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Factors affecting the voxel-based analysis of diffusion tensor imaging

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Chinese Science Bulletin 2014年第31期59卷 4077-4085页

作者： Jianli wang Binbin Nie Haitao Zhu Hua Liu jingjuan wang Shaofeng Duan Baoci Shan Key Laboratory of Nuclear Radiation and Nuclear Energy Technology Institute of High Energy PhysicsChinese Academy of Sciences Beijing Engineering Research Center of Radiographic Techniques and Equipment

Diffusion tensor imaging(DTI)provides a unique method to reveal the integrity of white matter microstructure ***-based analysis(VBA),which is a highly reproducible and user-independent technique,has been used to analyze DTI data in a number of *** anisotropy(FA),which is derived from DTI,is the most frequently used *** parameter setting during the DTI data preprocessing might affect the FA analysis ***,there is no reliable evidence on how the parameters affect the results of FA *** study sought to quantitatively investigate the factors that might affect the voxel-based analysis of FA;these include the interpolation during spatial normalization,smoothing kernel and statistical *** it is difficult to obtain the true information of the lesion in the patients,we simulated lesions on the healthy FA *** DTI data were obtained from 20 healthy *** FA maps were calculated using *** randomly divided these FA maps into two *** was used as a model patient group,and the other was used as a normal control *** lesions were added to the model patient group by decreasing the FA intensities in a specified region by 5%–50%.The model patient group and the normal control group were compared by two-sample t test statistic analysis voxelby-voxel to detect the simulated *** evaluated these factors by comparing the difference between the detected lesion through VBA and the simulated *** result showed that the space normalization of FA image should use the trilinear interpolation,and the smoothing kernel should be 2–3 times the voxel size of spatially normalized FA *** lesions with small intensity change,FWE correction must be cautiously *** study provided an important reference to the analysis of FA with VBA method.

关键词：扩散张量体素成像三线性插值可能影响统计分析结构完整性预处理过程

Flexible artificial synapse based on single-crystalline BiFeO_(3) thin film

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Nano Research 2022年第3期15卷 2682-2688页

作者： Zhen Zhao Amr Abdelsamie Rui Guo Shu Shi Jianhui Zhao Weinan Lin Kaixuan Sun jingjuan wang Junling wang Xiaobing Yan Jingsheng Chen Key Laboratory of Brain-like Neuromorphic Devices and Systems of Hebei Province College of Electron and Information EngineeringHebei UniversityBaoding 071002China Department of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Materials Science and Engineering National University of SingaporeSingapore 117576Singapore Department of Physics Southern University of Science and TechnologyShenzhen 518055China

Realization of functional flexible artificial synapse is a significant step toward neuromorphic ***,a flexible artificial synapse based on ferroelectric tunnel junctions(FTJs)is demonstrated,using BiFeO_(3)(BFO)thin film as the functional *** inorganic single crystalline FTJs grown on rigid perovskite substrates at high temperatures are integrated with the flexible plastic substrates,by using the water-soluble Sr_(3)Al_(2)O_(6)(SAO)as the sacrificial layer and the following *** transferred freestanding BFO thin film exhibits excellent ferroelectric ***,the memristive properties and the brain-like synaptic learning performance of the flexible FTJs are *** results show that multilevel resistance states were maintained well of the flexible artificial synapse,together with their stable synaptic learning *** work indicates the promising opportunity of ferroelectric thin film based flexible synapse used in the future neuromorphic computing system.

关键词： flexible ferroelectricity memristor artificial synapse

Superlow Power Consumption Artificial Synapses Based on WSe2 Quantum Dots Memristor for Neuromorphic Computing

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Research 2023年第2期2022卷 101-113页

作者： Zhongrong wang Wei wang Pan Liu Gongjie Liu Jiahang Li Jianhui Zhao Zhenyu Zhou jingjuan wang Yifei Pei Zhen Zhao Jiaxin Li Lei wang Zixuan Jian Yichao wang Jianxin Guo Xiaobing Yan Key Laboratory of Brain-Like Neuromorphic Devices and Systems of Hebei Province College of Electronic and Information EngineeringHebei UniversityBaoding 071002China Department of Clinical Laboratory Medicine Taizhou Central Hospital(Taizhou University Hospital)Taizhou 318000China College of Physics Science and Technology Hebei UniversityBaoding 071002China

As the emerging member of zero-dimension transition metal dichalcogenide,WSe2 quantum dots(QDs)have been applied to memristors and exhibited better resistance switching characteristics and miniaturization ***,low powe... 详细信息

关键词： Quantum dimension reliability

HfAlO-based ferroelectric memristors for artificial synaptic plasticity

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Frontiers of physics 2023年第6期18卷 163-171页

