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检索条件"作者=Jingkai gu"
57 条 记 录,以下是1-10 订阅
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Identification,structure elucidation and origin of a common pyridinium-thiocyanate intermediate in electrospray mass spectrometry among the benziamidazole-class proton pump inhibitors
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Journal of Pharmaceutical Analysis 2023年 第6期13卷 683-688页
作者: Dong Sun Chunyu Wang Yanxia Fan jingkai gu Research Center for Drug Metabolism School of Life SciencesJilin UniversityChangchun130012China State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun130012China Beijing Institute of Drug Metabolism Beijing102209China Jilin Institute for Drug Control Changchun130033China
During the analysis of benziamidazole-class irreversible proton pump inhibitors,an unusual mass spectral response with the mass-to-charge ratio at[Mt10]t intrigued us,as it couldn't be assigned to any literature known... 详细信息
来源: 维普期刊数据库 维普期刊数据库 评论
Current status of in vivo bioanalysis of nano drug delivery systems
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Journal of Pharmaceutical Analysis 2020年 第3期10卷 221-232页
作者: Tingting Wang Di Zhang Dong Sun jingkai gu Clinical Laboratory The First HospitalJilin UniversityChangchun130061PR China Research Institute of Translational Medicine The First HospitalJilin UniversityChangchun130061PR China Research Center for Drug Metabolism College of Life ScienceJilin UniversityChangchun130012PR China Department of Biopharmacy College of Life ScienceJilin UniversityChangchun130012PR China Key Laboratory of Molecular Pharmacology and Drug Evaluation Ministry of EducationYantai UniversityYantai264005PR China
The development of nano drug delivery systems(NDDSs)provides new approaches to fighting against *** NDDSs are specially designed to serve as carriers for the delivery of active pharmaceutical ingredients(APIs)to their... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Analytical methods for investigating in vivo fate of nanoliposomes:A review
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Journal of Pharmaceutical Analysis 2018年 第4期8卷 219-225页
作者: Chong Su Yingze Liu Yang He jingkai gu College of Life Science Jilin University Department of Pharmaceutical Sciences and Experimental Therapeutics College of Pharmacy University of lowa
Nanoliposomes are considered to be the most successful nanoparticle drug delivery system, but their fate in vivo has not been fully understood due to lack of reliable bioanalytical methods, which seriously limits the ... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
The biological fate of the polymer nanocarrier material monomethoxy poly(ethylene glycol)-block-poly(D,L-lactic acid)in rat
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Acta Pharmaceutica Sinica B 2021年 第4期11卷 1003-1009页
作者: Xiangjun Meng Zhi Zhang Jin Tong Hui Sun John Paul Fawcett jingkai gu Research Center for Drug Metabolism School of Life SciencesJilin UniversityChangchun 130012China Beijing Institute of Drug Metabolism Beijing 102209China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China
Monomethoxy poly(ethylene glycol)-block-poly(D,L-lactic acid)(PEG-PLA)is a typical amphiphilic di-block copolymer widely used as a nanoparticle carrier(nanocarrier)in drug *** the in vivo fate of PEG-PLA is required t... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Liquid chromatography–tandem mass spectrometry method for simultaneous determination of valproic acid and its ene-metabolites in epilepsy patient plasma
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Journal of Pharmaceutical Analysis 2016年 第2期6卷 112-116页
作者: Huan Lu Chong Su Lei Yin Liqiang gu jingkai gu Xiaohui Chen School of Pharmacy Shenyang Pharmaceutical University Research Center for Drug Metabolism College of Life ScienceJilin University Clinical Pharmacology Center Research Institute of Translational Medicine the First Hospital of Jilin University
A simple and high throughput method was developed and validated for simultaneous determination of valproic acid and its two toxicant ene-metabolites, 2-enevalproic acid and 4-enevalproic acid in epilepsy patient plasm... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Biological fate and interaction with cytochromes P450 of the nanocarrier material,D-α-tocopheryl polyethylene glycol 1000 succinate
