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Irreversible phenotypic perturbation and functional impairment of B cells during HIV-1 infection

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Frontiers of Medicine 2017年第4期11卷 536-547页

作者： jingjing yan Shuye Zhang Jun Sun Jianqing Xu Xiaoyang Zhang Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences Fudan University Shanghai 201508 China

Human immunodeficiency virus type 1 （HIV-1） infection can damage humoral immunity. The knowledge of B cell perturbations during chronic HIV-1 infection and their recovery after combined antiretroviral therapy （cART） is not complete yet, and thus attempts to further improve humoral immunity are impeded. In this study, an HIV-1 chronically infected cohort with similar demographics, infection history, genetic background, and HIV-1 genotype was established to probe B cell perturbations. Results showed that the B cells from this cohort were highly activated and prone to cell death, and B cell compartments were altered significantly. Notably, although cART partially reversed the hyperactivation and reduced tissue-like memory B cells, other B cell perturbations, including impaired expression of survival factor Bcl-2, costimulatory molecules, and shrunken resting memory B cells, were irreversible. Further functional characterization revealed that the influenza HA- specific antibody-secreting cells were significantly lower during HIV-1 infection, whereas the recalled antibody response to HIV-l-specific antigens was decreased after cART. Finally, CpG plus R848 treatment increased the survival of B cells and memory B cells in vitro from HIV-l-infected patients. In conclusion, this study identified irreversible B cell immune perturbations in chronic HIV-1 infections regardless of cART and proposed the potential strategy to enhance B cell functions through the improvement of cell survival.

关键词： B cell HIV-1 phenotype functionality antiretroviral therapy

Zircon U-Pb Dating of Leucogranite in Lhozag and Its Geological Significance

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Acta Geologica Sinica(English Edition) 2018年第2期92卷 876-878页

作者： GUO Linnan HUANG Chunmei SHI Qingshang yan jingjing Chengdu Center China Geological Survey School of Geosciences and Resources China University of Geosciences

The Himalayan leucograite, which is typical production of continent-continent collision orogenic belt, has become a research hotspot of the Tibetan Plateau. The research on the leucogranite would help to verify and improve the continent-continent collision orogenic theory. （Huang et al., 2017; Fig. la）. Previous studies show the Himalayan leucogranite was mainly melted from crust materials （Guo and Wilson, 2012）. But it remains controversial for the formation model as to whether it formed from gathering of dikes or diaper of deep magma chambers.

关键词： Pb Zircon U-Pb Dating of Leucogranite in Lhozag and Its Geological Significance

Evaluation of global gridded crop models in simulating sugarcane yield in China

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Atmospheric and Oceanic Science Letters 2023年第2期16卷 49-54页

作者： Dezhen Yin jingjing yan Fang Li Tianyuan Song International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina School of Resources and Environment Northeast Agricultural UniversityHarbinChina

中国是全球第三大甘蔗生产国,中国甘蔗产量模拟可服务于全球食糖和乙醇的生产和贸易.全球格点作物模式CLM5-crop和LPJmL已实现对甘蔗的模拟,但它们在中国的模拟能力未知.本文评估结果表明:两个模式均严重低估了甘蔗产量,模拟均不足观测... 详细信息

中国是全球第三大甘蔗生产国,中国甘蔗产量模拟可服务于全球食糖和乙醇的生产和贸易.全球格点作物模式CLM5-crop和LPJmL已实现对甘蔗的模拟,但它们在中国的模拟能力未知.本文评估结果表明:两个模式均严重低估了甘蔗产量,模拟均不足观测的1/***5-crop能有技巧地模拟产量的空间分布特征,而LPJmL不能.两个模式均不能合理模拟产量的年际变化,且低估了产量的上升趋势.模式低估甘蔗产量的部分原因是模式假设收割的是甘蔗的穗而非茎.

