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Inducing piezoelectricity in distorted rutile TiO_(2)for enhanced tetracycline hydrochloride degradation through photopiezocatalysis

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Journal of Advanced Ceramics 2024年第3期13卷 323-331页

作者： Taotao Xia Lizhen Lu Haoyu zhang jinghui Wang Zonghe Huang Hongyang Wang Weiyi Yang Shuang Gao Qi Li Key Laboratory of Advanced Technologies of Materials(Ministry of Education) School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Various material design strategies have been developed to enhance photocatalytic performance of TiO_(2).However,no report is available on applications of the photopiezocatalysis strategy on TiO_(2)due to its lack of piezoelectricity.Here we developed a low-temperature molten salt etching process to create rutile TiO_(2)nanoparticles by etching[MgO_(6)]octahedrons away from MgTiO_(3)by molten NH_(4)Cl,during which a lattice distortion occurred in TiO_(2).The lattice distortion broke the structure symmetry of rutile TiO_(2)and subsequently endowed these rutile TiO_(2)nanoparticles with an unusual piezoelectric response with the maximum effective piezoelectric coefficient(d_(33))of~41.6 pm/V,which had not previously been found in TiO_(2)photocatalysts.Thus,the photopiezocatalysis strategy was applied for the first time to enhance the photocatalytic performance of these TiO_(2)nanoparticles.The creation of lattice distortion to induce piezoelectricity could be extended to other photocatalysts that the photopiezocatalysis strategy has not been applied to and may generate novel functionalities for various technical applications.

关键词： photocatalysis TiO_(2) piezocatalysis molten salt etching process photopiezocatalysis

A Dynamic and Deadline-Oriented Road Pricing Mechanism for Urban Traffic Management

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Tsinghua Science and Technology 2022年第1期27卷 91-102页

作者： Jiahui Jin Xiaoxuan Zhu Biwei Wu jinghui zhang Yuxiang Wang the School of Computer Science and Engineering Southeast UniversityNanjing 211189China the Department of Computer Science and Engineering Hangzhou Dianzi UniversityHangzhou 310018China

Road pricing is an urban traffic management mechanism to reduce traffic congestion.Currently,most of the road pricing systems based on predefined charging tolls fail to consider the dynamics of urban traffic flows and travelers’demands on the arrival time.In this paper,we propose a method to dynamically adjust online road toll based on traffic conditions and travelers’demands to resolve the above-mentioned problems.The method,based on deep reinforcement learning,automatically allocates the optimal toll for each road during peak hours and guides vehicles to roads with lower toll charges.Moreover,it further considers travelers’demands to ensure that more vehicles arrive at their destinations before their estimated arrival time.Our method can increase the traffic volume effectively,as compared to the existing static mechanisms.

关键词： road pricing traffic congestion al eviation deep reinforcement learning

Bluetooth Low Energy Device Identification Based on Link Layer Broadcast Packet Fingerprinting

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Tsinghua Science and Technology 2023年第5期28卷 862-872页

作者： jinghui zhang Xinyang Li Junhe Li Qiangsheng Dai Zhen Ling Ming Yang School of Computer Science and Engineering Southeast UniversityNanjing 211189China School of Cyber Science and Engineering Southeast UniversityNanjing 211189China Research Institute State Grid Jiangsu Electric Power Company Ltd.Nanjing 210024China

With the rapid development of the Internet of Things(IoT),wireless technology has become an indispensable part of modern computing platforms and embedded systems.Wireless device fingerprint identification is deemed as a promising solution towards enhancing the security of device access authentication and communication process in the IoT scenario.However,the extraction of features from the network layer and its upper layers often confront restrictions from specific devices:the association with a certain wireless network and the access to the plaintext of the payload.Meanwhile,Bluetooth Low Energy(BLE)packets have been encrypted above the link layer,which makes those features difficult to extract.To tackle these problems,we introduce a novel method to identify BLE devices based on the fingerprint features in the data link layer.Initially,the BLE packets are collected through a receiver based on software-defined radio technology.Then,fields that reflect device differences in BLE broadcast packets are extracted through traffic analysis.Finally,a MultiLayer Perceptron(MLP)model is employed to recognize the category of BLE devices.An experimental result on a dataset with 15 types of BLE devices shows that the identification accuracy of the proposed method can reach 99.8%,which accomplishes better performance over previous work.

