了硫... 详细信息

以金属和升华硫为原料,利用温度梯度法合成硫化物;并用合成的MgS+1．5％ZRS2作为固体电解质,以Mo+MoS2 作为参比极研制了硫浓差电池．在1623 K利用该电池对碳饱和铁水(氧的活度α[O]≤ 2×10-6)中的硫含量进行了测定．进一步优化了硫浓差电池的结构,解决了电解质管的炸裂和漏气问题,同时采用特殊工艺抑制了硫化物水化．结果表明,该硫浓差电池的电动势信号稳定,重现性好且持续时间长．

关键词：硫浓差电池固体电解质参比极硫化物温度梯度法

Analysis of Corrosion Behavior of ZrO_(2)-C Slag-line Materials in Continuous Casting

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China's Refractories 2023年第3期32卷 10-13页

作者： TIAN chen ZHI Jianjun GAN Feifang FAN Zhengjie GAO Hua YUAN Lei LIU Guoqi YU jingkun LI Hongxia Key Laboratory of Electromagnetic Processing of Materials(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Baoshan Iron and Steel Co. LtdShanghai 201900China Sinosteel Luoyang Institute of Refractories Research Co. Ltd.Luoyang 471039China

In view of the service failure and low continuous casting production efficiency due to the corrosion of refractories at the slag-line in submerged entry nozzles,a submerged entry nozzle for low-carbon aluminum killed steel continuous casting in one steel plant was sampled and taken as the research object to analyze the causes and the mechanism of refractory corrosion at the *** results show that the core issue of the corrosion and necking of the slag-line materials is that the slag-line material are eroded,dissolved,and reacted by the mold flux ***,it is important to suppress or avoid the contact and reaction between the mold flux and slag-line materials.

关键词： continuous casting submerged entry nozzle slag-line slag corrosion resistance

Protective effects of baicalin on amyloid beta 25-35-induced apoptosis in human neuroblastoma SH-SY5Y cells

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Neural Regeneration Research 2010年第22期5卷 1739-1744页

作者： Miao Geng Hongyan chen Jianhua Wang Yazhuo Hu Jianwei Liu Jing Liu jingkun Pan Yuhong Gao Institute of Geriatrics Division of South Building Chinese PLA General Hospital Beijing 100853 China

Baicalin, a type of flavanoid, effectively prevents cellular apoptosis induced by various factors. However, little evidence is available regarding its role on amyloid β （Aβ） -induced neuronal apoptosis. The present study investigated the protective mechanisms of baicalin on Aβ-induced neuronal apoptosis. Flow cytometry and cation dye 5, 5＇, 6, 6＇-tetrachloro-1, 1＇, 3, 3＇-tetraethyl- benzimidazoly lcarbocyanine iodide （JC-1） were employed to measure mitochondrial membrane potential, and nitric oxide secretion and apoptotic-related factors, such as caspase-3, were comprehensively analyzed. Results demonstrated a protective effect of baicalin on Aβ-treated SH-SY5Y cell viability; the rate of apoptosis decreased, nitric oxide generation and expression of caspase-3 were effectively inhibited, and mitochondrial membrane potential was effectively protected. Baicalin inhibited Aβ-induced neuronal apoptosis via multiple targets and multiple pathways, such as the inhibition of free radical damage, reduction of caspase-3 expression, and protection of normal mitochondrial functions.

关键词： baicalin neuron apoptosis traditional Chinese medicine caspase-3 amyloid β neural regeneration