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Trace Elements Characteristics of Black Shales from the Ediacaran Doushantuo Formation, Hubei Province, South China： Implications for Redox and Open vs. Restricted Basin Conditions

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Journal of Earth Science 2018年第2期29卷 342-352页

作者： Bi Zhu Shaoyong Jiang Daohui Pi Lu Ge jinghong yang Institute of Isotope Hydrology School of Earth Sciences and Engineering Hohai University Nanjing 210098 China State Key Laboratory of Geological Processes and Mineral Resources Faculty of Earth Resources Collaborative Innovation Center for Exploration of Strategic Mineral Resources China University of Geosciences Wuhan 430074 China State Key Laboratory for Mineral Deposits Research School of Earth Sciences and Engineering Nanjing University Nanjing 210093 China

In the present study, we carried out trace element analyses of black shales of the Edia- caran Doushantou Formation from two sections （Jiulongwan, Baiguoyuan） in Hubei Province, South China. Mo-U characteristics of black shales from the two sections and compiled Mo-U data of Dou- shantuo black shales from sections of a variety of sedimentary facies described the temporal/spatial variability in the redox conditions of paleo-seawater during deposition of the Donshantuo Formation. Changes in Mo-U patterns of the Doushantuo Member II （DST2） shales of open marine environments are consistent with a shift from a predominately oxic to a predominately anoxic ocean during their deposition. Mo-U patterns of the DST2 black shales from intra-shelf sections reflect basin restriction may have happened in the intra-shelf basin and are compatible with the redox-stratified model of the intra-shelf basin. Mo-U patterns of black shales of the Doushantuo Member IV （DST4） reveal that the shales from intra-shelf sections have more pronounced Mo enrichment and more significant enrich- ment of Mo over U than the slope shales, indicating the operation of a Mn particulate shuttle in the intra-shelf basin. High Mo/TOC ratios of the DST4 at the intra-shelf sections, in combination with similar Mo-TOC patterns of the DST4 from both intra-shelf and slope sections, indicate the intra- shelf basin was well connected to the open ocean during deposition of the DST4.

关键词： Doushantuo Formation Mo-U eovariation Mo/TOC South China.

Rare Earth Element Geochemistry of Phosphatic Rocks in Neoproterozoic Ediacaran Doushantuo Formation in Hushan Section from the yangtze Gorges Area, South China

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Journal of Earth Science 2016年第2期27卷 204-210页

作者： Hong Xin Shaoyong Jiang jinghong yang Heping Wu Daohui Pi State Key Laboratory for Mineral Deposits Research Department of Earth Sciences Nanjing University State Key Laboratory of Geological Processes and Mineral Resources Collaborative Innovation Center for Exploration of Strategic Mineral Resources Faculty of Earth Resources China University of Geosciences

Phosphatic rocks are widely distributed in Neoproterozoic Ediacaran Doushantuo Formation in yangtze Gorges Area, South China. In this study, rare earth element geochemistry of eight phosphatic rock samples from the Hushan Section has been studied. All the samples display typical hat-shaped REE patterns, moderate negative Ce anomalies（Ce/Ce＊=0.55 to 0.67）, slightly positive Eu anomalies（Eu/Eu＊=1.05 to 1.22） and low Y/Ho ratios（38.2±5.6）. The hat-shaped REE patterns indicate diagenetic alteration of the primary REE signatures, which coincides with detrital siliciclastic sources of REE based on the Y/Ho ratios. The degree of Negative Ce anomalies and positive Eu anomalies may have recorded the redox features of diagenetic fluids, suggesting an anoxic environment during the phosphogenesis processes in Neoproterozoic Ediacaran Doushantuo Formation, South China. The geochemical comparison between the Lower Phosphorite Layer and Upper Phosphorite Layer at Hushan indicates a greater degree of diagenesis occurred in the Upper Layer than the Lower one. Besides the terrigenous sources of REE, organic materials could have also played a role on the REE characteristics.

关键词： phosphatic rocks rare earth element Ediacaran Doushantuo Formation yangtzeGorges area.

Bioadaptation of implants to In vitro and In vivo oxidative stress pathological conditions via nanotopography-induced FoxO1 signaling pathways to enhance Osteoimmunal regeneration

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Bioactive Materials 2021年第10期6卷 3164-3176页

作者： Jingyan Huang Ruoqi Li jinghong yang Min Cai Yichen Lee Anxun Wang Bin Cheng Yan Wang Hospital of Stomatology Guanghua School of StomatologySun Yat-sen University and Guangdong Key Laboratory of StomatologyGuangzhouGuangdong510055China Department of Oral and Maxillofacial Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong510080China

