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Metabolic reprogramming: a new option for the treatment of spinal cord injury

Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun xia Biao Yang Ronghao Wang Yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang jingkai Wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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Elemental composition x-ray fluorescence analysis with a TES-based high-resolution x-ray spectrometer

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中国物理B:英文版 2023年第9期32卷 67-73页

作者：吴秉骏夏经铠张硕傅强章辉谢晓明刘志 State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Center for Excellence in Superconducting Electronics Chinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China

The accurate analysis of the elemental composition plays a crucial role in the research of functional *** emitting characteristic x-ray fluorescence(XRF)photons can be used for precisely discriminating the specified *** detection accuracy of conventional XRF methodology using semiconductor detector is limited by the energy resolution,thus posing a challenge in accurately scaling the actual energy of each XRF *** adopt a novel high-resolution x-ray spectrometer based on the superconducting transition-edge sensor(TES)for the XRF spectroscopy measurement of different *** including high energy resolution,high detection efficiency and precise linearity of the new spectrometer will bring significant benefits in analyzing elemental composition via *** this paper,we study the Ledge emission line profiles of three adjacent rare earth elements with the evenly mixed sample of their oxide components:terbium,dysprosium and *** orders of magnitude better energy resolution are obtained compared to a commercial silicon drift *** this TES-based spectrometer,the spectral lines overlapped or interfered by background can be clearly distinguished,thus making the chemical component analysis more accurate and quantitative.A database of coefficient values for the line strength of the spectrum can then be constructed *** with the novel XRF spectrometer and an established coefficient database,a direct analysis of the composition proportion of a certain element in an unknown sample can be achieved with high accuracy.

关键词： x-ray emission spectra and fluorescence superconducting transition-edge sensor rare earth elements chemical composition analysis

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库尔勒香梨大果芽变的鉴定与评价

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中国农业科技导报 2024年第5期26卷 52-64页

作者：卢登洋童盼盼闫敏鲍荆凯刘鸣哲夏怡蕾吴翠云塔里木大学园艺与林学学院南疆特色果树高效优质栽培与深加工技术国家地方联合工程实验室新疆阿拉尔843300 新疆生产建设兵团塔里木盆地生物资源保护利用重点实验室新疆阿拉尔843300

为鉴定和评价库尔勒香梨大果芽变的性状,为生产栽培和遗传育种提供理论依据,在2020—2021年对库尔勒香梨(对照)及其大果芽变的植物学形态、生物学特性、品质特性进行比较分析。结果表明,大果芽变果实呈倒卵形,库尔勒香梨呈纺锤形;大果... 详细信息

为鉴定和评价库尔勒香梨大果芽变的性状,为生产栽培和遗传育种提供理论依据,在2020—2021年对库尔勒香梨(对照)及其大果芽变的植物学形态、生物学特性、品质特性进行比较分析。结果表明,大果芽变果实呈倒卵形,库尔勒香梨呈纺锤形;大果芽变的叶片保卫细胞宽度和果肉细胞长度均显著增大;在果实动态发育过程中,大果芽变的单果重及果实含水率均显著高于库尔勒香梨,在果实成熟期,与库尔勒香梨相比,大果芽变果实的可溶性糖含量及糖酸比分别显著提高78.39%和84.54%,石细胞含量显著降低33.33%。经表型性状和品质特性分析,判定大果芽变为库尔勒香梨的优良芽变,可作为品种改良及新品种选育的亲本材料。

关键词：库尔勒香梨大果芽变生物学特性果实品质

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Detecting neutrinos from supernova bursts in PandaX-4T

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Chinese Physics C 2024年第7期48卷 14-21页

