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Xuebijing injection,a Chinese patent medicine,against severe pneumonia:Current research progress and future perspectives

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结合医学学报:英文版 2023年第5期21卷 413-422页

作者： Mei Zhang Rui Zheng Wen-jing Liu Jun-ling Hou yu-lei Yang Hong-cai Shang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamilton L8S 4K1Canada

Severe pneumonia is one of the most common infectious diseases and the leading cause of sepsis and septic *** infection,balancing the patient’s immune status,and anti-coagulation therapy are all important elements in the treatment of severe *** multi-target agents,Xuebijing injection(XBJ)has shown unique advantages in targeting complex conditions and saving the lives of patients with severe *** review outlines progress in the understanding of XBJ’s anti-inflammatory,endotoxin antagonism,and anticoagulation *** the hundreds of publications released over the past few years,the key results from representative clinical studies of XBJ in the treatment of severe pneumonia were selected and *** was observed to effectively suppress the release of pro-inflammatory cytokines,counter the effects of endotoxin,and assert an anticoagulation effect in most clinical trials,which are consistent with experimental ***,this evidence suggests that XBJ could play an important and expanding role in clinical medicine,especially for sepsis,septic shock and severe pneumonia.

关键词： Xuebijing injection Severepneumonia Pneumonia,bacterial Pneumonia,viral Treatmentmechanism Clinical trial

Multimodal therapy in the management of primary orbital mesenchymal chondrosarcoma

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 306-311页

作者： yun Zhao jing-Wen Hui Sha-Sha yu Jin-Yong Lin Hong Zhao Department of Ocular Plastic&Orbital Disease Tianjin Eye HospitalTianjin 300020China Clinical College of Ophthalmology Tianjin Medical UniversityNankai University Affiliated Eye HospitalTianjin 300020China Tianjin Key Laboratory of Ophthalmology and Visual Science Tianjin 300020China Tianjin Eye Institute Tianjin 300020China

AIM:To evaluate the ophthalmic manifestations,radiographic features,and prognosis of Chinese patients with primary orbital mesenchymal chondrosarcoma(MCS).METHODS:The study included 6 cases with primary orbital MCS treated at Tianjin Eye Hospital from January 2009 to December *** ophthalmic manifestations,radiographic features,diagnosis,pathology,therapeutic regimens,and prognosis were retrospectively ***:Six patitents with primary orbital MCS were *** mean age at the first visit was 33y(range,25-42y).All six patients displayed manifestations of exophthalmos,diplopia,limitation of eye displacement,upper eyelid oedema,decreased visual acuity and *** mean disease history and range were 5 and 2-8mo,*** tumors were located in the superonasal extraconal compartment(2/6,33.3%),intraconal compartment(2/6,33.3%),and bitemporal extraconal compartment(2/6,33.3%),*** features were a well-defined,orbital mass with calcification and ossification on computed tomography(CT),and marked heterogenous enhancement on dynamic magnetic resonance imaging(MRI).Five patients were treated with tumor resection and one patient received orbital *** patients in the cohort received postoperative radiation therapy,two patients received chemotherapy,and one patient did not receive postoperative adjuvant therapy because he *** histopathologic classification revealed a tumour composed of a mixture of mature chondroid tissue surrounded by small,round,and undifferentiated mesenchymal *** revealed Bcl-2,vimetin,CD99,and S-100 were expressed were *** surgeries,two patients have developed a local *** median recurrence time of 58 mo(52-64 mo).One patient had distant recurrence included the lungs occurred 52mo after the initial ***:The possibilty of orbital MCS need to be considered when a painless,slowly growing orbital mass with calcification and os

关键词： orbital mesenchymal chondrosarcoma local recurrence metastasis ophthalmic manifestations radiographic features pathological diagnosis

STAT3基因突变阳性大颗粒淋巴细胞白血病相关纯红细胞再生障碍临床特征及结局研究

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中国实用内科杂志 2024年第4期44卷 321-325页

作者：王纬刘晓庆陈小玉张婷宫跃敏叶宝东吴雪梅孙京男陈曦宋玉华龙启强南京市第二医院南京中医药大学附属南京医院血液科江苏南京210037 南京医科大学第一附属医院江苏省人民医院血液科江苏南京210029 南京医科大学附属江宁医院血液内科江苏南京211199 浙江省中医院血液科浙江杭州310003 苏州大学第二附属医院血液科江苏苏州215004 吉林大学第一医院血液肿瘤中心吉林长春130061

目的探索STAT3基因突变阳性大颗粒淋巴细胞白血病(LGLL)相关纯红细胞再生障碍(PRCA)临床特征和结局。方法纳入2018年1月至2023年7月81例LGLL相关PRCA患者临床资料(登记于中国贫血东部协作组)进行分析。对LGLL相关PRCA患者进行STAT3基因... 详细信息