Varieties of pathological conditions,including diabetes,are closely related to oxidative stress(OS),but the osseointegration or bioadaptation of implants to OS and the related mechanism remain poorly explored.In this study,the antioxidation and osteoimmune regeneration of titanium implants with micro/nanotopographies were evaluated under H2O2-,lipopolysaccharide(LPS)-and hyperglycemia-mediated cellular OS models and in diabetic rats as a representative animal model of OS.TiO2 nanotube(TNT)coating on titanium implants directly induced superior osteogenic differentiation of bone mesenchymal stem cells(MSCs)and osseointegration compared with microscale sand blasted-acid etched topography(SLA)under OS,attributed to higher superoxide dismutase 2 activity,the neutralization of intracellular reactive oxygen species(ROS),and less apoptosis.Mechanistically,the oxidation resistance on TNT is driven by upregulated forkhead box transcription factor O1(FoxO1),which is abolished after knockdown of FoxO1 via shRNA in MSCs.Indirectly,TNT also alleviates OS in macrophages,therefore inducing a higher portion of the M2 phenotype under OS with increased secretion of the anti-inflammatory cytokine IL-10,further promoting the osseoimmunity capacity compared with SLA.The current study not only suggests the potential application of TiO2 nanotube-coated titanium implants in compromised conditions but also provides a systematic evaluation strategy for the future development of bone biomaterials.

关键词： Oxidative stress Osteogenesis TiO2 nanotubes FoxO1 Inflammation

Indole-3-acetic acid,a potential therapeutic target in Alzheimer's disease

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Science Bulletin 2024年第2期69卷 146-147页

作者： jinghong Li Department of Chemistry Center for Bioanalytical ChemistryKey Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing 100084China

Alzheimer's disease(AD)is a chronic and progressive neurodegenerative disease that is characterized by the presence of amyloid-β(Ap)plaques,hyperphosphorylated microtubule-associated tau protein(p-tau)neurofibrillary tangles and neuronal degeneration.According to recent data,AD is the most common global cause of dementia in the elderly.Although billions of dollars have been invested in research,there is still no effective drug for the treatment of AD;consequently,this disease imposes a huge burden on individuals,families,and healthcare systems[1,2].

关键词： Alzheimer tau degeneration

Glycerol ether biomarkers and their carbon isotopic compositions in a cold seep carbonate chimney from the Shenhu area, northern South China Sea

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Chinese Science Bulletin 2011年第16期56卷 1700-1707页

作者： GE Lu JIANG ShaoYong yang Tao yang jinghong WU NengYou ZHANG GuangXue LIU Jian State Key Laboratory for Mineral Deposits Research and Center for Marine Geochemistry Research Department of Earth Sciences Nanjing University Nanjing 210093 China Guangzhou Marine Geologwal Survey Guangzhou 510760 China

At modern cold seeps,the anaerobic oxidation of methane(AOM)is the dominant pathway for methane consumption in marine sediments.AOM,which is mediated by a consortium of methane oxidizing archaea and sulfate reducing bacteria,is proposed to be responsible for authigenic carbonate formation.A methane-derived carbonate chimney was collected from the Shenhu area, northern South China Sea.The membrane lipids and their very low carbon isotopic compositions(?115‰to?104‰)in the Shenhu chimney suggest the presence of an AOM process.Three specific archaeal and bacterial biomarkers were detected,including Ar,DAGE 1f,and monocyclic MDGD.Their strongly depleted??13C values(?115‰to?104‰),which are lower than those of the normal marine lipids in sediments,reveal biogenic methane as their origin.The carbonate deposits exhibiting a chimney structure indicate that a vigorous methane-rich fluid expulsion may have occurred at the seafloor.We propose that the decomposition of gas hydrates at depth is the likely cause of seepage and cold seep carbonate formation in the Shenhu area.

关键词：碳同位素组成生物标志物自生碳酸盐烟囱结构中国南海冷泉南海北部甘油醚

Recent development of aspiration pump in the aspiration thrombectomy system

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Medicine in Novel Technology and Devices 2024年第2期22卷 1-8页

作者： Chen Wei Jing Dong Hongyi yang jinghong Shi Huihui Fang yangjie Zuo Yubing Shi The Second Clinical College of Medicine Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina Department of Cardiology the Second Affiliated Hospital of Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina Institute of Integrative Medicine Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina School of Medical Technology Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina School of Engineering Staffordshire UniversityStoke-on-TrentStaffordshireUK

Vascular embolic diseases are associated with blockage of blood supply to vital organs and thus are lethal.Aspiration thrombectomy is becoming the primary choice for revascularization in the treatment of vascular occlusions condition.As the power source in the aspiration thrombectomy procedure,the aspiration pump directly influences the outcome of the operation.This research surveyed the current technical developments of the aspiration pump in China through reviewing information obtained from the patent database and technical literatures,commented on the issues in the current patent designs,and gave suggestions for future design improvement.This study can be used as a reference for researchers and developers of medical devices besides the neurosurgeons.

