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Tissue-resident macrophages exacerbate lung injury after remote sterile damage

Cellular & Molecular Immunology 2024年第4期21卷 332-348页

作者： Hanhui Zhong jingjing ji jinling Zhuang Ziying Xiong Pengyun Xie Xiaolei Liu Jundi Zheng Wangli Tian Xiaoyang Hong jing Tang The Department of Anesthesiology Affiliated Hospital of Guangdong Medical UniversityZhanjiangGuangdongChina The Department of Critical Care Medicine General Hospital of Southern Theater Command of PLAGuangzhouChina The Department of Respiratory Medicine Guangdong Provincial Hospital of Integrated Chinese and Western MedicineFoshanChina Pediatric Intensive Care Unit Senior Department of Pediatricsthe Seventh Medical Center of PLA General HospitalBeijingChina

Remote organ injury,which is a common secondary complication of sterile tissue damage,is a major cause of poor prognosis and is difficult to manage.Here,we report the critical role of tissue-resident macrophages in lung injury after trauma or stroke through the inflammatory response.We found that depleting tissue-resident macrophages rather than disrupting the recruitment of monocyte-derived macrophages attenuated lung injury after trauma or stroke.Our findings revealed that the release of circulating alarmins from sites of distant sterile tissue damage triggered an inflammatory response in lung-resident macrophages by binding to receptor for advanced glycation end products(RAGE)on the membrane,which activated epidermal growth factor receptor(EGFR).Mechanistically,ligand-activated RAGE triggered EGFR activation through an interaction,leading to Rab5-mediated RAGE internalization and EGFR phosphorylation,which subsequently recruited and activated P38;this,in turn,promoted RAGE translation and trafficking to the plasma membrane to increase the cellular response to RAGE ligands,consequently exacerbating inflammation.Our study also showed that the loss of RAGE or EGFR expression by adoptive transfer of macrophages,blocking the function of RAGE with a neutralizing antibody,or pharmacological inhibition of EGFR activation in macrophages could protect against trauma-or stroke-induced remote lung injury.Therefore,our study revealed that targeting the RAGE-EGFR signaling pathway in tissue-resident macrophages is a potential therapeutic approach for treating secondary complications of sterile damage.

关键词： tissue-resident macrophage RAGE remote sterile damage

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Machine learning-assisted sparse observation assimilation for real-time aerodynamic field perception

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Science China(Technological Sciences) 2024年第5期67卷 1458-1469页

作者： ZHAO QingYu HUANG Jun GUO YuXin PAN YuXuan ji jingjing HUANG YongAn State Key Laboratory of Intelligent Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Accurate aerodynamic distribution perception and real-time flight state evaluation are crucial for flight safety,e.g.,stall detection.However,the observations are usually sparse due to limitations in sensor mounting space and cost,and a reconstruction technology is urgently required.Herein,a machine learning-assisted assimilation method based on sparse observations has been proposed.Different from the traditional reconstruction methods focusing on boundary condition correction,the proposed method formulates the flow field pressure distribution as a linear superposition of flow field modes,thereby forming a real-time reconstruction pattern that combines offline modal extraction using computational fluid dynamics(CFD)with real-time determination of modal weights using a neural network.In this study,CFD simulations were conducted under 800different operating conditions for common modal extraction and model training.The weights of these modes were determined online based on merely five observations for reconstructing the full pressure field.A pressure reconstruction with a relative error of 6.1%and a mean square error of 0.003 was achieved within the prescribed condition range.The computational cost was just2 ms for each reconstruction run,significantly faster than the 20 min required by the classical reconstruction ensemble transform Kalman filter.It also showed that the method maintains almost the same accuracy amidst 1.5%measurement noise.As practical examples,shock waves and the change of lift coefficient were analyzed using the proposed method,providing remarkable evidence for the capability of the method in supporting stall detection.These validate the method’s effectiveness and explore its potential in real-time and accurate monitoring of an aircraft.

