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Preventing non-alcoholic fatty liver disease through Lactobacillus johnsonii BS15 by attenuating inflammation and mitochondrial injury and improving gut environment in obese mice

Preventing non-alcoholic fatty liver disease through Lactoba...

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中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会

作者： jinge xin Dong Zeng Hesong Wang Xueqin Ni Dan Yi Kangcheng Pan Bo Jing Animal Microecology Institute College of Veterinary MedicineSichuan Agricultural University Key Laboratory of Animal Disease and Human Health of Sichuan Province

The increasing prevalence of obesity worldwide is associated with a parallel increase in non-alcoholic fatty liver disease(NAFLD).To investigate the effect of Lactobacillus johnsonii BS 15 on NAFLD,120 male ICR mice were randomly divided into four groups and administrated with BS 15(2×10 cfu/0.2 mL or 2×10 cfu/0.2 mL)or phosphate buffered saline(PBS) throughout a 17-week experimental *** mice were fed with normal chow diet(NCD) five weeks before the experimental ***,with the exception of the PBS group,NCD was changed into high-fat diet(HFD) for the remaining experimental *** showed that BS15-treated HFD mice were protected from hepatic steatosis and hepatocyte ***15 exhibited a positive effect on liver lipid peroxidation through an anti-oxidative stress activity by enhancing the liver antioxidant defense *** addition,BS15 inhibited the insulin resistance;decreased the mRNA levels of acetyl-CoA carboxylase 1,fatty acid synthase,and peroxisome proliferator-activated receptor y;and increased the expression of the fasting-induced adipose factor in ***,BS 15 attenuated mitochondria abnormalities when the content of uncoupling protein-2 decreased and cytochrome c increased in NAFLD *** 15 also reduced the level of serum lipopolysaccharide in NAFLD mice by lowering the intestinal permeability and adjusting gut flora,followed by the downregulation of the TNFα mRNA level in liver and the serum level of C-reactive *** findings suggest that BS15 may be effective in preventing NAFLD induced by HFD.

关键词： Lactobacillus johnsonii non-alcoholic fatty liver disease intestinal permeability hepatocyte apoptosis hepatic inflammation oxidative stress

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The Prevention of non-alcoholic fatty liver disease in obese mice through Lactobacillus johnsonii BS15 by attenuating inflammation and mitochondrial injury and improving gut environment

The Prevention of non-alcoholic fatty liver disease in obese...

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中国畜牧兽医学会动物微生态学分会第十一次全国学术研讨会暨第五届会员代表大会

作者： Hesong Wang Dong-Zeng jinge xin Xueqin Ni Dan Yi Kangcheng Pan Bo Jing Animal Microecology Institute College of Veterinary MedicineSichuan Agricultural University Key Laboratory of Animal Disease and Human Health of Sichuan Province

The increasing prevalence of obesity worldwide is associated with a parallel increase in non-alcoholic fatty liver disease(NAFLD).To investigate the effect of Lactobacillus johnsonii BS15 on NAFLD.120 male 1CR mice were randomly divided into four groups and administrated with BS15(2×10 cfu/ 0.2 mL·or 2×10 cfu/ 0.2 mL) or phosphate buffered saline(PBS) throughout a 17-week experimental *** mice were fed with normal chow diet(NCD) five weeks before the experimental ***,with the exception of the PBS *** was changed into high-fat diet(HFD) for the remaining experimental *** showed that BS15-treated HFD mice were protected from hepatic steatosis and hepatocyte ***15 exhibited a positive effect on liver lipid peroxidation through an anti-oxidative stress activity by enhancing the liver antioxidant defense *** addition,BS15 inhibited the insulin resistance;decreased the mRNA levels of acetyl-CoA carboxylase 1,fatty acid synthase,and peroxisome proliferator-activated receptor γ;and increased the expression of the fasting-induced adipose factor in ***,BS15 attenuated mitochondria abnormalities when the content of uncoupling protein-2 decreased and cytochrome c increased in NAFLD ***15 also reduced the level of serum lipopolysaccharide in NAFLD mice by lowering the intestinal permeability and adjusting gut flora,followed by the downregulation of the TNFα mRNA level in liver and the serum level of C-reactive *** findings suggest that BS15 may be effective in preventing NAFLD induced by HFD.