关键词： Aspiration pump Thrombus Thrombectomy Vascular embolic diseases Aspiration thrombectomy

Real-time identification of multiple nanoclusters with a protein nanopore in single-cluster level

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Nano Research 2024年第1期17卷 262-269页

作者： Ling Zhang Peilei He Huang Chen Qingda Liu Libo Li Xun Wang jinghong Li Department of Chemistry Center for BioAnalytical ChemistryKey Laboratory of Bioorganic Phosphorus Chemistry&Chemical BiologyTsinghua UniversityBeijing 100084China School of Chemistry and Chemical Engineering Guangdong Prov Key Lab Green Chem Prod TechnolSouth China University of TechnologyGuangzhou 510640China New Cornerstone Science Laboratory Shenzhen 518054China Beijing Institute of Life Science and Technology Beijing 102206China Center for BioAnalytical Chemistry Hefei National Laboratory of Physical Science at MicroscaleUniversity of Science and Technology of ChinaHefei 230026China

It is important and challenging to analyze nanocluster structure with atomic precision.Herein,α-hemolysin nanopore was used to identify nanoclusters at the single molecule level by providing two-dimensional(2D)dwell time–current blockage spectra and translocation event frequency which sensitively depended on their structures.Nanoclusters such as Anderson,Keggin,Dawson,and a few lacunary Dawson polyoxometalates with very similar structures,even with only a two-atom difference,could be discriminated.This nanopore device could simultaneously measure multiple nanoclusters in a mixture qualitatively and quantitatively.Furthermore,molecular dynamics(MD)simulations provided microscopic understandings of the nanocluster translocation dynamics and yielded 2D dwell time–current blockage spectra in close agreement with experiments.The nanopore platform provides a novel powerful tool for nanocluster characterization.

关键词： nanopore single-molecule nanocluster polyoxometalates real-time detection

Geochemical characteristics of pore water in shallow sediments from Shenhu area of South China Sea and their significance for gas hydrate occurrence

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Chinese Science Bulletin 2010年第8期55卷 752-760页

作者： yang Tao JIANG ShaoYong GE Lu yang jinghong WU NengYou ZHANG GuangXue LIU Jian State Key Laboratory for Mineral Deposits Research Center for Marine Geochemistry Research Nanjing University Nanjing 210093 China Guangzhou Marine Geological Survey Guangzhou 510760 China

The Shenhu area is one of the promise target areas for marine gas hydrate exploration in the northern margin of the South China Sea.Pore water samples were collected from two piston cores (8.75 and 8.52 m) in site HS-A and site HS-B in the Shenhu area,and their major anion and cation contents and trace element contents have been analyzed in this study.Cl- concentrations in pore waters are similar to the seawater value and no systematic change along depth profiles has been found for the Cl- content in both sites.In site HS-A,the SO 2- 4 contents show a limited range in pore waters from 0 to 3 m depths,but a dramatic decrease is documented in depth below 3 m.Other elements such as Ca 2+,Mg 2+ and Sr 2+ show similar variation patterns as the SO 2- 4,i.e.,no variation in 0-3 m,but large decrease in depth below 3 m.In site HS-B,both the SO 4 and Ca 2+,Mg 2+ and Sr 2+ display a decrease pattern along the depth profile,but in 0-3 m the variation is less significant than those in depth below 3 m.In both sites HS-A and HS-B,I contents show a dramatic increase along depth profiles.Calculations show that the SMI depths are very shallow (10 and 11 m) in both sites,and the sulfate flux and I flux are very high.These geochemical characteristics and anomalies at Shenhu are quite similar to those found in other gas hydrate locations in the world,and a genetic link is suggested to be related to the gas hydrate occurrence at depths in the study area.In summary,we suggest that combined geochemical parameters in shallow sediment pore waters are useful indicators to indicate the gas hydrate occurrence at depths.

关键词：天然气水合物地球化学特征南中国海沉积物孔隙水浅层

Evolution of Monkeypox C9L RNA G-Quadruplex Elevates the Translation of Its Only Kelch-like Protein by Accelerating G-Quadruplex Unfolding Kinetics

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CCS Chemistry 2024年第4期6卷 953-963页

作者： Yicong Dai Xucong Teng Difei Hu Qiushuang Zhang jinghong Li Department of Chemistry Center for Bioanalytical ChemistryKey Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijing 100084 New Cornerstone Science Laboratory Shenzhen 518054 Beijing Life Science Academy Beijing 102209 Center for Bioanalytical Chemistry Hefei National Laboratory of Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026

Genomic surveillance of monkeypox virus(MPXV)is essential to explore the reason of its unusual outbreak.Current phylogenomic analysis of the MPXV genome mainly focuses on the effect of amino acid mutations.Herein,we explore the evolutionary variation of RNA G-quadruplex(RG4)of MPXV and find that the genome evolution of MPXV can also produce new effects through changes in the RG4 structure.This RG4 is located in MPXV’s only Kelch-like C9L gene,which encodes for an antagonist of the innate immune response.The evolution of this virus increases the unfolding kinetic constant of C9L RG4 and promotes the C9 protein level in living cells.Importantly,all reported MPXV genomes in 2022 carry the C9L-RG4-5 pattern with the highest unfolding kinetic constant.Additionally,the RG4 ligand,RGB-1,can impede the unfolding of C9L-RG4-5 and thereby reduce the C9 protein level.These findings carve out a new path to comprehensively understanding MPXV virology.

关键词： G-quadruplex RNA secondary structure unfolding kinetics monkeypox virus genomic evolution immune evasion