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Control of temperature dependent viscosity for manufacturing of Bi-doped active fiber

International Journal of Extreme Manufacturing 2024年第3期6卷 522-530页

作者： Rui Duan jingfei chen Hao Ke Tianxia Wei Ke Zhang Xueliang Li Xu Feng Qiuju Zheng Zhixue He Jianrong Qiu Shifeng Zhou State Key Laboratory of Luminescent Materials and Devices School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640People’s Republic of China Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques Guangdong Engineering Technology Research and Development Center of Special Optical Fiber Materials and DevicesGuangzhou 510640People’s Republic of China School of Materials Science and Engineering Qilu University of TechnologyJinanPeople’s Republic of China Peng cheng Laboratory Shenzhen 518000People’s Republic of China College of Optical Science and Engineering State Key Laboratory of Modern Optical InstrumentationZhejiang UniversityHangzhou 310027People’s Republic of China

Bi-activated photonic materials are promising for various applications in high-capacity telecommunication,tunable laser,and advanced bioimaging and *** various Bi-doped material candidates have been explored,manufacturing of Bi heavily doped fiber with excellent optical activity remains a long-standing ***,a novel viscosity evolutional behavior mediated strategy for manufacturing of Bi-doped active fiber with high dopant solubility is *** intrinsic relation among the evolution of Bi,reaction temperature and viscosity of the glass system is ***,the effective avenue to prevent the undesired deactivation of Bi during fiber drawing by tuning the temperature dependent viscosity evolution is *** applying the strategy,for the first time we demonstrate the success in fabrication of heavily doped Bi active ***,the principal fiber amplifier device is constructed and broadband optical signal amplification is *** findings indicate the effectiveness of the proposed temperature dependent viscosity mediated strategy for developing novel photonic active fiber,and they also demonstrate the great potential for application in the next-generation high-capacity telecommunication system.

关键词： infrared luminescence active fiber optical amplification

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Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model

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Neuroscience Bulletin 2024年第8期40卷 1037-1052页

作者： chenrui Yin Kefei Luo Xinyue Zhu Ronghang Zheng Yu Wang Guangdan Yu Xiaorui Wang Fei She Xiaoying chen Tao Li jingfei chen Baduojie Bian Yixun Su Jianqin Niu Yuxin Wang Department of Histology and Embryology Third Military Medical UniversityChongqing 400038China Department of Respiratory Diseases Central Medical Branch of PLA General HospitalBeijing 100853China China Astronaut Research and Training Center Beijing 100094China Department of Emergency the Fourth Medical Center of the Chinese PLA General HospitalBeijing 100142China Army 953 Hospital Shigatse Branch of Xinqiao HospitalThird Military Medical University(Army Medical University)Shigatse 857000China Research Centre Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China

Posttraumatic stress disorder(PTSD)is a complex mental disorder notable for traumatic experience *** current first-line treatments are linked with clinically important symptom reduction,a large proportion of patients retained to experience considerable residual symptoms,indicating pathogenic mechanism should be illustrated *** studies reported that newly formed myelin could shape neural circuit function and be implicated in fear memory ***,its role in PTSD remains to be *** this study,we adopted a restraint stress-induced PTSD mouse model and found that PTSD-related neuropsychiatric symptoms were accompanied by increased myelination in the posterior parietal cortex and ***,but not risperidone or sertraline,has a more profound rescue effect on neuropsychological behaviors and myelin *** mechanistic experiments revealed that fluoxetine could directly interfere with oligodendroglial differentiation by upregulating Wnt *** data demonstrated the correlation between PTSD and abnormal myelination,suggesting that the oligodendroglial lineage could be a target for PTSD treatment.

关键词： PTSD Fear memory Myelination Oligodendroglial differentiation Fluoxetine Wnt signaling

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单向双车道立交匝道路面加宽理论计算及仿真分析

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广东交通职业技术学院学报 2024年第4期23卷 1-7页

作者：殷宇翔陈竞飞广东省交通规划设计研究院集团股份有限公司广东广州510440

为确定不同条件下单向双车道立交匝道的加宽值,本文对比分析了中国、日本及美国规范中关于加宽值的计算思路,提出较为合理的单向双车道匝道加宽计算方法,并分析设计速度和曲线半径对加宽值的影响,对立交细则中Ⅱ型匝道加宽值进行了修正... 详细信息

为确定不同条件下单向双车道立交匝道的加宽值,本文对比分析了中国、日本及美国规范中关于加宽值的计算思路,提出较为合理的单向双车道匝道加宽计算方法,并分析设计速度和曲线半径对加宽值的影响,对立交细则中Ⅱ型匝道加宽值进行了修正,使用仿真软件Vissim分析不同交通环境下行车道宽度对通行情况的影响,最后结合工程实践,详细介绍了加宽计算方法,可为单向双车道立交匝道路面加宽提供参考。

