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超深厚表土层特殊凿井技术探究

建井技术 2024年第4期45卷 70-74页

作者：棘怀海翟景辉河南省正龙煤业有限公司城郊煤矿河南永城476600

为了开发超深厚土层下的固体矿物资源,以2000m深厚表土层建井为工程背景,通过总结深厚土层中井筒建设成果,并参考深土层井筒施工经验与理论研究,对冻结法、钻井法及混凝土帷幕法等特殊凿井法进行了可行性分析。研究表明:在本工程背景下... 详细信息

为了开发超深厚土层下的固体矿物资源,以2000m深厚表土层建井为工程背景,通过总结深厚土层中井筒建设成果,并参考深土层井筒施工经验与理论研究,对冻结法、钻井法及混凝土帷幕法等特殊凿井法进行了可行性分析。研究表明:在本工程背景下,使用单一的冻结法或使用单一的钻井法作为建井技术尚不成熟且实现难度较大;而采用冻结-帷幕凿井工艺具有一定的可行性。由于深井建设面临“高地应力、高地温、高水压”问题,为确保工程安全性,提出了冻结-帷幕凿井法,为后续超深厚土层凿井方法的选取提供了方向性的参考。

关键词：超深厚土层特殊凿井井壁冻结-帷幕凿井法可行性分析

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信迪利单抗致多器官免疫相关不良反应

药物不良反应杂志 2024年第2期26卷 118-120页

作者：李宁翟婧卉陈伟强王洁王媛媛刘艳雪宋燕青吉林大学第一医院临床药学部长春130000 吉林大学第一医院乐群院区药学部长春130031

1例67岁男性原发性肝癌患者因多次介入治疗后疾病进展,改为瑞戈非尼联合信迪利单抗方案治疗,用药1个周期后出现左侧面部表情肌和左侧上睑无力,全身肌肉疼痛伴呼吸困难。实验室检查示肌红蛋白8614μg/L,肌酸激酶(CK)17480 U/L,CK⁃MB质量... 详细信息

1例67岁男性原发性肝癌患者因多次介入治疗后疾病进展,改为瑞戈非尼联合信迪利单抗方案治疗,用药1个周期后出现左侧面部表情肌和左侧上睑无力,全身肌肉疼痛伴呼吸困难。实验室检查示肌红蛋白8614μg/L,肌酸激酶(CK)17480 U/L,CK⁃MB质量528μg/L,肌钙蛋白I 0.465μg/L,天冬氨酸转氨酶(AST)1069 U/L,丙氨酸转氨酶(ALT)493 U/L,乳酸脱氢酶(LDH)2469 U/L;心电图示新发左束支阻滞。考虑为信迪利单抗所致免疫相关性肌炎、免疫相关性肌痛、免疫相关性肝炎,不除外免疫相关心脏毒性。立即停用瑞戈非尼和信迪利单抗,给予甲泼尼龙500 mg冲击治疗(5 d后逐渐减量)、甘草酸单铵半胱氨酸氯化钠注射液和双环醇保肝、降肝酶治疗。7 d后,患者左侧面部表情肌及左侧眼睑无力较前缓解,胸闷较前缓解,全身肌肉无明显疼痛;15 d后实验室检查示肌红蛋白494μg/L,CK 537 U/L,CK⁃MB质量115μg/L,LDH 519 U/L,AST 52 U/L,ALT 77 U/L。治疗半年后停用甲泼尼龙,各项指标基本恢复正常,未再使用免疫治疗。

关键词：抗肿瘤药,免疫类免疫相关性肝损伤免疫相关性肌炎免疫相关心脏毒性信迪利单抗免疫检查点抑制剂

Effects of preventive acupuncture or moxibustion at the Guanyuan acupoint on expression of interleukin-2 and its receptors in hypothalamus, serum, and uterus of menopausal rats

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Neural Regeneration Research 2008年第1期3卷 49-52页

