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Association Between Dentin Matrix Protein 1 （rs10019009） Polymorphism and Ankylosing Spondylitis in a Chinese Han Population from Shandong Province

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Chinese Medical Journal 2016年第6期129卷 657-664页

作者： Jian-Min Liu Ya-Zhou Cui Geng-Lin Zhang Xiao-Yan Zhou jing-xiang pang Xue-Zheng Wang Jin-xiang Han Allergy and Clinical Immunology Research Centre First Affiliated Hospital of Liaoning Medical University Jinzhou Liaoning 121001 China National Laborat'ory for Bio-Drugs of Mini'stry of Health Provincial Laboratory fo'r Modern Medicine and Technology of Shanclong Research Center for Medicinal Biotechnology Shandong Academy of Medical Sciences Jinan Shandong 250062 China

Background： Ankylosing spondylitis （AS） is the most common rheumatic condition that is slowly progressive and predominantly affects adolescents. Pathological bone formation associated with AS is an important cause of disability. The aim of the study was to investigate the possible involvement of the genes related to endochondral ossification and ectopia ossification in genetic susceptibility to AS in a Chinese Han population. Methods： Sixty-eight single nucleotide polymorphisms （SNPs） from 13 genes were genotyped in discovery cohorts including 300 AS patients and 180 healthy controls. The rs10019009 in dentin matrix protein 1 （DMP1） gene shown as association with AS after multiple testing corrections in discovery cohorts was replicated in a validation independent cohort of 620 AS patients and 683 healthy controls. The rs 10019009 was assessed with bioin fomlatics including phylogenetic context, F-SNP and FastSNP functional predictions, secondary structure prediction, and molecular modeling. We performed a functional analysis of rs10019009 via reverse transcription-polymerase chain reaction, alkaline phosphatase （ALP） activity in human osteosarcoma U2OS cells. Results： Interestingly, the SNP rs10019009 was associated with AS in both the discovery cohort （P = 0.0012） and validation cohort （P - 0.0349）, as well as overall （P = 0.0004） in genetic case-control association analysis. After a multivariate logistic regression analysis, the effect of this genetic variant was observed to be independent of linkage disequilibrium. Via bioinformatics analysis, it was found that the amino acid change of the rs 10019009 led to changes of SNP function, secondary structure, tertiary confomlation, and splice mode. Finally, functional analysis ofrsl0019009 in U2OS cells demonstrated that the risk T allele of the rsl0019009 increased enzymatic activity of ALP, compared to that of the nonrisk allele （P = 0.0080）. Conclusions： These results suggested that the DMP1 gene seems to be involve

关键词： Alkaline Phosphatase Ankylosing Spondylitis Dentin Matrix Protein I Ectopic Mineralization Polymorphisms

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胆道生态系统：全局视角下的胆道外科关键科学问题

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中华外科杂志 2025年第1期63卷 39-44页

作者：王向付静海军军医大学第三附属医院胆道二科上海海军军医大学国家肝癌科学中心上海

随着胆道外科现代诊疗体系的建立与科学研究范式的转变, 无论是良性还是恶性胆道疾病, 均已进入精准化、个体化、全程化及多学科协作的诊疗和研究阶段。然而胆道外科医师仍面临着两大困境:(1)外科技术在降低良性胆道疾病致残率、提高胆... 详细信息

随着胆道外科现代诊疗体系的建立与科学研究范式的转变, 无论是良性还是恶性胆道疾病, 均已进入精准化、个体化、全程化及多学科协作的诊疗和研究阶段。然而胆道外科医师仍面临着两大困境:(1)外科技术在降低良性胆道疾病致残率、提高胆道肿瘤患者生存率方面进入了瓶颈期;(2)对于"切胆保胆""如何减黄"等临床争议, 传统的临床研究似乎难以给出确切答案。借鉴系统生物学的理念, 作者提出了"胆道生态系统"的概念框架:胆管是丛林, 血管、淋巴管、神经和免疫系统是土壤, 干细胞是种子, 胆汁是河流, 肝细胞是河流的发源地。良恶性疾病具有动态转化的特征;不同部位的胆管构成"大"环境, 胆汁形成"小"环境, 不同细胞组成"微"环境;细胞亚群具有不同状态及多样性, 并受复杂分子信号网络的调控。作者据此进一步凝练了胆道外科的若干关键科学问题, 提出了优化研究范式的建议, 旨在从全局视角推动学科交叉融合, 推动胆道外科临床及转化研究。

