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Vibration-assisted material damage mechanism:From indentation cracks to scratch cracks

Chinese Journal of Aeronautics 2024年第8期37卷 527-546页

作者： Bingrui LV Bin LIN Tianyi SUI Chunyan LIU Jinshuo ZHANG Longfei WANG Xuhui CHEN jingguo zhou Key Laboratory of Advanced Ceramics and Machining Technology Ministry of EducationTianjin UniversityTianjin 300072China Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education Tianjin UniversityTianjin 300072China Science and Technology of Advanced Functional Composite Laboratory Aerospace Research Institute of Materials and Processing TechnologyBeijing 100076China

Vibration-assisted grinding is one of the most promising technologies for manufacturing optical components due to its efficiency and quality ***,the damage and crack propagation mechanisms of materials in vibration-assisted grinding are not well *** order to elucidate the mechanism of abrasive scratching during vibration-assisted grinding,a kinematic model of vibration scratching was *** influence of process parameters on the evolution of vibration scratches to indentation or straight scratches is revealed by displacement metrics and velocity ***,scratch and vibration scratch experiments were performed on quartz glass,and the results showed that the vibration scratch cracks are a combination of indentation cracks and scratch *** scratch cracks change from indentation cracks to scratch cracks as the indenter moves from the entrance to the exit of the workpiece or as the vibration frequency changes from high to low.A vertical vibration scratch stress field model is established for the first time,which reveals that the maximum principal stress and tensile stress distribution is the fundamental cause for inducing the transformation of the vibration scratch cracking *** model provides a theoretical basis for understanding of the mechanism of material damage and crack propagation during vibration-assisted grinding.

关键词： Vibration assisted grinding Indentation Vibration scratch Material removal mechanism Stress field model Crack propagation mechanism

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分离-接触特征对钛合金超声振动辅助铣削加工特性影响规律研究

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机械工程学报 2024年第9期60卷 97-113页

作者：周京国张宇航隋天一行登海董宝昆付清宇付俊帆林彬天津大学机械工程学院天津300350 天津大学先进陶瓷与加工技术教育部重点实验室天津300350 中国舰船研究设计中心武汉430064 航空工业西安飞行自动控制研究所西安710076

超声振动铣削中分离-接触特征会影响钛合金的高效高质量加工,为了更深入的认识分离-接触特征对超声振动辅助铣削的影响,建立了接触率、平均切厚比的铣削模型,并提出基于平均切厚比的超声作用判别准则;通过开展铣削实验,讨论了周期性与... 详细信息

超声振动铣削中分离-接触特征会影响钛合金的高效高质量加工,为了更深入的认识分离-接触特征对超声振动辅助铣削的影响,建立了接触率、平均切厚比的铣削模型,并提出基于平均切厚比的超声作用判别准则;通过开展铣削实验,讨论了周期性与持续性接触超声铣削中接触率与平均切厚比的作用机理;研究了不同铣削与超声参数对刀具磨损的影响规律。结果表明:在纵向超声振动辅助铣削钛合金时,分离效应与平均切厚效应共同作用使得超声加工相较于传统加工能改善加工质量,在周期性接触铣削中,刀具-工件周期性接触的间歇切削现象引起的分离效应是铣削力与表面质量改善的主要因素,在持续性接触铣削中(接触率为1),单位周期的平均切削厚度降低现象引起的平均切厚效应使得在一定范围内刀具-工件不分离也能降低铣削力,改善表面质量;Ti-6Al-4V钛合金存在临界切入速度值,约为42m/min,合理搭配主轴转速及超声振幅可改变切入速度以防止刀具磨损,这对钛合金的高效高质量加工与工艺控制具有重要的作用。

关键词：接触率平均切厚比超声振动辅助铣削钛合金加工特性

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创伤中心实体化建设对严重多发伤患者的影响分析

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智慧健康 2024年第18期10卷 172-174页

作者：韦勇李海峰黄燕萍周靖国广西柳钢医疗有限公司医院急诊医学科广西柳州545001

目的探讨创伤中心实体化建设对严重多发伤患者的影响。方法选取2021年9月—2022年8月(未建立创伤中心时)收治的28例严重多发伤患者作为对照组研究对象,选取2023年2月—2023年10月(建立创伤中心时)收治的22例严重多发伤患者作为观察组研... 详细信息