关键词： aerodynamic force sparse observation neural networks pressure field reconstruction

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Effect of inferior vena cava respiratory variability-guided fluid therapy after laparoscopic hepatectomy:a randomized controlled clinical trial

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Chinese Medical Journal 2023年第13期136卷 1566-1572页

作者： jingjing ji Qian Ma Yali Tian Xueduo Shi Luning Chen Xinhua Zhu Decai Yu Yudong Qiu Bingbing Li Department of Anaesthesiology Affiliated Drum Tower HospitalNanjing UniversitySchool of MedicineNanjingJiangsu 210008China Department of Hepatobiliary Pancreatic Surgery Affiliated Drum Tower HospitalNanjing UniversitySchool of MedicineNanjingJiangsu 210008China

Background:After major liver resection,the volume status of patients is still undetermined.However,few concerns have been raised about postoperative fluid management.We aimed to compare gut function recovery and short-term prognosis of the patients after laparoscopic liver resection(LLR)with or without inferior vena cava(IVC)respiratory variability-directed fluid therapy in the anesthesia intensive care unit(AICU).Methods:This randomized controlled clinical trial enrolled 70 patients undergoing LLR.The IVC respiratory variability was used to optimize fluid management of the intervention group in AICU,while the standard practice of fluid management was used for the control group.The primary outcome was the time to flatus after surgery.The secondary outcomes included other indicators of gut function recovery after surgery,postoperative length of hospital stay(LOS),liver and kidney function,the severity of oxidative stress,and the incidence of severe complications associated with hepatectomy.Results:Compared with patients receiving standard fluid management,patients in the intervention group had a shorter time to anal exhaust after surgery(1.5±0.6 days vs.2.0±0.8 days)and lower C-reactive protein activity(21.4[95%confidence interval(CI):11.9-36.7]mg/L vs.44.8[95%CI:26.9-63.1]mg/L)24 h after surgery.There were no significant differences in the time to defecation,serum concentrations of D-lactic acid,malondialdehyde,renal function,and frequency of severe postoperative complications as well as the LOS between the groups.Conclusion:Postoperative IVC respiratory variability-directed fluid therapy in AICU was facilitated in bowel movement but elicited a negligible beneficial effect on the short-term prognosis of patients undergoing LLR.Trial Registration:ChiCTR-INR-17013093.

关键词： Inferior vena cava respiratory variation Laparoscopic liver resection Goal-directed fluid therapy Postoperative intestinal function recovery Ultrasound

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Molecular characterization and functional analysis of daf-8 in the pinewood nematode,Bursaphelenchus xylophilus

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Journal of Forestry Research 2022年第2期33卷 689-698页

作者： jinghan Wang Huan Hong Rong Xie jingjing ji Kai Guo Liqun Bai jia Tang Hongshi Yu jianren Ye jiafu Hu Nanjing Forestry University Nanjing 210037China Zhejiang Agricultural and Forestry University Hangzhou 311300China Yuhuan Natural Resources and Planning Bureau Taizhou 317600China School of BioSciences The University of MelbourneParkvilleVIC 3010Australia

Bursaphelenchus xylophilus,causal agent of pine wilt disease,causes extensive damage worldwide.Strate-gies are needed to inhibit population growth or block the spread of the invasive nematode to control pine wilt dis-ease.The gene daf-8 plays crucial roles in larval develop-ment and dauer formation in Caenorhabditis elegans,but little is known about its orthologue in B.xylophilus.In the present molecular characterization and functional analysis of daf-8 in B.xylophilus(Bx-daf-8),RT-qPCR showed that the expression of Bx-daf-8 gradually increased during the embryonic stage,peaked in the second-stage juvenile(J2),then dramatically dropped in the J3,and remained at that low level for the rest of its life.Bx-daf-8-transgenic C.elegans was employed to mimic the spatiotemporal expression of Bx-daf-8,which was expressed close to the pharynx during early embryogenesis and weakly throughout the whole body during late embryogenesis.It was observed in head neurons and tail ganglions throughout all postembryonic stages.B.xylophilus embryos were severely abnormal,and hatching rate decreased sharply after Bx-daf-8 knockdown.daf-16-1 and da-f16-2,downstream genes in the IIS pathway,also dropped sharply after Bx-daf-8 knockdown.We propose that TGFβmay crosstalk with the IIS pathway upstream of Bx-daf-16 and that daf-8 may act as a master regulator of daf-16 in B.xylophilus.However,knockdown of Bx-daf-8 did not lead to constitutive developmental arrest at the dauer larval stage,indicating that dauer entry in B.xylophilus might be controlled by several genes and is more complicated than in C.elegans.Bx-daf-8 alone did not control the dauer entry in B.xylophilus,but it was indispensable for embryogen-esis,providing a potential target for suppressing population growth of B.xylophilus.