关键词：道路工程立交匝道加宽值通行条件 Vissim仿真

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Structure-guided manipulation of the regioselectivity of the cyclosporine A hydroxylase CYP-sb21 from Sebekia benihana

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Synthetic and Systems Biotechnology 2020年第3期5卷 236-243页

作者： Fengwei Li Li Ma Xingwang Zhang jingfei chen Feifei Qi Yinyue Huang Zepeng Qu Lishan Yao Wei Zhang Eung-Soo Kim Shengying Li State Key Laboratory of Microbial Technology Shandong UniversityQingdaoShandong266237China Shandong Provincial Key Laboratory of Synthetic Biology CAS Key Laboratory of BiofuelsQingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdaoShandong266101China Department of Biological Engineering Inha UniversityIncheon22212South Korea Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong266237China

The cytochrome P450 enzyme CYP-sb21 from the rare actinomycete Sebekia benihana is capable of hydroxylating the immunosuppressive drug molecule cyclosporine A(CsA)primarily at the 4th N-methyl leucine(MeLeu4),giving rise toγ-hydroxy-N-methyl-L-Leu4-CsA(CsA-4-OH).This oxidative modification of CsA leads to dramatically reduced immunosuppressive activity while retaining the hair growth-promoting side-effect,thus demonstrating great application potential in both pharmaceutical and cosmetic ***,this P450 enzyme also hydroxylates CsA at the unwanted position of the 9th N-methyl leucine(MeLeu9),indicating that the regioselectivity needs to be improved for the development of CsA-4-OH into a commercial hair growth ***,we report the crystal structure of CYP-sb21 in its substrate-free form at 1.85Å.Together with sequence and 3D structure comparisons,Autodock-based substrate docking,molecular dynamics(MD)simulation,and site-directed mutagenesis,we identified a number of key residues including R294,E264,and M179 that can improve catalytic efficiency or change the regioselectivity of CYP-sb21 towards CsA,setting the stage for better enzymatic preparation of *** study also provides new insights into the substrate recognition and binding mechanism of P450 enzymes that accommodate bulky substrates.

关键词： Cytochrome P450 monooxygenase Crystal structure Cyclosporine A Regioselectivity Hair growth stimulator

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家具产业运营效率与国民经济产业结构耦合协调研究

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经济地理 2022年第7期42卷 159-166页

作者：陈竞飞田刚东北林业大学经济管理学院中国黑龙江哈尔滨150040 东北石油大学人文科学学院中国黑龙江大庆163316

基于家具产业运营效率与产业结构的耦合机制,分别构建家具产业运营效率与产业结构评价指标体系,运用SBM模型和熵值法分别对2008、2013和2018年我国30个省域家具产业运营效率和产业结构综合指数进行测算,利用耦合协调度模型及相对发展度... 详细信息

基于家具产业运营效率与产业结构的耦合机制,分别构建家具产业运营效率与产业结构评价指标体系,运用SBM模型和熵值法分别对2008、2013和2018年我国30个省域家具产业运营效率和产业结构综合指数进行测算,利用耦合协调度模型及相对发展度模型,探究家具产业运营效率与产业结构的耦合协调发展关系。结果表明:研究期内中国家具产业运营效率与产业结构的耦合协调发展总体上处于磨合阶段,家具产业运营效率超前于产业结构。家具产业运营效率与产业结构的耦合协调发展阶段呈“两头窄、中间宽”的梭形态势;家具产业运营效率与产业结构的相对发展状态呈“两头宽、中间窄”态势。家具产业运营效率与产业结构的耦合协调发展过程具有波动性,应注重提升家具产业与产业结构发展质量,促进家具产业与产业结构协调共进。

关键词：家具产业运营效率产业结构耦合协调度相对发展度 SBM模型熵值法

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Accelerating myelin degeneration in Alzheimer's disease mice

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解剖学杂志 2021年第S1期44卷 121-122页

作者： chen jingfei Liu Kun Wang Fei Li Ruixue Xiao Lan Mei Feng Department of Histology and Embryology Army Medical UniversityChongqing 400038

Alzheimer's disease(AD)is the most common cause of dementia,mainly manifested by cognition decline and memory *** research has revealed that myelin plays an important role for memory ***,the myelin dynamics in AD brains remains *** this study,we examined the myelin changes in the APP/PS1 mutant brains by immunostaining and transmission EM,and used the PLP-CreERt;mTomato/mGFP(mT/mG);APP/PS1 line to label and track pre existing myelin at the age of 4 *** results indicated that MBP expression was reduced in the 13-month old APP/PS1AD brains as compared to the age matched wild type brains.