关键词： Lactobacillus johnsonii non-alcoholic fatty liver disease intestinal permeability hepatocyte apoptosis hepatic inflammation oxidative stress

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Probiotic Lactobacillus johnsonii BS15 Prevents Memory Dysfunction Induced by Chronic High-Fluorine Intake through Modulating Intestinal Environment and Improving Gut Development

Probiotic Lactobacillus johnsonii BS15 Prevents Memory Dysfu...

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农场动物健康舒适养殖、生物安全与疫病防控全国研讨会暨中国畜牧兽医学会动物福利与健康养殖分会第四次学术研讨会

作者： Ning Sun Xueqin Ni Hesong Wang jinge xin Ying Zhao Kangcheng Pan Bo Jing Dong Zeng Animal Microecology Institute College of Veterinary MedicineSichuan Agricultural University Department of Gastroenterology Nanfang HospitalSouthern Medical University

In recent years,the influence of chronic fluorosis on the brain has been widely *** study aimed to demonstrate the potential mechanism underlying the impairment of memory function by excessive fluorine *** also evaluated whether improvement of intestinal microflora could be a potential therapy to prevent the negative influences from the perspective of gut-brain *** ICR mice were randomly divided into three groups and administered with either phosphate buffered saline(PBS)(Control and F groups)or Lactobacillus johnsonii BS15(FP group;daily amounts of 1×10 CFU/mL),a probiotic strain,by oral gavage throughout a 98-day experimental *** fluoride(100 mg/L) was added to the drinking water of the F and FP *** were sacrificed for sampling with or without water avoidance stress(WAS) at two phases of the experiment and behavioral tests including T-maze test and passive avoidance test were also *** on the results of behavioral tests,probiotic reversed the fluorineinduced memory *** addition,*** BS15 also increased the antioxidant capacities(serum and hippocampal tissue)and hippocampal synaptic plasticity-related mRNA expression after excessive fluoride ***,the increased colonization of *** BS15 also protected the small intestines from the damages of growth performance,visceral indexes,intestinal development digestive,and secretory functions by changing the structure of the microflora and then improving intestinal permeability and *** BS15 also improved the ability of flourosis mice against psychological stress indicated by the changes in behavioral tasks,hippocampal antioxidant levels,and synaptic plasticity-related mRNA *** johnsonii BS15 intake appears as a promising way to ameliorate fluorine-induced memory dysfunction,especially under psychological stress.

关键词： Fluorosis·Gut-brain axis·Memory impairment·Probiotic·Psychological stress

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Probiotic enhanced intestinal immunity in broilers against subclinical necrotic enteritis

Probiotic enhanced intestinal immunity in broilers against s...

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中国畜牧兽医学会动物微生态学分会第五届第十三次全国学术研讨会

作者： jinge xin Hesong Wang Xueqin Ni Xiaodan Qing Lei Liu Jing Lai Abdul Khalique Guangyao Li Kangcheng Pan Bo Jing Dong Zeng Animal Microecology Institute College of VeterinarySichuan Agricultural University

