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Phenomics 2021年第1期1卷 22-30页

作者： Gong Zhang Yongjian Zhang jingjie jin MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes Institute of Life and Health EngineeringCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Chi-Biotech Co.Ltd. Shenzhen 518000China

Aligning billions of reads generated by the next-generation sequencing(NGS)to reference sequences,termed“mapping”,is the time-consuming and computationally-intensive process in most NGS applications.A Fast,accurate and robust mapping algorithm is highly ***,we developed the FANSe3 mapping algorithm,which can map a 30×human wholegenome sequencing(WGS)dataset within 30 min,a 50×human whole exome sequencing(WES)dataset within 30 s,and a typical mRNA-seq dataset within seconds in a single-server node without the need for any hardware acceleration *** its predecessor FANSe2,the error rate of FANSe3 can be kept as low as 10-9 in most cases,this is more robust than the Burrows-Wheeler transform-based *** allowance hardly affected the identification of a driver somatic mutation in clinically relevant WGS data and provided robust gene expression profiles regardless of the parameter settings and sequencer *** novel algorithm,designed for high-performance cloud-computing after infrastructures,will break the bottleneck of speed and accuracy in NGS data analysis and promote NGS applications in various *** FANSe3 algorithm can be downloaded from the website:http://***-biote ***/fanse 3/.

关键词： Next-generation sequencing Mapping Speed Robustness

Zircon SHRIMP U–Pb age of Late Jurassic OIB-type volcanic rocks from the Tethyan Himalaya: constraints on the initial activity time of the Kerguelen mantle plume

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Acta Geochimica 2018年第3期37卷 441-455页

作者： Yuruo Shi Chenyang Hou J. Lawford Anderson Tianshui Yang Yiming Ma Weiwei Bian jingjie jin Beijing SHRIMP Center Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 China China University of Geosciences Beijing 100083 China Department of Earth and Environment Boston UniversityBoston MA 02215 USA

This work presents zircon U–Pb age and wholerock geochemical data for the volcanic rocks from the Lakang Formation in the southeastern Tethyan Himalaya and represents the initial activity of the Kerguelen mantle plume. SHRIMP U–Pb dating of zircons from the volcanic rocks yielded a ^(206) Pb/^(238) U age of 147 ± 2 Ma that reflects the time of Late Jurassic magmatism. Whole rock analyses of major and trace elements show that the volcanic rocks are characterized by high content of Ti O_2(2.62 wt%–4.25 wt%) and P_2O_5(0.38 wt%–0.68 wt%), highly fractionated in LREE/HREE [(La/Yb)N= 5.35–8.31] with no obvious anomaly of Eu, and HFSE enrichment with no obvious anomaly of Nb and Ta, which are similar to those of ocean island basalts and tholeiitic basaltic andesites indicating a mantle plume origin. The Kerguelen mantle plume produced a massive amount of magmatic rocks from Early Cretaceous to the present, which widely dispersed from their original localities of emplacement due to the changing motions of the Antarctic, Australian, and Indian plates. However, our new geochronological and geochemical results indicate that the Kerguelen mantle plume started from the Late Jurassic. Furthermore, we suggest that the Kerguelen mantle plume may played a significant role in the breakup of eastern Gondwanaland according to the available geochronological, geochemical and paleomagnetic data.

关键词： Volcanic rocks Late Jurassic ZirconSHRIMP U-Pb age Kerguelen mantle plume TethyanHimalaya Lakang Formation

Provenance and paleogeographic evolution of the Upper Paleozoic–Lower Mesozoic strata in northern Laos

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Journal of Earth Science 2024年

作者： jingjie jin Xin Qian Vongpaseuth Senebouttalath Yuzhi Zhang Yuejun Wang Guangdong Provincial Key Lab of Geodynamics and Geohazards， School of Earth Sciences and Engineering， Sun Yat-sen University， and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) Ministry of Energy and Mines， Department of Geology and Minerals