关键词： link layer fingerprint software-defined radio Bluetooth Low Energy(BLE)

Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner

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Protein & Cell 2024年第1期15卷 36-51页

作者： jinghui Lei Xiaoyu Jiang Daoyuan Huang Ying Jing Shanshan Yang Lingling Geng Yupeng Yan Fangshuo Zheng Fang Cheng Weiqi zhang Juan Carlos Izpisua Belmonte Guang-Hui Liu Si Wang Jing Qu Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center Intermational Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China National Laboratory of Biomacromolecules CAs Center for Excellence in BiomacromoleculesInstitute of BiophysicsBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Beijing 101408China Aging Biomarker Consortium China Altos Labs San DiegoCA 92121United State

Hypoxia-inducible factor(HIF-1α),a core transcription factor responding to changes in cellular oxygen levels,is closely associated with a wide range of physiological and pathological conditions.However,its differential impacts on vascular cell types and molecular programs modulating human vascular homeostasis and regeneration remain largely elusive.Here,we applied CRISPR/Cas9-mediated gene editing of human embryonic stem cells and directed differentiation to generate HIF-ia-deficient human vascular cells including vascular endothelial cells,vascular smooth muscle cells,and mesenchymal stem cells(MsCs),as a platform for discovering cell type-specific hypox-ia-induced response mechanisms.Through comparative molecular profiling across cell types under normoxic and hypoxic conditions,we provide insight into the indispensable role of HIF-1αin the promotion of ischemic vascular regeneration.We found human MSCs to be the vascular cell type most susceptible to HIF-1a deficiency,and that transcriptional inactivation of ANKZF1,an effector of HIF-1a,impaired pro-angiogenic processes.Altogether,our findings deepen the understanding of HIF-ia in human angiogenesis and support further explorations of novel therapeutic strategies of vascular regeneration against ischemic damage.

关键词： HIF-1 human ESC vascular cell regeneration

CRL2^(APPBP2)-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence

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Science China(Life Sciences) 2024年第3期67卷 460-474页

作者： Daoyuan Huang Qian Zhao Kuan Yang jinghui Lei Ying Jing Hongyu Li Chen zhang Shuai Ma Shuhui Sun Yusheng Cai Guibin Wang Jing Qu Weiqi zhang Si Wang Guang-Hui Liu Advanced Innovation Centerfor Human Brain Protection National Clinical Research Centerfor Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational MedicineCenter International Centerfor Aging and CancerBejing Municipal GeriatricMedical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute for Stem Cell and Regenerative Medicine Beijing100101China CAS Key Laboratory of Genomic and Precision Medicine Bejing Institute of Genomics and China National Center for BioinformationChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Sino-Danish Cllege University of Chinese Academy of SciencesBeijing101408China National Laboratory of Biomacromolecules CAS Center for Excelence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing100101China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China

Cullin-RING E3 ubiquitin ligases(CRLs),the largest family of multi-subunit E3 ubiquitin ligases in eukaryotic cells,represent core cellular machinery for executing protein degradation and maintaining proteostasis.Here,we asked what roles Cullin proteins play in human mesenchymal stem cell(hMSC)homeostasis and senescence.To this end,we conducted a comparative aging phenotype analysis by individually knocking down Cullin members in three senescence models:replicative senescent hMSCs,Hutchinson-Gilford Progeria Syndrome hMSCs,and Werner syndrome hMSCs.Among all family members,we found that CUL2 deficiency rendered hMSCs the most susceptible to senescence.To investigate CUL2-specific underlying mechanisms,we then applied CRISPR/Cas9-mediated gene editing technology to generate CUL2-deficient human embryonic stem cells(hESCs).When we differentiated these into h MSCs,we found that CUL2 deletion markedly accelerates hMSC senescence.Importantly,we identified that CUL2 targets and promotes ubiquitin proteasome-mediated degradation of TSPYL2(a known negative regulator of proliferation)through the substrate receptor protein APPBP2,which in turn downregulates one of the canonical aging marker-P21^(waf1/cip1),and thereby delays senescence.Our work provides important insights into how CRL2^(APPBP2)-mediated TSPYL2 degradation counteracts hMSC senescence,providing a molecular basis for directing intervention strategies against aging and aging-related diseases.

关键词： Cullins stem cell senescence aging proteostasis ubiquitination APPBP2 TSPYL2

Multicellular tumor spheroids bridge the gap between two-dimensional cancer cells and solid tumors: The role of lipid metabolism and distribution

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Chinese Chemical Letters 2023年第2期34卷 259-262页

作者： Peisi Xie jinghui zhang Pengfei Wu Yongjiang Wu Yanjun Hong Jianing Wang Zongwei Cai State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong KongChina College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen 518107China

