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Meta- analysis of association between K469E polymorphism of the ICAM-1 gene and retinopathy in type 2 diabetes

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 603-607页

作者： wen-Ying Fan Ning-pu Liu Beijing Tongren Eye Center Beijing Tongren HospitalBeijing Ophthalmology and Visual Sciences Key LaboratoryCapital Medical University

AIM: To collectively evaluate the association of intercellular adhesion molecule-1(ICAM-1) gene K469 E polymorphism(rs5498) with diabetic retinopathy(DR) in patients with type 2 diabetic mellitus(T2DM). METHODS: Overall review of available literatures relating K469 E polymorphism to the risk of DR was conducted on 4 electronic databases. Meta-analysis was performed by Stata 12.0 to calculate pooled odds ratios(ORs). Potential sources of heterogeneity and bias were ***: Seven studies with genotype frequency data including 1120 cases with DR and 956 diabetic controls free of DR were included. Meta-analysis did not show significant association of K469 E polymorphism with DR(P >0.05). A statistically significant association was detected between the K469 E polymorphism and proliferative DR(PDR) in Asians only in dominant model(GG+AG vs AA) with pooled OR of 0.729(95%CI: 0.564-0.942, P=0.016, P heterogeneity=0.143), however, this association was not detected in recessive model(AG +AA vs GG;OR=1.178, 95%CI: 0.898-1.545, P =0.236, P heterogeneity=0.248)or allelic model(G vs A; OR=0.769, 95% CI: 0.576-1.026,P =0.074, P heterogeneity=0.094). No publication bias was found by Funnel plot, Begg’s and Egger’s test. CONCLUSION: This research found no statistically significant association between ICAM-1 gene K469 E polymorphism and DR in patients with T2 DM, but showed significant association of the K469 E polymorphism with PDR in Asian diabetic patients only in dominant model. Further investigation would be required to consolidate the conclusion.

关键词： K469E polymorphism rs5498 intercellular adhesion molecule-1 diabetic retinopathy type 2 diabetes Meta-analysis

Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： wen-Chong Zhen jing Sun Xue-Ting Bai Qian Zhang Zi-Han Li Yi-Xin Zhang Rong-Xuan Xu Wei Wu Zhi-Han Yao Chun-wen pu Xiao-Feng Li School of public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

purpura annularis telangiectodes of Majocchi:A case report

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World Journal of Clinical Cases 2023年第16期11卷 3858-3863页

作者： Yun-jing pu Hong-jing Jiang Li Zhang Department of Dermatology Kunming Children's HospitalKunming 650034Yunnan ProvinceChina

BACKGROUND purpura annularis telangiectodes of Majocchi(PATM),also known as Majocchi,is a rare subclass of pigmented purpuric *** etiology of PATM is unknown,but it seems more common in children and young *** skin lesions are mostly symmetrical ring-shaped reddish-brown macules on the lower *** SUMMARY A 9-year-old girl,who has received treated in our department,presented with reddish-brown ring-shaped rash on both lower limbs that had been present for 6 *** lesions,red brownish annular or petaloid patches,were mostly found on ankles and lower limber,which do not fade when adding pressure and no feel of infiltration and no atrophy when touching those *** examination showed deposition of hemosiderin in papillary ***,dermoscopy showed the pigmentation in the center as well as the lavender patches on the edge of *** child was thus diagnosed with *** diagnosis,we suggested the patient avoid strenuous *** was given vitamin C tablets for oral and mometasone furoate cream for external *** examinations and treatment continue to support the clinical diagnosis to *** This is the first report of investigating PATM using dermoscopy,which can differentiate PATM from other diseases due to its unique microscopic feature under *** PATM is harmless,it still requires long-term ***,dermoscopy technique can be applied for observation of multi-site lesions and correlated with ***,we believe this approach could be generalized for future diagnosis of PATM.