The Late Paleozoic–Early Mesozoic sedimentary system of the Luang Prabang Paleotethyan back-arc basin in northern Laos is important for investigating sedimentary provenance， paleogeographic patterns， and the tectonic evolution of the Eastern Paleotethyan Ocean. This study presents systematic stratigraphy， petrology， geochemistry， and detrital zircon U–Pb–Hf isotopic analyses for the Late Carboniferous–Jurassic sedimentary strata on both sides of the Luang Prabang basin. Based on distinct stratigraphic ages and provenance characteristics， the clastic rock samples can be divided into four groups. The Group 1 Late Carboniferous–Early Permian samples from the western part of the basin yield detrital zircon age-peaks of ～348 and ～1425 Ma， with corresponding εHf(t) values ranging from -2.0 to +15.5 and +1.5 to +14， respectively. The age spectrum of Group 2 Late Carboniferous–Early Permian samples from the eastern part of the basin shows major age-peaks of ～287 and ～1860 Ma， with εHf(t) values of -5.9–-0.9 and -3.6–+4.2， respectively. Group 3 Late Permian–Triassic samples exhibit age-peaks of ～242 and ～1853 Ma， along with εHf(t) values of -0.7–+14.4 and -5.4–-1.8， respectively. Group 4 Middle–Late Jurassic samples yield age-peaks of ～237，～431，～813，～1833， and ～2460 Ma， lacking Late Devonian (413–345 Ma) detrital zircons. All these data collectively suggest that the Group 1 sample primarily originated from the Sukhothai Arc in western Indochina， Group 2 was from the Kontum and Truong Son in eastern Indochina， and Group 3 has a combined provenance of the Sukhothai， Kontum， and Truong Son. Regional comparisons suggest that the Jurassic provenance was mainly derived from South China， which was imported through the northern river system. Our data， combined with the regional angular unconformities between Jurassic continental strata and pre-Jurassic marine strata， suggest that the Luang Prabang basin transformed into a superimposed collisional retroforeland basin during the Ju

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New Zircon SHRIMP U-Pb Ages of the Langjiu Formation Volcanic Rocks in the Shiquanhe Area,Western Lhasa Terrane and their Implications

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Acta Geologica Sinica(English Edition) 2017年第2期91卷 737-738页

作者： BIAN Weiwei YANG Tianshui SHI Yuruo MA Yiming jin jingjie GAO Feng PENG Wenxiao ZHANG Shihong WU Huaichun LI Haiyan State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences School of Earth Sciences and Resources China University of Geosciences Beijing SHRIMP Center Institute of GeologyChinese Academy of Geological Sciences Guangzhou Institute of Geochemistry Chinese Academy of Sciences

Objective The potassic and ultrapotassic rocks relating to the India-Eurasia collision and continual plate convergence are widely distributed in the Lhasa terrane. These rocks are very important to understand the deep processes of the India-Eurasia collision and the uplift and evolution of the Tibetan Plateau. Although high-potassic volcanic rocks are also exposed in the western Lhasa terrane, their formation time is still uncertain for the lack of reliable dating. We carried out zircon U-Pb geochronological study on the Langjiu Formation volcanic rocks, which are part of the Early Cretaceous Zenong group volcanic rocks based on 1：250000 scale Shiquanhe regional geological survey report, in the Shiquanhe area of the western Lhasa terrane. These new age data not only offer chronological basis for the regional stratigraphic correlation and classification, but also provide an essential opportunity for revealing signatures of magmatic pulses hidden in the deep crust of the Lhasa terrane.

关键词： SHRIMP Pb New Zircon SHRIMP U-Pb Ages of the Langjiu Formation Volcanic Rocks in the Shiquanhe Area,Western Lhasa Terrane and their Implications

Translating mRNAs strongly correlate to proteins in a multivariate manner and their translation ratios are phenotype-specific

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Translating mRNAs strongly correlate to proteins in a multiv...

细胞—生命的基础——中国细胞生物学学会2013年全国学术大会·武汉

作者： Tong Wang Yizhi Cui jingjie jin Jiahui Guo Guibin Wang Xingfeng Yin Qing-Yu He Gong Zhang Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes Institute of Life and Health EngineeringJinan University

As a well-known phenomenon,total mRNAs poorly correlate to proteins in their abundances as *** findings calculated with bivariate models suggested even poorer such correlation, while focusing on the translating mRNAs(RNC-mRNAs) *** this study,we analyzed the relative abundances of mRNAs,RNC-mRNAs and proteins on genome-wide scale,comparing human

关键词： Translating mRNA Protein abundance Multivariate correlation Translation ratio Phenotype

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4-羟基苯并三氮唑合成新工艺

石油化工 2008年第2期37卷 187-190页

作者：夏明珠王风云雷武金敬杰南京理工大学化工学院江苏南京210094

以低毒性硫酸汞替代剧毒性氧化汞为催化剂,以苯并三氮唑(BTA)、发烟硫酸、浓硫酸和KOH为原料,采用两步法合成了4-羟基苯并三氮唑(4-OH-BTA),即先将BTA溶于浓硫酸中,以液液均相磺化反应合成4-磺酸基苯并三氮唑(4-SO3H-BTA),然后4-SO3H-BT... 详细信息

