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Current Medical Science 2022年第1期42卷 201-209页

作者： Meng-meng YIN Rui-chi WU jing GAO Shao-yan HU Xiao-ming LIU Xiao-fan ZHU Shu-hong SHEN Jing-yan TANG jing CHEN Qun HU Department of Pediatric Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Hematology/Oncology Shanghai Children’s Medical CenterShanghai Jiaotong University School of MedicineShanghai 200000China Children’s Hospital of Soochow University Suzhou 215000China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300000China

Objective:Cytogenetic abnormalities have been proven to be the most valuable parameter for risk stratification of childhood acute lymphoblastic leukemia(ALL).However,studies on the prevalence of cytogenetic abnormalities and their correlation to clinical features in Chinese pediatric patients are limited,especially large-scale studies.Methods:We collected the cytogenetics and clinical data of 1541 children newly diagnosed with ALL between 2001 and 2014 in four Chinese hospitals,and retrospectively analyzed their clinical features,prognosis and risk factors associated with pediatric ALL.

关键词： cytogenetics characteristics childhood Chinese acute lymphoblastic leukemia.

Insight into the role of ethylene glycol on thermodynamics and nucleation kinetics of dimethyl terephthalate in mixed solvent system

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Particuology 2024年第2期85卷 1-12页

作者： Yujin Zhang Chunyan Shi jing tang Li Liu Dongxia yan Qing Zhou Xingmei Lu Songyan Jia College of Chemical Engineering Shenyang University of Chemical TechnologyShenyang110142China Bejing Key Laboratoryoflonic Liquids Clean Process CAS Key LaboratoryofGreen Process and EngineeringState Key Laboratoryof Multiphase Complex SystemsInstitute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemistry and Chemical Engineering Qingdao UniversityQingdao266071China Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou450001China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Dissolution and nucleation are two essential processes for industrial crystallization.This paper in-vestigates the effect of ethylene glycol addition on the crystallization behavior of dimethyl terephthalate(DMT)in solution.The DMT solubility in mixed solvent system(methanol-ethylene glycol)was deter-mined by isothermal satiation approach,and the solubility was associated using seven models.The model fitting results were consistent with the experimental values.Based on the results,the metastable zone width(MSZW)of DMT was detected by the polythermal approach;the modified Sangwal's theory was used to investigate the nucleation behavior,which can provide a new way of thought for better analysis of the crystallization behavior.The results demonstrated that MSZW was associated with various elements,such as cooling rate,saturation temperature and mass fraction of ethylene glycol.The addition of ethylene glycol slowed down the nucleation rate as shown by the broadening of MSZW.We derive the solid-liquid interface energy,the nucleation driving force,the critical nucleation size and the critical Gibbs free energy according to the classical nucleation theory.It is demonstrated that the nucleation driving force and the solid-liquid interface energy are dependent and jointly influence the MSZW.

关键词： Dissolution Nucleation Solubility Apparent thermodynamic parameters Metastable zone width Solid-liquid interface energy

Heparanase-1 is downregulated in chemoradiotherapy orbital rhabdomyosarcoma and relates with tumor growth as well as angiogenesis

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 31-39页

作者： Wei-Qiang tang yan Hei jing Lin Department of Ophthalmology the Fourth Medical CentreChinese PLA General HospitalBeijing 100048China Department of Ophthalmology the Third Medical CentreChinese PLA General HospitalBeijing 100039China Department of Clinical Laboratory the Fourth Medical CentreChinese PLA General HospitalBeijing 100048China

