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Frontiers of Chemical Science and Engineering 2013年第3期7卷 322-328页

作者： Liang ZHU jingkang wang Tianjin Key Laboratory of Marine Resources and Chemistry College of Marine Science and Engineering Yianjin University of Sciencc & Technology Tianjin 300457 China School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

A simple and direct method without a deriva- tion step for routine analysis of tobramycin has been developed. This method used reversed-phase ion-pair high performance liquid chromatography （HPLC） with a refractive index （RI） detector and a C18 column which is stable at pH above 1.00. The presence of *** ] trifluoroacetic acid （TFA） in the mobile phase improved the protonation of tobramycin and the formation of ionpairs, and thus reduced its hydrophility. This unique separation-detection combination showed good linearity with correlation coefficients 0.9996 in the concentration range of *** 1. The quantitation limit and detection limit were determined to be 0.23 *** ~ and 0.071 mg. mL ~, respectively. Tobramycin was recovered in 98.00%, 98.84% and 99.64% for tobramycin solutions at concentrations of 2.25 ***^-1, *** 1 and 0.75 *** ＇, respectively. The relative standard deviations for six spiked samples ranged from 0.20% to 2.40%, indicating a good reproducibility of this method.

关键词： tobramycin aminoglycoside refractive index detector high-performance liquid chromatography ionpairing

Author correction to‘Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer’[Acta Pharm Sin B 11(2021)1853–1866]

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2358-2358页

作者： Yi Qian Meimei Zhao Qinghua Han jingkang wang Lixi Liao Heng Yang Dan Liu Pengfei Tu Hong Liang Kewu Zeng State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Proteomics Laboratory Medical and Healthy Analytical CenterPeking University Health Science CenterBeijing 100191China

The authors regret that the representative images of tumor tissue staining for the intraperitoneal injection of J13 in the left panel of Fig.5E and G(Page 1862)were incorrect due to an inadvertent mistake of copying and pasting in the process of assembling figures with Adobe Photoshop *** our studies,at least three biological replicates were included in each treatment group and at least three images were taken for different fields of each *** corrected version of Fig.5E and G have been provided below,and the change did not affect the results and conclusions of this *** original data of these figures have been provided to the Editorial Office,and the corresponding authors or the Editorial Office can be contacted for original data access.

关键词： correction figures assembling

Research progress on preparation and purification of fluorine-containing chemicals in lithium-ion batteries

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Chinese Journal of Chemical Engineering 2022年第1期35卷 73-84页

作者： Xiaobin Liu Zhenguo Gao Jingcai Cheng Junbo Gong jingkang wang State Key Laboratory of Chemical Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China CAS Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin Tianjin 300072China

With the development of digital products,electric vehicles and energy storage technology,electronic chemicals play an increasingly prominent role in the field of new energy such as lithium-ion *** chemicals have attracted extensive attention in various *** of high-end electronic chemicals are high purity and low impurity content,which requires a very strict separation and purification *** present,crystallization is a key technology for their separation and purification of electronic *** this work,the representative fluorine-containing compounds in cathode and anode materials,separator and electrolyte of lithium-ion batteries are *** latest technologies for the preparation and purification of four kinds of fluorine-containing battery chemicals by crystallization technology are *** addition,the research prospects and suggestions are put forward for the separation of fluorine-containing battery chemicals.

关键词： Battery chemicals Lithium-ion batteries Crystallization Fluorine-containing chemicals

Thermodynamic study on dynamic water and organic vapor sorption on amorphous valnemulin hydrochloride

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Frontiers of Chemical Science and Engineering 2015年第1期9卷 94-104页

作者： Jinbo OUYANG jingkang wang Yongli wang Qiuxiang YIN Hongxun HAO School of Chemical Engineering and Technology State Key Laboratory of Chemical Engineering Tianjin University Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin)

The sorption of water and organic vapors on valnemulin hydrochloride was determined by dynamic vapor sorption at 25 °C. The adsorption-desorption behavior of water vapor and a series of organic vapors was investigated to probe the structural changes in valnemulin hydrochloride before and after sorption. The isothermal adsorption equilibrium data was evaluated using Guggenheim-Anderson-de Boer(GAB) and Brunauer-Emmett-Teller(BET) models. The BET model is applicable only at low relative pressures(0.1￡RP￡0.4)while the GAB model is applicable in the whole range of RPs(0.1￡RP￡0.9). The sorption kinetics at high RPs was determined by fi tting the sorption data to the Avrami equation and the sorption content vs. time relationship could be predicted by the Avrami equation. Finally, the possible sorption mechanism of valnemulin hydrochloride was also discussed.

