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Multi-Scale Feature Fusion Model for Bridge Appearance Defect Detection

Big Data Mining and Analytics 2024年第1期7卷 1-11页

作者： Rong Pang yan yang Aiguo Huang yan Liu Peng Zhang Guangwu tang School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China China Merchants Chongqing Road Engineering Inspection Center Co. Ltd.Chongqing 400067China State Key Laboratory of Bridge Engineering Structural Dynamics Chongqing 400067China

Although the Faster Region-based Convolutional Neural Network(Faster R-CNN)model has obvious advantages in defect recognition,it still cannot overcome challenging problems,such as time-consuming,small targets,irregular shapes,and strong noise interference in bridge defect detection.To deal with these issues,this paper proposes a novel Multi-scale Feature Fusion(MFF)model for bridge appearance disease detection.First,the Faster R-CNN model adopts Region Of Interest(ROl)pooling,which omits the edge information of the target area,resulting in some missed detections and inaccuracies in both detecting and localizing bridge defects.Therefore,this paper proposes an MFF based on regional feature Aggregation(MFF-A),which reduces the missed detection rate of bridge defect detection and improves the positioning accuracy of the target area.Second,the Faster R-CNN model is insensitive to small targets,irregular shapes,and strong noises in bridge defect detection,which results in a long training time and low recognition accuracy.Accordingly,a novel Lightweight MFF(namely MFF-L)model for bridge appearance defect detection using a lightweight network EfficientNetV2 and a feature pyramid network is proposed,which fuses multi-scale features to shorten the training speed and improve recognition accuracy.Finally,the effectiveness of the proposed method is evaluated on the bridge disease dataset and public computational fluid dynamic dataset.

关键词： defect detection Multi-scale Feature Fusion(MFF) Region Of Interest(ROl)alignment lightweight network

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The Structure Entropy of Social Networks

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Journal of Systems Science & Complexity 2024年第3期37卷 1147-1162页

作者： LI Zhenpeng yan Zhihua yanG Jian tang Xijin School of Electronics and Information Engineering Taizhou UniversityLinhai 317000China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China Yunnan Key Laboratory of Smart City in Cyberspace Security Yuxi Normal UniversityYuci 653100China University of Chinese Academy of Sciences Beijing 100039China

Micro triadic structure is an important motif and serves the building block of complex networks.In this paper,the authors define structure entropy for a social network and explain this concept by using the coded triads proposed by Davis and Leinhardt in 1972.The proposed structure entropy serves as a new macro-evolution index to measure the network’s stability at a given timestamp.Empirical analysis of real-world network structure entropy discloses rich information on the mechanism that yields given triadic motifs frequency distribution.This paper illustrates the intrinsic link between the micro dyadic/triadic motifs and network structure entropy.Importantly,the authors find that the high proportion of reciprocity and transitivity results in the emergence of hierarchy,order,and cooperation of online social networks.

关键词： Dyadic and triadic motifs network structure entropy reciprocity and transitivity

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Structural uncertainty quantification of Reynolds-Averaged Navier–Stokes closures for various shock-wave/boundary layer interaction flows

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Chinese Journal of Aeronautics 2024年第3期37卷 34-48页

作者： Fanzhi ZENG Tianxin ZHANG Denggao tang Jinping LI Chao yan School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China School of Aeronautical Engineering Air Force Engineering UniversityXi’an 710038China

Accurate prediction of Shock-Wave/Boundary Layer Interaction(SWBLI)flows has been a persistent challenge for linear eddy viscosity models.A major limitation lies in the isotropic representation of the Reynolds stress,as assumed under the Boussinesq approximation.Recent studies have shown promise in improving the prediction capability for incompressible separation flows by perturbing the Reynolds-stress anisotropy tensor.However,it remains uncertain whether this approach is effective for SWBLI flows,which involve compressibility and discontinuity.To address this issue,this study systematically quantifies the structural uncertainty of the anisotropy for oblique SWBLI flows.The eigenspace perturbation method is applied to perturb the anisotropy tensor predicted by the Menter Shear–Stress Transport(SST)model and reveal the impacts of anisotropy on the prediction of quantities of interest,such as separation and reattachment positions,wall static pressure,skin friction,and heat flux.The results demonstrate the potential and reveal the challenges of eigenspace perturbation in improving the SST model.Furthermore,a detailed analysis of turbulent characteristics is performed to identify the source of uncertainty.The findings indicate that eigenspace perturbation primarily affects turbulent shear stress,while the prediction error of the SST model is more related to turbulent kinetic energy.