目的探讨创伤中心实体化建设对严重多发伤患者的影响。方法选取2021年9月—2022年8月(未建立创伤中心时)收治的28例严重多发伤患者作为对照组研究对象,选取2023年2月—2023年10月(建立创伤中心时)收治的22例严重多发伤患者作为观察组研究对象。对比两组的CT检查完成时间、急诊停留时间、输血时间、ICU住院时间、总住院时间、总住院费用、损伤控制手术1h内开始率及死亡率。结果观察组的CT检查完成时间、急诊停留时间、输血时间均短于对照组(P<0.05);观察组的ICU住院时间、总住院时间均短于对照组,总住院费用低于对照组(P<0.05);损伤控制手术1h内开始率高于对照组(P<0.05),且观察组死亡率低于对照组(P<0.05)。结论创伤中心实体化建设可提升严重多发伤患者的急救效率,缩短治疗时间,还可降低死亡率,值得推广实施。

关键词：创伤中心实体化建设严重多发伤住院时间住院成本死亡率

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Tinea incognito due tomicrosporum gypseum

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The Journal of Biomedical Research 2010年第1期24卷 81-83页

作者： Chunshui Yu ,jingguo zhou,Jianping Liu Department of Dermatology,the Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China Department of Dermatology the Affiliated Hospital of North Sichuan Medical College Nanchong 637000 China.

A 41-year-old woman presented with a pruritic rash on the face that was of 3 months duration. During that time, it had been successively misdiagnosed as psoriasis vulgaris, systemic lupus erythematosus, facial dermatitis at other hospitals, and had been treated with agents that included acitretin and prednisone. Finally, fungi were found in the lesions by optical microscopy, and the fungal culture was positive for Microsporum gypseum, and was diagnosed as a Microsporum gypseum infection. The lesions eventually cleared completely after 8 weeks of antifungal treatment.

关键词： tinea incognito Microsporum gypseum

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Cystic adenoid trichoepithelioma occurring in mother and daughter: Case report

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Journal of Medical Colleges of PLA(China) 2009年第5期24卷 309-310页

作者： Yu Chunshui zhou jingguo Liu Jianping Su Jiangwei Department of Dermatology Affiliated Hospital of North Sichuan Medical College Nanchong 637000 China

Multiple familial trichoepithelioma is a rare autosomal predominantly on the face. They are benign skin tumours trichoepithelioma occurring in two members of the same family dominant skin disease that presents as many... 详细信息

关键词： Trichoepithelioma Histopathology

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Three-channel CMOS transimpedance amplifier for LiDAR sensor receiver

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Journal of Systems Engineering and Electronics 2024年第1期35卷 74-80页

作者： LIU Ruqing ZHU jingguo JIANG Yan LI Feng JIANG Chenghao MENG Zhe Photoelectric R&D Center Academy of Opto-ElectronicsChinese Academy of SciencesBeijing 100094China

For time-of-flight(TOF)light detection and ranging(LiDAR),a three-channel high-performance transimpedance amplifier(TIA)with high immunity to input load capacitance is presented.A regulated cascade(RGC)as the input stage is at the core of the complementary metal oxide semiconductor(CMOS)circuit chip,giving it more immunity to input photodiode detectors.A simple smart output interface acting as a feedback structure,which is rarely found in other designs,reduces the chip size and power consumption *** circuit is designed using a 0.5μm CMOS process technology to achieve low *** device delivers a 33.87 dB?transimpedance gain at 350 *** a higher input load capacitance,it shows a-3 dB bandwidth of 461 MHz,indicating a better detector tolerance at the front end of the *** a 3.3 V supply voltage,the device consumes 5.2 mW,and the total chip area with three channels is 402.8×597.0μm2(including the test pads).

关键词： transimpedance amplifier(TIA) three-channel regulated cascade(RGC) light detection and ranging(LiDAR)

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The Th17 and Treg cells and its role in gout arthritis

The Th17 and Treg cells and its role in gout arthritis

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第十一届全国免疫学学术大会

作者： Zhong Xiaowu Yang Hong Qing Yufeng Xie Wenguang zhou jingguo Medicine Research Center the Affiliated Hospital of North Sichuan Medical College Institute of Rheumatology and Immunology North Sichuan Medical College Department of Rheumatology and Immunology of the Affiliated Hospital North Sichuan Medical College