关键词： Pigmented purpuric dermatoses Majocchi's disease Dermatoscope Histology Case report

槲皮素治疗非小细胞肺癌的网络药理学分析及细胞实验验证

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食品工业科技 2025年第2期46卷 334-342页

作者：王翊蒲晓芳山东中医药大学药学院山东中医药大学管理学院

目的：探究槲皮素治疗非小细胞肺癌（NSCLC）的潜在机制，并结合分子生物学实验验证。方法：通过SwisTargetPrediction和DrugBank数据库筛选槲皮素的靶点，通过GeneCards、TTD数据库收集NSCLC的疾病靶点，进行靶点映射获得槲皮素治疗NS... 详细信息

目的：探究槲皮素治疗非小细胞肺癌（NSCLC）的潜在机制，并结合分子生物学实验验证。方法：通过SwisTargetPrediction和DrugBank数据库筛选槲皮素的靶点，通过GeneCards、TTD数据库收集NSCLC的疾病靶点，进行靶点映射获得槲皮素治疗NSCLC的靶点，应用STRING数据库获取蛋白-蛋白相互作用（PPI）网络并进行分析，使用Cytoscape 3.7.2进行可视化；利用DAVID数据库进行靶点富集，进行基因本体论分析（GO）和京都基因与基因组百科全书分析（KEGG）。采用分子对接对核心靶点进行验证，并使用PLIP平台分析结合位点力学数据。通过细胞实验评估槲皮素对A549细胞增殖的影响，并利用qRT-PCR和Western blot对核心靶点进行验证。结果：网络药理学研究显示，槲皮素能够调控126个靶点，潜在治疗NSCLC的靶点有49个，核心通路为PI3K-Akt信号通路，核心靶点为PI3K、Akt、GSK-3β。分子对接实验初步发现，槲皮素与3个核心靶点均能产生强烈结合力。细胞实验结果显示，槲皮素低、中、高剂量组干预72 h后均能够显著抑制A549细胞的增殖活力（P<0.01），并下调PI3K、Akt、GSK-3β的mRNA表达水平（P<0.05）以及蛋白表达趋势。结论：本研究分析预测了槲皮素治疗NSCLC的潜在活性机制，通过实验验证发现槲皮素可能通过抑制PI3K/Akt/GSK-3β信号通路发挥抗癌作用。

关键词：槲皮素非小细胞肺癌网络药理学分子对接 PI3K/Akt/GSK-3β信号通路

来源：博看期刊

Plasmonic silver/silver oxide nanoparticles anchored bismuth vanadate as a novel visible-light ternary photocatalyst for degrading pharmaceutical micropollutants

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Journal of Environmental Sciences 2020年第10期32卷 21-32页

作者： Shengyan pu Zeng Yang jing Tang Hui Ma Shengyang Xue Yingchen Bai State Key Laboratory o f Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdK 610059SichitcmChina State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Department of Plant and Environmental Sciences Uniuersity of CopenhagenThorvaldsensvej 401871 FrederiksbergDenmark

The degradation of pharmaceutical micropollutants is an intensifying environmental problem and synthesis of efficient photocatalysts for this purpose is one of the foremost challenges ***,this study was conducted to develop novel plasmonic Ag/Ag2O/BiVO4 nanocomposite photocatalysts by simple precipitation and thermal decomposition methods,which could exhibit higher photocatalytic activity for mineralized pharmaceutical *** the different treatments,the best performance was observed for the Ag/Ag2O/BiVO4 nanocomposites (5 wt.%;10 min’s visible light irradiation)which exhibited 6.57 times higher photodegradation rate than the pure ***,the effects of different influencing factors on the photodegradation system of tetracycline hydrochloride (TC-HCl) were investigated and the feasibility for its practical application was explored through the specific light sources,water source and cycle *** mechanistic study demonstrated that the photogenerated holes (h^+),superoxide radicals (·O2^-)and hydroxyl radicals (·OH) participated in TC-HCl removal process,which is different from the pure BiVO4 reaction ***,the present work can provide a new approach for the formation of novel plasmonic photocatalysts with high photoactivity and can act as effective practical application for environmental remediation.

关键词： Ag/Ag_2O/BiVO_4 Tetracycline hydrochloride Photocatalytic degradation Pharmaceutical micropollutants

Recent advances in photonic crystal with unique structural colors:A review

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Journal of Materials Science & Technology 2023年第10期141卷 78-99页

作者： Keming Zhu Changqing Fang Mengyuan pu jing Song Dong Wang Xing Zhou School of Mechanical and Precision Instrument Engineering Xi’an University of TechnologyXi’an 710048China Faculty of Printing Packaging Engineering and Digital Media TechnologyXi’an University of TechnologyXi’an 710048China

Inspired by special color-forming organisms in nature,photonic crystal materials with structural color function have been developed significantly with great potential applications for displays,sensors,anti-counterfeiting inks,*** review aims to summarize the functions,self-assembly modes,and ap-plications of different kinds of photonic crystal *** preparation methods and characteristics of monodisperse inorganic nanoparticles,polymer nanoparticles,inorganic/organic core-shell nanoparti-cles,and MOFs are ***,we summarize the method of assembling colloidal parti-cles into photonic crystals,which is a template induction method,inkjet printing method,drop coating method,***,the potential application of structural color is presented including humidity re-sponse and magnetic field response in sensors fields,as well as the advantages and disadvantages of anti-counterfeiting,fabric coloring,displays,smart windows,and Biomedical ***,we present the development prospects and key problems of photonic crystals.

