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Big Data Analytics in Healthcare: Data-Driven Methods for Typical Treatment Pattern Mining

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Journal of Systems Science and Systems Engineering 2019年第6期28卷 694-714页

作者： Chonghui Guo jingfeng chen Institute of Systems Engineering Dalian University of TechnologyDalian 116024China

A huge volume of digitized clinical data is generated and accumulated rapidly since the widespread adoption of Electronic Medical Records (EMRs).These big data in healthcare hold the promise of propelling healthcare evolving from a proficiency-based art to a data-driven science,from a reactive mode to a proactive mode,from one-size-fits-all medicine to personalized *** paper first discusses the research background-big data analytics in healthcare,the research framework of big data analytics in healthcare,analysis of medical process,and the literature summary of treatment pattern *** the challenges for data-driven typical treatment pattern mining are highlighted,including similarity measure between treatment records,typical treatment pattern extraction,evaluation and recommendation,when considering the rich temporal and heterogeneous medical information in ***,three categories of typical treatment patterns are mined from doctor order content,duration,and sequence view respectively,which can provide a data-driven guideline to achieve the "5R" goal for rational drug use and clinical pathways.

关键词： Big data analytics healthcare electronic medical records typical treatment pattern

Mining Typical Treatment Duration Patterns for Rational Drug Use from Electronic Medical Records

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Journal of Systems Science and Systems Engineering 2019年第5期28卷 602-620页

作者： jingfeng chen Chonghui Guo Leilei Sun Menglin Lu Institute of Systems Engineering Dalian University of Technology Dalian 116024 China SKLSDE and BDBC Lab Beihang University Beijing 100083 China

Rational drug use requires that patients receive medications for an adequate period of *** adequate duration time of medications not only improve the therapeutic effect of medicines,but also reduce the side effects and adverse reactions of *** paper proposes a data-driven method to mine typical treatment duration patterns for rational drug use from electronic medical records (EMRs).Firstly,a quintuple is defined to describe drug use duration statistics (DUDS) for each drug and treatment record is further represented with DUDS vector (DUDSV).Next a similarity measure method is adopted to compute the similarity between treatment ***,a clustering algorithm is used to cluster all patient treatment records to extract typical treatment duration patterns including typical drug sets,effective drug use day sets,and the DUDSs of each typical *** the extracted typical treatment duration patterns are evaluated and annotated based on patients' demographic information,disease severity scores,treatment outcome and diagnostic ***,a real-world EMR dataset is performed to indicate that the approach we proposed can effectively mine typical treatment duration patterns from EMRs and recommend the appropriate treatment regimens for patients based on their admission information.

关键词： EMR data mining rational drug use typical treatment duration pattern similarity measure clustering

Potential effect of sedimentary iron-phosphorus accumulation on frequent algal bloom in the Pearl River Estuary

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Science China Earth Sciences 2007年第3期50卷 453-461页

作者： WENG HuanXin SUN XiangWei chen jingfeng chen JianFang chen LiHong chen XiangHua QIN YaChao Institute of Environment&Biogeochemistry Zhejiang UniversityHangzhou 310027China Second Institute of Oceanography State Oceanic AdministrationHangzhou 310027China

Based on laboratory culture of harmful alga on iron and phosphorus uptake, and the study of accu-mulation of iron-phosphorus in cores and release of iron and phosphorus from surficial sediments collected in the Pearl River Estuary, the reasons of the high frequency of phytoplankton bloom therein are discussed. The results show that Fe starvation can make algal growth rate slow down and the peak of cell number decrease. Fe and P contents in algal cell bear a significant correlation and the molar ratio of P:Fe is ~356:1, suggesting that algal uptake of Fe and P is synergistic. Total Fe and total P in sediments are positively correlated and Fe-P is the main species of inorganic sedimentary P. Through continuous leaching with agitation, 34.26%―80.21% of exchangeable P and 4.04%―22.52% of ex-changeable Fe are released from surficial sediments, implying that the accumulation of Fe-P in sedi-ments is available for providing nutrients (P and essential Fe) for the demand of phytoplankton bloom. These factors might be responsible for a higher frequency of red tides than other marine regions.