作者：庞彬宇阿布都沙拉木·阿布都克力木薄子豪陈葳谌勋程晨成兆侃崔祥仪樊英杰方德清符长波付孟婷耿立升 Karl Giboni 顾琳慧郭绪元韩晨成韩柯何昶达何金荣黄迪黄彦霖黄俊挺黄周侯汝全侯钰季向东巨永林李晨翔李家富李名川李帅杰李涛林箐刘江来陆聪聪芦晓盈罗棱尹罗云阳马文博马余刚冒亚军孟月宁旭阳祁宁春钱志成任祥祥 Nasir Shaheed 尚晓凤邵熙元申国防司琳孙文良谈安迪陶奕王安庆王萌王秋红王少博王思广王为王秀丽王舟魏月环武蒙蒙邬维浩夏经铠肖梦姣肖翔谢鹏伟燕斌斌颜玺雨杨继军杨勇姚玉坤喻纯旭袁影苑哲鑫宁张丹张敏桢张鹏张世博张澍张涛张洋张瀛心张园园赵力郑其斌周济芳周宁周小朋周永周钰博 New Cornerstone Science Laboratory Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai200240China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237ShandongChina Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237ShandongChina School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai519082China Department of Physics Yantai UniversityYantai 264005China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Peking UniversityBeijing 100871China School of Physics Beihang UniversityBeijing 102206China International Research Center for Nuclei and Particles in the Cosmos&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Physics and Microelectronics Zhengzhou UniversityZhengzhouHenan 450001China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics University of MarylandCollege ParkMaryland 20742USA State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Physics Nankai UniversityTian

Neutrinos from core-collapse supernovae are essential for understanding neutrino physics and stellar ***-phase xenon dark matter detectors can be used to track explosions of galactic supernovae by detecting neutrinos through coherent elastic neutrino-nucleus *** this study,a variation of progenitor masses and explosion models are assumed to predict neutrino fluxes and spectra,which result in the number of expected neutrino events ranging from 6.6 to 13.7 at a distance of 10 kpc over a 10-s duration with negligible backgrounds at *** specialized triggering alarms for monitoring supernova burst neutrinos are *** efficiency of detecting supernova explosions at various distances in the Milky Way is *** alarms will be implemented in the real-time supernova monitoring system at PandaX-4T in the near future,which will provide supernova early warnings for the astronomical community.

关键词： core-collapse supernovae neutrinos liquid xenon detectors supernova early warnings

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Determination of Double Beta Decay Half-Life of 136Xe with the PandaX-4T Natural Xenon Detector

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Research 2023年第2期2022卷 33-41页

作者： Lin Si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu xiaoying Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yujun Mao Yue Meng Nasir Shaheed xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian xiangxiang Ren Changsong Shang Guofang Shen Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu jingkai xia Mengjiao xiao xiang xiao Pengwei Xie Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Zhe Yuan Dan Zhang Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou xiaopeng Zhou Yong Zhou IMOE Key Laboratory for Particle Astrophysics and Cosmology Shanghai Key Laboratory for Particle Physics and Cosmology School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Sichuan Research Institute Shanghai Jiao Tong UniversityChengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-sen UniversityGuangzhou 510275China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao266237 ShandongChina Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao266237 ShandongChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China School of Physics Nankai UniversityTianjin 300071China Key Laboratory NuclearPyics and Ionampplication(MOE)Instituteof ModenPysics Fun Universty Shanghai 200433China School of Physics Peking UniversityBeijing 100871China Schol of Physics Beihang UniversityBejing 100191China International Research Center for Nuclei and Particles in the Cosmos Beijing key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai200093China Department of Physics University of MarylandCollge ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratoryof Particle Detetion and Electronics University of Scienceand Technology of ChinaHefei230026China Department of Modern Physics University of Science and Technology of ChinaHefei230026China SJTU ParisElite Instute of Technology Shanghai Jiao Tong UniversityShanghai 200240China

Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta *** report the measurement of DBD half-life of 136xe using the Pandax-4T dual-phase Time Projection Chamber(TPC)with 3.7-tonne natural xenon and the first 94.9-day physics data release.

关键词： decay double Determination

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LED电子束辐照实验在线监测系统

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核技术 2016年第5期39卷 37-43页

作者：马毅超朱纳党宏社钱森夏经凯王志刚刘超安广朋高峰张银鸿陕西科技大学西安710021 核探测与核电子学国家重点实验室北京100049 中国科学院高能物理研究所北京100049 中国科学院大学北京100049 天津工业大学天津300387

随着发光二极管(Light Emitting Diode,LED)应用需求的增加,对其电子束辐照效应的研究是目前的热点,因此需要设计一个数据获取系统,实时监测发光二极管性能参数在辐照过程中的变化。利用小电流计、功率计、光谱仪、低压电源等设备完成... 详细信息

