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帕利哌酮辅助治疗对精神分裂症患者实验室指标和临床症状的影响

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黑龙江医药 2023年第2期36卷 309-312页

作者：叶景恒江门市新会区第三人民医院药剂科广东江门529000

目的:探讨帕利哌酮辅助治疗对精神分裂症患者实验室指标和临床症状的影响。方法:选择本院2021年12月—2022年12月收治的100例精神分裂症患者为研究对象,按治疗方式的不同分为对照组和研究组,各50例;对照组予氯氮平治疗,在此基础上研究... 详细信息

目的:探讨帕利哌酮辅助治疗对精神分裂症患者实验室指标和临床症状的影响。方法:选择本院2021年12月—2022年12月收治的100例精神分裂症患者为研究对象,按治疗方式的不同分为对照组和研究组,各50例;对照组予氯氮平治疗,在此基础上研究组合并帕利哌酮治疗,比较两组治疗效果。结果:治疗后,研究组的FPG、TAG、TC、LDL、PRL、HDL-C以及PRL水平优于对照组(P<0.05);治疗后,研究组患者的IL-6、IL-1β、IL-2水平低于对照组(P<0.05);治疗后研究组WAIS-RC、PANSS以及LSR水平优于对照组(P<0.05)。结论:帕利哌酮辅助治疗对治疗精神分裂症具有积极意义,有效改善代谢及内分泌指标,降低机体炎症反应,稳定病情,疗效显著且安全性好,可在未来临床治疗加以运用和推广。

关键词：帕利哌酮精神分裂症实验室指标临床症状

Investigations of Water Flow Behaviors Induced by Local Temperature Variations through a Single Rough Fracture for the Enhanced Geothermal Systems

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Journal of Thermal Science 2024年第3期33卷 1055-1064页

作者： LI Jiawei ye Lin Department of Energy and Power Engineering Tsinghua UniversityBeijing100084China School of Power and Energy Northwestern Polytechnical UniversityXi’an710072China

In recent years,Enhanced Geothermal System(EGS)technologies have been applied to the geothermal resources production in the Hot Dry Rock(HDR).The core of EGS technologies is to adopt hydraulic fracturing in the reservoir to create a connected network of discrete fractures with the consideration of water as a working fluid for hydraulic fracturing and heat *** paper investigates the characteristics of water flow behaviors through a single rough fracture under different temperature and pressure conditions.A single fracture model with rough fracture surfaces is constructed and then characterized,and influences of the anisotropic factor on the average tortuosity and frictional resistance coefficient of water flow through a single fracture with rough surfaces have been compared and *** consideration of other impacting factors(temperature,pressure,fracture roughness),the impact of mass flow rate has also been *** simulation results present that changes of average tortuosity for water flow through a single rough facture are mainly affected by *** can be observed that higher temperature leads to larger average tortuosity but the frictional resistance coefficient shows an opposite *** for pressure conditions,it is found that effects of pressure on average tortuosity and frictional resistance coefficient is very small,which can be neglected under high pressure ***,the average tortuosity shows a progressively linear relationship with the mass flow *** the contrary,the frictional resistance coefficient has a negative relationship with the mass flow *** is revealed that when the mass flow rate reaches a critical point,the influences of temperature on the frictional resistance coefficient will be *** of single rough fractures with different anisotropic factors show that values of average tortuosity and frictional resistance coefficient have positive relationships with the increase

关键词： single rough fracture tortuosity frictional resistance enhanced geothermal system

Path-Dependent Progressive Failure Analysis for 3D-Printed Continuous Carbon Fibre Reinforced Composites

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Chinese Journal of Mechanical Engineering 2024年第4期37卷 84-93页

作者： Yuan Chen Lin ye School of System Design and Intelligent Manufacturing(SDIM) Southern University of Science and TechnologyShenzhen 518055China Shenzhen Key Laboratory of Intelligent Manufacturing for Continuous Carbon Fibre Reinforced Composites Southern University of Science and TechnologyShenzhen 518055China

In order to predict the damage behaviours of 3D-printed continuous carbon fibre(CCF)reinforced composites,when additional short carbon fibre(SCF)composite components are employed for continuous printing or special functionality,a novel path-dependent progressive failure(PDPF)numerical approach is ***,a progressive failure model using Hashin failure criteria with continuum damage mechanics to account for the damage initiation and evaluation of 3D-printed CCF reinforced polyamide(PA)composites is developed,based on actual fibre placement trajectories with physical measurements of 3D-printed CCF/PA ***,an elastic-plastic model is employed to predict the plastic damage behaviours of SCF/PA ***,the accuracy of the PDPF model was validated so as to study 3D-printed CCF/PA composites with either negative Poisson's ratio or high *** results demonstrate that the proposed PDPF model can achieve higher prediction accuracies in mechanical properties of these 3D-printed CCF/PA *** analyses show that the stress distribution is generally aggregated in the CCF areas along the fibre placement paths,and the shear damage and matrix tensile/compressive damage are the key damage *** study provides a new approach with valuable information for characterising complex 3D-printed continuous fibre-matrix composites with variable mechanical properties and multiple constituents.

