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China CDC weekly 2024年第24期6卷 563-567,I0001页

作者： Dan Huang Xiaomin Xu Bing Lyu jingguang li Yunfeng Zhao Yongning Wu School of Population Medicine and Public Health Chinese Academy of Medical Sciences Peking Union Medical CollegeBeijingChina NHC Key Lab of Food Safety Risk Assessment Research Unit of Food SafetyChina National Center for Food Safety Risk AssessmentBeijingChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina

What is already known about this topic?Chloropropanols,along with their fatty acid esters and glycidyl fatty acid esters(GEs),are prevalent contaminants in a variety of processed foods,posing potential health risks to *** is added by this report?In the Sixth China Total Diet Study(TDS),3-monochloropropane-1,2-diol esters(3-MCPD esters)and GEs were identified as the predominant chloropropanols and their esters in composite food ***(47.0%)and cereals(15.4%)were the major contributors to exposure among the 12 food categories *** are the implications for public health practice?The Sixth China TDS highlighted concerns regarding potential health risks associated with dietary exposure to *** study underscores the need for further attention in devising practical strategies to mitigate dietary exposure to GEs.

关键词： esters predominant 1,2

Benchmark Dose for Dioxin Based on Gestational Diabetes Mellitus Using Coexposure Statistical Methods and an Optimized Physiologically Based Toxicokinetic Model

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Environment & Health 2024年第9期2卷 661-671页

作者： Tao Ying Xin liu Lei Zhang Wencheng Cao Sheng Wen Yongning Wu Gengsheng He jingguang li School of Public Health Key Laboratory of Public Health Safety of the Ministry of EducationFudan UniversityShanghai 200032China NHC Key Laboratory of Food Safety Risk Assessment Chinese Academy of Medical Science Research Unit(No.2019RU014)China National Center for Food Safety Risk AssessmentBeijing 100021China Key Laboratory for Deep Processing of Major Grain and Oil(The Chinese Ministry of Education) College of Food Science and EngineeringWuhan Polytechnic UniversityWuhan 430023China China Hubei Provincial Center for Disease Control and Prevention Hubei Provincial Academy of Preventive MedicineHubei 430023China

Dioxins are ubiquitous endocrine-disrupting substances,but determining the effects and benchmark doses in situations of coexposure is highly *** objective of this study was to assess the relationship between dioxin andgestational diabetes mellitus(GDM),calculate the benchmark dose(BMD)of dioxin in coexposure scenarios,and derive a daily exposure threshold using an optimized physiologically based toxicokinetic(PBTK)*** on a nested casecontrol study including 77 cases with GDM and 154 controls,serum levels of 29 dioxin-like compounds(DLCs)along with 10 perfluoroalkyl acids(PFAAs),seven polybrominated diphenyl ethers(PBDEs),and five non-dioxin-like polychlorinated biphenyls(ndl-PCBs)were measured at 9−16 weeks of *** machine kernel regression(BKMR)was employed to identify significant chemicals,and probit and logistic models were used to calculate BMD adjusted for significant chemicals.A physiologically based toxicokinetic(PBTK)model was optimized using polyfluorinated dibenzo-p-dioxins and dibenzofurans(PFDD/Fs)data by the Bayesian−Monte Carlo Markov chain method and was used to determine the daily dietary exposure *** median serum level of total dioxin toxic equivalent(TEQ)was 7.72 pg TEQ/g *** regression analysis revealed that individuals in the fifth quantile of total TEQ level had significantly higher odds of developing GDM compared to those in the first quantile(OR,8.87;95%CI 3.19,27.58).The BKMR analysis identified dioxin TEQ and BDE-153 as the compounds with the greatest *** binary logistic and probit models showed that the BMD10(benchmark dose corresponding to a 10%extra risk)and BMDL_(10)(lower bound on the BMD_(10))were 3.71 and 3.46 pg TEQ/g fat,respectively,when accounting for coexposure to BDE-153 up to the 80%*** the optimized PBTK model and modifying factor,it was estimated that daily exposure should be below 4.34 pg TEQ kg^(−1)bw week^(−1)in order to not reach a harmful serum concen