Previous studies demonstrated that three-dimensional(3D) multicellular tumor spheroids(MCTS) could more closely mimic solid tumors than two-dimensional(2D) cancer cells in terms of the spatial structure, extracellular matrix-cell interaction, and gene expression pattern. However, no study has been reported on the differences in lipid metabolism and distribution among 2D cancer cells, MCTS, and solid tumors. Here, we used Hep G2 liver cancer cell lines to establish these three cancer models. The variations of lipid profiles and spatial distribution among them were explored by using mass spectrometry-based lipidomics and matrix-assisted laser desorption/ionization mass spectrometry imaging(MSI). The results revealed that MCTS, relative to 2D cells, had more shared lipid species with solid tumors. Furthermore,MCTS contained more comparable characteristics than 2D cells to solid tumors with respect to the relative abundance of most lipid classes and mass spectra patterns. MSI data showed that 46 of 71 lipids had similar spatial distribution between solid tumors and MCTS, while lipids in 2D cells had no specific spatial distribution. Interestingly, most of detected lipid species in sphingolipids and glycerolipids preferred locating in the necrotic region to the proliferative region of solid tumors and MCTS. Taken together, our study provides the evidence of lipid metabolism and distribution demonstrating that MCTS are a more suitable in vitro model to mimic solid tumors, which may offer insights into tumor metabolism and microenvironment.

关键词： Lipid metabolism Lipid distribution Two-dimensional cells Three-dimensional cell spheroids Solid tumors

Insulin-like growth factor 1 modulates the phosphorylation, expression, and activity of organic anion transporter 3 through protein kinase A signaling pathway

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Acta Pharmaceutica Sinica B 2020年第1期10卷 186-194页

作者： jinghui zhang Zhou Yu Guofeng You Department of Pharmaceutics RutgersThe State University of New JerseyPiscatawayNJ 08854USA

Organic anion transporter 3(OAT3)plays a vital role in removing a broad variety of anionic drugs from kidney,thus avoiding their possible toxicity in the body.In the current study,we investigated the role of insulin-like growth factor 1(IGF-1)in the regulation of OAT3.We showed that IGF-1 induced a dose-and time-dependent increase in OAT3 transport activity,which correlated well with an increase in OAT3 expression.The IGF-1-induced increase in OAT3 expression was blocked by protein kinase A(PKA)inhibitor H89.Moreover,IGF-1 induced an increase in OAT3 phosphorylation,which was also blocked by H89.These data suggest that the IGF-1 modulation of OAT3 occurred through PKA signaling pathway.To further confirm the involvement of PKA,we treated OAT3-expressing cells with PKA activator Bt’2-cAMP,followed by examining OAT activity and phosphorylation.We showed that OAT3 activity and phosphorylation were much enhanced in Bt2-cAMP-treated cells as compared to that in control cells.Finally,linsitinib,an anticancer drug that blocks the IGF-1 receptor,abrogated IGF-1-stimulated OAT3 transport activity.In conclusion,our study demonstrated that IGF-1 regulates OAT3 expression and transport activity through PKA signaling pathway,possibly by phosphorylating the transporter.

关键词： Organic anion transporter Drug transport Regulation IGF-1 PKA Phosphorylation

从知识到素养:数字教材建设的学理依据与逻辑向度

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当代教育科学 2024年第3期 63-70页

作者：张靖卉首都师范大学教育学院北京100037

数字教材建设是教育数字化转型中的重要环节,是人工智能时代推进知识向素养转化的核心基石。知识与素养之间内含学理关联:知识学习是素养生成的逻辑基础和过程条件,知识与素养构成动态生成的连续体。人工智能时代数字教材知识形态趋向... 详细信息

数字教材建设是教育数字化转型中的重要环节,是人工智能时代推进知识向素养转化的核心基石。知识与素养之间内含学理关联:知识学习是素养生成的逻辑基础和过程条件,知识与素养构成动态生成的连续体。人工智能时代数字教材知识形态趋向“软质化”与“跨界流动性”,知识结构趋向“图谱化”与“有限开放性”,知识性质趋向“境遇化”与“协同创生性”。为深入推进新课程改革中核心素养培育的目标,数字教材应在内容、关系与价值向度上,追寻基于意义建构的知识选择与整合,塑造凸显人机协同下学习者主体性的知识空间,探索知性与德性共生的知识呈现架构。

关键词：数字教材建设核心素养知识演进人机协同

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Mapping genetic variations in the first assembled human genome

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Quantitative Biology 2021年第4期9卷 361-365页

作者： jinghui zhang Department of Computational Biology St.Jude Children's Research HospitalMemphisTN 38105-3678USA

On June 26,2000,President Bill Clinton held aceremony at the White House announcing the completion of the human genome sequencing.Finally,the leaders of the two competing groups,Dr.Francis Collins from the National Institute of Health,and Dr.J.Craig Venter from Celera Genomics,shook their hands.As a scientist who had been actively involved in both the public and private sides of human genome sequencing,I can still feel the excitement of being a contributor of this landmark scientific project even after 20 years.Nowadays,I can also attest the significance of this achievement as the reference human genome sequence is being used every day by my research team to find cures for pediatric cancers.In this feature I would like to present a foot soldier’s account on assembling and analyzing the sequence of the human genome.

关键词： Mapping Clinton pediatric