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Detached-eddy simulation of turbulent coherent structures around groynes in a trapezoidal open channel

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Journal of Hydrodynamics 2020年第2期32卷 326-336页

作者： jing-xin zhang Jian Wang Xiang Fan Dongfang Liang Key Laboratory of Hydrodynamics(Ministry of Education) shanghai Jiao Tong UniversityShanghai200240China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China

The hydrodynamics in a straight open channel with a multiple-embayment groyne field was investigated using the detached-eddy simulation(DES).A series of short groynes were included on a 1:3 side slope of the *** work focuses on the turbulent coherent structures around groynes on an uneven *** around groyne fields are characterized by massive separation and highly unsteady *** can capture a wide spectrum of eddies at a lower computational cost than the large eddy simulation(LES)or direct numerical simulation(DNS).In the present work,a zonal DES model(ZDES)was used to simulate the flow around *** ZDES model is a modified version of the DES designed to overcome the model-stress depletion(MSD)of the RANS/LES hybrid *** vortex system consists of the horseshoe vortex(HV)formed at the base of the obstructions,the necklace vortex(NV)that wrapped the groyne tips near the free surface,and the shedding vortex(SV)underneath the free *** effects of the incident flow and local topography on the vortex evolution were investigated by analyzing the mean flow structures and the instantaneous turbulent flow *** important vortices cannot be captured because of the averaging process,while some flow structures cannot be observed in the instantaneous *** mean flow is only a reflection of the averaging process when complex vortices are present.

关键词： Open channel flow groyne free surface detached eddy simulation turbulent coherent structure

Numerical investigation of shallow wake behind a patch of rigid emergent vegetation

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Journal of Hydrodynamics 2021年第4期33卷 673-687页

作者： Jian Wang jing-xin zhang Dongfang Liang Lian Gan School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Key Laboratory of Hydrodynamics(Ministry of Education) Shanghai Jiao Tong UniversityShanghai200240China Department of Engineering University of CambridgeCambridgeUK Department of Engineering Durham UniversityDurhamUK

The shallow water flow through and around a patch of rigid emergent vegetation was investigated numerically. The mean flow field and turbulent structures were studied, especially their dependence on the solid volume fraction (SVF) of the patch and the bed friction. Two streamwise velocity scales, U1s at the starting point of the steady wake and U1e at the downstream end of the steady wake, and the length of the steady wake L1 were used to describe the steady wake behind the patch. U1s was found to be related to SVF only. However, U1e and L1 were influenced by both the SVF and the wake stability parameter S. For a sparse patch, U1e was equal to U1s, and L1 decreased with the increase of S. For a mid-dense patch, U1e was always smaller than U1s, and it increased with S and gradually approached U1s. The increase of U1e reduced the lateral velocity difference between the flows inside and outside the wake, which resulted in the increase of L1. For a highly dense patch, U1e and L1 did not increase unless S was larger than a critical value. A new parameter, r, was proposed to represent the development rate of the steady wake. The numerical results showed that r increased monotonously with S for mid-dense patches.

关键词： Shallow water vegetated flow wake bed friction

Design, Synthesis and Antifungal Activity of 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo[4,3-c]-quinoline-2-carboxamide Derivatives

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Chemical Research in Chinese Universities 2011年第6期27卷 955-957页

作者： YUAN jing SU xin zhang xin CONG Lin GUO Chun Key Laboratory of Structure-based Drug Design ＆ Discovery Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 P. R. China

A series of 6-fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo[4,3-c]quinoline-2-carboxamide derivatives was designed based on the bioisosterism and combination principle in drug design. The target compounds were synthesized from substituted aniline through Michael addition, cyclization, Mannich reaction and condensation with 4-substituted semicarbazides, and the structures were confirmed by mass spectrometry（MS） and 1H NMR. The antifungal assay was carried out in vitro by two-fold dilution. The result shows that all the compounds are of antifungal activities against the tested fungi at different levels.

关键词： 6-Fluoro-3 3a 4 5-tetrahydro-2H-pyrazolo[4 3-c]quinoline-2-carboxamide derivative Cysteine protease in-hibitor Antifungal activity

Synthesis of 11β-ether-17α-ethinyl-3,17β-estradiols with strong ER antagonist activities

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Chinese Chemical Letters 2014年第4期25卷 567-570页

作者： jing-xin zhang David C.Labaree Richard B.Hochberg Department of Obstetrics Gynecology & Reproductive SciencesYale University School of Medicine

We have previously found that several families of nonpolar short chain 11β-ethers and esters ofestradiol are selective estrogen receptor modulators （SERMs）. Surprisingly, the transformation from potent estrogen to anti-estrogen occurs when the 11β-side chain is increased slightly in length from four to five non-hydrogen atoms. To generate strong antagonists for preclinical development, we have synthesized other similar ER ligands with 11β-ethers and with an additional ethinyl group at the 17β-position in order to slow metabolism of the steroidal moiety. Here we report the synthesis and biological activity of two such compounds （11β-i-PrO-propyl and 11β-t-BuO-propyl ethers） with extremely strong antagonist activities.

