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Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3176-3241页

作者： Pelin Lu Dongxue Ruan Meiqi Huang Mi Tian Kangshun Zhu Ziqi gan Zecong Xiao Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630PR China Department of Minimally Invasive Interventional Radiology and Laboratory of Interventional RadiologyThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260PR China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120PR China Department of Stomatology Chengdu Second People's HospitalChengdu 610021PR China Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhou 510055PR China

The applications of hydrogels have expanded significantly due to their versatile,highly tunable properties and breakthroughs in biomaterial *** this review,we cover the major achievements and the potential of hydrogels in therapeutic applications,focusing primarily on two areas:emerging cell-based therapies and promising non-cell therapeutic *** the context of cell therapy,we discuss the capacity of hydrogels to overcome the existing translational challenges faced by mainstream cell therapy paradigms,provide a detailed discussion on the advantages and principal design considerations of hydrogels for boosting the efficacy of cell therapy,as well as list specific examples of their applications in different disease *** then explore the potential of hydrogels in drug delivery,physical intervention therapies,and other non-cell therapeutic areas(e.g.,bioadhesives,artificial tissues,and biosensors),emphasizing their utility beyond mere delivery ***,we complement our discussion on the latest progress and challenges in the clinical application of hydrogels and outline future research directions,particularly in terms of integration with advanced biomanufacturing *** review aims to present a comprehensive view and critical insights into the design and selection of hydrogels for both cell therapy and noncell therapies,tailored to meet the therapeutic requirements of diverse diseases and situations.

关键词： directions overcome breakthrough

Direct laser writing on halide perovskites:from mechanisms to applications

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Light(Advanced Manufacturing) 2024年第1期5卷 93-114页

作者： Yuhang Sheng Xiaoming Wen Baohua Jia Zhixing gan Center for Future Optoelectronic Functional Materials School of Computer and Electronic Information/School of Artificial IntelligenceNanjing Normal UniversityNanjing 210023China Centre for Atomaterials and Nanomanufacturing School of ScienceRMIT UniversityMelbourne3000 VictoriaAustralia

Metal halide perovskites have emerged as game-changing semiconductor materials in *** an efficient micro-/nano-manufacturing technology,direct laser writing(DLW)has been extensively used to fabricate patterns,micro/nanostructures,and pixel arrays on perovskites to promote their optoelectronic *** to the unique ionic properties and soft lattices of perovskites,DLW can introduce rich light-matter interactions,including laser ablation,crystallisation,ion migration,phase segregation,photoreaction,and other transitions,which enable diverse functionalities in addition to the intrinsic properties of *** on their patterned structures,perovskites have numerous applications in displays,optical information encryption,solar cells,light-emitting diodes,lasers,photodetectors,and planar lenses,which are comprehensively discussed in this ***,we discuss the challenges that must be addressed for the future development of this fascinating field.

关键词： Direct laser writing Halide perovskites Laser-matter interactions Optoelectronics

Effects of dry-wet cycles on the mechanical properties of sandstone with unloading-induced damage

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Journal of Mountain Science 2024年第10期21卷 3474-3486页

作者： NAN gan ZHANG Jiaming LUO Yi WANG Xinlong HU Zhongyi Faculty of Engineering China University of Geosciences(Wuhan)Wuhan 430074China

Sandstone is the fundamental material in various engineering and construction ***,the mechanical integrity of sandstone can be compromised by initial unloading damage resulting from activities such as engineering ***,this degradation is further exacerbated under periodic dry-wet environmental *** study investigated the effects of dry-wet cycles and unloading on the mechanical properties of jointed fine sandstone using uniaxial and triaxial compression *** tests were performed on rock samples subjected to varying unloading degrees and different numbers of dry-wet *** results demonstrate that with an increase in the unloading degree from 0%to 70%,there is a corresponding decrease in peak stress ranging from 10%to 33%.Additionally,the cohesion exhibits a reduction of approximately 20%to 25%,while the internal friction angle experiences a decline of about 3.5%to 6%.These findings emphasize a significant unloading ***,the degree of peak stress degradation in unloading jointed fine sandstone diminishes with an increase in confining pressure,suggesting that confining pressure mitigates the deterioration caused by dry-wet ***,as the number of dry-wet cycles increases,there is a notable decline in the mechanical properties of the sandstone,evidencing significant dry-wet *** the Drucker Prager criterion,this study establishes a strength criterion and fracture criterion,denoted asσ1(m,n)and,to quantify the combined impacts of dry-wet cycles and unloading on jointed fine sandstone,which provides a comprehensive understanding of its mechanical behavior under such conditions.

