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Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina quan Ling Wang jing Ren Chenguang Zheng Jiajia Yang Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

Leclercia adecarboxylata infective endocarditis in a man with mitral stenosis:A case report and review of the literature

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World Journal of Clinical Cases 2022年第29期10卷 10670-10680页

作者： Rui tan Jiang-quan Yu jing Wang Rui-Qiang Zheng Department of Critical Care Medicine Northern Jiangsu People’s HospitalYangzhou 225001Jiangsu ProvinceChina

BACKGROUND Infective endocarditis(IE) is a rare disease with a high mortality *** adecarboxylata(***) is a movable Gram-negative bacillus of enterobacteriaceae,and it can rarely be a pathogen which often affects immunodeficient *** are about three cases of immunocompetent patients with monomicrobial *** *** are only three reported cases of IE caused by *** in the *** mitral valve is often affected in IE,and the prognosis for IE with mitral valve lesions is often *** SUMMARY A 51-year-old man was found to have moderate to severe mitral stenosis on *** came to our Cardiothoracic Surgery Department for surgical management.A diastolic murmur was heard on auscultation of the heart in the mitral *** the second day of hospitalisation,he presented with slurred speech,reduced muscle strength in the left limb,and acute cerebral infarction on cranial computed *** treatment was decided to *** the ninth day of admission,the patient developed a sudden high fever and shock and was transferred to the Cardiac Intensive Care Unit,where echocardiogram revealed an anterior mitral valve leaflet *** empirical anti-infective treatment with vancomycin(1g q12h),an emergency valve replacement was *** culture identified *** treatment with piperacillin-tazobactam(4.5g q8h) was added for 4 ***-up echocardiography showed normal bioprosthetic valve function after mitral valve *** We report the first case of *** IE in China,and clinicians should pay attention to this pathogen.

关键词： Leclercia adecarboxylata Infective endocarditis Mitral valve Vegetation Cerebral infarction Case report

Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-quan Xu Jia-Bao Liao Wei-Bo Wen jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Effect of levocarnitine on TIMP-1,ICAM-1 expression of rats with coronary heart disease and its myocardial protection effect

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Asian Pacific Journal of Tropical Medicine 2016年第3期9卷 264-268页

作者： Shi-Xun Wang Lei tan Jian Wang jing-quan Zhong Key Laboratory of Cardiovascular Remodeling and Function Research.Chinese Ministry of Education and Chinese Ministry of Health.State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine.Qilu Hospital of Shandong University Department of Cardiology.Weifang People's Hospital

Objective:To study the effect of levocarnitine(L-CN) on tissue inhibitor of metalloproteinase-1(TIMP-1) and intercellular adhesion molecule-1(ICAM-1) expression of rats with coronary heart disease and evaluate the protective effect of L-CN on myocardial ***:Highfat diet feeding and intraperitoneal injection of pituitrin was performed on rats in model group and CHD Model of rats was *** with successful model-building were selected and divided into L-CN group and Ctrl group *** in L-CN group were given L-CN treatment,with intraperitoneal injection of 200 mg·kg^(-1)?d^(-1) and successive administration for 3 *** in Ctrl group were given equal volumes of normal *** was collected from carotid artery at different time and expression quantity of creatine kinase-MB(CK-MB) and Troponin Ⅰ(Tn Ⅰ)in serum was *** in each group were put to death and were separated to obtain the myocardial ***-time PCR and Western Blotting hybridization were performed to detect the ***-1 expression in myocardial tissue in each *** analysis was employed to explore the expression changes of TIMP-1 and *** ELISA test was used lo analyse the expression changes of myocardial necrosis marker- CK-MB and Tn I to learn the effect of L-CN and its myocardial protective ***:The total cholesterol,triglyceride and blood glucose levels of rats in model group were significantly higher than that in control group,which indicated that due to high-fat diet feeding,blood lipid of rats in model group was obviously higher than that in control *** myocardial tissue of rats in model group,TIMP-I level significantly reduced and ICAM-1 level significantly increased(P<0.0l).In model group,after L-CN ***-I level had double increase,while ICAM-1 level had 43%of decrease in L-CN group compared with Ctrl *** L-CN intervention ***-MB and Tn Ⅰ content in L-CN group relatively reduced compared with Ctrl