关键词： dioxin gestational diabetes mellitus coexposure benchmark dose physiologically based toxicokinetic model

超高效液相色谱-串联质谱法测定人体尿液中6种双酚类化合物

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卫生研究 2024年第3期53卷 447-454页

作者：裴紫薇卓勤张磊李敬光赵云峰中国疾病预防控制中心营养与健康所国家卫生健康委公共营养与健康重点实验室北京100050 国家食品安全风险评估中心中国医学科学院创新单元(2019RU014号)北京100021

目的开发并验证测定尿液中6种双酚类化合物(双酚S、双酚F、双酚A、2,2′-亚甲基双酚、双酚AF、双酚AP)的固相萃取-超高效液相色谱-串联质谱检测方法。方法尿样酶解后,经WAX固相萃取柱快速净化和提取目标物,以水和甲醇为流动相在色谱柱AC... 详细信息

目的开发并验证测定尿液中6种双酚类化合物(双酚S、双酚F、双酚A、2,2′-亚甲基双酚、双酚AF、双酚AP)的固相萃取-超高效液相色谱-串联质谱检测方法。方法尿样酶解后,经WAX固相萃取柱快速净化和提取目标物,以水和甲醇为流动相在色谱柱ACQUITY BEH C_(18)(2.1 mm×100 mm,1.7μm)上进行分离,最后在电喷雾负离子模式下进行多反应监测,内标法进行定量。结果目标化合物在0.1~50.0 ng/mL的范围内相关系数(r)均大于0.998,线性良好,检出限均低于0.1 ng/mL。3个加标浓度(0.5、5.0和50.0 ng/mL)下的目标化合物回收率均在80%~120%,相对标准偏差小于20%(n=5)。对标准参考物质进行检测,检出浓度在参考范围内。结论该方法能够对尿液中6种双酚类化合物进行快速、准确的检测,适用于人体尿液中双酚类化合物的痕量分析。

关键词：尿液双酚类化合物固相萃取超高效液相色谱-串联质谱

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建筑环境监测与健康风险评估平台研发

暖通空调 2024年第10期54卷 27-31,17页

作者：蒋小红刘捷成李景广上海建科环境技术有限公司上海

当前,建筑室内外环境的人员外暴露健康风险问题日益受到重视。为满足人们随时了解当前建筑环境及健康风险的需求,本文设计并实现了一个建筑环境监测与健康风险评估平台,可为用户提供建筑室内外空气健康数据的实时监测、展示、评估等。... 详细信息

当前,建筑室内外环境的人员外暴露健康风险问题日益受到重视。为满足人们随时了解当前建筑环境及健康风险的需求,本文设计并实现了一个建筑环境监测与健康风险评估平台,可为用户提供建筑室内外空气健康数据的实时监测、展示、评估等。该平台可更加精准地评估空气污染,实现建筑环境性能提升的定量评估,为建筑环境保障管理及运维决策提供支撑。

关键词：室内外环境人员外暴露建筑环境健康风险监测平台

上海地区分户式供暖排放NO_(2)对室内外环境空气质量影响数值模拟研究

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暖通空调 2024年第5期54卷 80-84页

作者：章重洋李景广李旻雯刘帆上海建科集团股份有限公司上海上海理工大学上海

以上海市区6层居住建筑为例,采用CFD数值模拟方法研究了室外风速、室外风向、燃气壁挂炉排放等级等因素影响下分户式供暖排放的NO_(2)的扩散特性,并将模拟结果与现有标准中NO_(2)浓度限值作了比较。结果表明:自然通风会使壁挂炉排放的NO... 详细信息