目的探索STAT3基因突变阳性大颗粒淋巴细胞白血病(LGLL)相关纯红细胞再生障碍(PRCA)临床特征和结局。方法纳入2018年1月至2023年7月81例LGLL相关PRCA患者临床资料(登记于中国贫血东部协作组)进行分析。对LGLL相关PRCA患者进行STAT3基因突变筛选,分析STAT3基因突变阳性患者的临床特征、免疫抑制治疗反应及预后生存。结果21例STAT3突变阳性的LGLL相关PRCA患者,15例(71%)exon 21突变阳性,4例(19%)exon 20突变阳性,1例exon 20和21双突变阳性,1例exon13突变阳性。Y640F为高频突变位点(42.9%)。STAT3突变患者接受环孢素(CsA)治疗的完全反应率(CRR)和总反应率(ORR)分别为31.3%和56.3%,环磷酰胺联合泼尼松(CP)方案在STAT3突变组中的CRR及ORR均高于CsA(53.8%比31.3%,P=0.274;84.6%比56.3%,P=0.130);且复发率更低(77.8%比18.2%,P=0.022)。结论STAT3基因高频突变位于exon 21,最常见位点为Y640F,CP方案疗效较CsA好,复发率低。

关键词： STAT3基因突变大颗粒淋巴细胞白血病纯红细胞再生障碍环孢素环磷酰胺疗效

Inhibition mechanisms of ammonia and sulfate in high-solids anaerobic digesters for food waste treatment: Microbial community and element distributions responses

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Chinese Chemical Letters 2023年第2期34卷 342-348页

作者： Likui Feng Weixin Zhao yu Liu Yan Chen Shufei He jing Ding Qingliang Zhao Liangliang Wei State Key Laboratory of Urban Water Resources and Environment(SKLUWRE) School of EnvironmentHarbin Institute of TechnologyHarbin 150090China Baicheng Municipal Party Committee Office Baicheng 137000China

The horizontal flow anaerobic digester indicated that high ammonia (2923 mg/L) and SO42-(3653 mg/L)would influence the performance of methane production with food waste as ***,bottle anaerobic digestion reactors were carried out to investigate the effect of ammonia/sulfate concentrations on the methane *** results manifested that the anaerobic digesters with an ammonia concentration of 3500 mg/L or sulfate of 1600 mg/L showed the best performance of methane production,with an average methane yield of 0.32 and 0.33 L (g VS)^(-1)d^(-1),***,a higher ammonia (6500 mg/L) or sulfate (1600-3500 mg/L) level hindered the bioconversion of C from liquid to gas phase (2.68%or 1.73%CH_(4)-Gas,respectively),while insignificantly for the hydrolyzation of C and N from solid to liquid *** to sulfate,high ammonia nitrogen seriously inhibited the methanation process,leading to a significant carbon accumulation in the anaerobic reactor,especially for propionic *** predominant archaea Methanosarcina at genus level indicated that aceticlastic methanogenesis was the major methanogenic ***,high ammonia level suppressed the activity of Methanosarcina,while modest sulfate improved H_(2)-consuming methanogens activity.A large fraction of unclassified bacteria within the Firmicutes (43.78%-63.17%) and Bacteroidetes (24.20%-33.30%) phylum played an important role in substrates hydrolysis.

关键词： Anaerobic digestion Ammonia/sulfate inhibition Element transformation Food waste Microbial community

若尔盖国家自然公园四川片区不同生境下土壤细菌群落结构及多样性分析

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西南农业学报 2024年第7期37卷 1581-1589页

作者：郭静微魏真真代英王毛李伟袁方柯陈玉林马玉兰泽仁措肖敏四川省农业科学研究院植物保护研究所成都610066 阿坝州生态保护与发展研究院四川汶川623000 阿坝州农业农村局农产品质量安全中心四川马尔康624000

[目的]揭示若尔盖国家自然公园四川片区不同生境下土壤细菌的群落结构及物种多样性。[方法]以若尔盖国家公园四川片区不同生境下的5种土壤(沼泽土、亚高山草甸土、草甸土、褐土和风沙土)为研究对象,借助高通量测序技术对土壤细菌多样性... 详细信息