关键词： 3D printing Continuous carbon fibre Modelling Energy absorption Negative Poisson's ratio

A modified stochastic model for LS+AR hybrid method and its application in polar motion short-term prediction

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Geodesy and Geodynamics 2024年第1期15卷 100-105页

作者： Fei ye Yunbin Yuan State Key Laboratory of Geodesy and Earth's Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China BeiDou High-precision Satellite Navigation and Location Service Hunan Engineering Research Center Hunan Institute of Geomatics Sciences and TechnologyChangsha 410007China Hunan Continuously Operating Reference Stations(HNCORS)Data Center Hunan Institute of Geomatics Sciences and TechnologyChangsha 410007China

Short-term(up to 30 days)predictions of Earth Rotation Parameters(ERPs)such as Polar Motion(PM:PMX and PMY)play an essential role in real-time applications related to high-precision reference frame ***,least squares(LS)+auto-regressive(AR)hybrid method is one of the main techniques of PM ***,the weighted LS+AR hybrid method performs well for PM short-term ***,the corresponding covariance information of LS fitting residuals deserves further exploration in the AR *** this study,we have derived a modified stochastic model for the LS+AR hybrid method,namely the weighted LS+weighted AR hybrid *** using the PM data products of IERS EOP 14 C04,the numerical results indicate that for PM short-term forecasting,the proposed weighted LS+weighted AR hybrid method shows an advantage over both the LS+AR hybrid method and the weighted LS+AR hybrid *** to the mean absolute errors(MAEs)of PMX/PMY sho rt-term prediction of the LS+AR hybrid method and the weighted LS+AR hybrid method,the weighted LS+weighted AR hybrid method shows average improvements of 6.61%/12.08%and 0.24%/11.65%,***,for the slopes of the linear regression lines fitted to the errors of each method,the growth of the prediction error of the proposed method is slower than that of the other two methods.

关键词： Stochastic model LS+AR Short-term prediction The earth rotation parameter(ERP) Observation model

In-depth insights into critical role of aromatic C（sp2）–H on Li+ storage

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Rare Metals 2024年第10期43卷 5449-5452页

作者： Ling Qin ye Zhou China-UK Low Carbon College Shanghai Jiao Tong University

The development of high-sloping-capacity carbons enables the creation of high-power lithium-ion batteries and capacitors （LIBs/LICs）.Among the various heteroatomdoped carbon materials,hydrogen-rich carbon appears to be a promising candidate due to its facile synthesis and high capacity for Li+***,conclusive data are still lacking to elucidate the fundamental function of the hydrogen-terminated groups （C-H configuration） in Li+*** and his co-workers have utilized an ion-catalyzed self-template method to synthesize the hydrogen-rich carbon nanoribbon （HCNR） with high specific and rate *** HCNR?s Li+storage mechanism is clarified by the use of in situ spectroscopy methods,which reveals that the sp2-hybridization of the

关键词： Aromatization

Global precipitation change during the Holocene:a combination of records and simulations

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Frontiers of Earth Science 2024年第1期18卷 112-126页

作者： Wangting ye Yu LI Key Laboratory of Western China᾽s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesCenter for Hydrologic Cycle and Water Resources in Arid RegionLanzhou UniversityLanzhou 730000China

Precipitation can shape our climate both in the present and the *** though we have made significant advances in studying the mechanisms of millennial-scale climate changes through high-resolution records,we still cannot quantitatively characterize the global spatiotemporal precipitation variations within the ***,we developed a new approach to integrating data from 349 globally distributed records and climate models to reconstruct regional and global precipitation patterns over the last 12000 *** results reveal that precipitation reconstructions can be divided into monsoon-driven and westerly driven *** results suggest that an arid climate was experienced in the late glacial and early Holocene epoch(~12−7.4 cal ka BP),attaining a middle Holocene optimum(~7.4−3.5 cal ka BP),and drier after the middle *** to our reconstructions,the global precipitation reconstruction increased from the early Holocene until 3.8 cal ka BP and then subsequently *** addition,our reconstructions better reproduce the low-frequency events and extreme precipitation at the millennial scale in the hemispheres,but the performance of the reconstructions in the equatorial Pacific and the Southern Hemisphere of Africa and the Americas is *** resolution of the record and the simulation capability of the climate model remain important means to improve our understanding of past climate change.