以上海市区6层居住建筑为例,采用CFD数值模拟方法研究了室外风速、室外风向、燃气壁挂炉排放等级等因素影响下分户式供暖排放的NO_(2)的扩散特性,并将模拟结果与现有标准中NO_(2)浓度限值作了比较。结果表明:自然通风会使壁挂炉排放的NO_(2)由室外向室内传输,导致室内NO_(2)浓度超标,壁挂炉排放等级越低,室内外传输导致的超标问题越严重;风向越接近正北,室内和区域微环境内NO_(2)浓度总体水平越高;建筑顶层污染物浓度最高,底层最低;区域微环境中NO_(2)浓度分布受壁挂炉排放等级、室外风速和风向等因素影响显著,排放等级越高、风速越大,越有利于污染物在环境中的扩散稀释。

关键词：分户式供暖燃气壁挂炉 NO_(2) 扩散特性空气质量排放等级风速风向

电子垃圾回收地区与一般暴露地区新生儿脐血全氟与多氟烷基化合物暴露水平比较

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环境与职业医学 2024年第8期41卷 876-883页

作者：杂亚格日里李敬光王雨昕崔师伟张磊孙新中国疾病预防控制中心职业卫生与中毒控制所化学污染与健康安全重点实验室国家食品安全风险评估中心国家卫生健康委员会食品安全风险评估重点实验室

[背景]全氟与多氟烷基化合物（PFAS）是一类典型的持久性有机污染物。PFAS工业生产与消费是城市地区该物质暴露主要原因。而电子垃圾回收活动也是PFAS环境暴露的重要来源之一。[目的]比较电子垃圾回收地区与以现代化经济发展为背景的一... 详细信息

[背景]全氟与多氟烷基化合物（PFAS）是一类典型的持久性有机污染物。PFAS工业生产与消费是城市地区该物质暴露主要原因。而电子垃圾回收活动也是PFAS环境暴露的重要来源之一。[目的]比较电子垃圾回收地区与以现代化经济发展为背景的一般暴露地区（后称一般暴露地区）新生儿脐带血清中传统及新型PFAS暴露表征差异。[方法]依托于2018年开展的一项出生队列，以募集的85例孕妇为研究对象（电子垃圾回收地区孕妇36名，一般暴露地区孕妇49名）。孕妇分娩时采集新生儿脐带血，应用超高效液相色谱-串联质谱方法检测血液常见的28种PFAS暴露水平，采用结构式问卷调查孕妇的社会人口学特征。采用Mann-Whitney U检验比较电子垃圾回收地区与一般暴露地区新生儿PFAS暴露水平。以地区因素为自变量，以自然对数转化的PFAS暴露水平为应变量，采用多因素线性回归模型探究是否为电子垃圾回收地区对新生儿PFAS暴露特征的影响。[结果]新生儿脐带血中共检出22种PFAS，其中13种同系物在两个地区样本检出率均为100%。电子垃圾回收地区和一般暴露地区新生儿脐带血∑PFAS暴露水平中位数分别为14.19和14.02 ng·mL-1，其中直链全氟辛酸（L-PFOA）暴露水平最高，中位数浓度分别为5.49和6.39 ng·mL-1。经Mann-Whitney U检验发现，电子垃圾回收地区脐带血中长链全氟癸酸（PFDA）、全氟十一酸（PFUnDA）、全氟十二酸（PFDoDA）和全氟十三酸（PFTrDA）以及全氟辛烷磺酸新型替代物6∶2氯代多氟烷基醚磺酸盐（6∶2 Cl-PFESA）和8∶2氯代多氟烷基醚磺酸盐（8∶2 CI-PFESA）暴露水平中位数高于一般暴露地区；而短链全氟戊酸（PFPeA）、全氟己酸（PFHxA）以及全氟辛酸（PFOA）的支链异构体包括全氟-6-甲基庚酸（iso-PFOA）、全氟-5-甲基庚酸（5m-PFOA）和全氟-4-甲基庚酸（4m-PFOA）暴露水平中位数低于一般暴露地区（P <0.05）。多因素线性回归调整模型发现，与一般暴露地区相比，电子垃圾回收地区脐带血中长链PFDA、PFUnDA、PFDoDA、PFTrDA，与新型替代物6:2 Cl-PFESA和8:2 Cl-PFESA暴露水平升高至1.95（95%CI:1.39～2.75）、2.10（95%CI:1.58～2.75）、2.12（95%CI:1.39～3.25）、2.64（95%CI:1.63～4.22）、3.46（95%CI:2.34～5.10）和3.25（95%CI:2.01～5.26）倍；而短链PFPeA、PFHxA、支链PFOA（br-PFOA）暴露水平是其0.44（95%Cl:0.38～0.52）、0.30（95%Cl:0.16～0.57）、0.50（95%Cl:0.38～0.67）倍。[结论]电子垃圾回收地区和一般暴露地区新生儿脐带血清中PFAS广泛存在。与一般暴露地区比较，电子垃圾回收地区新生儿脐带血中部分长链全氟烷酸（PFCA）与新兴PFAS替代物暴露水平更高，而一般暴露地区部分短链PFCA与PFOA支链异构体暴露水平更高。