[目的]揭示若尔盖国家自然公园四川片区不同生境下土壤细菌的群落结构及物种多样性。[方法]以若尔盖国家公园四川片区不同生境下的5种土壤(沼泽土、亚高山草甸土、草甸土、褐土和风沙土)为研究对象,借助高通量测序技术对土壤细菌多样性和群落结构进行分析,并讨论土壤理化性质与菌群结构的关系。[结果](1)在土壤细菌分类研究中,共鉴定出36个门,其中优势菌群为放线菌门(Actinobacteriota)、变形菌门(Proteobacteria)、厚壁菌门(Firmicutes)、酸杆菌门(Acidobacteriota)和绿弯菌门(Chloroflexi)。(2)在不同土壤细菌α-多样性分析中,亚高山草甸土(YGS)的Chao1、Observed Species、Shannon和Simpson指数均为最高,表明该土壤中细菌群落数量和多样性最高。(3)在不同土壤细菌β-多样性分析中,褐土(HT)、沼泽土(ZZT)、亚高山草甸土(YGS)以及风沙土(ST)相互高度重叠,表明该地区这4种土壤细菌群落结构组成相似,而草甸土(CD)土壤细菌群落具有显著差异(P<0.05)。(4)对不同生境的RDA冗余分析中,放线菌门与土壤pH呈正相关;变形菌门与土壤pH和全钾(TK)呈正相关;厚壁菌门与有机质(SOM)、全氮(TN)、全磷(TP)和含水量(MC)显著正相关。[结论]本研究揭示了若尔盖自然公园四川片区不同生境下土壤细菌群落组成结构的差异性和多样性,以及这些差异与环境因子的强相关性。该结果不仅有助于深化对土壤微生物生态学的理解,而且为土壤生态系统的管理提供了科学依据。

关键词：若尔盖国家公园土壤细菌群落结构高通量测序

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Hydrological and sediment connectivity under freeze-thaw meltwater compound erosion conditions on a loessal slope

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International Soil and Water Conservation Research 2023年第2期11卷 402-411页

作者： Tian Wang jingsi Li jingming Hou Yongyong Ma Peng Li yu Tong jing Li Zhanbin Li State Key Laboratory of Eco-hydraulics in Northwest Arid Region of China Xi'an University of TechnologyXi'an710048ShaanxiChina Key Laboratory of National Forestry Administration on Ecological Hydrology and Disaster Prevention in Arid Regions Xian University of TechnologyXi'an 710048ShaanxiChina Shaanxi Province Institute of Water Resources and Electric Power Investigation and Design Xi'an710005ShaanxiChina

Freeze-thaw processes can influence hydrology,soil erosion,and morphological development by altering the connectivity between active pathways of water and sediment *** flow experi-ments were conducted involving frozen,shallow thawed,and unfrozen soil slopes under 1,2,and 4 L/min runoff rates at a temperature of approximately 5℃.In this study,hydrological connectivity was analysed via the simplified hydrological curve and relative surface connection *** con-nectivity was analysed via the sediment structure connectivity and sediment functional *** indicated that hydrological connectivity was greatest on frozen slopes(FS),followed by shallow thawed slopes(STS),and unfrozen slopes(UFS)given a constant flow *** connectivity increased with increasing runoff rate for each freeze-thaw *** condition and runoff rate exhibited a positive response to the hydrological *** structure connectivity increased with increasing runoff rate for each slope *** ordering of sediment structure connectivity across freeze-thaw condition was that FS was greater than STS while STS was greater than UFS inde-pendent of flow *** functional connectivity included longitudinal,lateral,and vertical con-nectivity *** longitudinal and vertical connectivity indicated a trend of first increasing and then decreasing under the different runoff rates and freeze-thaw *** a given runoff rate,the ordering of sediment longitudinal and vertical connectivity across freeze-thaw condition was that FS was greater than STS while STS was greater than *** lateral connectivity exhibited a trend of first decreasing and then *** ordering of sediment lateral connectivity across freeze-thaw condition was that UFS was greater than STS while STS was greater than *** could more easily reach longitudinal and vertical *** longitudinal and vertical co

关键词： Freeze-thaw Runoff Erosion Structureand functional connectivity Loessal slope

Tracing surface seawater mixing and nutrient transport by^(222)Rn on the northern coast of Beibu Gulf,China

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海洋学报:英文版 2023年第8期42卷 87-98页

作者： Hao Wang Qiangqiang Zhong Fule Zhang Suiyuan Chen Hongyan Bao jing Lin Dekun Huang Tao yu College of Marine Sciences Shanghai Ocean UniversityShanghai 201306China Third Institute of Oceanography Ministry of Natural ResourcesXiamen 361005China Observation and Research Station of Coastal Wetland Ecosystem in Beibu Gulf Ministry of Natural ResourcesBeihai 536015China State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China