关键词： sedimentary Fe-P iron limitation harmful algal bloom Pearl River Estuary

Sex But Not Altitude, Modulates Phenotypic Covariations Between Growth and Physiological Traits in Adult Asiatic Toads

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Asian Herpetological Research 2022年第1期13卷 34-42页

作者： Ping LI Song TAN Zhongyi YAO Gaohui LIU Jinzhong FU jingfeng chen CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan ProvinceChengdu Institute of BiologyChinese Academy of SciencesChengdu 610041SichuanChina University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education College of Life SciencesSichuan UniversityChengdu 610065SichuanChina Chinese Research Academy of Environmental Sciences Beijing 100012China Department of Integrative Biology University of GuelphGuelph N1G 2W1Canada

The pace-of-life syndrome(POLS) hypothesis predicts that most variation in life history, physiology,and behavior among individuals, popula tions, and species falls along a continuum from slow to fast pace of life. While there is evidence for climatic gradientmediated POLS patterns among species, this approach has rarely been explicitly used to study POLS patterns among-and within-populations. In addition, the roles of sex in POLS evolution among-or within-populations are largely unknown. In this study, we investigated the effects of altitudinal gradient and sex on the covariations between growth rate and several physiological traits closely associated with POLS(blood glucose, baselineand stress-induced glucocorticoids(GCs), hemolysis and hemagglutination) in the Asiatic toad Bufo *** to our expectation, altitudinal gradient had no influence on the covariations between growth rate and physiological traits, neither at the among-nor withinpopulation level, indicating that these trait integrations have similar fitness payoffs across hierarchical *** contrast, we found evidence for sex-specific POLS composition: there was a negative covariance structure between growth rate and baseline GCs-but only in females, and a positive covariance structure between growth rate and baseline GCs-but only in females, and a positive covariance structure between growth rate and hemagglutination-but only in males. This observation indicates that these trait associations differ dramatically in advancing fitness for each sex, and supports the idea that sex-specific POLS composition could evolve in species in which the reproductive roles largely differ between the sexes.

关键词： Bufo gargarizans constraint glucocorticoids immunity metabolism phenotypic integration physiological pace-of-life syndrome

Direction Finding with Cyclostationarity Analysis Against Frequency Interference

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Journal of Communications and Information Networks 2022年第1期7卷 88-95页

作者： Han Liu jingfeng chen Ziheng Ding Gang Ni Chong He Ronghong Jin Department of Electronic Engineering Shanghai Jiao Tong UniversityShanghai 200240China

In this paper, a novel anti-interference direction finding(DF)method for amplitude comparison method based on cyclostationarity is proposed. With the periodic properties of the communication signals, the desired signal’s amplitude value can be effectively obtained even though there is an interference signal whose frequency spectrum overlaps with the desired signal in the environment,and the corresponding incident angle can be estimated accurately with the amplitude comparison method. The influence of interference signal on the amplitude comparison method is discussed and the proposed method’s theoretical feasibility is also analyzed. Compared with the conventional method,simulations are provided to demonstrate the anti-interference capability of the proposed method. The amplitude comparison DF system working at 2.44 GHz and 5.8 GHz is also constructed to verify its feasibility.

关键词： cyclostationarity cyclic autocorrelation function(CAF) amplitude comparison method direction finding(DF)

Effects of Dietary Protein Variations at Different Life-stages on Vocal Dominance of the African Clawed Frogs

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Asian Herpetological Research 2020年第3期11卷 249-256页

作者： Yan CAO Jiangyan SHEN Xiaocui WANG Song TAN Ping LI Jianghong RAN Yezhong TANG jingfeng chen Thematic Area of Biodiversity and Ecosystem Services Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041SichuanChina Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education College of Life SciencesSichuan UniversityChengdu 610041SichuanChina University of the Chinese Academy of Sciences Beijing 100049China

How nutritional conditions during early development affect an organism’s phenotype at adulthood is still poorly understood despite a plethora of research on developmental ***"environmental matching"hypothesis predicts that individuals will have high fitness providing that their adult environment"matches"what they experienced during *** contrast,the"silver spoon"hypothesis predicts that individuals who obtain better developmental resources will be generally *** we tested these two hypotheses and examined the underlying hormonal mechanisms by manipulating the early dietary protein content of African clawed frogs(Xenopus laevis)for a year with a 2×2 factorial experimental *** found that only a lowprotein food during development enhanced the vocal competition ability of male ***,and that vocal dominance was associated with higher cortisol levels but not related with testosterone *** results were not congruent with the"environmental matching"hypothesis or with the"silver spoon"hypothesis,suggesting the behavioral plasticity during development is more complex than our expectation in amphibians.

关键词： aggression developmental effects environmentalmatching silver spoon social status vocal competition Xenopus laevis

Disturbance Attenuation State-Feedback Control for Uncertain Interconnected Systems

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Journal of Systems Engineering and Electronics 2002年第4期13卷 66-72页

作者： chen Qi, Bai jingfeng & chen Yazhu Biomedical Instrument Institute, Shanghai Jiaotong University, Shanghai 200030, P. R. China Biomedical Instrument Institute Shanghai Jiaotong University Shanghai 200030 P. R. China

This paper studies the problem of robust H∞ control design for a class of uncertain interconnected systems via state feedback. This class of systems are described by a state space model, which contains unknown nonlinear interaction and time-varying norm-bounded parametric uncertainties in state equation. Using the Riccati-equation-based approach we design state feedback control laws, which guarantee the decentralized stability with disturbance attenuation for the interconnected uncertain systems. A simple example of an interconnected uncertain linear system is presented to illustrate the results.