Along with banning of antibiotics,necrotic enteritis(NE),especially subclinical NE(SNE) whereby no clinical signs are present in chicks,has become one of the most threatening problems in poultry ***,increasing attention has been focused on research and application of effective probiotic strains,as an alternative to antibiotics,to prevent SNE in *** the present study,we evaluated the effects of Lactobacillus johnsonii BS15 on prevention of SNE in ***,assessment determined growth performance and indexes related to intestinal mucosal immunity in the ileum and cecal tonsil of broilers.A total of 300 one-day-old Cobb 500 chicks were randomly distributed into the following five groups:control group(fed with basal diet + de Man,Rogosa,and Sharpe liquid medium[normal diet]),SNE group(normal diet),BS15 group(basal diet + 1 × 10 colony-forming units BS15/g as fed[BS15 diet]),treatment group(normal diet[days 1-28]+ BS15 diet[days 29-42]),and prevention group(BS15 diet[days 1-28]+ normal diet[days 29-42]) throughout a 42-day experimental *** infection was treated for all chicks in the SNE,BS15,treatment,and prevention *** present results demonstrated that BS15 supplementation of feeds in BS15 and prevention groups exerted a positive effect on preventing negative influences on growth performance;these negative influences included low body weight gain and increased feed conversion ratio caused by *** no changes were detected in all determined indexes in cecal tonsils,BS15-treated broilers were free from SNE-caused damage in villi in the ***15 inhibited SNE-caused decrease in immunoglobulins in the *** the lamina propria of ileum,T-cell subsets of lymphocytes influenced by SNE were also controlled by ***15 affected antioxidant abilities of the ileum and controlled SNE-induced mitochondrion-mediated apoptosis by positively changing contents and/or mRNA expression levels of apoptosis-related ***

关键词： Subclinical necrotic enteritis Lactobacillus johnsonii intestinal immunity probiotic broiler

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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang Yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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Recent progress in constructing fluorinated solid-electrolyte interphases for stable lithium metal anodes

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 270-291页

作者： Di Zhang Pengfei Lv Wei Qin xin He Yuanhua He Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of ChinaGuanghan 618307China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium metal batteries(LMBs)are emerging as a promising energy storage solution owing to their high energy density and specific ***,the non-uniform plating of lithium and the potential rupture of the solid-electrolyte interphase(SEI)during extended cycling use may result in dendrite growth,which can penetrate the separator and pose significant short-circuit *** a stable SEI is essential for the long-term operation of the ***-rich SEI has garnered significant attention for its ability to effectively passivate electrodes,regulate lithium deposition,and inhibit electrolyte *** the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode *** paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal *** focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI *** instance,combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the *** metals with LiF significantly improves electrochemical performance at the SEI/anode interface,with a necessary focus on reducing electron tunneling ***,incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity,though maintaining structural stability over long cycles remains a critical area for future *** alloys combined with LiF increase surface energy and lithium affinity,challenges such as dendrite growth and volume expansion *** summary,this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

关键词： LiF lithium metal anodes solid-electrolyte interphase interface cycling stability

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Research status and prospects of the fractal analysis of metal material surfaces and interfaces

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin Dai Xuefeng Liu xin Ma Shaojie Tian Qinghe Cui Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu xin Shao Qinqin Wang xin Dong Bin Duan Feiyang xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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Electronic structure and ultraviolet spectra of p-C_(6)H_(4)-C_(20)

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原子与分子物理学报 2025年第3期42卷 21-28页

作者： CHEN xin School of Materials and Chemical Engineering West Anhui UniversityLu’an 237012China

Geometry optimization of p-C_(6)H_(4)-connected cyclo[20]carbon(p-C_(6)H_(4)-C_(20))was carried out at M062X/6-311G(d,p)level,three kinds of bond orders(Mayer,Laplacian,and Wiberg),electron-hole distributions,localized orbital locators(LOL),and infrared(IR)spectrum were also performed at the same *** on TD-DFT M062X/6-311G(d,p)method,the first 20 excited states and ultraviolet(UV)spectra of p-C_(6)H_(4)-C_(20) were *** results of π-electron delocalization analyses prove thatπ-electron delocalization of p-C_(6)H_(4)-C_(20) is more likely to occur on shorter C-C bonds rather than longer C-C bonds,and inside/outside of the ring plane rather than above/below the ring *** absorption peaks of p-C_(6)H_(4)-C_(20) locate at about 319 nm and 236 nm,respectively.

关键词： p-C_(6)H_(4)-C_(20) Bone orders UV spectrum Electron-hole analyses π-electron delocalization analyses

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Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?

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Nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing Fan Ruimin Li xin Zhang Wanyu Zhao Zhenghui Pan Xiaowei Yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration

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