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pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging

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Chinese Journal of Polymer Science 2024年第1期42卷 7-13,I0005页

作者： jing-Yuan Xiang Wen-Long Zhang he-Ting Li Ya-Ning he Department of Chemical Engineering Key Laboratory of Advanced Materials(MOE)Tsinghua UniversityBejing 100084China

This work reported an AIE fluorescent probe for tumor imaging based on the p H induced self-assembly strategy. The fluorescent probe was composed of an acid-responsive soluble copolymer PEG-b-PAMA-DMMA with a maleic acid amide group and an anionic soluble aggregation-induced emission fluorogen(AIEgen) TPE-2SO_(3)^(-). The polymer could be transformed into a protonated amine-containing polymer after the hydrolysis of maleic acid amide in acidic tumor microenvironment, which would be further self-assembled with TPE-2SO_(3)^(-)to form aggregated nanoparticles. The transition of TPE-2SO_(3)^(-)from dispersed state to aggregated state led to an obvious increase in fluorescence intensity due to its AIE characteristics.

关键词： p H-responsive Self-assembly Fluorescent probe AIE Tumor imaging

Chemotherapy induces breast cancer stem cell enrichment through repression of glutathione S-transferase Mu

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Genes & Diseases 2024年第2期11卷 528-531页

作者： jing.he Yiran Yu Yilin he Jie he Guangyu Ji Haiquan Lu The Second Hospital and Advanced Medical Research Institute Cheeloo College of MedicineShandong UniversityJinanShandong 250012China Department of Nursing The First Affiliated Hospital of Shandong First Medical UniversityJinanShandong 250014China School of Medicine Xinjiang Medical UniversityUrumqiXinjiang 830054China School of Medicine Binzhou Medical UniversityYantaiShandong 264003China Oncology Department Jinan Zhangqiu District People's HospitalJinanShandong 250200China Key Laboratory for Experimental Teratology of the Ministry of Education Cheeloo College of MedicineShandong UniversityJinanShandong 250012China Center for Reproductive Medicine Shandong UniversityJinanShandong 250012China

Triple-negative breast cancer(TNBC)has aggressive characteristics as exemplified by the high risk of recurrence,metastasis,and patient mortality.1 Cytotoxic chemotherapy may reduce tumor burden initially,but leave behind chemo-resistant breast cancer stem cells(BCSCs)that lead to tumor recurrence and metastasis.2 Chemotherapy induces BCsC enrichment through the activation of glutathione biosynthesis pathways,which increases intracellular glutathione levels and specifies the BCSC phenotype through complicated downstream signaling pathways.3 Glutathione S-transferases(GSTs),a superfamily(which contains seven cytosolic classes:Alpha,Kappa,Mu,Omega,Pi,Theta,and Zeta,and one microsomal class MGSTs)of phase Il enzymes that catalyze the conjugation of glutathione with electrophilic compounds,play a critical role in detoxification and chemotherapy resistance of cancer ***,the role of GSTs in the regulation of BCSCs is largely elusive.

关键词： chemotherapy breast metastasis

Transfer of Highest Weight Modules and Small Unipotent Representations

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Acta Mathematica Sinica,English Series 2024年第3期40卷 772-791页

作者： Hai An he jing Song HUANG Kayue Daniel WONG Department of Mathematics College of SciencesShanghai UniversityShanghai 200444P.R.China Newtouch Center for Mathematics of Shanghai University Shanghai 200444P.R.China Mathematics Research Center School of Science and EngineeringThe Chinese University of Hong KongShenzhen 518172P.R.China

We study the transfer between small special unipotent representations for all equal rank real forms of type E_(6) and E_(7). As a consequence, one can verify these modules are unitarity using the results of Wallach an... 详细信息

关键词： Unipotent representations Wallach representations Transfer of unitary modules

Experimental investigation on the anisotropy of friction property for dry and water-saturated rock

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Friction 2024年第9期12卷 2064-2082页

作者： Qing YANG Mingming he Jinrui ZHAO Mingchen DING jing WANG State Key Laboratory of Eco-hydraulics in Northwest Arid Region Xi’an University of TechnologyXi’an 710048China China Communication Construction Company Mechanical and Electrical Engineering Co. Ltd.Beijing 100088China