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Acta Pharmaceutica Sinica B 2022年 第7期12卷 3156-3166页
作者: Tianming Ren Runzhi Li Liqiang Zhao J.Paul Fawcett Dong Sun jingkai gu Research Center for Drug Metabolism School of Life SciencesJilin UniversityChangchun 130012China State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun 130012China Beijing Institute of Drug Metabolism Beijing 102209China
D-a-Tocopheryl polyethylene glycol 1000 succinate(TPGS,also known as vitamin E-TPGS)is a biodegradable amphiphilic polymer prepared by esterification of vitamin E with polyethylene glycol(PEG)*** is approved by the US... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Disposition and fate of polyoxyethylene glycerol ricinoleate as determined by LC-Q-TOF MS coupled with MS^(ALL),SWATH and HR MS/MS techniques
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Chinese Chemical Letters 2021年 第10期32卷 3237-3240页
作者: Ruifeng Bai Dong Sun Yuqin Shan Zhiqiong guo Dafeng Chu John Paul Fawcett jingkai gu Center for Drug Metabolism Research School of Life SciencesJilin UniversityChangchun 130012China
Polyoxyethylene glycerol ricinoleate(PGR) serves as a solubilizer/emulsifier that is commonly used in pharmaceutical formulations despite being associated with severe anaphylactoid hypersensitivity *** EL?(CrEL) is th... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Impact of molecular weight on the mechanism of cellular uptake of polyethylene glycols(PEGs) with particular reference to P-glycoprotein
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Acta Pharmaceutica Sinica B 2020年 第10期10卷 2002-2009页
作者: Tingting Wang Yingjie guo Yang He Tianming Ren Lei Yin John Paul Fawcett jingkai gu Huimin Sun Clinical Laboratory First HospitalJilin UniversityChangchun 130061China Research Institute of Translational Medicine First HospitalJilin UniversityChangchun 130061China Research Center for Drug Metabolism College of Life ScienceJilin UniversityChangchun 130012China Department of Pharmaceutical Sciences and Experimental Therapeutics College of PharmacyUniversity of IowaIowa City IA 52242USA Beijing Institute of Drug Metabolism Beijing 102209China National Institutes for Food and Drug Control Beijing 100050China
Polyethylene glycols(PEGs)in general use are polydisperse molecules with molecular weight(MW)distributed around an average value applied in their designation e.g.,PEG *** research has shown that PEGs can act as P-glyc... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Separation and simultaneous quantitation of PGF2α and its epimer 8-iso-PGF2α using modifier-assisted differential mobility spectrometry tandem mass spectrometry
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Acta Pharmaceutica Sinica B 2018年 第2期8卷 228-234页
作者: Chunsu Liang Hui Sun Xiangjun Meng Lei Yina J.Paul Fawcett Huaidong Yu Ting Liu jingkai gu Research Center for Drug Metabolism School of Life Sciences Jilin University School of Pharmacy University of Otago Shanghai AB Sciex Analytical Instrument Trading Co. Ltd.
Because many therapeutic agents are contaminated by epimeric impurities or form epimers as a result of metabolism, analytical tools capable of determining epimers are increasingly in demand. This article is a proof-of... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Full-profile pharmacokinetics, anticancer activity and toxicity of an extended release trivalent PEGylated irinotecan prodrug
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Acta Pharmaceutica Sinica B 2023年 第8期13卷 3444-3453页
作者: Shiwen Song Dong Sun Hong Wang Jinliang Wang Huijing Yan Xuan Zhao John Paul Fawcett Xin Xu Deqi Cai jingkai gu Research Center for Drug Metabolism School of Life SciencesJilin UniversityChangchun 130012China Center for Food and Drug Inspection of NMPA Changchun 130012China Jen Kem Technology Co. Ltd.Tianjin 300450China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China Beijing Institute of Drug Metabolism Beijing 102209China
Irinotecan is an anticancer topoisomerase I inhibitor that acts as a prodrug of the active metabolite,***,the limited utility of irinotecan is attributed to its pH-dependent stability,short half-life and dose-limiting... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论