关键词： Photonic crystal Structural color Self-assembly Monodisperse nanoparticles Patterned nanostructures

An investigation on the dosimetric impact of hip prosthesis in radiotherapy

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Nuclear Science and Techniques 2016年第1期27卷 29-36页

作者： wen-Cheng Shao Yan-Ling Bai wen-Bo Zhao pu-Nan Sun Feng-Li Liu Department of Radiation Physics Harbin Medical University Cancer Hospital Beijing Xiao Qing Environmental Engineering Co. LtdHarbin office School of physical science and technology Heilongjiang University

The objectives of this study are to evaluate the dosimetric impact of hip prosthesis using ELEKTA linac X-rays and compare the dose perturbations of metallic and nonmetallic hip prostheses. The local dose distributions of typical hip prostheses were calculated for 4, 8, and 15 MV beams by Geant4. Three prosthesis materials were selected in calculation to reveal the relation between material type and local dose perturbations of prostheses. Furthermore,the effect of nominal energy on prosthesis perturbation was also discussed and analyzed. Taking the calculated dose to the hip joint as reference, considerable differences were observed between prostheses and hip joints. In the prosthesis shadow region, the relative dose decreasing was up to 36, 21, and 16 % for the Co–Cr–Mo alloy, titanium alloy, and ceramic prostheses, respectively. In backscattering region, the relative dose increasing was about1–7 %. Overall, the results show that the dose perturbation effect of prostheses was mainly determined by material type, nominal energy, and density. Among these typical hip prostheses, ceramic prosthesis introduces the lowest dose perturbations.

关键词：髋关节剂量学假体放射治疗扰动效应 Geant4 X射线剂量直线加速器

Broadcast encryption schemes based on RSA

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The Journal of China Universities of Posts and Telecommunications 2009年第1期16卷 69-75页

作者： MU Ning-bo HU Yu-pu OU Hai-wen The Ministry of Education Key Laboratory of Computer Networks and Information Security Xidian University Xi'an 710071 China Key Laboratory of Information Security and Secrecy Beijing Institute of Electronic Science and Technology Beijing 100070 China

Three broadcast schemes for small receiver set using the property of RSA modulus are presented. They can solve the problem of data redundancy when the size of receiver set is small. In the proposed schemes, the center uses one key to encrypt the message and can revoke authorization conveniently. Every authorized user only needs to store one decryption key of a constant size. Among these three schemes, the first one has indistinguishability against adaptive chosen ciphertext attack （IND-CCA2） secure, and any collusion of authorized users cannot produce a new decryption key but the sizes of encryption modulus and ciphertext are linear in the number of receivers. In the second scheme, the size of ciphertext is half of the first one and any two authorized users can produce a new decryption key, but the center can identify them using the traitor tracing algorithm. The third one is the most efficient but the center cannot identify the traitors exactly.

关键词： broadcast encryption traitor tracing authorization revocation RSA

Evidence of potential change in nonsequential double ionization

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Chinese Physics B 2021年第2期30卷 262-267页

作者： Changchun Jia pu Zhang Hua wen Zhangjin Chen School of Physics and Material Science Anhui UniversityHefei 230039China Department of Physics College of ScienceShantou UniversityShantou 515063China

Recently,the quantitative rescattering model(QRS)for nonsequential double ionization(NSDI)is modified by taking into account the potential change(PC)due to the presence of electric field at the time of *** the improved QRS model,we simulate the longitudinal momentum distributions of doubly charged ions He2+by projecting the correlated two-electron momentum distributions for NSDI of He onto the main *** obtained results are compared directly with the experimental data at different *** is found that when the PC is considered,the width of momentum distributions reduces and the agreement between theory and experiment is improved.

关键词： nonsequential double ionization quantitative rescattering model potential change momentum distribution of doubly charged ion