作者： Jie Yang Zixuan Jian Zhongrong wang Jianhui Zhao Zhenyu Zhou Yong Sun Mengmeng Hao Linxia wang Pan Liu jingjuan wang Yifei Pei Zhen Zhao Wei wang Xiaobing Yan Key Laboratory of Brain-Like Neuromorphic Devices and Systems of Hebei Province College of Electron and Information EngineeringHebei UniversityBaoding 071002China Laboratory of Solid State Optoelectronics Information Technology Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Department of Materials Science and Engineering National University of Singapore Singapore 117576Singapore

Memristors have received much attention for their ability to achieve multi-level storage and synaptic ***,the main factor that hinders the application of memristors to simulate neural synapses is the instability of the formation and breakage of conductive filaments inside traditional memristors,which makes it difficult to simulate the function of biological synapses in ***,the resistance change of ferroelectric memristors relies on the polarization inversion of the ferroelectric thin film,thus avoiding the above *** this study,a Pd/HfAlO/LSMO/STO/Si ferroelectric memristor is proposed,which can achieve resistive switching properties through the combined action of ferroelectricity and oxygen *** I−V curves show that the device has good stability and *** addition,the effect of pulse sequence modulation on the conductance was investigated,and the biological synaptic function and learning behavior were simulated *** results of the above studies provide a basis for the development of ferroelectric memristors with neurosynaptic-like behaviors.

关键词： memristor ferroelectric domain polarization resistance regulation artificial synapse

Mechanism of Guangdong Shenqu in regulating intestinal flora in mice with food stagnation and internal heat based on 16S rDNA sequencing

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Journal of Traditional Chinese Medical Sciences 2024年第2期11卷 232-244页

作者： Yani Jiang Zhenhong Zhang Han Chen Yanmin wang Yanrui Xu Zijie Chen Yan Xu jingjuan wang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China School of Chinese Traditional Medicine Beijing University of Chinese MedicineBeijing102488China Department of Chemistry Cleveland State UniversityCleveland44115USA

Objective:To investigate the effect of Guangdong Shenqu(GSQ)on intestinal flora structure in mice with food stagnation through 16S rDNA ***: Mice were randomly assigned to control,model,GSQ low-dose(GSQL),GSQ medium-dose(GSQM),GSQ high-dose(GSQH),and lacidophilin tablets(LAB)groups,with each group containing 10 mice.A food stagnation and internal heat mouse model was established through intragastric administration of a mixture of beeswax and olive oil(1:15).The control group was administered normal saline,and the model group was administered beeswax and olive oil to maintain a *** GSQL(2 g/kg),GSQM(4 g/kg),GSQH(8 g/kg),and LAB groups(0.625 g/kg)were administered corresponding drugs for 5 *** administration,16S rDNA sequencing was performed to assess gut microbiota in mouse fecal ***: The model group exhibited significant intestinal flora *** GSQ administration,the abundance and diversity index of the intestinal flora increased significantly,the number of bacterial species was regulated,andαandβdiversity were *** administration increased the abundance of probiotics,including Clostridia,Lachnospirales,and Lactobacillus,whereas the abundance of conditional pathogenic bacteria,such as Allobaculum,Erysipelotrichaceae,and Bacteroides *** prediction analysis indicated that the pathogenesis of food stagnation and GSQ intervention were primarily associated with carbohydrate,lipid,and amino acid metabolism,among other metabolic ***: The digestive mechanism of GSQ may be attributed to its role in restoring diversity and abundance within the intestinal flora,thereby improving the composition and structure of the intestinal flora in mice and subsequently influencing the regulation of metabolic pathways.

关键词： Guangdong Shenqu Food stagnation Gut microbiota High-throughput gene sequencing Species annotation Metabolic pathway

Artificial nociceptor based on TiO nanosheet memristor

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Science China Materials 2021年第7期64卷 1703-1712页

作者： Jinling Lan Gang Cao jingjuan wang Xiaobing Yan Key Laboratory of Brain-Like Neuromorphic Devices and Systems of Hebei Province College of Electron and Information EngineeringHebei UniversityBaoding 071002China Department of Materials Science and Engineering National University of SingaporeSingapore 117576Singapore

With the development of technology,the learning and memory functions of artificial memristor synapses are necessary for realizing artificial neural networks and neural neuromorphic *** to their high scalability performance,nanosheet materials have been widely employed in cellular-level learning,but the behaviors of nociceptor based on nanosheet materials have rarely been ***,we present a memristor with an Al/TiO_(2)/Pt *** electroforming,the memristor device showed a gradual conductance regulation and could simulate synaptic functions such as the potentiation and depression of synaptic *** also designed a new scheme that verifies the pain sensitization,desensitization,allodynia,and hyperalgesia behaviors of real nociceptors in the fabricated *** with these behaviors can significantly improve the quality of intelligent electronic *** fitting showed that the high resistance and low resistance states were consistent with the hopping conduction *** work promises the application of TiO_(2)-based devices in next-generation neuromorphological systems.