关键词：胆道疾病胆道肿瘤胆道生态系统普通外科学范式转变多组学技术

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苹果的MA贮藏

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河南科学 1986年第Z1期 151-156页

作者：杨德兴戴京晶庞向宇韩恒芬河南省科学院生物研究所

采用 MA 技术贮藏中熟苹果金冠（Golden Delicious）和元帅（Delicious）,可大幅度的降低贮藏环境中的 O2分压并提高 CO2分压,使催熟激素乙烯的生成受到强烈抑制,内源乙烯含量由231.6 PPM 下降至98.9PPM,外部乙烯浓度降低一倍左右。MA ... 详细信息

采用 MA 技术贮藏中熟苹果金冠（Golden Delicious）和元帅（Delicious）,可大幅度的降低贮藏环境中的 O2分压并提高 CO2分压,使催熟激素乙烯的生成受到强烈抑制,内源乙烯含量由231.6 PPM 下降至98.9PPM,外部乙烯浓度降低一倍左右。MA 环境可使果实的呼吸速率降低约40%,后熟作用受到明显抑制,贮藏寿命延长30-40天。经 MA 处理的果实,果肉硬度比对照组高1-2磅/cm2,好果率、果肉含水量、滴定酸等皆高于对照,果品品质得到明显改善。

关键词：苹果 MA 贮藏乙烯

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MiR-142-3p Regulates ILC1s by Targeting HMGB1 via the NF-κB Pathway in a Mouse Model of Early Pregnancy Loss

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Current Medical Science 2024年第1期44卷 195-211页

作者： xiang-li pang Jie LI jing WANG Si-si YAN jing YANG Department of Obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhan 430060China Reproductive Medical Center Renmin Hospital of Wuhan UniversityWuhan 430060China Clinic Research Center for Assisted Reproductive Technology and Embryonic Development in Hubei Province Wuhan 430060China

Objective Innate lymphoid cells(ILCs)are a class of newly discovered *** 1 ILCs(ILC1s)are identified in the decidua of humans and *** mobility group box 1(HMGB1)is predicted to be one of the target genes of miR-142-3p,which is closely related to pregnancy-related ***,miR-142-3p and HMGB1 are involved in regulating the NF-κB signaling *** study aimed to examine the regulatory effect of miR-142-3p on ILC1s and the underlying mechanism involving HMGB1 and the NF-κB signaling *** Mouse models of normal pregnancy and abortion were constructed,and the alterations of ILC1s,miR-142-3p,ILC1 transcription factor(T-bet),and pro-inflammatory cytokines of ILC1s(TNF-α,IFN-γand IL-2)were detected in mice from different *** targeting regulation of HMGB1 by miR-142-3p in ILC1s,and the expression of HMGB1 in normal pregnant mice and abortive mice were *** addition,the regulatory effects of miR-142-3p and HMGB1 on ILC1s were detected in vitro by CCK-8,Annexin-V/PI,ELISA,and RT-PCR,***,changes of the NF-κB signaling pathway in ILC1s were examined in the different *** the in vivo studies,miR-142-3p-Agomir was injected in the uterus of abortive mice to evaluate the abortion rate and alterations of ILC1s at the maternal-fetal interface,and further detect the expression of HMGB1,pro-inflammatory cytokines,and the NF-κB signaling *** The number of ILC1s was significantly increased,the level of HMGB1 was significantly upregulated,and that of miR-142-3p was considerably downregulated in the abortive mice as compared with the normal pregnant mice(all P<0.05).In addition,miR-142-3p was found to drastically inhibit the activation of the NF-κB signaling pathway(P<0.05).The number of ILC1s and the levels of pro-inflammatory cytokines were significantly downregulated and the activation of the NF-κB signaling pathway was inhibited in the miR-142-3p Agomir group(all P<0.05).Conclusion

关键词： maternal-fetal interface group 1 innate lymphoid cells(ILCis) high mobility group box 1(HMGB1) miR-142-3p abortion

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Estimation of the interaction force between human and passive lower limb exoskeleton device during level ground walking

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Biomimetic Intelligence & Robotics 2022年第3期2卷 9-21页