以低毒性硫酸汞替代剧毒性氧化汞为催化剂,以苯并三氮唑(BTA)、发烟硫酸、浓硫酸和KOH为原料,采用两步法合成了4-羟基苯并三氮唑(4-OH-BTA),即先将BTA溶于浓硫酸中,以液液均相磺化反应合成4-磺酸基苯并三氮唑(4-SO3H-BTA),然后4-SO3H-BTA在强碱性条件下水解反应合成了4-OH-BTA;分别考察了工艺条件对两步合成反应的影响。实验结果表明,磺化反应的最佳工艺条件为:m(浓硫酸)∶m(发烟硫酸)=60∶40、磺化温度130℃、n(硫酸汞)∶n(BTA)=0.010,在此条件下4-SO3H-BTA的收率为84.1%;水解反应的最佳工艺条件为∶n(KOH)∶n(4-SO3H-BTA)=4.0、水解温度235℃,在此条件下4-OH-BTA的收率为61.0%;两步反应的总收率为51.3%,比氧化汞为催化剂的合成工艺提高了20%左右。

关键词：苯并三氮唑 4-磺酸基苯并三氮唑 4-羟基苯并三氮唑硫酸汞催化合成

基于UPLC-MS技术的阿尔茨海默病模型大鼠尿液代谢组学

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沈阳药科大学学报 2018年第3期35卷 199-206页

作者：张翠台晶杰崔文静金艺徐海燕袁波沈阳药科大学药学院辽宁沈阳110016

目的基于代谢组学研究策略,研究大鼠尿液中内源性代谢物的变化,探寻与阿尔茨海默病(Alzheimer's disease,AD)相关的潜在生物标志物,为AD的临床诊断提供新的思路。方法大鼠双侧海马注射凝聚态β淀粉样蛋白1-42(Aβ1-42)建立AD模型,采用... 详细信息

目的基于代谢组学研究策略,研究大鼠尿液中内源性代谢物的变化,探寻与阿尔茨海默病(Alzheimer's disease,AD)相关的潜在生物标志物,为AD的临床诊断提供新的思路。方法大鼠双侧海马注射凝聚态β淀粉样蛋白1-42(Aβ1-42)建立AD模型,采用超高效液相色谱质谱联用(UPLCMS)技术对模型组和假手术组大鼠尿液代谢物谱进行分析测定,以OPLS(orthogonal partial least squares)方法对得到的数据进行统计学分析,研究2组之间内源性代谢产物的差异。结果经OPLS分析,2组大鼠尿液的代谢特征存在明显差异,发现了8个与AD相关的潜在生物标志物(含有2个未知化合物)。与假手术组相比,AD模型组大鼠尿液中苯丙氨酸、苯乙酰甘氨酸、N2-琥珀酰-L-鸟氨酸、高香草酸的含量明显升高(P<0.05,P<0.01),而肌酸酐、异戊酰丙氨酸含量则明显降低(P<0.01)。结论 AD模型组大鼠与假手术组大鼠在尿液代谢水平上具有明显差异,具有明显变化的代谢物(苯丙氨酸、苯乙酰甘氨酸、N2-琥珀酰-L-鸟氨酸、高香草酸、肌酸酐、异戊酰丙氨酸)有可能作为AD潜在的尿液生物标志物,为AD的早期临床诊断和治疗提供参考。

关键词：阿尔茨海默病代谢组学生物标志物大鼠尿液超高效液相色谱质谱联用

基于ICU应急救治团队主导体外膜肺氧合支持下的院内安全转运的应用效果

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中国医药导报 2024年第16期21卷 52-55页

作者：金静洁王徐赢胡珍珍浙江省温州市中心医院重症医学科浙江温州325000

目的分析基于重症监护病房(ICU)应急救治团队主导体外膜肺氧合支持下的院内安全转运的应用效果。方法选取2022年2月至2023年6月浙江省温州市中心医院体外膜肺氧合支持下的院内安全转运患者92例及其家属92名为研究对象,按照随机数字表法... 详细信息

目的分析基于重症监护病房(ICU)应急救治团队主导体外膜肺氧合支持下的院内安全转运的应用效果。方法选取2022年2月至2023年6月浙江省温州市中心医院体外膜肺氧合支持下的院内安全转运患者92例及其家属92名为研究对象,按照随机数字表法将其分为对照组(46例)和试验组(46例)。对照组实施常规转运,试验组由ICU应急救治团队实施转运。比较两组生命体征、不良事件发生率、家属满意度。结果转运后,两组血氧饱和度低于转运前,且试验组高于对照组,差异有统计学意义(P<0.05)。两组心率、呼吸频率高于转运前,试验组低于对照组,差异有统计学意义(P<0.05)。试验组不良事件总发生率低于对照组,差异有统计学意义(P<0.05)。试验组家属满意度高于对照组,差异有统计学意义(P<0.05)。结论ICU应急救治团队实施体外膜肺氧合支持下的院内安全转运可减少患者生命体征波动,降低不良事件发生率,提高家属满意度。

