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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu jingjie ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of parkinsonism.This review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest parkinsonism.We conducted a thorough literature search using reputable databases such as PubMed and Web of Science.Selection criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical applications.The findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting prognosis.Moreover,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo biomarker.This validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic depletion.In summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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The metabolic brain network in patients with Parkinson's disease based on ^(18)F-FDG PET imaging: evaluation of neuronal injury and regeneration

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Neural Regeneration Research 2014年第7期9卷 763-765页

作者： jingjie ge Ping Wu Chuantao Zuo PET Center Huashan HospitalFudan University

Over the past two decades, the development of functional imaging methods has greatly promoted our understanding on the changes of neurons following neurodegenerative disorders, such as Parkin- son＇s disease （PD）. The application of a spatial covariance analysis on 18F-FDG PET imaging has led to the identification of a distinc- tive disease-related metabolic pattern. This pattern has proven to be useful in clinical diagnosis, disease progression monitoring as well as assessment of the neuronal changes before and after clinical treatment. It may potentially serve as an objective biomarker on disease progression monitoring, assessment, histological and func- tional evaluation of related diseases.

关键词： FDG F-FDG PET imaging evaluation of neuronal injury and regeneration PET

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Synthesis of amorphous Pd-based nanocatalysts for efficient alcoholysis of styrene oxide and electrochemical hydrogen evolution

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Nano Research 2023年第4期16卷 4650-4655页

作者： Yiyao ge jingjie ge Biao Huang Xixi Wang Guigao Liu Xiang-Huan Shan Lu Ma Bo Chen Guanghua Liu Songmo Du An Zhang Hongfei Cheng Qingbo Wa Shiyao Lu Lujiang Li Qinbai Yun Kuo Yuan Qinxin Luo Zhichuan J.Xu Yonghua Du Hua Zhang Department of Chemistry City University of Hong KongHong KongChina Hong Kong Branch of National Precious Metals Material Engineering Research Center(NPMM) City University of Hong KongHong KongChina Shenzhen Research Institute City University of Hong KongShenzhen 518057China Department of Chemical and Biological Engineering HKUST Jockey Club Institute for Advanced Study&Energy InstituteThe Hong Kong University of Science and TechnologyHong KongChina School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Chemistry University of Science and Technology of ChinaHefei 230026China National Synchrotron Light Source II Brookhaven National LaboratoryUptonNew York 11973USA State Key Laboratory of New Ceramics&Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Amorphous nanomaterials with long-range disordered structures could possess distinct properties and promising applications,especially in catalysis,as compared with their conventional crystalline counterparts.It is imperative to achieve the controlled preparation of amorphous noble metal-based nanomaterials for the exploration of their phase-dependent applications.Here,we report a facile wet-chemical reduction strategy to synthesize various amorphous multimetallic Pd-based nanomaterials,including PdRu,PdRh,and PdRuRh.The phase-dependent catalytic performances of distinct Pd-based nanomaterials towards diverse catalytic applications have been demonstrated.Specifically,the usage of PdRu nanocatalysts with amorphous and crystalline face-centered cubic(fcc)phases can efficiently switch the ring-opening route of styrene oxide to obtain different products with high selectivity through alcoholysis reaction and hydrogenation reaction,respectively.Moreover,when used as an electrocatalyst for hydrogen evolution reaction(HER),the synthesized amorphous PdRh nanocatalyst exhibits low overpotential and high turnover frequency values,outperforming its crystalline fcc counterpart and most of the reported Pd-based HER electrocatalysts.

关键词： amorphous nanomaterials Pd-based nanocatalysts phase engineering of nanomaterials ring-opening reaction of styrene oxide electrocatalytic hydrogen evolution

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Na_(0.44)MnO_(2)颗粒尺寸对其作为水系钠离子电池正极性能的影响

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真空科学与技术学报 2024年第2期44卷 115-124页

作者：黄璧成余灵辉葛婧捷徐梽川南洋理工大学材料科学与工程学院新加坡639798

水溶性钠离子电池是一种与锂离子电池相辅相成的技术,因其相对较低的成本、改善的安全性和环境友好的电解液而备受青睐。然而,较低的电极容量限制了这种电池的应用。Na_(0.44)MnO_(2)是一种用于钠离子电池的高容量阴极材料,其理论容量为... 详细信息