作者： Muye pang Zihan Luo Biwei Tang jing Luo Kui xiang School of Automation Intelligent System Research InstituteWuhan University of TechnologyWuhanChina

To develop sophisticated and efficient control strategies for exoskeleton devices,acquiring the information of interaction forces between the wearer and the wearable device is ***,obtaining the interaction force via conventional methods,such as direct measurement using force sensors,is *** paper proposes a kinematic data-based estimation method to evaluate the interaction force between human lower limbs and passive exoskeleton links during level ground *** conventional methods,the proposed method requires no force sensors and is computationally cheaper to obtain the calculation *** obtain more accurate kinematic data,a marker refinement algorithm based on bilevel optimization framework is *** interaction force is evaluated by a spring model,which is used to imitate the binding behavior between human limbs and the exoskeleton *** deflection of the spring model is calculated based on the assumption that the phase delay between human limb and exoskeleton link can be presented by the sequence of frames of kinematic *** results of six subjects indicate that our proposed method can estimate the interaction forces during level ground ***,a case study of bandage location optimization is conducted to demonstrate the usefulness of obtaining the interaction information.

关键词： Interaction force estimation Passive lower limb exoskeleton Level ground walking Bilevel optimization

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Retrospective Analysis of Clinical Characteristics and Neonatal Outcomes of Pregnant Women with SARS-COV-2 Infection

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Current Medical Science 2021年第2期41卷 306-311页

作者： Yu CHEN xiang-li pang Wen-ping DING xiang-chi PENG jing YANG Yan ZHOU Reproductive Medicine Center Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Reproductive Medical Center Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Diagnostic Ultrasound Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechologyWuhan 430015China Department of Obstetrics and Gynecology Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China

This retrospective study aimed to investigate the clinical characteristics and neonatal outcomes of pregnant women with SARS-COV-2 in Wuhan Children's Hospital and further suggested a possible management strategy for infected pregnant women under epidemic *** this study,8 pregnant women with SARS-COV-2 who were admitted into Wuhan Children's Hospital,China from February 1,2020 to March 30,2020 and the clinical features,laboratory data,maternal and neonatal outcomes were *** mean age of the women at the time of admission was 30.6 *** mean gestational age of the women was 37 weeks±4 days,and one woman presented with dichorionic diamniotic(DCDA)twin *** for one woman who was febrile,others had no typical clinical *** all pregnant women,the count of white blood cells and lymphocytes appeared normal,but 6 had a lower percentage of lymphocytes.C-reactive protein(CRP)levels were normal for all the *** neonate was tested positive for the coronavirus IgG and IgM *** clinical symptoms of the pregnant women with SARS-COV-2 were mild,and the laboratory data showed similar characteristics to those of non-infected pregnant *** one neonate was tested positive for coronavirus,there is a possibility of vertical transmission of *** and efficient screening,triage,and isolation of pregnant women are ffective management strategies to reduce nosocomial infection during the SARS-COV-2 epidemic.

关键词： SARS-COV-2 vertical transmission pregnant women neonates clinical features maternal and child outcomes

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文旅融合背景下历史文化园高质量发展研究——以包公故里文化园为例

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四川旅游学院学报 2025年第1期 40-46页

作者：项松林魏静安徽建筑大学公共管理学院安徽合肥230601

历史文化园是一种以历史文化为主题,通过景观、文物、文化活动等手段,再现和展示特定历史时期、历史名人或文化传统的公共空间,具有经济、文化、教育等价值。“以文兴旅,以旅彰文”,文旅融合发展的新模式为历史文化园的“出圈”与高质... 详细信息

历史文化园是一种以历史文化为主题,通过景观、文物、文化活动等手段,再现和展示特定历史时期、历史名人或文化传统的公共空间,具有经济、文化、教育等价值。“以文兴旅,以旅彰文”,文旅融合发展的新模式为历史文化园的“出圈”与高质量发展提供了新思路与新契机。包公故里文化园是新时代展示包公文化、弘扬廉政精神的重要基地,在文旅融合方面已有初步的探索与实践,但仍存在文化特色不鲜明、文旅业态不丰富、社会知名度不够高等问题。新发展阶段推进历史文化园高质量发展,要强化顶层设计,建构文旅融合新架构;优化产业链,铸造文旅融合新模式;创新宣传方式,提升文旅融合新品位;加强组织支撑,完善文旅融合新体制。