作者： Xiaohong Li Yuwei He Jieping Xie Lufen Zhang Dengfang Zhou jinghui zhai Rui Zhan Jun Zhou Limin Qu Yangchun Tian School of Acupuncture and Moxibustion Beijing University of Chinese Medicine Beijing 100029 China First Affiliated Hospital of Anhui College of Traditional Chinese Medicine Hefei 230038 Anhui Province China Basic Medical College Beijing University of Chinese Medicine Beijing 100029 China

BACKGROUND： Previous studies have indicated preventive acupuncture and moxibustion at the Guanyuan point have positive effects on the immune system of menopausal rats. OBJECTIVE： To observe the effects of preventive acupuncture or moxibustion at the Guanyuan point on interleukin-2 （IL-2） and its receptor （IL-2R mRNA） levels in hypothalamus, serum, and uterus of menopausal rats. DESIGN： Randomized control animal experiment. SETTING： School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine. MATERIALS： This study was performed at the Laboratory of Beijing University of Chinese Medicine from November 2004 to July 2005. The vaginal smear method was used to determine the estrus cycle of 9.5-month-old Sprague Dawley （SD） female rats. Three continuous estrus cycles were measured, and 160 rats with estrus cycle disorder, weighing （300 _＋ 20） g, were included in this study. The rats were randomly divided into four groups： preventive acupuncture group （n =48）, preventive moxibustion group （n =48）, model groups （n =48）, and 10-month-old group （n =16）. Sixteen 3.5-month-old healthy SD female rats, weighing （240 ± 20） g, were also assigned to the young group. All rats were clean grade and were purchased from the Laboratory Animal Center, Beijing University of Chinese Medicine. The experiment was in accordance with animal ethics standards. METHODS： Acupuncture was applied to the preventive acupuncture group at 10 months of age. The needle was inserted upward and perpendicularly two fen to a point that was two fen below the Guanyuan point. The rats freely moved around during needle retention （20 minutes）. Acupuncture was administered twice a week and continued for eight weeks. A moxa cone （small） moxibustion was applied to the preventive moxibustion group at 10 months of age. The rats were caught gently and kept at the same position as the preventive acupuncture group. The moxa cone was ignited and held to the Guanyuan point directly. Only one moxa cone was use

关键词： preventive acupuncture preventive moxibustion Guanyuan IL-2 IL-2R mRNA menopausal rats

GEOCHEMISTRY OF EARLY PRECAMBRIAN K-GRANITE IN THE TIANZHEN-HUAI'AN AREA AND ITS TECTONIC SIGNIFICANCE

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Scientia Geologica Sinica 2000年第2期 181-193页

作者： Li Yonggang Guo jinghui and zhai Mingguo (Institute of Geology and Geophysics, Chinese Academy of sciences Beijing 100029)

To the south of Archaean Huai'an Complex along the frontier of Shanxi, Inner Mongolia and Hebei, the granite belt separated with Archaean Huai'an Complex by high-pressure granulite complex is an individual petrotectonic unit more than 20 km in the width. The granite belt extends intermittently about 200 km from the south of Tianzhen to Xigeyu and Erdaolin of Xuanhua. The extensional direction is consistent with that of regional gneissosity and major stuctural line. The granite belt consists of some middle-small scale of granite bodies and relict bodies. Most of them are characterized by red-colored potassic granites and high-Pressure granulite inclusions. The mineral assemblage of Qz+Per+P1± Gt+Bi ±Hb (brown)+Mt and the compositions of garnet and biotite in some of granite bodies indicate that they underwent granulitic facies metamorphism. The compositions of most of granites are close to subsolvus granites and show the evolutional tendency of calc-alkaline series. The geochendcal featues of granites show that they are rich in K, Rb and Ba, and poor in Zr, Y and Yb, and some samPles is also deplete in Th, Ta and Nb. Granites formed by the melting of different types of source rocks and have similar geochemical features with collisional granite. Their zircon U-Pb data yield a uniform age of 237OMa,which indicates they formed in Archaean

关键词： FeO high ITS GEOCHEMISTRY OF EARLY PRECAMBRIAN K-GRANITE IN THE TIANZHEN-HUAI’AN AREA AND ITS TECTONIC SIGNIFICANCE Ta

Sm-Nd age dating of highpressure granulites and amphibolite from Sanggan area,North China craton

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Sm-Nd age dating of highpressure granulites and amphibolite ...