水溶性钠离子电池是一种与锂离子电池相辅相成的技术,因其相对较低的成本、改善的安全性和环境友好的电解液而备受青睐。然而,较低的电极容量限制了这种电池的应用。Na_(0.44)MnO_(2)是一种用于钠离子电池的高容量阴极材料,其理论容量为121 mAh/g。文章研究了Na_(0.44)MnO_(2)的尺寸效应对阴极性能的影响。纳米棒通过热处理MnO_(2)纳米片前驱体制备而成,其尺寸通过CTAB和KMnO_(4)的比例进行调控。然后,Na_(0.44)MnO_(2)纳米棒被用作水溶性钠离子电池的活性材料。纳米棒阴极在1 C的初始循环中提供了60 mAh/g的容量,并在经过200个循环后保持了55 mAh/g,比Na_(0.44)MnO_(2)块状阴极高出37.5%。在高倍率的5 C下,该阴极在经过200个循环后仍能提供47 mAh/g的高容量。容量的增加归因于减小的电荷传递阻抗和纳米棒具有较高比表面积所带来的改善的钠离子扩散性能。

关键词：钠离子电池正极水系电解液尺寸

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Methanol electro-oxidation to formate on iron-substituted lanthanum cobaltite perovskite oxides

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eScience 2022年第1期2卷 87-94页

作者： Fanxu Meng Chencheng Dai Zheng Liu Songzhu Luo jingjie ge Yan Duan Gao Chen Chao Wei Riccardo Ruixi Chen Jiarui Wang Daniel Mandler Zhichuan J.Xu School of Materials Science and Engineering Nanyang Technological University50 NanyangAvenueSingapore639798Singapore Energy Research Institute@NTU ERI@N Interdisciplinary Graduate SchoolTechnological UniversityNanyangSingapore639798Singapore Singapore-HUJ Alliance for Research and Enterprise NEW-CREATE Phase IICampus for Research Excellence and Technological Enterprise(CREATE)Singapore138602Singapore Institute of Chemistry The Hebrew University of JerusalemJerusalem9190401Israel

Electrochemically producing formate by oxidizing methanol is a promising way to add value to methanol.Noble metal-based electrocatalysts,which have been extensively studied for the methanol oxidation reaction,can catalyze the complete oxidation of methanol to carbon dioxide,but not the mild oxidation to formate.As a result,exploring efficient and earth-abundant electrocatalysts for formate production from methanol is of interest.Herein,we present the electro-oxidation of methanol to formate,catalyzed by iron-substituted lanthanum cobaltite(LaCo_(1-x)Fe_(x)O_(3)).The Fe/Co ratio in the oxides greatly influences the activity and selectivity.This effect is attributed to the higher affinity of Fe and Co to the two reactants:CH3OH and OH,respectively.Because a balance between these affinities is favored,LaCo_(0.5)Fe_(0.5)O_(3) shows the highest formate production rate,at 24.5 mmol h^(-1) g_(oxide)^(-1),and a relatively high Faradaic efficiency of 44.4%in a series of(LaCo_(1-x)Fe_(x)O_(3))samples(x=0.00,0.25,0.50,0.75,1.00)at 1.6 V versus a reversible hydrogen electrode.

关键词： Methanol Electro-oxidation Formate Oxides Perovskite

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Dopaminergic Damage Pattern Predicts Phenoconversion Time in Isolated Rapid Eye Movement Sleep Behaviour Disorder

Dopaminergic Damage Pattern Predicts Phenoconversion Time in...

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中国睡眠研究会第十五届全国学术年会

作者： jingjie ge Ping Wu Huan Yu Huashan Hospital Fudan University

Purpose: The exact phenoconversion time from isolated rapid eye movement(REM) sleep behaviour disorder(iRBD) to synucleinopathies remains unpredictable.This study investigated wholebrain dopaminergic damage pattern(DDP) with disease progression and predicted phenoconversion time in individual patients.Methods: Age-matched 33 iRBD patients and 20 healthy controls with 11C-CFT-PET scans were enrolled.The patients were followed up 2-10(6.7 ± 2.0) years.The phenoconversion year was defined as the base year, and every two years before conversion was defined as a stage.Support vector machine with leave-one-out cross-validation strategy was used to perform prediction.Results: Dopaminergic degeneration of iRBD was found to occur about 6 years before conversion and then abnormal brain regions gradually expanded.Using DDP, area under curve(AUC) was 0.879(90% sensitivity and 88.3% specificity) for predicting conversion in 0-2 years, 0.807(72.7% sensitivity and 83.3% specificity) in 2-4 years, 0.940(100% sensitivity and 84.6% specificity) in 4-6 years and 0.879(100% sensitivity and 80.7% specificity) over 6 years.In individual patients, predicted stages correlated with whole-brain dopaminergic levels(r =-0.740, p gest that DDP could accurately predict phenoconversion time of individual iRBD patients, which may help to screen patients for early intervention.