关键词： valnemulin hydrochloride water vapor organic vapors sorption kinetics

Molecular mechanism of crystal nucleation from solution

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Science China Chemistry 2021年第9期64卷 1460-1481页

作者： Xin Li jingkang wang Ting wang Na wang Shuyi Zong Xin Huang Hongxun Hao National Engineering Research Center of Industrial Crystallization Technology School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin300072China School of Chemical Engineering and Technology Hainan UniversityHaikou570228China

Nucleation from solution is fundamental to many natural and industrial *** understanding of molecular mechanism of nucleation from solution is conducive to predict crystal structure,control polymorph and design desired crystal *** this review,the nucleation theories,including classical nucleation theory(CNT),nonclassical nucleation theory,as well as other new proposed theories,were reprised,and the molecular mechanism of these theories was ***,the molecular process of nucleation,including the current study techniques,the effect of molecular self-assembly in solutions,desolvation process,as well as the properties of solvent and crystal structure on nucleation from solution were ***,the relationship of molecular conformation in solution and in crystal,and the effect of solute molecular flexibility on nucleation were ***,the current challenges and future scopes of crystal nucleation from solution were discussed.

关键词： nucleation molecular assembly molecular conformation polymorphism solution chemistry

Recent Developments in the Crystallization Process： Toward the Pharmaceutical Industry

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Engineering 2017年第3期3卷 343-353页

作者： Zhenguo Gao Sohrab Rohani Junbo Gong jingkang wang Department of Chemical and Biochemical Engineering The University of Western Ontario London ON N6A 5B9 Canada School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

Crystallization is one of the oldest separation and purification unit operations, and has recently contributed to significant improvements in producing higher-value products with specific properties and in building efficient manufacturing processes. In this paper, we review recent developments in crystal engineering and crystallization process design and control in the pharmaceutical industry. We systematically summarize recent methods for understanding and developing new types of crystals such as co-crystals, polymorphs, and solvates, and include several milestones such as the launch of the first co-crystal drug, Entresto （No- vartis）, and the continuous manufacture of Orkambi （Vertex）. Conventional batch and continuous processes, which are becoming increasingly mature, are being coupled with various control strategies and the recently developed crystallizers are thus adapting to the needs of the pharmaceutical industry. The development of crystallization process design and control has led to the appearance of several new and innovative crystal- lizer geometries for continuous operation and improved performance. This paper also reviews major recent orogress in the area of process analytical technology.

关键词： Crystallization Crystal engineering Polymorphism Crystallization process design and control Crystal size distribution

Dissolution behavior,thermodynamic and kinetic analysis of malonamide by experimental measurement and molecular simulation

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Chinese Journal of Chemical Engineering 2023年第1期53卷 260-269页

作者： Peng Yang Shengzhe Jia Yan wang Zongqiu Li Songgu Wu jingkang wang Junbo Gong School of Chemical Engineering and Technology State Key Laboratory of Chemical EngineeringTianjin UniversityTianjin 300072China School of Pharmaceutical Sciences(Shandong Analysis and Testing Center) Qilu University of Technology(Shandong Academy of Sciences)Jinan 250014China

In this study,the solid structure,dissolution behavior,thermodynamic properties and nucleation kinetics of malonamide were ***,the Hirshfeld surface analysis and molecular electrostatic potential surface were plotted to reveal the percentage contribution of various intermolecular contacts and location of the strongest hydrogen ***,the solubility of malonamide in 12 solvents was determined by dynamic method at temperatures from 278.15 K to 318.15 *** thermodynamic models were applied to analyze solubility *** addition,the thermodynamic properties were calculated to further analyze and discuss the dissolution behavior of ***,the physicochemical properties of solvents were explored to express the solvent *** results illustrate“like dissolves like”,“mass transfer”and“solvent–solute interaction”rules play the synergistic effects on the dissolution *** molecular dynamic simulation,including radial distribution function analysis and solvent free energy,was used to further explain the dissolution *** last,the nucleation rate and effective interfacial energy in methanol solvent was measured and calculated to reveal the nucleation behaviour.