新型水解蛋清蛋白短肽对大鼠结肠炎症的保护作用

中国科学院地质与地球物理研究所2001学术年会

作者： GUO jinghui & zhai Mingguo Institute of Geology and Geophysics,Chinese Academy of Sciences, Beijing 100029,China

The high pressure(HP) metamorphic age has been dated to HP rocks from the Sanggan area,North China *** have got garnet+whole rock isochron ages of (1 842±38) Ma for HP granulite,and(1 856±26) Ma for HP *** Sm-Nd whole rock isochron of HP granulites give out an age of(1870±150) Ma with Nd depleted mantle model age of(2402—2 482) *** the Nd isotope homogenization during the peak metamorphism of the HP granulite,Sm-Nd closure temperature and the retention of Nd isotopic memory in garnets partially broken down during decompression,all these isochron ages are thought to be HP metamorphic ***,we proposed that the HP metamorphism took place at the end of Paleoproterozoic during the large-scale collision and assembly of the North China craton.

关键词： Sm-Nd dating high pressure granulite Paleoproterozoic collision North China craton

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中国食品学报 2021年第8期21卷 121-127页

作者：魏秋红高欢刘晓月翟婧卉宋燕青吉林大学第一医院药学部长春130000

目的:通过酶解方法获得新型水解蛋清蛋白短肽(HEpep),探究其对细菌内毒素脂多糖(LPS)所致大鼠结肠炎症的保护作用。方法:将60只雄性SD大鼠随机分为空白组、模型组、HEpep高剂量组和低剂量组。HEpep高【2 g/(kg·d)】、低剂量组【1 g/(kg... 详细信息

目的:通过酶解方法获得新型水解蛋清蛋白短肽(HEpep),探究其对细菌内毒素脂多糖(LPS)所致大鼠结肠炎症的保护作用。方法:将60只雄性SD大鼠随机分为空白组、模型组、HEpep高剂量组和低剂量组。HEpep高【2 g/(kg·d)】、低剂量组【1 g/(kg·d)】连续7 d灌胃给药,空白组和模型组采用生理盐水同步处理;第7天腹腔注射LPS 10 mg/kg,给药8 h后经腹主动脉取血并收集结肠组织;通过HE染色和TUNEL染色观察结肠上皮细胞凋亡和病理组织学变化;通过ELISA试剂盒检测血清、组织中炎症因子肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)水平变化;通过生化试剂盒检测血清、组织中氧化应激指标超氧化物歧化酶(SOD)、丙二醛(MDA)及过氧化氢酶(CAT)的变化。结果:HEpep能够显著缓解LPS所致大鼠结肠炎症反应,改善结肠组织病理性损伤和结肠上皮细胞凋亡,降低组织和血清中TNF-α和IL-6炎症因子水平,对LPS所致氧化应激损伤具有明显的保护作用。结论:HEpep可减轻LPS所致大鼠结肠炎症反应,其作用机制与抗炎、抗氧化及抗凋亡有关。

关键词：蛋清蛋白短肽结肠炎抗炎抗氧化

Nature and origin of the Wenquan granite:Implications for the provenance of Proterozoic A-type granites in the North China craton

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Nature and origin of the Wenquan granite:Implications for th...