关键词：全氟与多氟烷基化合物脐带血电子垃圾回收地区暴露水平

Characterizing the Exposome of Food Contamination and China Total Diet Study: Project for Improving Food Safety Risk Assessment in China

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China CDC weekly 2022年第9期4卷 157-160,I0001页

作者： Bing Lyu jingguang li Yongning Wu NHC Key Laboratory of Food Safety Risk Assessment Chinese Academy of Medical Sciences Research Unit(No.2019RU014)China National Center for Food Safety Risk AssessmentBeijingChina

Over the past 30 years,China,as a developing country with a huge population and large geographical heterogeneity,has made a big leap from a shortage of food to basically the elimination of ***,there has been a challenge moving from traditional agriculture and farming practices with numerous small food businesses and short supply chains to larger scale production and longer supply *** an adequate supply of safe,nutritious,high-quality food requires regulatory oversight based on scientific *** the global distribution of human food and ingredients,this is a shared challenge *** only way to steadily improve the food safety situation globally and in China is to follow the risk analysis framework with the joint efforts of all stakeholders(1).Since 2009,the Chinese risk assessment system has been developed in accordance with the Food Safety Law of the People’s Republic of China.

关键词： chains globally farming

Particle-bound PCDD/Fs in the Atmosphere of an Electronic Waste Dismantling Area in China

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Biomedical and Environmental Sciences 2011年第2期24卷 102-111页

作者： WEN Sheng GONG Yan li jingguang SHI TingMing ZHAO YunFeng WU YongNing National Institute for Nutrition and Food Safety Chinese Center for Disease Control and PreventionBeijing 100050 China Hubei Provincial Centre for Disease Control and Prevention Wuhan 430079Hubei China Institute of Agricultural Quality Standards & Testing Technology Hubei Academy ofAgriculture Science Wuhan 430064 Hubei China