关键词： Shock-wave/boundary layer interaction(SWBLI) Turbulence models Uncertainty analysis Eigenspace perturbation Anisotropy

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Sciadopitysin exerts anticancer effects on HepG2 hepatocellular carcinoma cells by regulating reactive oxygen species-mediated signaling pathways

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BIOCELL 2024年第7期48卷 1055-1069页

作者： yan-NAN LI YUN-HONG XIU yan-JUN tang jing-LONG CAO WEN-SHUANG HOU AN-QI WANG TIAN-ZHU LI CHENG-HAO JIN Department of Biochemistry and Molecular Biology Heilongjiang Bayi Agricultural UniversityDaqingChina Hemodialysis Center Daqing Oilfield General HospitalDaqingChina Department of Food Science and Engineering Heilongjiang Bayi Agricultural UniversityDaqingChina Department of Molecular Biology Chifeng UniversityChifengChina National Coarse Cereals Engineering Research Center DaqingChina

Objectives:Sciadopitysin(SP)is aﬂavonoid in Ginkgo biloba that exhibits various pharmacological activities.This study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma(HCC)cells.Methods:Network pharmacology was used for target prediction analysis.Cell Counting Kit-8(CCK-8)assay was used to test the cell viability.Flow cytometry was used to test the cell cycle distribution,apoptosis status,and reactive oxygen species(ROS)levels.Transwell and wound-healing assay was used to test the migration effect of SP on HepG2 cells.Western Blot assay was used to test the expression levels of proteins.Results:Network pharmacology analysis results showed that the mitogen-activated protein kinase(MAPK)and other signaling pathways are involved in the SP anti-HCC biological process.CCK-8 assay results demonstrated that SP showed an obvious killing effect on three types of HCC cells and low cytotoxic effect on normal cells.Western Blot andﬂow cytometry results showed that SP regulated MAPK/signal transducer and activator of transcription 3(STAT3)/nuclear factor kappa-B(NF-κB)signaling pathway to induce mitochondrion-dependent apoptosis in HepG2 cells.Additionally,SP can arrest the G0/G1 phase cell cycle via the protein kinase B(AKT)/p21/p27/cyclin-dependent kinase(CDK)/Cyclin signaling pathway.Wound healing and transwell assays showed that SP inhibited cell motility and invasion through the AKT/glycogen synthase kinase3β(GSK-3β)/vimentin/β-catenin signaling pathway.Conclusion:Theseﬁndings demonstrated that SP induced mitochondrion-dependent apoptosis,arrested cell cycle in the G0/G1 phase,and inhibited cell migration by regulating the ROS-mediated signaling pathway in HepG2 cells.Thus,SP could serve as a therapeutic agent for the treatment of human HCC.

关键词： Sciadopitysin Hepatocellular carcinoma Apoptosis Cell cycle Cell migration

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Cyber-Physical Resilience Enhancement for Power Transmission Systems with Energy Storage Systems

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 844-855页

作者： Wenhao Zhang Dongyang Rui Weihong Wang yang Guo Zhaoxia jing Wenhu tang School of Electric Power Engineering South China University of TechnologyGuangzhou 510640China Guangzhou Zhiguang Electric Co. Ltd and Zhiguang Research Institute(Guangzhou)Co.LtdGuangzhou 510765China

In a power system, when extreme events occur, such as ice storm, large scale blackouts may be unavoidable. Such small probability but high risk events have huge impact on power systems. Most resilience research in power systems only considers faults on the physical side, which would lead to overly idealistic results. This paper proposes a two-stage cyber-physical resilience enhancement method considering energy storage (ES) systems. The first stage calculates optimal planning of ES systems, and the second stage assesses resilience and enhancement of ES systems during the disaster. In the proposed model, cyber faults indirectly damage the system by disabling monitoring and control function of control center. As a result, when detection and response process of physical faults are blocked by cyber failures, serious load shedding occurs. Such a cyber-physical coupling mechanism of fault, response, restoration process is demonstrated in the modified IEEE Reliable Test System-79 (RTS-79). Simulation results show compared with the physical-only system, the cyber-physical system has a more accurate but degraded resilient performance. Besides, ES systems setting at proper place effectively enhance resilience of the cyber-physical transmission system with less load Shedding.