关键词：重症监护病房应急救治团队体外膜肺氧合院内安全转运生命体征

重症监护室机械通气患者应用中药口腔冲洗预防呼吸机相关性肺炎的效果

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中国医药导报 2024年第14期21卷 114-116页

作者：王徐赢金静洁胡珍珍浙江省温州市中心医院重症医学科浙江温州325000

目的分析重症监护室(ICU)机械通气患者应用中药口腔冲洗预防呼吸机相关性肺炎的效果。方法选取2022年7月至2023年6月浙江省温州市中心医院收治的ICU机械通气患者160例为研究对象,按照随机数字表法将其分为对照组和观察组,各80例。对... 详细信息

目的分析重症监护室(ICU)机械通气患者应用中药口腔冲洗预防呼吸机相关性肺炎的效果。方法选取2022年7月至2023年6月浙江省温州市中心医院收治的ICU机械通气患者160例为研究对象,按照随机数字表法将其分为对照组和观察组,各80例。对照组给予囊上引流,观察组给予中药口腔冲洗联合囊上引流。两组均干预1周。比较两组干预前后呼吸机相关性肺炎发生情况、血气指标[动脉血氧饱和度(SaO_(2))、动脉血二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))、pH值]、乳酸水平。结果观察组呼吸机相关性肺炎总发生率低于对照组(P<0.05)。干预后,两组SaO_(2)、PaO_(2)、pH值水平较干预前升高,PaCO_(2)水平较干预前降低,且观察组SaO_(2)、PaO_(2)、pH值水平高于对照组,PaCO_(2)水平低于对照组(P<0.05)。干预后,两组乳酸水平较干预前降低,且观察组低于对照组(P<0.05)。结论 ICU机械通气患者应用中药口腔冲洗后口呼吸机相关性肺炎发生率降低,血气指标改善。

关键词：重症医学病房机械通气中药口腔冲洗囊上引流呼吸机相关性肺炎

广西柳东地区火山岩锆石U-Pb-Hf同位素特征及其对岩浆源区的限定

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中国地质 2022年第4期49卷 1309-1322页

作者：魏春夏陆刚杨锋李巍钟锋运金靖杰潘艺文梁力杰白晓广西壮族自治区区域地质调查研究院广西桂林541002 桂林理工大学广西隐伏金属矿产勘查重点实验室广西桂林541004 广西壮族自治区二七〇地质队广西柳州545005 广西三一〇核地质队广西桂林541004

【研究目的】柳东地区位于右江盆地东缘,近年来该地区早三叠世石炮组中首次发现一套火山岩夹层,为研究盆地东缘的构造演化特征提供了重要依据。【研究方法】本文以新发现的柳东地区火山岩为研究对象,通过LA-ICP-MS锆石U-Pb年龄及Hf同位... 详细信息

【研究目的】柳东地区位于右江盆地东缘,近年来该地区早三叠世石炮组中首次发现一套火山岩夹层,为研究盆地东缘的构造演化特征提供了重要依据。【研究方法】本文以新发现的柳东地区火山岩为研究对象,通过LA-ICP-MS锆石U-Pb年龄及Hf同位素分析,研究右江盆地东缘火山岩的形成时代及岩浆源区特征。【研究结果】结果表明,火山岩的岩性为凝灰岩-凝灰质熔岩-凝灰质火山角砾岩组合,指示了典型的火山岩特征。其2件凝灰岩样品中锆石LA-ICP-MS U-Pb加权平均年龄分别为(244.0±1.9)Ma和(247.1±0.9)Ma,锆石微量元素(U、Th、Hf、Nb)表现出大陆岩浆弧属性特征。锆石Hf同位素结果显示ε_(Hf)(t)为-13.2~-1.2,二阶段模式年龄(T_(DM)^(C))为1.35~2.06 Ga,其岩浆源区主要为地壳物质,平均地壳存留年龄为1.7~2.06 Ga。【结论】该火山岩夹层与其所出露的地层时代基本相符,属于早三叠世末期—中三叠世早期火山喷发产物,火山岩形成于火山弧-同碰撞的构造环境,代表了弧后盆地的沉积环境,与印支期古特提斯洋的闭合相关。该成果为古特提斯构造域的演化研究提供了新的基础资料,具有重要意义。

关键词：火山岩锆石U-Pb-Hf 火山弧相关古特提斯地质调查工程广西柳州东部