Objective:To investigate the possible role of Th17/Treg cells in gout arthritis(GA). Methods: The PBMCs of 32 acute gout patients(AG), 34 interval gout patients(IG) and 26 healthy controls(HC) were collected. The clinical data and laboratory of them were enrolled. The percentages of Th17 and Treg cells were detected by flow cytometry. The expression of Foxp3 and ROR-γt mRNA in PBMCs were measured using RT-qPCR. SPSS21.0 was used for analysis. The measurement data were compared by one factor analysis of variance test. The correlation between variables was used by Spearman correlation analysis. Results: The percentage of Th17 cells in PBMCs of AG group was(2.85%±0.92%) was significantly increased(P0.05). The proportion of Treg cells in the PBMCs of AG and IG group were(3.39±1.37)%, which was significantly lower(P0.05). The proportion of TH17/Treg cells in AG group was higher than IG and HC group. Compared with HC group, the expression of ROR-γt mRNA in AG and IG group were higher(P0.05). The expression of Foxp3 mRNA were significantly lower(P0.05). The correlation analysis found the correlation of ROR-γt and Foxp3 mRNA expression levels in AG was positive correlation(r = 1.000, P<0.01), but negative correlation in IG(r=-0.999, P= 0.00). Th17 cells percentage was foundcorrelate significantly with AST in GA patients(r=-0.361, P<0.01). Conclusions: Disturbed Th17/Treg balance in GA patients may have an important role in the pathogenesis of GA.

关键词： Gouty arthritis Th17 cells Treg cells Foxp3 ROR-γt

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痛风的动物模型与模式动物

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中华风湿病学杂志 2017年第7期21卷 433-435页

作者：周京国成都医学院附属医院风湿免疫科 610500

实验动物具有生物体的完整性和系统性，所以任何一个外来刺激会引起实验动物全身各个系统出现连锁反应。因为实验动物的这个特性，它被用来建立模型作为人类认识生命过程中生理病理变化的活的“精密仪器”。

关键词：动物模型痛风实验动物生理病理变化连锁反应精密仪器生命过程生物体

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Dual‑Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease

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Nano-Micro Letters 2024年第6期16卷 439-457页

作者： Dandan Chu Mengyang Zhao Shisong Rong Wonho Jhe Xiaolu Cai Yi Xiao Wei Zhang Xingchen Geng Zhanrong Li Xingcai Zhang jingguo Li Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhou 450003People’s Republic of China Department of Ophthalmology Mass Eye and EarMass General BrighamHarvard Medical SchoolBostonMA 02114USA School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA College of Chemistry Zhengzhou UniversityZhengzhou 450001People’s Republic of China

Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual *** incidence of DED is gradually increasing with the highfrequency use of electronic *** inflammation is core cause of the DED vicious cycle,reactive oxygen species(ROS)play a pivotal role in the vicious cycle by regulating inflammation from ***,current therapies merely targeting inflammation show the failure of DED ***,a novel dual-atom nanozymes(DAN)-based eye drops are *** antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic *** in vitro and in vivo results demonstrate the DAN is endowed with superior biological activity in scavenging excessive ROS,inhibiting NLRP3 inflammasome activation,decreasing proinflammatory cytokines expression,and suppressing cell ***,the DAN effectively alleviate ocular inflammation,promote corneal epithelial repair,recover goblet cell density and tear secretion,thus breaking the DED vicious *** findings open an avenue to make the DAN as an intervention form to DED and ROSmediated inflammatory diseases.

关键词： Dry eye disease DAN Dual-atom nanozyme Vicious cycle NLRP3 inflammasome Nanomedicine

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辅助鼻内镜微创手术治疗鼻咽纤维血管瘤的价值

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中国现代医生 2008年第32期46卷 11-12页

作者：周靖国江苏省镇江市第一人民医院江苏镇江212000

目的探讨选择性栓塞联合鼻内镜治疗鼻咽纤维血管瘤(JNA)的临床价值。方法收集22例确诊为鼻咽纤维血管瘤患者,其中13例行术前选择性栓塞联合鼻内镜微创治疗,9例行直接手术切除,统计患者治疗过程的平均出血量、输血量及手术时间。结果联... 详细信息

目的探讨选择性栓塞联合鼻内镜治疗鼻咽纤维血管瘤(JNA)的临床价值。方法收集22例确诊为鼻咽纤维血管瘤患者,其中13例行术前选择性栓塞联合鼻内镜微创治疗,9例行直接手术切除,统计患者治疗过程的平均出血量、输血量及手术时间。结果联合治疗组平均术中出血量为(400±200)mL,而输血量为(350±250)mL;而直接手术切除组术中出血量及输血量分别为(1210±400)L和(1180±500)mL。联合治疗组及直接手术切除组的手术时间分别为(95±10)min和(145±20)min。结论选择性栓塞联合鼻内镜微创手术对鼻咽纤维血管瘤疗效确切,此技术能有效减少术中出血量,操作简单,费用低廉,是一种有效的鼻咽纤维血管瘤治疗方法,值得在临床推广。

关键词：栓塞鼻内镜手术血管造影鼻咽纤维血管瘤

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