关键词： Levocarnitine Coronary heart disease TIMP-1 ICAM-1

DeepM6ASeq-EL:prediction of human N6-methyladenosine(m^(6)A)sites with LSTM and ensemble learning

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Frontiers of Computer Science 2022年第2期16卷 27-33页

作者： Juntao CHEN quan ZOU jing LI Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610051China Hainan Key Laboratory for Computational Science and Application Hainan Normal UniversityHaikou 571158China College of Intelligence and Computing Tianjin UniversityTianjin 300350China

N6-methyladenosine(m^(6)A)is a prevalent methylation modification and plays a vital role in various biological processes,such as metabolism,mRNA processing,synthesis,and *** studies have suggested that m^(6)A modification is related to common diseases such as cancer,tumours,and ***,accurate prediction of methylation sites in RNA sequences has emerged as a critical issue in the area of ***,traditional high-throughput sequencing and wet bench experimental techniques have the disadvantages of high costs,significant time requirements and inaccurate identification of *** through the use of traditional experimental methods,researchers have produced many large databases of m^(6)A *** the support of these basic databases and existing deep learning methods,we developed an m^(6)A site predictor named DeepM6ASeq-EL,which integrates an ensemble of five LSTM and CNN classifiers with the combined strategy of hard *** to the state-of-the-art prediction method WHISTLE(average AUC 0.948 and 0.880),the DeepM6ASeq-EL had a lower accuracy in m^(6)A site prediction(average AUC:0.861 for the full transcript models and 0.809 for the mature messenger RNA models)when tested on six independent datasets.

关键词： N6-methyladenosine site prediction LSTM CNN ensemble learning

Aerial refueling scheduling of multi-receiver and multi-tanker under spatial-temporal constraints for forest firefighting

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Chinese Journal of Aeronautics 2024年第5期37卷 71-91,I0001页

作者： jing HUANG Jiaqi XING Jinrui REN quan quan Youmin ZHANG Department of Information and Control Engineering Xi’an University of TechnologyXi’an 710048China Jiujiang Measuring Test Technology Research Institute Jiujiang 332000China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Automation Xi’an University of Posts&TelecommunicationsShaanxiXi’an 710121China Department of Mechanical Industrial and Aerospace EngineeringConcordia UniversityMontreal H3G 1M8Canada

Forest fires pose a significant threat to human life and property,so the utilization of unmanned aircraft systems provides new ways for forest *** the constrained load capacities of these aircraft,aerial refueling becomes crucial to extend their operational time and *** order to address the complexities of firefighting missions involving multi-receiver and multi-tanker deployed from various airports,first,a fuel consumption calculation model for aerial refueling scheduling is established based on the receiver ***,two distinct methods,including an integrated one and a decomposed one,are designed to address the challenges of establishing refueling airspace and allocating tasks for *** methods aim to optimize total fuel consumption of the receivers and tankers within the aerial refueling scheduling *** optimization problem is established as nonlinear optimization models along with *** integrated method seamlessly combines refueling rendezvous point scheduling and tanker task allocation into unified *** has a complete solution space and excels in optimizing total fuel *** decomposed method,through the separation of rendezvous point scheduling and task allocation,achieves a reduced computational ***,this comes at the cost of sacrificing optimality by excluding specific feasible ***,numerical simulations are carried out to verify the feasibility and effectiveness of the proposed *** simulations yield insights crucial for the practical engineering application of both the integrated and decomposed methods in real-world *** comprehensive approach aims to enhance the efficiency of forest firefighting operations,mitigating the risks posed by forest fires to human life and property.