关键词： APP/PS1 myelin Alzheimer

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2型糖尿病患者血浆氧化三甲胺水平与颈动脉粥样硬化的相关性研究

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中国糖尿病杂志 2021年第2期29卷 122-126页

作者：陈静非刘飞宝鸡市中心医院神经内科一科 721000 宝鸡市中心医院综合内科 721000

目的探讨T2DM患者血浆氧化三甲胺(TMAO)水平与颈动脉粥样硬化(CAS)的相关性。方法选取2019年1~12月于宝鸡市中心医院神经内科住院治疗的214例T2DM患者,根据颈动脉超声检查结果分为CAS组和单纯T2DM组,同期健康体检人群80名为正常对照(NC... 详细信息

目的探讨T2DM患者血浆氧化三甲胺(TMAO)水平与颈动脉粥样硬化(CAS)的相关性。方法选取2019年1~12月于宝鸡市中心医院神经内科住院治疗的214例T2DM患者,根据颈动脉超声检查结果分为CAS组和单纯T2DM组,同期健康体检人群80名为正常对照(NC)组。高效液相色谱串联质谱法测定血浆TMAO浓度。结果 CAS、T2DM组血浆TMAO高于NC组,且CAS组高于T2DM组[4.70(3.79,5.80)vs 3.02(2.53,3.41)vs 2.24(1.78,2.54),P<0.001)]。Spearman相关性分析显示,T2DM患者血浆TMAO水平与CIMT、DM病程、FPG、HbA1c和TC呈正相关(P<0.05)。二元Logisitic回归分析结果显示,血浆TMAO水平升高是T2DM患者合并CAS的独立危险因素(OR 3.283,95%CI 1.974,5.461,P<0.001)。受试者工作特征曲线显示,血浆TMAO预测T2DM患者合并CAS的曲线下面积为0.866(0.819,0.914),临界值为3.635μmol/L时,灵敏度和特异度为80.3%、82.3%。结论 T2DM患者血浆TMAO水平与CAS密切相关。

关键词：糖尿病,2型颈动脉粥样硬化氧化三甲胺

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Myelin degeneration and diminished myelin renewal contribute to age-related memory deficits

Myelin degeneration and diminished myelin renewal contribute...

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中国解剖学会2021年年会

作者： Wang Fei Ren Shuyu chen jingfei Lin Kun Xiao Lan Mei Feng Department of Histology and Embryology Basic Medical CollegeChong Qing CollegeArmy Medical UniversityKey Lab of Brain-inspired Intelligence

Age-related decline in cognition represents a major unaddressed health problem for the *** remodeling persists throughout the lifespan,but little is known about the longitudinal dynamics and functional significance during *** characterize myelin dynamics during aging,we examined pre-existing and newly formed myelin in mature adult (4-6 months), middle-aged (10-14 months) and old (18-22 months) mice by lineage tracing and histology.

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Accelerating myelin degeneration in Alzheimer's disease mice

Accelerating myelin degeneration in Alzheimer's disease mice

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中国解剖学会2021年年会

作者： chen jingfei Liu Kun Wang Fei Li Ruixue Xiao Lan Mei Feng Department of Histology and Embryology Army Medical University

Alzheimer’s disease (AD) is the most common cause of dementia,mainly manifested by cognition decline and memory *** research has revealed that myelin plays an important role for memory ***, the myelin dynamics in AD brains remains *** this study,we examined the myelin changes in the APP/PS1 mutant brains by immunostaining and transmission EM,and used the PLP-CreERt

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基于CiteSpace的全球炭疽研究演化及其热点可视化分析

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微生物学报 2020年第10期60卷 2161-2171页

作者：陈静飞王怀璋梁婷中国人民解放军陆军防化学院北京102205 中国人民解放军32169部队西藏林芝860000

最新研究估算全球约有18.3亿人生活在炭疽风险区域内。经过几十年的发展,全球炭疽研究成果数量丰硕且总量在增长。【目的】对全球炭疽研究文献进行探析,以获取其研究领域演化趋势及热点变化。【方法】基于WOS来源文献,运用科学计量方法,... 详细信息

最新研究估算全球约有18.3亿人生活在炭疽风险区域内。经过几十年的发展,全球炭疽研究成果数量丰硕且总量在增长。【目的】对全球炭疽研究文献进行探析,以获取其研究领域演化趋势及热点变化。【方法】基于WOS来源文献,运用科学计量方法,对1998–2018年全球炭疽研究进行可视化分析,综合运用CiteSpace可视化分析软件中文献共被引、文献突现、关键词共现等工具,探析全球炭疽研究领域演化趋势及其热点变化。【结果】全球炭疽研究可分为1998–2004年"多维暴发"、2005–2013年"持续探索"和2014–2018年"新兴热点"3个研究阶段。【结论】炭疽快速实时痕量检测和新型炭疽疫苗有可能成为未来全球炭疽研究热点。

关键词：炭疽可视化分析研究综述 CiteSpace WOS数据库

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