检索结果-南通市图书馆

升降散对流感病毒鼠肺适应株FM1感染小鼠免疫功能的影响

在线全文

学校读者我要写书评

暂无评论

中药药理与临床 2016年第5期32卷 8-13页

作者：南淑玲徐顺富陈许李凤吕明安李静徐伟赵黎安徽中医药大学合肥230038

目的:研究升降散对亚甲型流感病毒鼠肺适应株FM1感染小鼠免疫功能的影响。方法:建立亚甲型流感病毒鼠肺适应株FM1感染小鼠肺炎模型,用升降散全方、升降散拆方、升降散与麻黄杏仁甘草石膏汤合方治疗后,第5天用EliSA方法检测小鼠支气管肺... 详细信息

目的:研究升降散对亚甲型流感病毒鼠肺适应株FM1感染小鼠免疫功能的影响。方法:建立亚甲型流感病毒鼠肺适应株FM1感染小鼠肺炎模型,用升降散全方、升降散拆方、升降散与麻黄杏仁甘草石膏汤合方治疗后,第5天用EliSA方法检测小鼠支气管肺泡、大小肠灌洗液中sIgA、血清中炎性细胞因子IL-1β、IL-6、TNF-α、IL-10、IL-lra、sTNFR的含量;流式细胞仪法测定外周全血中T细胞亚群CD4^+、CD8^+的百分比和CD4^+/CD8^+值;计算胸腺指数和脾指数。结果:模型组小鼠较正常组小鼠支气管肺泡、大小肠灌洗液中sIgA含量显著降低,血清IL-1β、IL-6、TNF-α、IL-10、IL-lra、sTNFR的含量显著升高,全血CD8^+的百分比增高,CD4^+百分比和CD4^+/CD8^+值下降,胸腺指数明显降低,但对脾指数无明显影响。升降散(4.55g/kg)能显著提升支气管肺泡、大小肠灌洗液中sIgA含量,降低血清IL-1βIL-6,TNF-α含量,升高IL-10、IL-lrα、sTNFR的含量、全血CD4^+百分比、CD4^+/CD8^+值及胸腺指数,升降散组对这些指标的改善作用优于拆方组而逊于合方组。结论:升降散增加黏膜分泌IgA,调控炎性因子和抗炎因子的平衡及提高T细胞亚群的比值,是其改善肺部炎症的机制之一,也是升降散治疗病毒性肺炎效用机制的初步阐明。

关键词：升降散亚甲型流感病毒FM1 分泌型免疫球蛋白A 细胞因子 T细胞亚群

Mechanism of action of linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-lin li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou li wei-Quan Xu Jia-Bao liao wei-Bo Wen jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Mechanism of boron removal from Si-Al melt by Ar-H_2 gas mixtures

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2016年第11期26卷 3046-3051页

作者：李京伟白枭龙班伯源何秋湘陈健中国科学院应用技术研究所新型薄膜太阳能电池重点实验室合肥230031

A new method about purification of metallurgical grade silicon （MG-Si） by a combination of Si-Al solvent refining andgas blowing treatment was proposed. The morphologies and transformation of impurity phases, especially for boron and iron in Si-Al melt were investigated during Ar-H2 gas blowing treatment. The mechanism of boron removal was discussed. The resultsindicate that gas blowing can refine grain size and increase nucleation of the primary Si. Boron can be effectively removed fromMG-Si using the Ar-H2 gas blowing technique during the Si-Al solvent refining. Compared with the sample without gas blowing,the removal efficiency of boron increases from 45.83% to 74.73% after 2.5 h gas blowing. The main impurity phases containingboron are in the form of TiB2, AlB2 and VB compounds and iron-containing one is in the form of β-Al5FeSi intermetallic *** of boron combines [H] to transform into gas BxHy （BH, BH2） and diffuses towards the surface of the melt and is volatilized byAr-H2 gas blowing treatment under electromagnetic stirring.

关键词： metallurgical grade silicon Si-Al melt gas blowing boron removal

Dip2a regulates stress susceptibility in the basolateral amygdala

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： jing li Zixuan He weitai Chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu Yang Lei Xiao Zhiyong Kan jing Guo Qiang li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

在线全文

学校读者我要写书评

暂无评论

基于高速公路交通量的城市交通联系强度评价

交通运输工程与信息学报 2021年第1期19卷 143-150页

作者：陈津怡魏景丽李铁柱孙赫杨东南大学交通学院南京211189 中交第一公路勘察设计研究院有限公司南京211100

为了量化城市间基于高速公路交通量的交通联系强度,提出将高速公路基础设施供给与实际产生的交通量协同考虑的计算方法。基于江苏省高速公路所有进出口的年平均日交通量OD数据,结合城市间高速公路里程及长途客车双向发车班次数据,分别... 详细信息

为了量化城市间基于高速公路交通量的交通联系强度,提出将高速公路基础设施供给与实际产生的交通量协同考虑的计算方法。基于江苏省高速公路所有进出口的年平均日交通量OD数据,结合城市间高速公路里程及长途客车双向发车班次数据,分别计算江苏省13个地级行政区之间基于高速公路的交通联系强度,并基于此分析江苏省各城市的首位联系城市及次位联系城市。结果表明,苏州市与江苏省其他城市的交通联系最强,且苏州与无锡、常州共同构成的苏锡常都市圈也对区域交通产生较大影响;南京、南通等与其他城市交通联系强度较大的城市,因其经济发展水平、地理位置等优势,形成了区域交通中心,对周边城市交通的辐射带动作用大。

关键词：高速公路交通量交通联系强度公路基础设施城市群城市联系模式

A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng li wei Yue Nam‑Young Kim Yang li Guozhen Shen Jong‑Chul Lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China State Key Laboratory of Integrated Chips and Systems Fudan UniversityShanghai 200433People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

在线全文

学校读者我要写书评

暂无评论

化工实验操作仿真的Flash实现

计算机工程与设计 2005年第12期26卷 3264-3266页

作者：卫静莉刘高亮卢培晔中北大学分校化学工程系山西太原030008

运用网络多媒体开发工具Flash实现化工实验装置及操作过程仿真,完成了化工实验仿真软件的设备动画和操作部分。介绍了设计思想和制作方法,给出了主要制作步骤及程序源代码,生成的实验操作过程形象、直观,软件体积小巧,适应当前网络教学... 详细信息

运用网络多媒体开发工具Flash实现化工实验装置及操作过程仿真,完成了化工实验仿真软件的设备动画和操作部分。介绍了设计思想和制作方法,给出了主要制作步骤及程序源代码,生成的实验操作过程形象、直观,软件体积小巧,适应当前网络教学等领域的发展和需求。通过构建基于Flash的化工实验室虚拟装置及操作,可提高高校实验室硬件资源的利用。

关键词：化工实验装置仿真操作 Flash 实验教学

基于Top-Down方法的平地机前桥系统研究

在线全文

学校读者我要写书评

暂无评论

建筑机械化 2018年第3期39卷 15-16,37页

作者：魏静卜莉莉范伟岩徐州徐工筑路机械有限公司江苏徐州221004

将Top-Down这种"自上而下"的设计方法和工具应用于平地机前桥系统设计,实现平地机前桥系统的复合运动空间模拟分析,并可实现快速的变型设计。该方法缩短了设计周期,提高了设计效率及设计质量。

关键词：平地机前桥系统 Top-Down 自上而下