关键词： Cyber-physical faults energy storage systems resilience enhancement transmission systems

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Xuebijing improves intestinal microcirculation dysfunction in septic rats by regulating the VEGF-A/PI3K/Akt signaling pathway

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World Journal of Emergency Medicine 2024年第3期15卷 206-213页

作者： A-ling tang yan Li Li-chao Sun Xiao-yu Liu Nan Gao Sheng-tao yan Guo-qiang Zhang Department of Emergency China-Japan Friendship HospitalBeijing 100029China Graduate School Beijing University of Chinese MedicineBeijing 100105China

BACKGROUND:This study aims to explore whether Xuebijing(XBJ) can improve intestinal microcirculation dysfunction in sepsis and its mechanism.METHODS:A rat model of sepsis was established by cecal ligation and puncture(CLP).A total of 30 male SD rats were divided into four groups:sham group,CLP group,XBJ + axitinib group,and XBJ group.XBJ was intraperitoneally injected 2 h before CLP.Hemodynamic data(blood pressure and heart rate) were recorded.The intestinal microcirculation data of the rats were analyzed via microcirculation imaging.Enzyme-linked immunosorbent assay(ELISA) kits were used to detect the serum levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α) in the rats.Histological analysis and transmission electron microscopy were used to analyze the injury of small intestinal microvascular endothelial cells and small intestinal mucosa in rats.The expression of vascular endothelial growth factor A(VEGF-A),phosphoinositide 3-kinase(PI3K),phosphorylated PI3K(p-PI3K),protein kinase B(Akt),and phosphorylated Akt(p-Akt) in the small intestine was analyzed via Western blotting.RESULTS:XBJ improved intestinal microcirculation dysfunction in septic rats,alleviated the injury of small intestinal microvascular endothelial cells and small intestinal mucosa,and reduced the systemic inflammatory response.Moreover,XBJ upregulated the expression of VEGF-A,p-PI3K/total PI3K,and p-Akt/total Akt in the rat small intestine.CONCLUSION:XBJ may improve intestinal microcirculation dysfunction in septic rats possibly through the VEGF-A/PI3K/Akt signaling pathway.

关键词： Sepsis Xuebijing Vascular endothelial growth factor A Microcirculation Rat Phosphoinositide 3-kinase Protein kinase B

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A novel predictor of unsustained return of spontaneous circulation in cardiac arrest patients through a combination of capnography and pulse oximetry: a multicenter observational study

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World Journal of Emergency Medicine 2024年第1期15卷 16-22页

作者： jing yang Hanqi tang Shihuan Shao Feng Xu yangyang Fu Shengyong Xu Chen Li yan Li yang Liu Joseph Harold Walline Huadong Zhu Yuguo Chen Xuezhong Yu Jun Xu Emergency Department State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Emergency Department Peking University People’s HospitalBeijing 100044China Department of Emergency and Chest Pain Center Shandong Provincial Clinical Research Center for Emergency and Critical Care MedicineKey Laboratory of Emergency and Critical Care Medicine of Shandong ProvinceQilu Hospital of Shandong UniversityJinan 250012China Emergency Department Beijing Jishuitan HospitalBeijing 100035China Emergency Department Tianjin Medical University General HospitalTianjin 300052China Department of Emergency Medicine Penn State Health Milton S.Hershey Medical Center and Penn State College of MedicineHershey 17033USA