The transport and diffusion of substances in seawater are limited by the mixing motion of water bodies,while the main forms of mixing in offshore water bodies are advection and eddy *** eddy diffusion process of water indicates the possible transport direction of dissolved ***,the complex environment in the coastal zone makes it difficult to quantitatively assess the water diffusion process.^(222)Rn is a useful tool to trace the diffusion process of water ***,studies on the^(222)Rn distribution and its behavior in the Beibu Gulf are *** this study,the activity distribution characteristics of^(222)Rn in surface seawater of the Guangxi shelf area of the Beibu Gulf were *** on the one-dimensional,steady-state model,the vorticity diffusion coefficient of^(222)Rn in the horizontal direction was calculated as(0.42−2.13)×10^(8) m^(2)/d,and the offshore fluxes of^(222)Rn under the influence of water mixing were calculated as 2.00×10^(12) Bq/***,the horizontal transport fluxes of silicate,phosphate,nitrite and nitrate were 6.28×10^(−3)mol/(m^(2)·d),0.10×10^(−3)mol/(m^(2)·d),0.20×10^(−3)mol/(m^(2)·d)and 4.15×10^(−3)mol/(m^(2)·d),*** results indicate that the study of eddy current diffusion in offshore marine water facilitates a deeper understanding of the water mixing process and nutrient transport and migration.

关键词： ^(222)Rn water mixing nutrients vorticity diffusion coefficient horizontal transport flux

Response of Growing Season Gross Primary Production to El Nino in Different Phases of the Pacific Decadal Oscillation over Eastern China Based on Bayesian Model Averaging

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Advances in Atmospheric Sciences 2021年第9期38卷 1580-1595页

作者： yueyue LI Li DAN jing PENG Junbang WANG Fuqiang YANG Dongdong GAO Xiujing YANG Qiang yu Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of ScienceBeijing 100049China Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China National Ecosystem Science Data Center Key Laboratory of Ecosystem Network Observation and ModelingInstitute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest A&F UniversityShaanxi 712100China School of Life Sciences University of Technology SydneySydney 2007NSWAustralia

Gross primary production(GPP) plays a crucial part in the carbon cycle of terrestrial ecosystems.A set of validated monthly GPP data from 1957 to 2010 in 0.5°× 0.5° grids of China was weighted from the Multi-scale Terrestrial Model Intercomparison Project using Bayesian model averaging(BMA).The spatial anomalies of detrended BMA GPP during the growing seasons of typical El Nino years indicated that GPP response to El Nino varies with Pacific Decadal Oscillation(PDO) phases: when the PDO was in the cool phase,it was likely that GPP was greater in northern China(32°–38°N,111°–122°E) and less in the Yangtze River valley(28°–32°N,111°–122°E);in contrast,when PDO was in the warm phase,the GPP anomalies were usually reversed in these two *** consistent spatiotemporal pattern and high partial correlation revealed that rainfall dominated this *** previously published findings on how El Nino during different phases of PDO affecting rainfall in eastern China make the statistical relationship between GPP and El Nino in this study theoretically *** paper not only introduces an effective way to use BMA in grids that have mixed plant function types,but also makes it possible to evaluate the carbon cycle in eastern China based on the prediction of El Nino and PDO.

关键词： East China Bayesian model averaging Gross primary production El Nino Pacific Decadal Oscillation Monsoon rainfall

Optical characterization of defects in narrow-gap HgCdTe for infrared detector applications

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Chinese Physics B 2019年第1期28卷 52-64页

作者： Fang-yu yue Su-yu Ma Jin Hong Ping-Xiong Yang Cheng-Bin jing Ye Chen Jun-Hao Chu Key Laboratory of Polar Materials and Devices(MOE) Department of OptoelectronicsSchool of Information Science TechnologyEast China Normal UniversityShanghai 200241China National Laboratory for Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China

Narrow-gap Hg_(1-x)Cd_x Te material with a composition x of about 0.3 plays an extremely important role in mid-infrared detection applications. In this work, the optical properties of doped HgCdTe with x ≈ 0.3 are reviewed, including the defects and defect levels of intrinsic V_(Hg) and the extrinsic amphoteric arsenic(As) dopants, which can act as shallow/deep donors and acceptors. The influence of the defects on the determination of band-edge electronic structure is discussed when absorption or photoluminescence spectra are considered. The inconsistency between these two optical techniques is demonstrated and analyzed by taking into account the Fermi level position as a function of composition, doping level,conductivity type, and temperature. The defect level and its evolution, especially in As-doped HgCdTe, are presented. Our results provide a systematic understanding of the mechanisms and help for optimizing annealing conditions towards p-type As-activation, and eventually for fabricating high performance mid-infrared detectors.

关键词： HgCdTe defects annealing procedures optical characterization