关键词： Unloading Dry-wet cycle Jointed fine sandstone Strength criterion fracture criterion Mechanical properties

Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2

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Science China(Life Sciences) 2024年第6期67卷 1305-1307页

作者： Songlin gan Wen-Si Yang Liting Wei Zhiguo Zhang Rui-Ming Xu Key Laboratory of Epigenetic Regulation and Intervention Institute of BiophysicsChinese Academy of SciencesBeijing 100101China School of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Institute for Cancer Genetics Department of Pediatrics and Department of Genetics and DevelopmentColumbia University Irving Medical CenterNew York 10032USA School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Dear Editor,The passage of DNA replication forks during eukaryotic cell division disrupts the nucleosomes they encounter,and de novo assembly of nucleosomes onto replicated DNA must take place to restore chromatin ***... 详细信息

关键词： structure nucleosome passage

Band-like transport in solution-processed perylene diimide dianion films with high Hall mobility

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National Science Review 2024年第5期11卷 264-271页

作者： Yanhua Jia Qinglin Jiang Hanlin gan Bohan Wang Xiandong He Jiadong Zhou Zetong Ma Jiang Zhang Yuguang Ma Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of Technology Department of Physics South China University of Technology

It is crucial to prepare high-mobility organic polycrystalline film through solution ***,the delocalized carrier transport of polycrystalline films in organic semiconductors has rarely been investigated through Hall-effect *** study presents a strategy for building strong intermolecular interactions to fabricate solution-crystallized p-type perylene diimide（PDI） dianion films with a closer intermolecular π-π stacking distance of 3.25 ?.The highly delocalized carriers enable a competitive Hall mobility of 3 cm2V-1s-1,comparable to that of the reported high-mobility organic single *** PDI dianion films exhibit a high electrical conductivity of 17 S cm-1and typical band-like transport,as evidenced by the negative temperature linear coefficient of mobility proportional to T-3/*** work demonstrates that,as the intermolecular π-π interactions become strong enough,they will display high mobility and conductivity,providing a new approach to developing high-mobility organic semiconductor materials.

关键词： band-like transport dianion aggregates Hall mobility solution-processed perylene diimide

Effect of Oxygen-Rich Combustion on Flame Propagation of Syngas in a Half-Open Pipe at Elevated Temperatures

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Journal of Thermal Science 2024年第5期33卷 1920-1934页

作者： LI Ningning DENG Haoxin XU Zhuangzhuang YAN Mengmeng WEI Shengnan SUN Guangzhen WEN Xiaoping gan Haowen WANG Fahui School of Mechanical and Power Engineering Henan Polytechnic UniversityJiaozuo 454003China

The investigation of syngas flame propagation has great benefits for the effective use of gas *** essay sets out to study the flame propagation of premixed oxygen-rich combustion(oxygen enrichment coefficient in volumeΩ:0.21,0.27,0.32,0.37)of syngas(H_(2):CO=2:8)in half-closed rectangular ducts at elevated temperatures(T:300 K,400 K,500 K)and evaluate the effects of initial temperature and oxygen enrichment coefficient on the LBV from sensitivity analysis and kinetic *** paper presents the effect of the expansion effect on laminar burning velocity for the first time,and separates the effect of the expansion effect on laminar burning velocity by a new *** shows that as the initial temperature goes up,the faster the exponential growth phase of the flame front velocity,the slower the slow growth *** smaller and earlier the maximum flame front velocity arrives,the slower the average flame speed *** the oxygen enrichment coefficient goes up,the peak value of the flame front velocity gradually ***-rich combustion and increasing initial temperature inhibit flame propagation in a half-open tube,but promote laminar burning velocity,which increases the key chemical bond and adiabatic flame *** net reaction rate shows that oxygen-rich combustion mainly promotes the combustion reaction of H_(2)(R2).However,increasing the initial temperature mainly promoted the oxidation of CO(R29).Analysis of the reaction path showed that oxygen-rich combustion and increased initial temperature promoted the reaction of H_(2)and CO with key chemical bonds,increased OH concentration,and inhibited OH cracking reaction.

关键词： gas turbines oxyfuel combustion numerical simulation combustion kinetics fire and flame

Photocatalytic oxidation of methane to methanol over zinc titanate supported silver catalysts

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Journal of Rare Earths 2024年第5期42卷 899-906,I0004页

作者： Yuyan gan Jinbi Huang Qian Lv Yanru Li Lizhi Wu YU Tang Yuanxing Fang Pengfei Zhu Li Tan Institute of Molecule Catalysis and In-Situ/Operando Studies State Key Laboratory of Photocatalysis on Energy and EnvironmentCollege of ChemistryFuzhou UniversityFuzhou350108China School of Environmental Science and Engineering Shaanxi University of Science and TechnologyXi'an 70021China