关键词： nanosheets nociceptor memristors artificial synapses sensitization

Memristive device with highly continuous conduction modulation and its underlying physical mechanism for electronic synapse application

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Science China Materials 2021年第1期64卷 179-188页

作者： Jing Zhang Tao Yang jingjuan wang Jianhui Zhao Xiaobing Yan Key Laboratory of Brain-Like Neuromorphic Devices and Systems of Hebei Province College of Electron and Information EngineeringHebei UniversityBaoding071002China University of Chinese Academy of Sciences Beijing100049China

Emerging memristors can be used as artificial synapses for emulating memory and computational *** this work,inspired by the memristive properties of tantalum dioxide,we designed a memristor with a structure of TiN/Ta2O5-x/HfxZr1-xO2(x=0.5)/Pt(TTHZOP).The device conductance can be continuously tuned by adjusting the voltage pulse parameters(i.e.,amplitude,width,and number)of voltage ***,for both of negative and positive parts,the current-voltage curves of the sweep cycle appear to better adjust the gradual distribution in successive twenty *** to the fine fitting results of twenty positive and negative current-voltage(I-V)curves,the probability of an electron jumping over an energy barrier and the width of the energy barrier were analyzed in *** is found that the electron tunneling mechanism at the interface is responsible for gradual conduction change under successive external electrical stimulation consisting of both bulk and interface *** proposed TTHZOP memristor is a promising candidate in potential applications that mimic artificial biosynaptic adaptation and analog brain computation.

关键词： memristor artificial synapse synaptic plasticity continuous conduction

八段锦联合吸气肌力量训练对老年尘肺病人运动耐力和呼吸功能的影响

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护理研究 2022年第3期36卷 562-564页

作者：王晶娟中国人民解放军总医院海南医院海南572000

目的:探讨八段锦联合吸气肌力量训练(IMST)对老年尘肺病人运动耐力和呼吸功能的影响。方法:选取我院2018年1月—2020年1月收治的80例老年尘肺病人病人为研究对象,采用随机数表法将病人分为对照组和研究组,每组40例。对照组病人接受常规... 详细信息

目的:探讨八段锦联合吸气肌力量训练(IMST)对老年尘肺病人运动耐力和呼吸功能的影响。方法:选取我院2018年1月—2020年1月收治的80例老年尘肺病人病人为研究对象,采用随机数表法将病人分为对照组和研究组,每组40例。对照组病人接受常规治疗及护理干预,研究组病人在对照组基础上接受八段锦与IMST干预。比较两组病人肺功能、经皮脉搏血氧饱和度、运动耐力、呼吸困难改善程度及生活质量。结果:干预后,研究组病人第1秒用力呼气量、最大通气能力及经皮脉搏血氧饱和度水平高于对照组,6 min步行距离测试距离长于对照组,Borg呼吸困难评分低于对照组,圣·乔治呼吸问卷评分高于对照组,差异均有统计学意义(P<0.05)。结论:将八段锦联合IMST应用于老年尘肺病人,可促进病人肺功能恢复,缓解呼吸困难症状,提升病人运动耐力,提高病人生活质量。

关键词：老年人尘肺八段锦吸气肌力量训练肺功能运动耐力呼吸困难护理

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中国区域创新能力空间演化及其空间溢出效应

经济地理 2017年第9期37卷 11-18页

作者：焦敬娟王姣娥程珂北京交通大学经济管理学院中国北京100044 中国科学院区域可持续发展分析与模拟重点实验室中国北京100101 中国科学院地理科学与资源研究所中国北京100101 湖南大学工商管理学院中国湖南长沙410082

随着知识经济和科学技术的发展,创新驱动逐渐成为国家或区域谋求竞争优势的决定性因素。文章分别从创新投入、创新产出和创新潜力等三个方面,探讨2003—2013年各省份区域创新能力发展水平及其空间演化特征,采用空间计量模型(滞后、误差... 详细信息

随着知识经济和科学技术的发展,创新驱动逐渐成为国家或区域谋求竞争优势的决定性因素。文章分别从创新投入、创新产出和创新潜力等三个方面,探讨2003—2013年各省份区域创新能力发展水平及其空间演化特征,采用空间计量模型(滞后、误差、杜宾),分析和评价区域创新能力的空间溢出效应。研究表明:我国各省市区域创新能力均有明显提升,但空间差异总体呈扩大态势,空间集聚态势略有降低;空间上,区域创新能力呈明显的东中西地带性;山东和陕西区域创新能力在全国地位有所提升,而辽宁省地位明显降低;省域及邻近省份区域创新能力的提升均对经济发展产生正向溢出效应,且其溢出效应呈明显的东中西地带性。

关键词：创新发展创新能力空间溢出空间计量省域尺度中国