BACKGROUND:Unsustained return of spontaneous circulation(ROSC)is a critical barrier to survival in cardiac arrest patients.This study examined whether end-tidal carbon dioxide(ETCO_(2))and pulse oximetry photoplethysmogram(POP)parameters can be used to identify unsustained ROSC.METHODS:We conducted a multicenter observational prospective cohort study of consecutive patients with cardiac arrest from 2013 to 2014.Patients’general information,ETCO_(2),and POP parameters were collected and statistically analyzed.RESULTS:The included 105 ROSC episodes(from 80 cardiac arrest patients)comprised 51 sustained ROSC episodes and 54 unsustained ROSC episodes.The 24-hour survival rate was significantly higher in the sustained ROSC group than in the unsustained ROSC group(29.2%vs.9.4%,P<0.05).The logistic regression analysis showed that the difference between after and before ROSC in ETCO_(2)(ΔETCO_(2))and the difference between after and before ROCS in area under the curve of POP(ΔAUCp)were independently associated with sustained ROSC(odds ratio[OR]=0.931,95%confi dence interval[95%CI]0.881-0.984,P=0.011 and OR=0.998,95%CI 0.997-0.999,P<0.001).The area under the receiver operating characteristic curve ofΔETCO_(2),ΔAUCp,and the combination of both to predict unsustained ROSC were 0.752(95%CI 0.660-0.844),0.883(95%CI 0.818-0.948),and 0.902(95%CI 0.842-0.962),respectively.CONCLUSION:Patients with unsustained ROSC have a poor prognosis.The combination ofΔETCO_(2) andΔAUCp showed signifi cant predictive value for unsustained ROSC.

关键词： Return of spontaneous circulation Pulse oximetry photoplethysmogram End-tidal carbon dioxide Cardiac arrest Cardiopulmonary resuscitation

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Interface optimization of graphene paper-Cu composite prepared by electrodeposition

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Journal of Iron and Steel Research(International) 2024年第1期31卷 64-73页

作者： jing Guo Hai-jing Wang Shuang-juan Liu Peng Zhang jing-yu tang Wei-yang Zhang Han-jie Guo Peng-cheng Wang Cai Meng School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Advanced Technology and Materials Co. Ltd.Beijing100083China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei230027AnhuiChina

A room-temperature electrodeposition method with an organic electrolyte was developed to fabricate a HNO3-pretreated graphene paper Cu(GP'-Cu)composite.To improve the interfacial bonding of GP'-Cu composite,magnetron sputtering technology was used to create a"sandwich"structural gradient GP'-Cu composite.The selection of the intermediate transition layer metal was based on two-dimensional disregistry.Scanning electron microscopy,X-ray photoelectron spectroscopy,and other analytical methods confirmed that the addition of an intermediate transition metal(Cr,Ni)layer reduced the gap distance and enhanced the interfacial bonding of the GP'and Cu deposited layers.The GP'-Ni-Cu composite exhibited the largest increase in tensile strength and conductivity.In addition,it had the highest thermal diffusivity and elongation at break among the GP'-Cu,GP'-Cr-Cu and GP'-Ni-Cu composites.

关键词： Graphene paper Two-dimensional disregistry Magnetron sputtering Metal composite

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Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease

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Neural Regeneration Research 2024年第8期19卷 1759-1767页

作者： Zihang Zhou Yalong yan Heng Gu Ruiao Sun Zihan Liao Ke Xue Chuanxi tang Department of Neurobiology Xuzhou Key Laboratory of NeurobiologyXuzhou Medical UniversityXuzhouJiangsu ProvinceChina

Parkinson’s disease can affect not only motor functions but also cognitive abilities,leading to cognitive impairment.One common issue in Parkinson’s disease with cognitive dysfunction is the difficulty in executive functioning.Executive functions help us plan,organize,and control our actions based on our goals.The brain area responsible for executive functions is called the prefrontal co rtex.It acts as the command center for the brain,especially when it comes to regulating executive functions.The role of the prefrontal cortex in cognitive processes is influenced by a chemical messenger called dopamine.However,little is known about how dopamine affects the cognitive functions of patients with Parkinson’s disease.In this article,the authors review the latest research on this topic.They start by looking at how the dopaminergic syste m,is alte red in Parkinson’s disease with executive dysfunction.Then,they explore how these changes in dopamine impact the synaptic structure,electrical activity,and connection components of the prefrontal cortex.The authors also summarize the relationship between Parkinson’s disease and dopamine-related cognitive issues.This information may offer valuable insights and directions for further research and improvement in the clinical treatment of cognitive impairment in Parkinson’s disease.

关键词： dopamine dopamine receptor dopamine transporter executive dysfunction neural network neural oscillation prefrontal cortex synaptic plasticity

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-yan Sun Lingyun Nie jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and memory.Kinesin-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains unknown.In this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative spines.Furthermore,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic plasticity.Knockdown of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and talin1.Knocking down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive abilities.Taken together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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