关键词：全球格点作物模式模式评估甘蔗产量中国

Water-in-salt electrolyte ion-matched N/O codoped porous carbons for high-performance supercapacitors

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Chinese Chemical Letters 2020年第2期31卷 579-582页

作者： jingjing yan Dazhang Zhu Yaokang Lv Wei Xiong Mingxian Liu Lihua Gan Shanghai Key Lab of Chemical Assessment and Sustainability School of Chemical Science and EngineeringTongji UniversityShanghai 200092China College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China Key Laboratory for Green Chemical Process of Ministry of Education School of Chemistry and Environmental EngineeringWuhan Institute of TechnologyWuhan 430073China College of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou 450001China

Pore size and distribution in carbon-based materials are regarded to be a key factor to affect the electrochemical capacitive performances of the resultant *** this study,nitrogen and oxygen codoped porous carbons(NOPCs) are fabricated based on a simple Schiff-base reaction between m-phenylenediamine and *** NOPCs have tunable morphologies,high surface areas,abundant heteroatom *** importantly,the carbons show a dominant micropores of 0.5-0.8 nm,comparable to the ionic sizes of LiTFSI(Li^+0.069 nm;TFSI-0.79 nm) water-in-salt electrolyte with a high potential window of 2.2 ***,the fabricated symmetric supercapacitor gives a high energy output of 30.5 Wh/kg at 1 kW/kg,and high stability after successive 10,000 cycles with ^96.8% *** study provides promising potential to develop high-energy supercapacitors.

关键词： N/O Codoped Porous carbon Water-in-salt electrolyte Pore/ion size matching Symmetrical supercapacitor High energy density

Biosynthesis of Silver Nanoparticles by Septoria apii and Trichoderma koningii

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Chinese Journal of Chemistry 2013年第4期31卷 529-533页

作者： Weidong Huang jingjing yan Yue Wang Cailing Hou Tianchun Dai Zhimin Wang School of Agriculture and Biology Shanghai Jiao Tong University Shanghai 200240 China

Silver nanoparticles were synthesized by Septoria apii and Trichoderma koningii for the first time and charac- terized systematically.

关键词： silver nanoparticles Septoria apii Trichoderma koningii

Complexation of DNA with cationic surfactants as studied by small-angle X-ray scattering

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Science China Chemistry 2014年第12期57卷 1738-1745页

作者： NIU Lin yan jingjing yanG Xuyan BURGER Christian RONG LiXia HSIAO Benjamin LIANG DeHai Beijing National Laboratory for Molecular Sciences the Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education Department of Polymer Science and Engineering College of Chemistry and Molecular Engineering Peking University Department of Chemistry State University of New York at Stony Brook

The phase behaviors of the complex formed by didodecyldimethylammonium bromide（DDAB）and cetyltrimethylammonium bromide（CTAB）interacting with three different types of DNAs,salmon testes DNA（~2000 bp）,21-bp double-stranded oligonucleotides（oligo-ds DNA）,and 21-nt single-stranded oligonucleotides（oligo-ss DNA）were studied by synchrotron small-angle X-ray *** was found that the DNA length and flexibility,together with the positive/negative charge ratio,determined the final *** higher charge ratios,the DNA length exhibited negligible *** oligo-ds DNA and salmon DNA formed inverted hexagonal packing of cylinders with CTAB,as well as bilayered lamella with ***,at lower charge ratios,oligo-ds DNA formed a distorted hexagonal phase with CTAB and a new structure with DDAB,which was different from the behaviors of salmon *** flexible oligo-ss DNA formed rich structures that were subject to environmental *** study also indicated that the structures of the complex formed by oligo-ss DNA took much longer to mature than the structures formed by oligo-ds *** attributed this result to the conformational adjustment of oligo-ss DNA in the complex.

关键词： phase behavior DNA surfactant synchrotron small-angle X-ray scattering kinetics

Model-Based Embedded Compiled Software Fault Positioning

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Wuhan University Journal of Natural Sciences 2017年第3期22卷 263-268页

作者： LIU Jinshuo CHEN Jian ZHANG Weixin XU Xiangyang yan jingjing School of Computer Wuhan University Wuhan 430072Hubei China Tianjin Electric Power Science Research Institute Tianjin 300000 China

Software fault positioning is one of the most effective activities in program debugging. In this paper, we propose a model-based fault positioning method to detect the faults of embedded program without source code. The system takes the machine code of embedded software as input and translates the code into high-level language C with the software reverse engineering program. Then, the static analysis on the high-level program is taken to obtain a control flow graph（CFG）, which is denoted as a node-tree and each node is a basic block. According to the faults found by the field testing, we construct a fault model by extracting the features of the faulty code obtained by ranking the Ochiai coefficient of basic blocks. The model can be effectively used to locate the faults of the embedded program. Our method is evaluated on ST chips of the smart meter with the corresponding source code. The experiment shows that the proposed method has an effectiveness about 87% on the fault detection.