关键词： Estrogen receptor SERM Antagonist Estradiol

Concise Synthesis of(±)-epi-Chrysotricine

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Chinese Chemical Letters 2001年第3期12卷 199-202页

作者： Guang xing WANG jing xin zhang Shu Feng CHEN Xiao Tian LIANG Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050

epi-Chrysotricine 6 was synthesized by a cascade stereoselective oxidative cyclization of 5-hydroxyalkene 3 using tert-butyl hydroperoxide(TBHP) catalyzed by VO(acac)2.

关键词： (±)-epi-chrysotricine dilithium salt of harman VO(acac)2 TBHP oxidation

Optimized liver resection range and perioperative safety in patients with high levels of indocyanine green R15

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Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 495-498页

作者： Rui Tang xin-jing zhang Meng-Jiao Liao Ang Li Wen-Ping Zhao Qian Lu Hepatopancreatobiliary Center Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineInstitute for Precision MedicineTsinghua UniversityBeijing 102218China Department of General Surgery the Fifth Affiliated Hospital of Zunyi Medical UniversityZhuhai 519100China

The indocyanine green(ICG)clearance test is an objective measurement of functional liver reserve(FLR)[1].The liver can preserve normal functions with a 70%−80%functional liver volume resection[2]and the remnant is capable of ***,liver regenerative properties are affected by hepatitis,fatty liver,cirrhosis and damage caused by chemotherapy[3].ICG combined with the Child-Pugh score are main criteria for evaluating FLR.A safe hepatectomy procedure requires the remnant liver to be 25%−30%of the normal *** patients with an indocyanine green retention rate at 15 min(ICG-R15)>20%,segment liver resection,limited hepatectomy or tumor enucleation is recommended,but there has been no clear clarification of the essential remnant liver volume[4].In China,the experts’consensus of preoperative evaluation of liver reserve function incorporates ICGR15 tests.

关键词： resection patients cyanine

Solid Phase Synthesis of β-Carbolines

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Chinese Chemical Letters 2000年第11期11卷 955-956页

作者： jing xin zhang, Xiao Chuan TAN, Ping XIE, Xiao Tian LIANG Institute of Material Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050 Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China Peking Union Med Coll Beijing 100050 Peoples R China

Synthesis of β-carbolines on solid phase using TCCA as the key reagent is developed.

关键词： Solid phase synthesis β-carbolines TCCA.

STUDIES ON FISCHER TROPSCH SYNTHESIS OVER Fe-Cu-K CATALYST Ⅱ.PRODUCT DISTRIBUTION AND COMPOSITION

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Journal of Energy Chemistry 1995年第1期 77-85页

作者： LIU Zhao-Tie ZHOU jing-Laizhang Zhi-xin zhang Bi-JiangInstitute of Coal Chemistry, Academia Sinica To whom correspondence should be addressed.

In part I, we investigated some behavior of copper- potassium promoted iron catalyst for the synthesis of hydrocarbon from hydrogen and carbon monoxide, with particular attention to the influence of reaction temperature, operating pressure, space velocity, H2/CO ratio in feed gas and particle size of catalyst on CO conversion. In this part, more attention was paid to the whole product distribution, such as wax, oil, oxygenate and the composition of oil and oxygenate. It is seen that the operating conditions greatly affect the whole product distribution and its composition.

关键词： Fischer-Tropsch synthesis composition of oil and water fixed-bed reactor Fe-Cu-K catalyst

Expression of Hepatitis C Virus E2 Ectodomain in *** and Its Application in the Detection of Anti-E2 Antibodies in Human Sera

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Acta Biochimica et Biophysica Sinica 2004年第1期36卷 57-63页

作者： jing LIU, xin-xin zhang, Shen-Ying zhang, Min LU, Yu-Ying KONG, Yuan WANG, and Guang-Di LI ( State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, Shanghai 200031, China 2 Department of Infectious Diseases, Ruijin Hospital, Second Medical University of Shanghai, Shanghai 200025, China ) State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences the Chinese Academy of Sciences Shanghai 200031 Chin

The second envelope glycoprotein （E2） of hepatitis C virus has been shown to bind human target cells and has become a major target for the development of anti-HCV vaccines. Anti-E2 antibodies have been suggested to be of clinical significance in diagnosis, treatment and prognosis of hepatitis C. However, large-scale expression and purification of E2 proteins in mammalian cells is difficult. As an alternative, E2 fragment （aa 385-730） with a four-amino-acid mutation （aa 568-571 PCNI to RVTS） was expressed as hexa-histidine-tagged full length protein [E2N730（m）] in E. coli and purified to over 85% purity. Purified E2N730（m） was specifically recognized by homologous hepatitis C patient serum in Western blot, suggesting that it displayed E2specific antigenicity. Rabbit antiserum raised against E2N730（m） recognized E2 glyco-proteins expressed in mammalian cells in Western blot. Purified E2N730（m） was used to detect anti-E2 antibodies in human sera and showed better specificity and sensitivity than previousl

关键词： hepatitis C virus envelope protein E2 expression and purification Escherichia coll