The direct activation of methane under mild condition to achieve highly selective of oxygenates is a challenging *** this study,a well dispersed silver supported ZnTiO_(3) catalyst was prepared to achieve selective preparation of methanol from methane and water under mild condition.X-ray diffraction,transmission electron microscopy and X-ray photoelectron spectroscopy characterizations demonstrate that silver species are uniformly dispersed on ZnTiO_(3) surface in the form of metallic silver *** photoelectric characterizations reveal that the addition of silver species enhances light absorption and promotes charge separation of the *** the reaction conditions of 50℃and 3 MPa,the methanol is obtained as the only liquid product over the designed Ag/ZnTiO_(3) catalyst under light *** this photocatalytic process,the holes generated by ZnTiO_(3) activate water to produce intermediate·OH,which further reacts with methane to synthesize *** silver species as co-catalysts extend the light absorption range of ZnTiO_(3) as well as promote charge separation.

关键词： Photocatalytic Methane oxidation Zinc titanate Silver Methanol

New recessive compound heterozygous variants of RP1L1 in RP1L1 maculopathy

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 107-112页

作者： Wen-Chao Cao Qing-Shan Chen Run gan Tao Huang Xiao-He Yan The Second Clinical Medical College Jinan UniversityShenzhen 518040Guangdong ProvinceChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChin

AIM:To identify a maculopathy patient caused by new recessive compound heterozygous variants in ***:Comprehensive retinal morphological and functional examinations were evaluated for the patient with RP1L1 *** sequence capture array technique was used to screen potential pathologic *** chain reaction and Sanger sequencing were used to confirm the screening ***:Fundus examination showed round macular lesions appeared in both *** coherence tomography showed that the inner segment/outer segment continuity was disorganized and disruptive in the left eye,but it was uneven and slightly elevated in the right *** autofluorescence showed patchy hyper-autofluorescence in the *** field examination indicates central defects in both ***(ERG)and multifocal ERG showed no obvious *** fluorescein angiography in the macula showed obviously irregular hyper-fluorescence in the right eye and slightly hyper-fluorescence in the left *** found that the proband carried a missense variant(c.1972C>T)and a deletion variant(c.4717_4718del)of RP1L1,which were originated from the parents and formed compound heterozygous *** variants are likely pathogenic according to the ACMG *** imaging,ERG and detailed medical history are important diagnostic tools for differentiating between acquired and inherited retinal ***:A maculopathy case with detailed retinal phenotype and new recessive compound heterozygous variants of RP1L1 is identified in a Chinese family,which expands the understanding of phenotype and genotype in RP1L1 maculopathy.

关键词： maculopathy recessive compound heterozygous variants RP1L1

High Density 3D Carbon Tube Nanoarray Electrode Boosting the Capacitance of Filter Capacitor

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Nano-Micro Letters 2024年第11期16卷 242-254页

作者： gan Chen Fangming Han Huachun Ma Pei Li Ziyan Zhou Pengxiang Wang Xiaoyan Li Guowen Meng Bingqing Wei Key Laboratory of Materials Physics and Anhui Key Laboratory of Nanomaterials and NanotechnologyInstitute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031People’s Republic of China Department of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026People’s Republic of China Department of Mechanical Engineering University of DelawareNewarkDE 19716USA Mechano‑X Institute Applied Mechanics LaboratoryDepartment of Engineering MechanicsTsinghua UniversityBeijing 100084People’s Republic of China

Electric double-layer capacitors(EDLCs)with fast frequency response are regarded as small-scale alternatives to the commercial bulky aluminum electrolytic *** carbon-based nanoarray electrodes with precise alignment and smooth ion channels is crucial for enhancing EDLCs’***,controlling the density of macropore-dominated nanoarray electrodes poses challenges in boosting the capacitance of line-filtering ***,a simple technique to finely adjust the vertical-pore diameter and inter-spacing in three-dimensional nanoporous anodic aluminum oxide(3D-AAO)template is achieved,and 3D compactly arranged carbon tube(3D-CACT)nanoarrays are created as electrodes for symmetrical EDLCs using nanoporous 3D-AAO template-assisted chemical vapor deposition of *** 3D-CACT electrodes demonstrate a high surface area of 253.0 m^(2) g^(−1),a D/G band intensity ratio of 0.94,and a C/O atomic ratio of *** a result,the high-density 3D-CT nanoarray-based sandwich-type EDLCs demonstrate a record high specific areal capacitance of 3.23 mF cm^(-2) at 120 Hz and exceptional fast frequency response due to the vertically aligned and highly ordered nanoarray of closely packed CT *** 3D-CT nanoarray electrode-based EDLCs could serve as line filters in integrated circuits,aiding power system miniaturization.

关键词： Compactly arranged Three-dimensional carbon tube nanoarray Dimensional carbon tube nanoarray Fast frequency response Electric double-layer capacitors Layer capacitors AC line-filtering Filtering