随着发光二极管(Light Emitting Diode,LED)应用需求的增加,对其电子束辐照效应的研究是目前的热点,因此需要设计一个数据获取系统,实时监测发光二极管性能参数在辐照过程中的变化。利用小电流计、功率计、光谱仪、低压电源等设备完成系统硬件搭建,以Lab VIEW为开发平台完成了对串行通讯接口RS-232、通用串行总线(Universal Serial Bus,USB)和局域网(Local Area Network,LAN)三种接口通信协议的软件实现,并进行数据存储和显示,在局域网内利用远程桌面连接实现远程监测。利用该系统完成了在1.5 Ge V电子束辐照过程中对Ga N光电特性参数和环境参数的实时采集、存储和显示。

关键词：发光二极管电子束辐照在线监测系统

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Dark matter direct search sensitivity of the PandaX-4T experiment

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Science China(Physics,Mechanics & Astronomy) 2019年第3期62卷 49-57页

作者： HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen xiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji xiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao Kaixiang Ni JinHua Ning xiangxiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu jingkai xia MengJiao xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou xiaoPeng Zhou Shanghai Key Laboratory for Particle Physics and Cosmology Institute of Nuclear and Particle Physics (INPC) (INPC) and School of Physics and AstronomyShanghai Jiao Tong University School of Physics and Technology Xinjiang University Shanghai Key Laboratory for Particle Physics and Cosmology Institute of Nuclear and Particle Physics (INPC) and School of Physics and AstronomyShanghai Jiao Tong University Yalong River Hydropower Development Company Ltd. Shanghai Institute of Applied Physics Chinese Academy of Sciences School of Mechanical Engineering Shanghai Jiao Tong University School of Physics and Key Laboratory of Particle Physics and Particle Irradiation(MOE)(MOE) Shandong University School of Physics Nankai University Tsung-Dao Lee Institute School of Physics Peking University Department of Physics University of Maryland College Park School of Physics and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong University Center of High Energy Physics Peking University School of Medical Instrument and Food Engineering University of Shanghai for Science and Technology

The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2.

关键词： dark matter WIMPs direct detection xenon

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GaN基LED高能电子束流辐照效应研究

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核技术 2016年第12期39卷 51-55页

作者：刘超于莉媛王志刚钱森夏经铠朱纳高峰安广朋马毅超党宏社吴英蕾杨洁天津工业大学天津300387 核探测与核电子学国家重点实验室北京100049 中国科学院高能物理研究所北京100049 中国科学院大学北京100049 陕西科技大学西安710021

使用高能电子辐照对GaN基蓝光发光二极管(Light Emitting Diode,LED)光电学性能的影响进行研究。高能电子束流分别对不同组别的LED样品进行辐照实验,并通过自动测控系统对辐照过程中LED的电流、光强、光谱峰值波长进行全程测控。随后,... 详细信息

使用高能电子辐照对GaN基蓝光发光二极管(Light Emitting Diode,LED)光电学性能的影响进行研究。高能电子束流分别对不同组别的LED样品进行辐照实验,并通过自动测控系统对辐照过程中LED的电流、光强、光谱峰值波长进行全程测控。随后,在室温无辐照环境下对上述不同组别的LED样品进行跟踪对比测试研究。实验结果表明,高能辐照对LED的改性有明显效果,具体表现在工作电流和发光功率变化时受辐照影响的稳定性有所改善,光谱峰值波长出现蓝移。同时,GaN基LED在辐照过程中是否通电对LED的光电学性能有显著影响。

关键词：高能电子辐照 GaN 发光二极管光电学性能

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Constraining self-interacting dark matter with the full dataset of PandaX-II

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Science China(Physics,Mechanics & Astronomy) 2021年第11期64卷 2-7页