关键词： Interconnected system State feedback Internal stability H~∞ control.

Time-Modulated Arrays:A Four-Dimensional Antenna Array Controlled by Switches

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Journal of Communications and Information Networks 2018年第1期3卷 1-14页

作者： Chong He Lele Wang jingfeng chen Ronghong Jin Department of Electronic Engineering Shanghai Jiao Tong UniversityShanghai 200240China

With the rapid development of modern electronic technologies,antenna arrays typically operate in very complex electromagnetic ***,owing to the various errors such as systematic errors and random errors,conventional antenna arrays have relatively high *** modulated arrays(TMAs),also known as four-dimensional(4-D)antenna arrays,introduce time as an additional dimension for generating ultra-low sidelobes at fundamental component and realizing real-time beam scanning by harmonic ***,the harmonic components can also be developed for various new applications including wireless communications and radar *** this review,we introduce comprehensively the fundamental methodologies and recent applications of *** aims to stimulate continuing efforts for the understanding of TMAs and explore their applications in various *** methods mentioned in this review include three aspects:sideband radiation suppression,power efficiency of TMAs,and applications of harmonic *** methods either improve the existing TMAs or promote the practical applications of ***,to suppress the sideband radiation,a method using non-uniform periodical modulation is *** proposed method has an advantage of low computation and can be easily used for synthesizing a real-time radiation pattern according to the environmental ***,a TMA structure using reconfigurable power dividers/combiner is introduced to improve the power efficiency of feeding ***,three applications of harmonic component including direction finding,calibration method,and space division multiple access are separately introduced to illustrate the development potential of TMAs.

关键词： TMAs sideband radiation suppression reconfigurable power dividers/combiner direction finding calibration method space division multiple access

基于多生物学途径虚拟筛选人参皂苷Rg3治疗黑色素瘤的蛋白靶点

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河南中医 2025年第2期45卷 263-271页

作者：陈靖峰张诗琪黄雨杭唐乾王立皓曹洪玉郑学仿大连大学辽宁大连116622

目的:采用多种生物信息学方法探讨人参皂苷Rg3治疗黑色素瘤的作用机制。方法:利用Genecards、在线人类孟德尔遗传数据库(Online Mendelian Inheritance in Man, OMIM)和治疗靶标数据库(Therapeutic Target Database, TTD)筛选黑色素瘤... 详细信息

目的:采用多种生物信息学方法探讨人参皂苷Rg3治疗黑色素瘤的作用机制。方法:利用Genecards、在线人类孟德尔遗传数据库(Online Mendelian Inheritance in Man, OMIM)和治疗靶标数据库(Therapeutic Target Database, TTD)筛选黑色素瘤相关靶点。将靶点导入String数据库构建蛋白质互作(protein-protein interaction, PPI)网络,采用R语言igraph包拓扑分析后采用Cytoscape进行网络可视化。采用Discovery studio 2022(DS)分析靶蛋白的结合位点后进行Autodock Vina刚性和LibDock半柔性分子对接筛选人参皂苷Rg3治疗黑色素瘤的关键靶点。使用R语言对筛选出的关键靶点进行基因本体(Gene Ontology, GO)富集分析和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes, KEGG)信号通路富集分析。采用分子动力学模拟方法探讨靶点蛋白-人参皂苷Rg3相互作用机制。结果:基于GeneCards、OMIM及TTD数据库筛选确定了341个疾病靶点。PPI网络拓扑分析鉴定出115个核心靶点。通过刚性和半柔性分子对接筛选出DNA甲基转移酶3A(DNA methyltransferases 3A,DNMT3A)、趋化因子CC亚家族受体2(CC subfamily receptor 2,CCR2)和趋化因子CXC亚家族受体4(CXC subfamily receptor 4,CXCR4)等19个关键靶蛋白与Rg3具有良好的结合亲和力。KEGG和GO富集分析表明CCR2、CXCR4、DNMT3A等蛋白参与机体的多种生物学功能和途径。分子动力学模拟分析证实了CCR2-Rg3、DNMT3A-Rg3与CXCR4-Rg3的稳定性。结论:DNMT3A、CCR2等为黑色素瘤治疗中人参皂苷Rg3的关键高选择性和高稳定性靶蛋白,人参皂苷Rg3可通过抗感染、调节免疫、影响细胞衰老等发挥抗黑色素瘤的作用,为进一步研究人参皂苷Rg3抗黑色素瘤的应用提供理论支持。

关键词：人参皂苷Rg3 黑色素瘤网络药理学分子对接分子动力学模拟