关键词： Malonamide Solubility Thermodynamic properties Molecular simulation Nucleation rate

The solubility of cefquinome sulfate in pure and mixed solvents

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Frontiers of Chemical Science and Engineering 2016年第2期10卷 245-254页

作者： Rongbao Qi jingkang wang Junxiao Ye Hongxun Hao Ying Bao State Key Laboratory of Chemical Engineering School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin) Tianjin 300072 China

Solid-liquid equilibrium data of cefquinome sulfate is important to develop industrial crystallization processes for cefquinome sulfate. The solubilities of cefquinome sulfate in five pure solvents （methanol, ethanol, ethylene glycol, acetic acid and water） from 277.15 to 305.15 K and in a binary acetone-water solvent from 278.15 to 293.15 K were measured at atmospheric pressure. The pure-solvent solubility data was correlated to the modified Apelblat and Van＇t Hoff equations whereas the mixed-solvent system data was correlated to the modified Apelblat, Van＇t Hoff, CNIBS/R-K and Jouy- ban-Acree models. It was found that the solubilities of cefquinome sulfate in all tested solvents decreased with the increasing of temperature. In addition, the thermodynamic properties of the dissolution processes, including standard Gibbs free energy, enthalpy and entropy changes, were calculated using the Van＇t Hoff equation. It was found that the dissolution of cefquinome sulfate is exothermic.

关键词： cefquinome sulfate solubility thermodynamic properties

Progress of Pharmaceutical Continuous Crystallization

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Engineering 2017年第3期3卷 354-364页

作者： Dejiang Zhang Shijie Xu Shichao Du jingkang wang Junbo Gong School of Chemical Engineering and Technology State Key Laboratory of Chemical Engineering Tianjin University Tianjin 300072. China Collaborative Innovation Center of Chemical Science and Chemical Engineering Tianjin University Tianjin 300072 China

Crystallization is an important unit operation in the pharmaceutical industry. At present, most pharmaceutical crystallization processes are performed in batches. However, due to product variability from batch to batch and to the low productivity of batch crystallization, continuous crystallization is gaining increasing attention. In the past few years, progress has been made to allow the products of continuous crystallization to meet different requirements. This review summarizes the progress in pharmaceutical continuous crystallization from a product engineering perspective. The advantages and disadvantages of different types of continuous crystallization are compared, with the main difference between the two main types of crystallizers being their difference in residence time distribution. Approaches that use continuous crystallization to meet different quality requirements are summarized. Continuous crystallization has advantages in terms of size and morphology control. However, it also has the problem of a process yield that may be lower than that of a batch process, especially in the production of chirality crystals. Finally, different control strategies are compared.

关键词： Continuous crystallization Pharmaceutical MSMPR Tubular crystallizer Control strategy

Permeability analysis and seepage process study on crystal layer in melt crystallization with fractal and porous media theory

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Frontiers of Chemical Science and Engineering 2011年第4期5卷 435-441页

作者： Xiaobin JIANG Baohong HOU Yongli wang jingkang wang State Research Center of Industrialization for Crystallization Technology School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

In this paper a porous media seepage model was applied to analyze the permeability and study the seepage process of crystal pillar formed in the preparation of electronic grade phosphoric acid(EGPA).By inspecting the seeping process,the structure parameter of crystal pillar could be *** basic ideal models(perfectly separated model and perfectly connected model)were presented and a characterized factorφwas introduced to modify the model.A good simulation result was obtained which met the experiment result *** relationship betweenφand permeability were also *** characterized factorφshowed potential application on optimizing process.

关键词： melt crystallization porous media fractal permeability hyperpure material simulation