关键词： Daf-8 Expression pattern RNAi Embryogenesis Bursaphelenchus xylophilus

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金融结构与经济增长关系的统计检验——基于河南省的实证

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统计与决策 2024年第6期40卷 139-144页

作者：徐晓飞吉晶晶北京语言大学商学院北京100083 对外经济贸易大学国际经济贸易学院北京100105

文章基于2010—2020年河南省18个地级市的面板数据,通过构建固定效应模型和调节效应模型,研究金融结构与经济增长之间的关系。结果显示:河南省金融结构与经济增长之间存在“倒U”型关系,临界值为2.3311,在临界值左侧,金融结构会产生正... 详细信息

文章基于2010—2020年河南省18个地级市的面板数据,通过构建固定效应模型和调节效应模型,研究金融结构与经济增长之间的关系。结果显示:河南省金融结构与经济增长之间存在“倒U”型关系,临界值为2.3311,在临界值左侧,金融结构会产生正向经济增长效应,而越过临界值后,金融结构的经济增长效应转为负向;产业结构高级化对两者关系具有调节效应,随着产业结构高级化的推进,临界点将左移,且曲线变得更陡;分组回归结果显示,在产业结构高级化水平较高的地区,金融结构与经济增长仍满足“倒U”型非线性关系,在产业结构高级化水平较低的地区,金融结构与经济增长正向相关。

关键词：金融结构经济增长产业结构高级化河南省

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Characteristics and Outcome of Exertional Heatstroke Patients Complicated by Acute Hepatic Injury:A Cohort Study

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Journal of Clinical and Translational Hepatology 2021年第5期9卷 655-660页

作者： jingjing ji jinghua Gao Conglin Wang Leifang Ouyang Zheying Liu Zhifeng Liu Department of Critical Care Medicine General Hospital of Southern Theater Command of PLAGuangzhouGuangdongChina Key Laboratory of Hot Zone Trauma Care and Tissue Repair of PLA General Hospital of Southern Theater Command of PLAGuangzhouGuangdongChina

Background and Aims:Exertional heatstroke(EHS)is associated with strenuous physical activity in hot environments.The present study aimed to investigate dynamic changes of hepatic function indices in EHS patients and determine risk factors for death.Methods:This single-center retrospective cohort study considered all patients with EHS admitted to the intensive care unit at the General Hospital of Southern Theater Command of PLA from October 2008 to May 2019.Data on general characteristics,organ function parameters,and the 90-day outcome of enrolled patients were collected.Hepatic indices were collected dynamically,and patients with acute hepatic injury(AHI)were identified by plasma total bilirubin(TBIL)≥34.2μmol/L and an international normalized ratio≥1.5,or with any grade of hepatic encephalopathy.Results:In patients who survived,TBIL,alanine aminotransferase and aspartate aminotransferase were increased at 24 h,peaked at 2–3 days,and began to decrease at 5 days.In non-survivors,TBIL continuously increased post-admission.The area under the receiver operating characteristic curve for the prediction of mortality based on sequential organ failure assessment(SOFA)scores was 89.8%,and the optimal cutoff value was 7.5.Myocardial injury and infection were identified as independent risk factors for death in EHS patients with AHI.Conclusions:In EHS patients,hepatic dysfunction usually occurred within 24 h.Patients with AHI had more severe clinical conditions,and significantly increased 90-day mortality rates.SOFA scores over 7.5,complicated with myocardial injury or infection,were found to be risk factors for death in EHS patients with AHI.

关键词： Exertional heatstroke Acute hepatic injury Mortality TBIL SOFA

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微生物杀虫剂联合施用对草地贪夜蛾幼虫的防治效果

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植物保护学报 2024年第1期51卷 186-192页

作者：朱凯辉贾静静秦双涂雄兵吉训聪中国农业科学院植物保护研究所植物病虫害生物学国家重点实验室北京100193 海南省农业科学院植物保护研究所海南省农业科学院农产品质量安全与标准研究中心海口571100

为提高微生物杀虫剂对草地贪夜蛾Spodoptera frugiperda的防治效果,利用球孢白僵菌Beauveria bassiana IPPB343、IPPB1237与金龟子绿僵菌Metarhizium anisopliae IPPM330189三种昆虫病原真菌,斜纹夜蛾核型多角体病毒(Spodoptera litura nuclear polyhedrosis viruses,SLNPV)、甘蓝夜蛾核型多角体病毒(Mamestra brassicae nuclear polyhedrosis viruses,MBNPV)2种昆虫病毒和短稳杆菌Empedobacter brevis昆虫病原细菌,设置9种联合施用药剂组合,评价6种微生物杀虫剂单独使用以及不同药剂联合施用组合对草地贪夜蛾幼虫的毒力以及田间防治效果。结果表明,与6种微生物杀虫剂单独使用相比,9种联合施用组合均能提升微生物杀虫剂对草地贪夜蛾的毒力水平与田间防治效果。施药后7 d时,金龟子绿僵菌IPPM330189+MBNPV药剂组合的防治效果最好且增效最明显,对草地贪夜蛾的田间防治效果达到88.75%,协同毒力指数为23.78。此外,金龟子绿僵菌IPPM330189+短稳杆菌悬浮剂药剂组合施药后7 d对草地贪夜蛾的田间防治效果达到87.45%,协同毒力指数也可达到21.72。表明微生物杀虫剂联合施用可显著提升其对草地贪夜蛾的防治效果。