中国科学院地质与地球物理研究所第11届（2011年度）学术年会

作者： Neng Jiang~*,jinghui Guo,Mingguo zhai State Key Laboratory of Lithospheric Evolution,Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing,China

The Proterozoic Wenquan granite occurs at the northern margin of the North China *** U-Pb zircon ages reveal that the Wenquan granite was emplaced at 1697±7 Ma,and is thus approximately coeval with the 1753±23 Ma Changsaoying granite and the 1683±4 Ma Shachang granite found in the *** ubiquitous occurrence of titanite and magnetite demonstrates that the granites are oxidized. Geochemically,they show most of the characteristics of typical A-type granites,such as high contents of alkalis(i.e.,high KO + NaO,with KO/NaO > 1),Rb,Y,Nb and rare earth elements(REE,except for Eu),high FeO/MgO and Ga/Al ratios and low contents of CaO,A1O,and *** negative bulk rock initial Nd and zircon initial Hf isotopic ratios suggest that they were most likely derived from the late Archean lower *** three Proterozoic A-type granites are believed to be genetically related to the breakup of the Columbia supercontinent.

关键词： Proterozoic A-type granite North China craton Late Archean lower crust

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无煤柱沿空掘巷技术在永夏矿区的应用

能源与环保 2018年第6期40卷 208-211,217页

作者：翟景辉刘旦龙河南能源化工集团永煤公司城郊煤矿河南永城476600

针对永夏矿区城郊煤矿十四辅助采区轨道巷完全沿空掘进围岩控制问题,分析了无煤柱沿空掘巷在资源采出率、围岩应力环境、施工效率等方面的优越性。通过建立完全沿空掘巷围岩力学模型,较为详细的分析了中厚煤层无煤柱沿空掘巷围岩应力分... 详细信息

针对永夏矿区城郊煤矿十四辅助采区轨道巷完全沿空掘进围岩控制问题,分析了无煤柱沿空掘巷在资源采出率、围岩应力环境、施工效率等方面的优越性。通过建立完全沿空掘巷围岩力学模型,较为详细的分析了中厚煤层无煤柱沿空掘巷围岩应力分布规律、上覆岩层的赋存状态,总结了完全沿空掘巷围岩的变形特征,并提出无煤柱完全沿空掘巷围岩控制需要解决的关键问题。有针对性地制定了围岩控制方案,顶板采用"锚网梯+锚索补强"、沿空侧帮部通过"留设薄煤皮+打设29U型钢棚柱"、实体煤侧帮部采用"锚网帯+锚索补强"的联合支护技术方案。现场施工后设置矿压观测站,对无煤柱沿空掘巷围岩控制技术实施效果进行了跟踪监测。观测结果显示,巷道施工后顶板离层量及顶帮变形量较留设煤柱施工大幅减少,验证了技术方案的有效性。

关键词：无煤柱沿空掘巷窜矸围岩控制矿压观测站

高瓦斯综放开采覆岩导气裂隙带高度演化规律研究

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矿业研究与开发 2021年第9期41卷 92-97页

作者：翟景辉任帅王方田毕寸光安阳市主焦煤业有限责任公司河南安阳市455100 中国矿业大学矿业工程学院江苏徐州市221116

为探究高瓦斯厚煤层综放开采覆岩裂隙带高度演化规律,以主焦煤矿2303综放工作面为研究背景,通过正交试验研究了采厚、硬岩比例系数、煤层倾角、采深等因素对综放面导气裂隙带发育高度的影响特征,总结了各因素与导气裂隙带高度之间的关... 详细信息

为探究高瓦斯厚煤层综放开采覆岩裂隙带高度演化规律,以主焦煤矿2303综放工作面为研究背景,通过正交试验研究了采厚、硬岩比例系数、煤层倾角、采深等因素对综放面导气裂隙带发育高度的影响特征,总结了各因素与导气裂隙带高度之间的关联性。通过UDEC软件模拟了综放面"两带"覆岩运移特征,模拟结果为:工作面充分采动时垮落带高度为21.7 m,裂隙带高度为45.0 m,台阶下沉现象明显。采用钻孔窥视仪对2303工作面"两带"进行探测,对比采动前后的覆岩裂隙情况可得:垮落带高度为20.7 m,裂隙带高度为44.3 m,与数值模拟结果一致。

关键词：综放开采高瓦斯覆岩运移导气裂隙带