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Atomically dispersed Au_1 catalyst towards efficient electrochemical synthesis of ammonia

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Science Bulletin 2018年第19期63卷 1246-1253页

作者： Xiaoqian Wang Wenyu Wang Man Qiao geng Wu Wenxing Chen Tongwei Yuan Qian Xu Min Chen Yan Zhang Xin Wang Jing Wang jingjie ge Xun Hong Yafei Li Yuen Wu Yadong Li Department of Chemistry iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) University of Science and Technology of China Hefei 230026 China Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials School of Chemistry and Materials Science. Nanjing Normal University Nanjing 210023 China Department of Chemistry and Collaborative Innovation Center for Nanomaterial Science and Engineering. Tsinghua University. Beijing 100084 China NEST Laboratory Department of Chemistry. College of Science Shanghai University Shanghai 200444 China National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230029 China

Tremendous efforts have been devoted to explore energy-efficient strategies of ammonia synthesis to replace Haber–Bosch process which accounts for 1.4% of the annual energy consumption. In this study,atomically dispersed Au_1 catalyst is synthesized and applied in electrochemical synthesis of ammonia under ambient conditions. A high NH_4^+ Faradaic efficiency of 11.1% achieved by our Au_1 catalyst surpasses most of reported catalysts under comparable conditions. Benefiting from efficient atom utilization, an NH_4^+ yield rate of 1,305 lg h^(-1) mg_(Au)^(-1) has been reached, which is roughly 22.5 times as high as that by supported Au nanoparticles. We also demonstrate that by employing our Au_1 catalyst, NH4+can be electrochemically produced directly from N_2 and H_2 with an energy utilization rate of 4.02 mmol kJ^(-1). Our study provides a possibility of replacing the Haber–Bosch process with environmentally benign and energy-efficient electrochemical strategies.

关键词：电气化学催化剂氨合成原子直接生产精力收益率利用率

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基于^(18)F-Florbetaben PET显像可视化阿尔茨海默病脑内β-淀粉样蛋白异常沉积

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中国医学影像学杂志 2024年第5期32卷 420-425页

作者：林华媚杨赟豪鲁佳荧张政伟陈淑芬葛璟洁管一晖左传涛复旦大学附属华山医院核医学/PET中心上海200235 复旦大学附属华山医院神经内科上海200040

目的基于氟[^(18)F]贝他苯(^(18)F-FBB)淀粉样蛋白(Aβ)PET显像,分析不同认知损害严重程度阿尔茨海默病(AD)患者不同脑区的Aβ异常沉积特征,以及与认知功能的相关性。资料与方法回顾性纳入2022年8月—2023年10月在复旦大学附属华山医院... 详细信息

目的基于氟[^(18)F]贝他苯(^(18)F-FBB)淀粉样蛋白(Aβ)PET显像,分析不同认知损害严重程度阿尔茨海默病(AD)患者不同脑区的Aβ异常沉积特征,以及与认知功能的相关性。资料与方法回顾性纳入2022年8月—2023年10月在复旦大学附属华山医院就诊的18例临床诊断高度可能AD患者,且^(18)F-FBB PET显像均证实存在脑内Aβ异常沉积。根据症状严重程度分为AD源性轻度认知损害(MCI)组8例和痴呆组10例,另纳入正常对照者12例。基于脑部结构相MRI和自动解剖标记模板对3组受试者额叶、外侧顶叶、外侧颞叶、前后扣带回及复合皮质脑区Aβ异常沉积标准化摄取值比值进行半定量分析,并比较组间差异,分析AD患者脑内Aβ沉积程度与简易智能测试量表、蒙特利尔认知评估评分的相关性。结果AD源性MCI和痴呆组在额叶、外侧颞叶、外侧顶叶、前后扣带回及复合皮质Aβ异常沉积的标准化摄取值比值均显著高于对照组(t=7.442~9.151,P均0.05)。AD源性MCI和痴呆组脑内Aβ沉积程度与简易智能测试量表、蒙特利尔认知评估评分均无显著相关性(r=-0.049~0.050,P均>0.05)。结论AD源性MCI和痴呆组患者脑内Aβ异常沉积均显著高于正常对照组。但Aβ沉积无法鉴别不同认知损害程度的AD患者,在反映Aβ沉积评估AD临床症状的严重程度方面具有一定局限性。