Friction properties of rock are closely connected with the *** anisotropy of rock friction can provide a valuable assessment for geotechnical and geological *** this study,the rotary friction tests were conducted to analyze the water effect on the friction property and the friction anisotropy of the four types of *** drilling response model(DD-model)was employed to characterize the rotary friction behavior of the *** parameters of this model include the three types of friction parameters:1/ς,μ,and f,where 1/ςandμare constant,and f is a variable.A quantitative method is proposed for assessing the anisotropy of rock *** results of the rotary friction tests indicate that the relation between torque force and thrust force conforms to the *** changes of two friction constants 1/ςandμfrom dry state to water-saturated state suggest that the water effect on the friction strength of the rocks exhibits significant *** friction strength determined by the friction variable f increases first,then decreases,and finally stabilizes with the increasing of *** is an anisotropy index calculated by the proposed *** percentage difference of the average value of AIf between water-saturated and dry states shows the degree of the water effect on the friction anisotropy of the rocks,mudstone(MU)>granite(GR)>fine sandstone(FS)>argillaceous siltstone(AS).The quantitative model is hopefully constructed for characterizing the relation between the anisotropic friction strength of rock and the moisture state in future.

关键词： anisotropy rotary friction test drilling response model(DD-model) effective stress law

Cooperative composites anchored with single atom Pb and carbon confined PbO nanoparticles for superior lead-carbon batteries

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Journal of Energy Chemistry 2024年第10期97卷 486-497,I0010页

作者： Puqiang he Yi Yang Hui Huang jing Huang Hongbiao Wang Yapeng he Zhongcheng Guo Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina Metallurgical Electrode Material Engineering Technology Research Center of Yunnan Province Kunming 650106YunnanChina Kunming hendera Technology Co.LTD. Kunming 650106YunnanChina

The mitigation of sulphation and parasitic hydrogen evolution is considered as prominent research emphasis for the development of lead-carbon batteries(LCBs)in large-scale energy storage ***,cooperative Pb-C composites consisting of single atom Pb and carbon-encapsulated PbO nanoparticles were prepared by freeze-drying technique and pyrolytic reduction to address above *** innovative use of Pb^(2+)to cross-link sodium alginate enabled a uniform distribution of Pb in the composites,generating Pb-C-PbO three-phase *** analysis and theoretical calculations revealed the synergistic interactions between single-atom Pb and PbO nanoparticles in suppressing parasitic hydrogen evolution and promoting the adsorption of Pb *** presence of monatomic Pb and PbO enhanced the affinity of the composites for the negative active materials and facilitated the transformation of the active materials from bulk into spherical shapes to enhance the specific surface area,thereby counteracting *** the coordinated integration of various functionalities offered by Pb@C-x,the cycle life of the battery at HRPSoC reaches 7025 cycles,which is two times for LCB with pure carbon ***,the discharge capacity increased from 3.52 to 3.79 *** study provides substantial insights into the construction of Pb-C composites for LCBs to inhibit negative sulphation and hydrogen evolution.

关键词： Lead-carbon battery Negative sulphation Hydrogen evolution Single-atom Lead carbon composites

Synergistically constructed lamination-like network of redox-active polyimide and MXene via π-π interactions for aqueous NH_(4)^(+) storage

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Chinese Journal of Chemical Engineering 2024年第7期71卷 217-224页

作者： jing.he Hongye Xuan jing Jin Ke Yu Changyao Liyang Lintong Hu Minjie Shi Chao Yan School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Jiangsu New Yangzi Shipbuilding Co. LtdJingjiang 214532China

As a nonmetallic charge carrier,ammonium ion(NH_(4)^(+))has garnered significant attention in the construction of aqueous batteries due to its advantages of low molar mass,small hydration size and rapid diffusion in aqueous *** are a kind of potential electro-active materials for aqueous NH_(4)^(+)***,traditional polymer electrodes are typically created by covering the bulky collectors with excessive additives,which could lead to low volume capacity and unsatisfactory ***,a nanoparticle-like polyimide(PI)was synthesized and then combined with MXene nanosheets to synergistically construct an additive-free and self-standing PI@MXene composite ***,the redox-active PI nanoparticles are enclosed between conductive MXene flakes to create a 3D lamination-like network that promotes electron transmission,while theπ-πinteractions existing between PI and MXene contribute to the enhanced structural integrity and stability within the composite *** such,it delivers superior aqueous NH_(4)^(+)storage behaviors in terms of a notable specific capacity of 110.7 mA·h·cm^(–3) and a long lifespan with only 0.0064%drop each ***,in-situ Raman and UV–Vis examinations provide evidence of reversible and stable redox mechanism of the PI@MXene composite electrode during NH_(4)^(+)uptake/removal,highlighting its significance in the area of electrochemical energy storage.