关键词： Aerial refueling Scheduling Planning Spatial-temporal constraint Firefighting

Enhancement in Magnetorheological Effect of Magnetorheological Elastomers by Surface Modification of Iron Particles

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Chinese Journal of Chemical Physics 2008年第1期21卷 87-92页

作者： Wan-quan Jiang jing-jing Yao Xing-long Gong Lin Chen Department of Chemistry University of Science and Technology of China Hefei 230026 China CA5 Key Laboratory of Mechanical Behavior and Design of Materials Department of Mechanics andMechanical Engineering University of Science and Technology of China Hefei 230027 China

In order to obtain magnetorheological （MR） elastomers with high magnetorheological effect, a family of anisotropic rubber-based MR elastomers was developed using a new form of chemical modification. Three different kinds of surfactants, i.e. anionic, nonionic and compound surfactants, were employed separately to modify iron particles. The MR effect was evaluated by measuring the dynamic shear modulus of MR elastomer with a magneto-combined dynamic mechanical analyzer. Results show that the relative MR effect can be up to 188% when the iron particles are modified with 15% Span 80. Besides the surface activity of Span 80, however, such high modifying effect is partly due to the plasticizing effect of Span 80. Compared with the single surfactant, the superior surface activity of compound surfactant makes the relative MR effect reach 77% at a low content of 0.4%. Scanning electron microscope observation shows that the modification of compound surfactant results in perfect compatibility between particles and rubber matrix and special self-assembled structure of particles. Such special structure has been proved beneficial to the improvement of the relative MR effect.

关键词： Magnetorheological elastomers Shear modulus Surfactant Microstructure

Excavator Energy-saving Efficiency Based on Diesel Engine Cylinder Deactivation Technology

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Chinese Journal of Mechanical Engineering 2012年第5期25卷 897-904页

作者： YANG jing quan Long YANG Yang Key Laboratory of Advanced Transducers and Intelligent Control System of Ministry of Education Taiyuan University of Technology Taiyuan 030024 China The State Key Lab of Fluid Power Transmission and Control Zhejiang University Hangzhou 31002 7 China

The hydraulic excavator energy-saving research mainly embodies the following three measures： to improve the performance of diesel engine and hydraulic component, to improve the hydraulic system, and to improve the power matching of diesel-hydraulic system-actuator. Although the above measures have certain energy-saving effect, but because the hydraulic excavator load changes frequently and fluctuates dramatically, so the diesel engine often works in high-speed and light load condition, and the fuel consumption is higher. Therefore, in order to improve the economy of diesel engine in light load, and reduce the fuel consumption of hydraulic excavator, energy management concept is proposed based on diesel engine cylinder deactivation technology. By comparing the universal characteristic under diesel normal and deactivated cylinder condition, the mechanism that fuel consumption can be reduced significantly by adopting cylinder deactivation technology under part of loads condition can be clarified. The simulation models for hydraulic system and diesel engine are established by using AMESim software, and fuel combustion consumption by using cylinder-deactivation-technology is studied through digital simulation approach. In this way, the zone of cylinder deactivation is specified. The testing system for the excavator with this technology is set up based on simulated results, and the results show that the diesel engine can still work at high efficiency with part of loads after adopting this technology; fuel consumption is dropped down to 11% and 13% under economic and heavy-load mode respectively under the condition of driving requirements. The research provides references to the energy-saving study of the hydraulic excavators.

关键词： diesel engine cylinder deactivation hydraulic excavator energy-saving

Effect of Strong Magnetic Field on Gamow-Teller Transition Electron Capture of Iron Group Nuclei at Crusts of Neutron Stars

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Communications in Theoretical Physics 2008年第1期49卷 239-242页

作者： LIU jing-jing LUO Zhi-quan Institute of Theoretical Physics China West Normal University Nanchong 637002 China

The electron capture of Gamow--Teller transition on iron group nuclei is investigated in a strong magnetic. field at the crusts of neutron stars. The results show that the magnetic field has only a slight effect on the electron capture rates with the range of the magnetic fields （10^9 - 10^13 G） on surfaces of most neutron stars, whereas for some magnetars whose range of the magnetic field is 10^13 - 10^18 G, the electron capture rates of most iron group nuclei would be debased greatly and may be even decreased overrun 3 orders of magnitude by the strong magnetic field.

关键词： strong magnetic field Gamow-Teller transition electron capture neutron star