关键词：阿尔茨海默病淀粉样蛋白氟[^(18)F]贝他苯认知损害严重程度正电子发射断层摄影术

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基于ComBat方法调谐^(18)F-FDG PET脑显像的初步研究

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中华核医学与分子影像杂志 2024年第7期44卷 412-416页

作者：焦方阳王丹朱毓华鲁佳荧琚紫昭徐蒨葛璟洁华涛吴平施匡宇管一晖左传涛复旦大学附属华山医院核医学/PET中心上海200235 陆军军医大学大坪医院核医学科重庆400042 瑞士伯尔尼大学核医学科伯尔尼3010

目的基于ComBat方法对同一厂家不同型号PET采集的脑显像数据进行影像调谐,探讨该同质化方法对数据中心效应的影响。方法用2台不同型号PET/CT仪(德国Siemens Biograph64 TruePoint与Biograph128 mCT)对三维(3D)Hoffman脑模型进行^(18)F-F... 详细信息

目的基于ComBat方法对同一厂家不同型号PET采集的脑显像数据进行影像调谐,探讨该同质化方法对数据中心效应的影响。方法用2台不同型号PET/CT仪(德国Siemens Biograph64 TruePoint与Biograph128 mCT)对三维(3D)Hoffman脑模型进行^(18)F-FDG PET显像;对14名健康受试者[男8名、女6名;年龄(57.7±9.5)岁]用Biograph64 TruePoint、12名健康受试者[男9名、女3名;年龄(55.8±10.5)岁]用Biograph128 mCT PET/CT仪行^(18)F-FDG PET脑显像(受试者来源:复旦大学附属华山医院;时间:2020年11月至2023年3月)。依据自动解剖标记(AAL)脑模板将全脑划分为116个脑区,应用ComBat同质化方法对采集的脑模型及健康受试者ROI内PET数据进行影像调谐。对2台PET/CT所得数据影像调谐前后的放射性计数、SUV比值(SUVR)进行Mann-Whitney U检验;对健康受试者的数据进行基于体素的统计参数图(SPM)两独立样本t检验。结果对于3D Hoffman脑模型,Biograph64 TruePoint和Biograph128 mCT PET/CT的调谐前放射性计数[5590.33(4961.67,6102.95)与6116.03(5420.97,6660.66);z=-9.35,P0.05;SUVR:1.04(1.01,1.09)~2.32(2.24,2.40);z值:-0.82~0,均P>0.05]。SPM分析显示调谐前2台PET/CT仪采集的健康受试者脑内葡萄糖代谢在大脑皮质、基底节、中脑及小脑存在差异,调谐后有差异的脑区明显减少。结论ComBat同质化方法可有效地消除同一厂家不同型号PET/CT间系统性技术差异,为多中心脑显像研究提供1种简单、易实现的调谐方法。

关键词：脑图像处理,计算机辅助正电子发射断层显像术氟脱氧葡萄糖F18

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Ir-skinned Ir-Cu Nanoparticles with Enhanced Activity for Oxygen Reduction Reaction

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Chemical Research in Chinese Universities 2020年第3期36卷 467-472页

作者： WANG Jiarui ZHOU Ye SUN Libo ge jingjie WANG Jingxian DAI Chencheng XU Zhichuan School of Materials Science&Engineehng Nanyang Technological University50 Nanyang Avenue 639798Singapore Solar Fuels Laboratory Nanyang Technological University50 Nanyang Avenue 639798Singapore Energy^Research Institute@NTU ERI@NInterdisciplinary Graduate SchoolNanyang Technological University50 Nanyang Avenue 639798Singapore

The development of methanol-tolerate oxygen reduction reaction(ORR)electrocatalysts is of special significance to direct methanol fuel cells system.Irdium is known for its better methanol tolerance than platinum and able to survive in harsh acidic environment.However,its activity is relatively low and thus the approach to improve Ir's ORR is desired.Herein,bimetallic Ir-Cu nanoparticles(NPs)with controllablc Ir/Cu compositions(ca.1:2 to 4:1,atomic ratio)are synthesized via a galvanic replacement-based chemical method.The as-synthesized Ir-Cu NPs are investigated as ORR catalysts after electrochemically leaching out the surface Cu and forming Ir-skinned structures.Around 2-to 3-fold enhancement in the intrinsic activity has been observed in these Ir-skinned Ir-Cu catalysts compared to Ir counterpart.The approach is demonstrated to be a promising way to prepare efficient Ir ORR catalysts and lower catalyst cost.

关键词： Iridium Copper Nanoparticle Dealloying Oxygen reduction reaction

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