关键词： Holocene equatorial glacial

A novel relationship between elastic modulus and void ratio associated with principal stress for coral calcareous sand

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 1033-1048页

作者： Ran Gao Jianhong ye State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China

Elastic moduli,*** modulus G and bulk modulus K,are important parameters of geotechnical materials,which are not only the indices for the evaluation of the deformation ability of soils but also the important basic parameters for the development of the constitutive models of geotechnical *** this study,a series of triaxial loading-unloading-reloading shear tests and isotropic loading-unloadingreloading tests are conducted to study several typical mechanical properties of coral calcareous sand(CCS),and the void ratio evolution during loading,unloading and *** test results show that the stress-strain curves during multiple unloading processes are almost parallel,and their slopes are much greater than the deformation modulus at the initial stage of *** relationship between the confining pressure and the volumetric strain can be defined approximately by a hyperbolic equation under the condition of monotonic loading of confining *** the condition of confining pressure unloading,the evolution of void ratio is linear in the e-lnp0 plane,and these lines are a series of almost parallel lines if there are multiple processes of *** on the experimental results,it is found that the modified Hardin formulae for the elastic modulus estimation have a significant deviation from the tested values for *** on the experimental results,it is proposed that the elastic modulus of soils should be determined by the intersection line of two spatial surfaces in the G/K-e-p’/pa space(pa:atmosphere pressure).“ye formulation”is further proposed for the estimation of the elastic modulus of *** new estimation formulation for soil elastic modulus would provide a new method to accurately describe the mechanical behavior of granular soils.

关键词： Coral calcareous sand(CCS) Elastic shear modulus Elastic bulk modulus Triaxial test Estimation formulation ye formulation

Improved LS+MAR hybrid method to UT1-UTC ultra-short-term prediction by using first-order-difference UT1-UTC

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Geodesy and Geodynamics 2024年第4期15卷 379-385页

作者： Fei ye Yunbin Yuan BeiDou High-precision Satellite Navigation and Location Service Hunan Engineering Research Center Hunan Institute of Geomatics Sciences and TechnologyChangsha410007China State Key Laboratory of Geodesy and Earth's Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan430077China HNCORS Data Center Hunan Institute of Geomatics Sciences and TechnologyChangsha 410007China

Accurate ultra-short-term prediction of the Earth rotation parameters(ERP)holds paramount impor-tance for real-time applications,particularly in reference frame *** them,diurnal rota-tion(UT1-UTC)which cannot be directly estimated through Global Navigation Satellite System(GNSS)techniques,significantly affects the rapid and ultra-rapid orbit determination of GNsS ***-ently,the traditional LS(least squares)+AR(autoregressive)and LS+MAR(multivariate autoregressive)hybrid methods stand as primary approaches for UT1-UTC ultra-short-term predictions(1-10 days).The LS+MAR hybrid method relies on the UT1-UTC and LOD(length of day)***,the correlation between LOD and first-order-difference UT1-UTC is stronger than that between LOD and *** light of this,and with the aid of the first-order-difference UT1-UTC,we propose an enhanced LS+MAR hybrid method to UT1-UTC ultra-short-term *** using the UT1-UTC and LOD data series of the IERS(International Earth Rotation and Reference Systems Service)EOP 14 C04 product,we conducted a thorough analysis and evaluation of the improved method's prediction performance compared to the traditional LS+AR and LS+MAR hybrid *** to the numerical results over more than 210 days,they demonstrate that,when considering the correlation information between the LoD and the first-order-difference UT1-UTC,the mean absolute errors(MAEs)of the improved LS+MAR hybrid method range from 21 to 934μs in 1-10 days *** comparison to the traditional LS+AR hybrid method,the MAEs show a reduction of 7-53μs in 1-10 days predictions,with corresponding improvement percentages ranging from 1 to 28%.Similarly,when compared to the traditional LS+MAR hybrid method,the MAEs have a reduction of 5-42μs in 1-10 days predictions,with corresponding improvement percentages ranging from 4-20%.Additionally,when aided by GNSS-derived LOD data series,the MAEs of improved LS+MAR hybrid method experience further

关键词： UT1-UTCultra-short-termprediction Rapidandultra-rapidproducts LS+AR and LS+MAR Correlation First-order-differenceUT1-UTC

General formalism for dirty extreme-mass-ratio inspirals

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 22-29页

作者： ye Jiang Wen-Biao Han Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Shanghai Frontiers Science Center for Gravitational Wave Detection Shanghai 200240China

Detecting the environment around the supermassive black holes and tests of general relativity are important applications of extreme-mass-ratio inspirals(EMRIs).There is still a challenge to efficiently describe various“dirty”impacts on the inspirals,such as dark matter,gas,dipole radiation,and electromagnetic *** this study,we find the inherent linearity of the asymptotic solution of the inhomogeneous Teukolsky *** the basis of this property,we completely decouple the factors of the perturber and the background spacetime in the energy fluxes and *** the new decoupling form,the waveforms of EMRIs with non-geodesic motion in Kerr spacetime can be conveniently *** will help to resolve the environment(including gas,field,dark matter,electromagnetic interaction)around supermassive black holes and test general relativity.

关键词： gravitational wave Teukolsky equation extreme-mass-ratio inspirals