关键词： Synergetic coupling Composite materials Polyimide Energy storage Aqueous ammonium ion batteries

Microstructure and mechanical properties of a cast TRIP-assisted multiphase stainless steel

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China Foundry 2024年第3期21卷 221-228页

作者： Meng-xin Wang Zi-xiang Wu jing-yu he Xiang Chen School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

Stainless steels are used in a wide range of complex environments due to their excellent corrosion *** stainless steels can offer an excellent combination of strength,toughness and corrosion resistance due to the coexistence of different *** microstructure and mechanical properties of a novel cast multiphase stainless steel,composed of martensite,ferrite,and austenite,were investigated following appropriate heat treatment processes:solution treatment at 1,050℃ for 0.5 h followed by water quenching to room temperature,and aging treatment at 500℃ for 4 h followed by water quenching to room *** show reversed austenite is formed by diffusion of Ni element during aging process,and the enrichment of Ni atoms directly determines the mechanical stability of *** austenite with a lower Ni content undergoes a martensitic transformation during plastic *** tensile strength of the specimen exceeds 1,100 MPa and the elongation exceeds 24%after solid solution,and further increases to 1,247 MPa and 25%after aging *** enhancement is due to the TRIP effect of austenite and the precipitation of the nanoscale G-phase pinning dislocations in ferrite and martensite.

关键词： multiphase stainless steel mechanical properties TRIP effect reversed austenite G-phase

Optimal allocation method of electric/air braking force of high-speed train considering axle load transfer

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High-Speed Railway 2024年第2期2卷 77-84页

作者： Feng Guo jing.he College of Electrical and Information Engineering Hunan University of TechnologyZhuzhou 412007China

Reasonable distribution of braking force is a factor for a smooth,safe,and comfortable braking of trains.A dynamic optimal allocation strategy of electric-air braking force is proposed in this paper to solve the problem of the lack of consideration of adhesion difference of train wheelsets in the existing high-speed train electric-air braking force optimal allocation *** this method,the braking strategy gives priority to the use of electric braking *** force model of a single train in the braking process is analyzed to calculate the change of adhesion between the wheel and rail of each wheelset after axle load transfer,and then the adhesion of the train is estimated in real ***,with the goal of maximizing the total adhesion utilization ratio of trailer/motor vehicles,a linear programming distribution function is *** proportional coefficient of adhesion utilization ratio of each train and the application upper limit of braking force in the function is updated according to the change time point of wheelset ***,the braking force is dynamically *** simulation results of Matlab/Simulink show that the proposed algorithm not only uses the different adhesion limits of each trailer to reduce the total amount of braking force undertaken by the motor vehicle,but also considers the adhesion difference of each *** strategy can effectively reduce the risk and time of motor vehicles during the braking process and improve the stability of the train braking.

关键词： Braking force allocation Wheelset Dynamicity Axle load transfer total Adhesion utilization ratio

A Method of Generating Semi-Experimental Biomedical Datasets

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Journal of Beijing Institute of Technology 2024年第3期33卷 219-226页

作者： jing Wang Naike Du Zi he Xiuzhu Ye School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China

This paper proposed a method to generate semi-experimental biomedical datasets based on full-wave simulation *** system noise such as antenna port couplings is fully considered in the proposed datasets,which is more realistic than synthetical *** this paper,datasets containing different shapes are constructed based on the relative permittivities of human ***,a back-propagation scheme is used to obtain the rough reconstructions,which will be fed into a U-net convolutional neural network(CNN)to recover the high-resolution *** results show that the network trained on the datasets generated by the proposed method can obtain satisfying reconstruction results and is promising to be applied in real-time biomedical imaging.

关键词： electromagnetic imaging dataset biomedical imaging