关键词：草地贪夜蛾昆虫病原真菌昆虫病毒昆虫病原细菌生物源杀虫剂联合施用防治效果

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用于氨电氧化反应生成硝酸盐/亚硝酸盐的金属基电催化剂:过去、现在和未来

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Chinese Journal of Catalysis 2024年第1期56卷 25-50页

作者：田芸睿谭皓天李霞贾晶晶毛子贤刘健梁骥天津大学材料科学与工程学院先进陶瓷与机械加工技术教育部重点实验室天津300350 内蒙古大学化学化工学院内蒙古呼和浩特010021

亚硝酸盐和硝酸盐(统称为NO_(2/3)−)是工业、农业和食品工程中的重要物质.目前通过Ostwald氧化法制备亚硝酸盐和硝酸盐过程常常伴随着大量的能源消耗和温室气体排放.氨的电催化氧化是一种低排放和节能的低温工艺过程,可以持续生产NO_(2/... 详细信息

亚硝酸盐和硝酸盐(统称为NO_(2/3)−)是工业、农业和食品工程中的重要物质.目前通过Ostwald氧化法制备亚硝酸盐和硝酸盐过程常常伴随着大量的能源消耗和温室气体排放.氨的电催化氧化是一种低排放和节能的低温工艺过程,可以持续生产NO_(2/3)−,避免了有害的N2O的形成,并且可以完全由可再生电力供电.目前对氨氧化反应的研究大多集中在氨裂解制氢和直接氨燃料电池上,而对氨转化为NO_(2/3)−的研究关注较少.因此,本文在总结近年来氨电催化工作的基础上,对催化剂的反应机理和设计思路进行了综述.本文从电催化氨氧化反应(AOR)可能的反应机理入手,介绍了AOR的反应条件、检测方法、原位表征方法以及理论计算的研究成果,在总结了影响AOR催化剂催化性能因素的基础上提出了近年来电催化剂的设计策略以及合成方法,并对未来氨领域的发展提出展望.首先,基于反应原理以及反应中间体的吸附路径等方面讨论了AOR的关键难点.然后,系统性总结了AOR的测试要求以及原位拉曼、原位红外、原位电化学质谱和原位X射线吸收光谱等技术在AOR机理研究中的重要作用,讨论了密度泛函理论对于研究AOR催化过程中的反应能垒和催化剂电子轨道分布的贡献.催化剂合金设计、界面工程、非晶化处理、单原子或双原子调制等可控策略有助于抑制副反应的进行以及电解过程中产生的腐蚀性物质对电极的破坏.最后,介绍了氨氧化在光、热以及生物催化领域的应用进展,提出了当前AOR所面临的挑战和解决策略,如将先进的材料设计与理论计算相结合,有助于寻找新的高性能AOR电催化剂.催化体系的改进和反应器的优化将加速大规模绿色、高效、低能耗电催化制备NO_(2/3)−的产业化.综上所述,AOR领域取得的进展说明氨电氧化制备NO_(2/3)−用于工业生产具有可行性,这为满足不断增长的NO_(2/3)−供应需求带来了新的机遇.尽管AOR仍面临性能不高、工艺不成熟等难题,但随着理论与实验研究的结合,原位表征技术不断地开发利用,未来高效、稳定的AOR催化剂会不断的出现.本文也为生成NO_(2/3)−的催化剂的研发提供理论参考.