AIM:To determine the role of heparanase-1(HPSE-1)in orbital rhabdomyosarcoma(RMS),and to investigate the feasibility of HPSE-1 targeted therapy for RMS.METHODS:Immunohistochemistry was performed to analyze HPSE-1 expression in 51 cases of orbital RMS patients(including 28 cases of embryonal RMS and 23 cases of alveolar RMS),among whom there were 27 treated and 24 untreated with preoperative chemoradiotherapy.In vitro,studies were conducted to examine the effect of HPSE-1 silencing on RMS cell proliferation and tube formation of human umbilical vein endothelial cells(HUVECs).RD cells(an RMS cell line)and HUVECs were infected with HPSE-1 sh RNA lentivirus at a multiplicity of infection(MOI)of 10 and 30 separately.Real-time PCR and Western blot were applied to detect the m RNA and protein expression levels of HPSE-1.Cell viability of treated or control RD cells was evaluated by cell counting kit-8(CCK-8)assay.Matrigel tube formation assay was used to evaluate the effect of HPSE-1 RNAi on the tube formation of HUVECs.RESULTS:Immunohistochemistry showed that the expression rate of HPSE-1 protein was 92.9%in orbital embr yonal RMS and 91.3%in orbital alveolar RMS.Tissue from alveolar orbital RMS did not show relatively stronger staining than that from the embryonal orbital RMS.However,despite the types of RMS,comparing the cases treated chemoradiotherapy with those untreated,we have observed that chemoradiotherapy resulted in weaker staining in patients’tissues.The expression levels of HPSE-1 declined significantly in both the m RNA and protein levels in HPSE-1 sh RNA transfected RD cells.The CCK-8 assay showed that lentivirus-mediated HPSE-1 silencing resulted in significantly reduced RD cells viability in vitro.Silencing HPSE-1 expression also inhibited VEGF-induced tube formation of HUVECs in Matrigel.CONCLUSION:HPSE-1 silencing may be a promising therapy for the inhibition of orbital RMS progression.

关键词： heparanase-1 rhabdomyosarcoma CCK-8 tube formation chemoradiotherapy

Nursing perspective of the expert consensus on diagnosis and treatment of integrated Chinese and Western medicine in lung cancer

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Journal of Integrative Nursing 2022年第1期4卷 1-7页

作者： jing ZHANG Tao MA Shuhong LIU yan ZHAO Ling tang School of Nursing Beijing University of Chinese MedicineBeijingChina Experimental Center Dongfang Hospital of Beijing University of Chinese MedicineBeijingChina Department of Oncology Dongfang Hospital of Beijing University of Chinese MedicineBeijingChina Department of Nursing Dongfang Hospital of Beijing University of Chinese MedicineBeijingChina

Lung cancer is a malignant tumor with the highest incidence and mortality in China,which seriously affects the quality of life of patients.Traditional Chinese medicine(TCM)plays a unique advantage in the treatment and rehabilitation of lung cancer.In order to standardize TCM diagnosis and treatment and disease management of clinical medical workers,the Chinese Association of Integrative Medicine issued the“Expert Consensus on the Diagnosis and Treatment of Lung Cancer by Integrated Traditional Chinese and Western Medicine”in August 2021.Experts’recommendations were made on the clinical staging and syndrome differentiation and classification of lung cancer,characteristic TCM therapies,and nursing care of integrated traditional Chinese and Western medicine.This article interpreted the Consensus on the above aspects from a nursing perspective,hoping to provide references for clinical medical workers in the treatment and nursing care of lung cancer.

关键词： Consensus integrated traditional Chinese and Western medicine nursing lung cancer traditional Chinese medicine nursing

Multi-style video stylization based on texture advection

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Science China(Information Sciences) 2015年第11期58卷 90-102页

作者： tang Ying ZHANG yan SHI XiaoYing FAN jing School of Computer Science and Technology Zhejiang University of Technology Key Laboratory of Visual Media Intelligent Process Technology of Zhejiang Province School of Software Engineering Hangzhou Dianzi University

Artistic video stylization, which is widely used in multimedia entertainment, transforms a given video into different artistic styles. Most of the existing video stylization algorithms can simulate single or limited video artistic styles. Although some algorithms can achieve multi-style video processing, these algorithms are complex and difficult to implement. To solve this problem, we propose a multi-styled video stylization algorithm based on texture advection, where different artistic styles are synthesized and transferred from user-specified texture samples of desired styles. We use the direction field-guided texture synthesis to compute the texture layer that represents the artistic style. Painterly directional video styles are simulated competently by the orientation changes in the synthesized anisotropic textures. There appeared local distorted region of the texture layer during texture advection under the optical flow field. To address this issue, we propose the texture inpaint to synthesize the limited distorted region and make the stylized video temporally coherent. We also accelerate the video stylization by using the CUDA parallel computing framework that parallelly computes the morphological operations used for video abstraction. Finally, we produce stylized videos of multiple artistic styles with satisfactory experimental results, including the styles of oil painting, watercolor painting and stylized lines drawing.