关键词：文旅融合历史文化园高质量发展包公故里文化园

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Heading constraint algorithm for foot-mounted PNS using low-cost IMU

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Journal of Systems Engineering and Electronics 2022年第3期33卷 727-736页

作者： GUI jing ZHAO Heming XU xiang School of Electronic and Information Engineering Soochow UniversitySuzhou 215006China

Foot-mounted pedestrian navigation system(PNS)is a common solution to pedestrian navigation using micro-electro mechanical system(MEMS)inertial *** inherent problems of inertial navigation system(INS)by the traditional algorithm,such as the accumulated errors and the lack of observation of heading and altitude information,have become obstacles to the application and development of the *** this paper,we introduce a heuristic heading constraint *** of all,according to the movement characteristics of human gait,we use the generalized likelihood ratio test(GLRT)detector and introduce a time threshold to classify the human gait,so that we can effectively identify the stationary state of the *** addition,based on zero velocity update(ZUPT)and zero angular rate update(ZARU),the cumulative error of the inertial measurement unit(IMU)is limited and corrected,and then a heuristic heading estimation is used to constrain and correct the heading of the *** simulation and experiments with low-cost IMU,the method is proved to reduce the localization error of end-point to less than 1%of the total distance,and it has great value in application.

关键词： pedestrian navigation system(PNS) zero velocity update(ZUPT) gait detection heading constraint

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On the Prescribed Boundary Mean Curvature Problem via Local Pohozaev Identities

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Acta Mathematica Sinica,English Series 2023年第10期39卷 1951-1979页

作者： Qiu xiang BIAN jing CHEN jing YANG School of Science Jiangsu University of Science and TechnologyZhenjiang 212003P.R.China School of Mathematics and Statistics and Hubei Key Laboratory Mathematical Sciences Central China Normal UniversityWuhan 430079P.R.China

This paper deals with the following prescribed boundary mean curvature problem in B^(N){−Δu=0,u>0,∂_(u)∂_(ν)+N−2/2 u=N−2/2 K˜(y)u^(2−1),y∈B^(N)y∈S^(N−1),where K˜(y)=K˜(|y|,y˜)is a bounded nonnegative function with y=(y,y˜)∈R^(2)×R^(N−3),2=2(N−1)/N−*** the finite-dimensional reduction method and local Pohozaev type of identities,we prove that if N≥5 and K˜(r,y˜)has a stable critical point(r_(0),y˜_(0))with r0>0 and K˜(r0,y˜0)>0,then the above problem has infinitely many solutions,whose energy can be made arbitrarily *** our result fill the gap that the above critical points may include the saddle points of K˜(r,y˜).

关键词： Infinitely many solutions prescribed boundary mean curvature finite reduction local Pohozaev identities

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A pyramid-based approach to visual exploration of a large volume of vehicle trajectory data

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Frontiers of Earth Science 2012年第4期6卷 345-353页

作者： jing SUN xiang LI Key Laboratory of Geographical Information Science (Ministry of Education) East China Normal University Shanghai 200062 China

Advances in positioning and wireless commu- nicating technologies make it possible to collect large volumes of trajectory data of moving vehicles in a fast and convenient fashion. These data can be applied to traffic studies. Behind this application, a methodological issue that still requires particular attention is the way these data should be spatially visualized. Trajectory data physically consists of a large number of positioning points. With the dramatic increase of data volume, it becomes a challenge to display and explore these data. Existing commercial software often employs vector-based indexing structures to facilitate the display of a large volume of points, but their performance downgrades quickly when the number of points is very large, for example, tens of millions. In this paper, a pyramid-based approach is proposed. A pyramid method initially is invented to facilitate the display of raster images through the tradeoff between storage space and display time. A pyramid is a set of images at different levels with different resolutions. In this paper, we convert vector-based point data into raster data, and build a grid- based indexing structure in a 2D plane. Then, an image pyramid is built. Moreover, at the same level of a pyramid, image is segmented into mosaics with respect to the requirements of data storage and management. Algorithms or procedures on grid-based indexing structure, image pyramid, image segmentation, and visualization operations are given in this paper. A case study with taxi trajectory data in Shanghai is conducted. Results demonstrate that the proposed method outperforms the existing commercial software.

关键词： large volumes of trajectory data visualization grid-based indexing structure image pyramid

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