关键词： code reverse engineering model-based test fault positioning

High-energy aqueous supercapacitors enabled by N/O codoped carbon nanosheets and“water-in-salt”electrolyte

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Chinese Chemical Letters 2022年第5期33卷 2681-2686页

作者： jingjing yan Ling Miao Hui Duan Dazhang Zhu Yaokang Lv Liangchun Li Lihua Gan Mingxian Liu Shanghai Key Lab of Chemical Assessment and Sustainability School of Chemical Science and EngineeringTongji UniversityShanghai 200092China School of Chemical Engineering Anhui University of Science and TechnologyHuainan 232001China College of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou 450001China College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China

A facile fabrication strategy is reported to obtain N/O codoped porous carbon nanosheets for pur-pose of ameliorating the charge transfer and accumulation in the concentrated LiTFSI(lithium bis(trifluoromethane sulfonyl)imide)*** tunning the feed ratio of comonomers,the porous nanosheet structure is endowed with a significant ion-adsorption surface area(1630 m^(2)/g)and intercon-nected hierarchical porosity;meanwhile,high-level N/O dopants(N:3.58 at%,O:12.91 at%)increase the effective contact area for electrolyte ions,and further facilitate rapid ion/electron *** from the advantageous features,carbon nanosheets electrode reveal an enhanced specific capacitance(375 F/g)in three-electrode configuration and the H_(2)SO_(4)-based device yields a high gravimetric energy density of 11.4 Wh/***,the ion-diffusion highways in porous carbon nanosheets contribute to the 2.25 V LiTFSI-based symmetric device with a high energy delivery up to 33.1 Wh/*** work offers an in-spiring strategy for facile fabrication of carbon nanosheets,and demonstrates their promising application in“water-in-salt”electrolyte-based supercapacitor systems.

关键词： Porous carbon nanosheets N/O codoping Water-in-salt electrolyte High-energy supercapacitor

Robust frequency-upconversion lasing operated at 400 K from inorganic perovskites microcavity

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Nano Research 2022年第1期15卷 492-501页

作者： Zhifeng Shi Fei Zhang jingjing yan Yuan Zhang Xu Chen Shu Chen Di Wu Xinjian Li Yu Zhang Chongxin Shan Key Laboratory of Materials Physics of Ministry of Education School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityQianjin Street 2699Changchun 130012China

Multi-photon-pumped lasing based on metal-halide perovskites is promising for nonlinear optics and practical frequency-upconversion devices in integrated photonic ***,at present almost all the multi-photon-pumped lasing emissions from perovskite microcavities were limited for two-photon excitation,and also suffered from a compromise in room temperature or low temperature operation *** this study,based on the vapor-phase epitaxial CsPbBr3 microplatelets with high crystallinity,self-formed high-quality microcavities,and great thermal stability,low-threshold and high-quality factor whispering gallery mode lasing was realized under single-,two-,and three-photon excitation,and the lasing action is very stable under continuous pulsed laser irradiation(~3.6×10^(7) laser shots).More importantly,the three-photon-pumped lasing can be efficiently sustained at a high temperature of~400 K,and the characteristic temperature was determined to be as high as~152.6 K,indicating the highly temperature-insensitive gain *** that this is the first report on high-temperature three-photon-pumped lasing on perovskite ***,an aggressive thermal cycling test(two cycles,290-400-290 K)was further performed to indicate the stability and repeatability of the multi-photon-pumped lasing *** can be anticipated that the results obtained represent a significant step toward the temperature-insensitive frequency-upconversion lasing,inspiring the exploitation of advantageous perovskites for novel applications.

关键词： frequency-upconversion lasing perovskite microcavity high-temperature characteristic temperature stability