关键词： non-photorealistic rendering video stylization texture synthesis direction field CUDA

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

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Frontiers of Medicine 2023年第4期17卷 714-728页

作者： Tianzhuo Wang Huiying Guo Lei Zhang Miao Yu Qianchen Li jing Zhang yan tang Hongquan Zhang Jun Zhan Program for Cancer and Cell Biology Department of Human AnatomyHistology and EmbryologySchool of Basic Medical SciencesBeijing 100191China Peking University International Cancer Institute Beijing 100191China MOE Key Laboratory of Carcinogenesis and Translational Research and State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science CenterBeijing 100191China

FRMD6,a member of the 4.1 ezrin-radixin-moesin domain-containing protein family,has been reported to inhibit tumor progression in multiple cancers.Here,we demonstrate the involvement of FRMD6 in lung cancer progression.We find that FRMD6 is overexpressed in lung cancer tissues relative to in normal lung tissues.In addition,the enhanced expression of FRMD6 is associated with poor outcomes in patients with lung squamous cell carcinoma(n=75,P=0.0054)and lung adenocarcinoma(n=94,P=0.0330).Cell migration and proliferation in vitro and tumor formation in vivo are promoted by FRMD6 but are suppressed by the depletion of FRMD6.Mechanistically,FRMD6 interacts and colocalizes with mTOR and S6K,which are the key molecules of the mTOR signaling pathway.FRMD6 markedly enhances the interaction between mTOR and S6K,subsequently increasing the levels of endogenous pS6K and downstream pS6 in lung cancer cells.Furthermore,knocking out FRMD6 inhibits the activation of the mTOR signaling pathway in Frmd6^(−/−)gene KO MEFs and mice.Altogether,our results show that FRMD6 contributes to lung cancer progression by activating the mTOR signaling pathway.

关键词： FRMD6 lung cancer mTOR pathway

Geochronology and Geochemistry of Ore-related Granitoids in the Giant Gariatong Rb Deposit,Tibet and Implications for Rb Metallogeny in China

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 83-103页

作者： LIN Bin tang Juxing tang Pan SUN yan QI jing MSANTOSH XIE Jinling DENG Shilin LI Faqiao XIE Fuwei ZHOU Aorigele MNR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China SinoProbe Laboratory Chinese Academy of Geological SciencesBeijing 100094China The Key Laboratory of the Ministry of Education on Solid Waste Treatment and Recycling School of Environment and ResourceSouthwest University of Science and TechnologyMianyangSichuan 621010China School of Earth Sciences and Resources China University of Geosciences(Beijing)Beijing 100083China Department of Earth Sciences University of AdelaideAdelaide SA-5005Australia Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu 610031China Regional Geological Survey Team of the Tibetan Bureau of Geology and Mineral Exploration and Development Lhasa 851400China College of Earth Science and Key Laboratory of Tectonic Controlled Mineralization and Oil Reservoirs Chengdu University of TechnologyChengdu 610059China

Rubidium(Rb)deposits mostly occur in the South China and Central Asia orogenic belts and are often closely associated with highly differentiated granites.This study investigates a newly-discovered giant Rb deposit at Gariatong in the Central Lhasa terrane in Tibet.Detailed field studies and logging data revealed that the Rb mineralization mainly occurs in monzogranite and is related to greisenization.LA-ICP-MS U-Pb dating of zircon yielded ages of 19.1±0.2 Ma and 19.0±0.2 Ma for greisenized monzogranite and fresh monzogranite,respectively.The monzogranites are characterized as strongly peraluminous,with high contents of SiO2,Al2O3,K2O and Na2O as well as a high differentiation index.They are enriched in light rare earth and large ion lithophile elements with significant negative Eu anomalies and depleted high fieldstrength elements.Petrological and geochemical features of these ore-related monzogranites suggest that they are highly fractionated S-type granites,derived from remelting of crustal materials in a post-collisional setting.The geochemistry of zircon and apatite points to a low oxygen fugacity of the ore-related monzogranite during the magma’s evolution.The discovery of the Gariatong Rb deposit suggests that the Central Lhasa terrane may be an important region for rare metal mineralization.