作者： Jijun Yang Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Shengming He Di Huang Yan Huang Ran Huo Yanlin Huang Zhou Huang xiangdong Ji Yonglin Ju Shuaijie Li Qing Lin Huaxuan Liu Jianglai Liu xiaoying Lu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Nasir Shaheed Kaixiang Ni Jinhua Ning Xuyang Ning xiangxiang Ren Changsong Shang Guofang Shen Lin Si Andi Tan Anqing Wang Hongwei Wang Meng Wang QiuHong Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu jingkai xia Mengjiao xiao xiang xiao Pengwei Xie Binbin Yan Yong Yang Chunxu Yu Hai-Bo Yu Jumin Yuan Ying Yuan Xinning Zeng Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou xiaopeng Zhou School of Physics and Astronomy Shanghai Jiao Tong UniversityMOE Key Laboratory for Particle Astrophysics and CosmologyShanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China Shanghai Jiao Tong University Sichuan Research Institude Chengdu 610213China Yalong River Hydropower Development Company Ltd.Chengdu 610051China School of Physics Sun Yat-sen UniversityGaungzhou 510275China Tsung-Dao Lee Institute Shanghai 200240China School of Physics Nankai UniversityTianjin 300071China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Peking UniversityBeijing 100871China School of Physics Beihang UniversityBeijing 100191China International Research Center for Nuclei and Particles in the Cosmos&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China Shandong Institute of Advanced Technology Jinan 250103China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Physics University of MarylandCollege ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityJinan 250100China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Department of Physics and Astronomy University of CaliforniaRiversideCalifornia 92507USA Center of High Energy Physics Peking UniversityBeijing 100871China

Self-interacting dark matter(SIDM)is a leading candidate proposed to solve discrepancies between predictions of the prevailing cold dark matter theory and observations of *** SIDM models predict the existence of a light force carrier that mediates strong dark matter *** the mediator couples to the standard model particles,it could produce characteristic signals in dark matter direct detection *** report searches for signals of SIDM models with a light mediator using the full dataset of the PandaX-II experiment,basing on a total exposure of 132 *** significant excess over background is found,and our likelihood analysis leads to a strong upper limit on the dark matter-nucleon coupling *** further combine the PandaX-II constraints and those from observations of the light element abundances in the early universe,and show that direct detection and cosmological probes can provide complementary constraints on dark matter models with a light mediator.

关键词： dark matter direct detection self-interacting dark matter

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A conductive supramolecular hydrogel creates ideal endogenous niches to promote spinal cord injury repair

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Bioactive Materials 2022年第9期7卷 103-119页

作者： Biao Yang Chengzhen Liang Di Chen Feng Cheng Yuang Zhang Shaoke Wang Jiawei Shu xianpeng Huang jingkai Wang Kaishun xia Liwei Ying Kesi Shi Chenggui Wang Xuhua Wang Fangcai Li Qian Zhao Qixin Chen Department of Orthopedics Surgery The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009ZhejiangChina Orthopedics Research Institute of Zhejiang University Hangzhou310009ZhejiangChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou310009ZhejiangChina Ningbo Research Institute of Zhejiang University Ningbo315100ZhejiangChina State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027ZhejiangChina NHC and CAMS Key Laboratory of Medical Neurobiology MOE Frontier Science Center for Brain Research and Brain-Machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhou310003ZhejiangChina

The current effective method for treatment of spinal cord injury(SCI)is to reconstruct the biological microenvironment by filling the injured cavity area and increasing neuronal differentiation of neural stem cells(NSCs)to repair ***,the method is characterized by several challenges including irregular wounds,and mechanical and electrical mismatch of the material-tissue *** the current study,a unique and facile agarose/gelatin/polypyrrole(Aga/Gel/PPy,AGP3)hydrogel with similar conductivity and modulus as the spinal cord was developed by altering the concentration of Aga and *** gelation occurred through non-covalent interactions,and the physically crosslinked features made the AGP3 hydrogels *** vitro cultures showed that AGP3 hydrogel exhibited excellent biocompatibility,and promoted differentiation of NSCs toward neurons whereas it inhibited over-proliferation of *** in vivo implanted AGP3 hydrogel completely covered the tissue defects and reduced injured cavity *** vivo studies further showed that the AGP3 hydrogel provided a biocompatible microenvironment for promoting endogenous neurogenesis rather than glial fibrosis formation,resulting in significant functional *** sequencing analysis further indicated that AGP3 hydrogel significantly modulated expression of neurogenesis-related genes through intracellular Ca2+signaling ***,this supramolecular strategy produces AGP3 hydrogel that can be used as favorable biomaterials for SCI repair by filling the cavity and imitating the physiological properties of the spinal cord.

关键词： Conducting polymer Supramolecular hydrogels Biomimetic scaffolds Nerve regeneration Spinal cord injury

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