关键词：氨氧化反应硝酸盐亚硝酸盐非贵金属催化剂氨

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沙库巴曲缬沙坦对慢性心力衰竭模型小鼠心功能的影响及其作用机制

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中国药业 2024年第3期33卷 74-80页

作者：陈静静吉秋霞南通大学附属海安医院江苏南通226600

目的探讨沙库巴曲缬沙坦对慢性心力衰竭(CHF)模型小鼠心功能的影响及其作用机制。方法通过主动脉缩窄术复制CHF模型小鼠,将40只建模成功的小鼠分为模型组(B组)、沙库巴曲缬沙坦组(C组)、沙库巴曲缬沙坦+EX-527组(D组)、沙库巴曲缬沙坦+C... 详细信息

目的探讨沙库巴曲缬沙坦对慢性心力衰竭(CHF)模型小鼠心功能的影响及其作用机制。方法通过主动脉缩窄术复制CHF模型小鼠,将40只建模成功的小鼠分为模型组(B组)、沙库巴曲缬沙坦组(C组)、沙库巴曲缬沙坦+EX-527组(D组)、沙库巴曲缬沙坦+Compound C组(E组),各10只;另取10只仅开胸未手术小鼠作为对照组(A组)。C组、D组、E组小鼠均灌胃68 mg/kg沙库巴曲缬沙坦(连续4周),D组和E组小鼠另分别腹腔注射1次5 mg/kg沉默信息调节因子2相关酶类1(Sirt1)抑制剂EX-527和20 mg/kg腺苷酸活化蛋白激酶(AMPK)抑制剂Compound C;A组和B组小鼠均分别灌胃、腹腔注射等量生理盐水。测定小鼠超声心动图指标左室射血分数(LVEF)、左室收缩末期内径(LVESd)、左室舒张末期内径(LVEDd);苏木精-伊红(HE)染色,观察小鼠的心肌组织病理形态;采用酶联免疫吸附试验(ELISA)检测小鼠血浆肌酸激酶MB型同工酶(CK-MB)、心肌肌钙蛋白Ⅰ(cTnⅠ)、白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)、超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)水平;采用TUNEL法计数小鼠凋亡心肌细胞;采用实时荧光定量聚合酶链式反应(qRT-PCR)法和免疫印迹(Western blot)法测定小鼠心肌组织胱天蛋白酶3(caspase-3)、Sirt1、AMPK、过氧化物酶体增殖体激活受体γ辅助激活因子-1α(PGC-1α)mRNA和蛋白表达水平。结果与B组比较,C组小鼠心肌细胞变性、炎性细胞浸润程度减轻;LVEF,血浆SOD和GSH-Px水平,心肌组织Sirt1,AMPK,PGC-1αmRNA和蛋白表达水平均显著升高(P<0.05);LVEDd,LVESd,血浆CK-MB,cTnⅠ,IL-6,TNF-α,MDA水平,心肌细胞凋亡率,心肌组织caspase-3 mRNA和蛋白表达水平均显著降低(P<0.05)。与C组比较,D组、E组小鼠心肌损伤程度加重;LVEF,血浆SOD和GSH-Px水平,心肌组织Sirt1,AMPK,PGC-1αmRNA和蛋白表达水平均显著降低(P<0.05);LVEDd,LVESd,血浆CK-MB,cTnⅠ,IL-6,TNF-α,MDA水平,心肌细胞凋亡率,心肌组织caspase-3 mRNA和蛋白表达水平均显著升高(P<0.05)。结论沙库巴曲缬沙坦可能通过激活Sirt1/AMPK/PGC-1α信号通路而影响CHF模型小鼠的心功能。

关键词：沙库巴曲缬沙坦慢性心力衰竭沉默信息调节因子2相关酶类1 腺苷酸活化蛋白激酶过氧化物酶体增殖体激活受体γ辅助激活因子-1α

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盐城市滨海县城区区域枯水期水环境质量调查分析

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环保科技 2024年第3期30卷 8-12,38页

作者：吉祝美季节马晶晶江苏省盐城环境监测中心江苏盐城224000

笔者采用单因子评价法分析与评价枯水期滨海县城区及开发区工业园区范围水质污染特征和现状。调查范围面积约50.8 km^(2),包括主要河道、城市内河、开发区工业园区内部河道及周边支流。调查区域内地表水水质呈重度污染状况,主要原因为... 详细信息

笔者采用单因子评价法分析与评价枯水期滨海县城区及开发区工业园区范围水质污染特征和现状。调查范围面积约50.8 km^(2),包括主要河道、城市内河、开发区工业园区内部河道及周边支流。调查区域内地表水水质呈重度污染状况,主要原因为时值枯水期,水体长期滞留,在无充足水源补充的情况下,由于环境基础设施建设滞后,区域内生活污染物和工业污染物不断入河导致地表水污染日益加重。该评价结果能为滨海县水环境保护和科学治理提供依据。

关键词：滨海县城区水环境质量现场调查污染来源枯水期

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