关键词： LA-ICP-MS U-Pb dating geochemistry Rb metallogeny Gariatong Tibet

The impacts of market reform on the market penetration of natural gas-fired electricity and renewable energy in China

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Petroleum Science 2017年第4期14卷 831-841页

作者： Li-jing Zhu yan Li yan-yan tang Yao-Ming Li Qi Zhang Academy of Chinese Energy Strategy China University of Petroleum-BeijingBeijing 102249China

Natural gas-fired electricity(NGFE) is expected to play a more important role in the future due to its characteristics of low pollution, high efficiency and flexibility. However, its development in China is impeded by its high regulation price compared with coal power. Market reform is therefore of vital importance to promote the penetration of NGFE. The objective of this study is to analyze the impacts of market reform and the renewable electricity(RE) subsidy policy on the promotion of NGFE and RE. A dynamic game-theoretic model is developed to analyze the interaction among the NG supplier, the power sector and the power grid. Three scenarios are proposed with different policies, including a fixed regulation price of NG and electricity, real-time pricing(RTP) of NG and electricity, and subsidy targeted at RE. The results show that:(1) market reform can sharply decrease the NG price and consequently promote the development of NGFE and RE;(2) subsidy targeted at RE not only promotes the penetration of NGFE and RE, but also increases the utilization ratio of renewables significantly;(3) market reform and the subsidy also enhance consumers’ welfare by reducing their power consumption expenditure.

关键词： Natural gas-fired electricity Renewable electricity Real-time pricing Market reform Game-theoretic model

A Comparative Study on Participatory MicroRegeneration of Old Communities: From the Perspective of Social Capital

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China City Planning Review 2019年第4期28卷 50-58页

作者： tang yan Zhang Lu Li jing School of Architecture Tsinghua UniversityBeijingP.R.China School of Architectural Arts Northern University of TechnologyBeijingP.R.China

Along with the rise of democratic consciousness and the slowdown of urbanization and economic growth speed, the community development path in contemporary China is under transition, aiming at a more bottom-up and small-scale planning and design process. In order to reveal how the "social capital" affects the public participation and social governance in the process of community micro-regeneration in China, this paper takes two old communities in Chaoyang District of Beijing as examples, to compare the impacts of various social capital levels on participatory community planning and design. The study proves the significance of community social capital and community self-government for the success of residents’ participation and community regeneration, as well as providing suggestions on how to improve public participation effects by strengthening social capital of communities.

关键词： social capital micro-regeneration old community community governance

Thermodynamic analysis on the formation mechanism of MgO·Al_2O_3 spinel type inclusions in casing steel

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International Journal of Minerals,Metallurgy and Materials 2010年第1期17卷 32-38页

作者： Hai-yan tang jing-she Li School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China

MgO·Al2O3 spinel type inclusions in casing steel were analyzed by scanning electron microscope （SEM） and energy dispersive spectrometer （EDS）. The results show that there are three forms. One is pure MgO·Al2O3 spinel, another is the composite oxide of the Mg-Al-Ca-Si-O system, and the third is the complex with oxide as a core covered by sulfide. The formation mechanisms were studied. The influences of slag basicity and vacuum degree on the magnesium content during the vacuum treatment of molten steel and furnace lining in molten steel were calculated with the coexistence theory of slag structure. The results show that the magnesium content increases with the increase in slag basicity and aluminum content in molten steel, and decreases with the increase in CO partial pressure.

关键词： magnesium-aluminum spinel basicity theoretical model formation mechanism