Objective Particulate samples from the atmosphere in an electronic waste dismantling area were collected to investigate the levels and sources of polychlorinated dibenzo‐p‐dioxins and dibenzofurans （PCDD/Fs）. Methods Particulate samples including total suspended particulates （TSP） and particulate matter 2.5 μm diameter （PM2.5） were collected on selected non‐rainy days in summer （Jul 10–12, 2006） and winter （Jan 11–13, 2007） from Fengjiang （FJ）, an electronic waste （e‐waste） dismantling area in eastern China, and an adjacent area Luqiao （LQ）. The samples were analyzed by isotope dilution‐high resolution gas chromatography / high resolution mass spectrometry （HRGC/HRMS）. Results In FJ, the mean PCDD/F concentrations （mean TEQ values） were 280.6 pg Nm‐3 （3.432 pg WHO‐TEQ Nm‐3） for the TSP samples and 223.3 pg Nm‐3 （3.180 pg WHO‐TEQ Nm‐3） for the PM2.5 samples. The total PCDD/F concentrations and TEQs in the PM2.5 samples were about 66.8%‐108.0% of the TSP samples, indicating that the fine particles contained higher levels of PCDD/Fs than coarse particles. The PCDD/F levels in FJ were much higher than those detected in common urban areas around the world, suggesting that the study area was heavily polluted by PCDD/Fs. Furthermore, the total average daily PCDD/F intake in FJ was estimated at 62.11 pg WHO‐TEQ kg‐1·day‐1 for adults and 110.11 pg WHO‐TEQ kg‐1·day‐1 for children, which greatly exceeds the WHO （1998） tolerable daily intake of 1–4 pg of WHO‐TEQ kg‐1·day‐1. Conclusion The PCDD/F homologues and congener profiles confirmed that the PCDD/Fs in FJ originated from crude e‐waste recycling activities. The severe dioxin pollution present in FJ has also substantially influenced the adjacent area of LQ through atmospheric transport. Open burning of medical waste was another source of PCDD/Fs identified in LQ.

关键词： PCDD/Fs Particle Source E‐waste

Occurrence of perfluoroalkyl substances in matched human serum,urine,hair and nail

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Journal of Environmental Sciences 2018年第5期30卷 191-197页

作者： Yuxin Wang Yuxin Zhong jingguang li Jianqing Zhang Bing Lyu Yunfeng Zhao Yongning Wu The Key Laboratory of Food Safety Risk Assessment Ministry of HealthChina National Center for Food Safety Risk AssessmentBeijing 100021China Department of Pancreatogastric Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100021China Shenzhen Center for Disease Control and Prevention Shenzhen 518055China

The purpose of this study was to determine perfluoroalkyl substances（PFASs） in human serum, urine, hair and nail from general populations, and to investigate the possibility for human urine, hair and nail used as the biomonitoring sample for PFASs exposure. We detected the concentrations of PFHx A, PFOA, PFNA, PFDA, PFUn DA, PFDo A, PFHx S and PFOS in 39 matched human serum, urine, hair and nail samples from Shenzhen in China. The detection frequency and the median level of PFOS were all higher than that of the other PFASs in four matrices. The median concentration of PFOS in serum, urine, hair, and nail were 9.24 ng/mL, 13.96 ng/L, 0.58 ng/g and 0.63 ng/g, respectively. The results of spearman correlation test indicated that nail was an ideal matrix for biomonitoring PFOS rather than human urine and hair in general populations for the non-invasive sampling.

关键词： Perfluoroalkyl substances (PFASs) Human serum Urine Hair and nail

Exposure to Fipronil Insecticide in the Sixth Total Diet Study-China,2016-2019

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China CDC weekly 2022年第9期4卷 185-189,I0009-I0011页

作者： Zhibin liu Dawei Chen Bing Lyu jingguang li Yunfeng Zhao Yongning Wu NHC Key Laboratory of Food Safety Risk Assessment Chinese Academy of Medical Science Research Unit(No.2019RU014)China National Center for Food Safety Risk AssessmentBeijingChina Nanchang Key Laboratory of Detection and Control of Food Safety Nanchang Inspection and Testing CenterNanchangJiangxi ProvinceChina

Summary What is already known about this topic?Fipronil is classified as a“possible human carcinogen”by the United States Environmental Protection ***-term exposure to fipronil may cause damage to liver,thyroid,and ***,fipronil and its metabolites are ubiquitous in the environment and *** is added by this report?The dietary intake of fipronil in China was within acceptable levels with low health *** were the main dietary intake contributor of fipronil for Chinese adult populations(55.3%),followed by vegetables(30.7%),meats(5.90%),cereals(5.30%),and other food categories contributed less than 2%.What are the implications for public health practice?The study results will help health managers understand the health risk of fipronil,and help to better formulate monitoring plans in *** is still necessary to strengthen the monitoring of fipronil in foods,especially animal-derived foods.

关键词： cereal intake nil