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Effect of Dermabrasion and ReCell on Large Superficial Facial Scars Caused by Burn, Trauma and Acnes

Chinese Medical Sciences Journal 2016年第3期31卷 173-173,174,175,176,177,178,179页

作者： Pan-xi Yu Wen-qi Diao Zuo-liang Qi jing-long cai Department No. 16 Plastic Surgery Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100144 China Department of Respiratory Medicine Peking University Third Hospital Beijing 100191 China Department of Dermatology Peking Xiang-Yun Dermatological Hospital Beijing 100068 China

Objective To explore the effects of dermabrasion combined with ReCell on large superficial facial scars caused by burn, trauma and acnes. Methods Nineteen patients with large superficial facial scars were treated by the same surgeon with dermabrasion combined with ReCell？. According to the etiology, patients were classified into post-burning group （n=5）, post-traumatic group （n=7） and post-acne group （n=7）. Fifteen patients completed the follow-ups, 5 patients in each group. Healing time, complication rate, the preoperative and 18-month-post-operative assessments using Patient Satisfaction Score （PSS）, Vancouver Scar Scale （VSS）, and Patient and Observer Scar Assessment Scale （POSAS） of each group were analyzed to compare the effect of the combined therapy on *** The healing time of post-burning group （19.6±4.0 days）, post-traumatic group （15.8±2.6 days）, and post-acne group （11.4±3.1 days） varied remarkably （F=7.701, P=0.007）. The complication rates were 60%, 20%, and 0 respectively. The post-operative POSAS improved significantly in all groups （P〈0.05）, where the most significant improvement was shown in the post-acne group （P〈0.05）. The post-operative PSS and VSS improved only in the post-traumatic group and post-acne group （all P〈0.05）, where the more significant improvement was also shown in the post-acne group （P〈0.05）. Conclusions The combined treatment of dermabrasion and ReCell has remarkable effect on acne scars, moderate effect on traumatic scars and is not suggested for burn scars. POSAS should be applied to assess the therapeutic effects of treatments for large irregular scars.

关键词： dermabrasion ReCell scars Patient and Observer Scar Assessment Scale

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Platelet-based bioactive systems guided precision targeting and immune regulation for cancer therapy

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Nano Research 2024年第9期17卷 8269-8284页

作者： Xinyi cai long Qiu Zhenying Diao Lintao cai Ting Yin Hong Pan Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen 518055China School of pharmacy Guangdong Medical UniversityDongguan 523808China Sino-Euro Center of Biomedicine and Health Shenzhen 518024China

The antitumor effects of conventional drug carriers are often attenuated and limited in application by biological barriers associated with tumor heterogeneity and resistance brought about by low tumor *** the rapid development of nanotechnology,naturally derived bioactive materials,and live cell carriers,a promising strategy emerges for targeting the tumor microenvironment(TME)for precision cancer *** unique injury-targeting properties of platelets can significantly extend functional activity,which cannot be achieved with conventional *** this review,three strategies based on platelet-engineered materials are systematically described,namely nanoparticles for platelet membrane camouflage,engineered activated platelets,and targeted-platelets ***-based nanomaterials can effectively coordinate local and distant tumor-host crosstalk with controlled active tumor site recognition and killing effects due to the presence of specific membrane proteins on the surface and the self-secretion of a large number of *** advances in platelets for effectively overcoming biological barriers and reducing immune resistance in cancer immunotherapy applications will be discussed in future clinical *** review provides an overview of recent research advances in platelet-based bioactive material-directed immunotherapy and chemotherapy to inform future antitumor combination therapies.

关键词： platelets bionic targeting immune modulation precision therapy deep penetration

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Nanomedicine targeting ferroptosis to overcome anticancer therapeutic resistance

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Science China(Life Sciences) 2024年第1期67卷 19-40页

作者： jing cai Xiaoding Xu Phei Er Saw Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineMedical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Nanhai Translational Innovation Center of Precision Immunology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityFoshan 528200China

A potential reason for the failure of tumor therapies is treatment *** to chemotherapy,radiotherapy,and immunotherapy continues to be a major obstacle in clinic,resulting in tumor recurrence and *** major mechanisms of therapy resistance are inhibitions of cell deaths,like apoptosis and necrosis,through drug inactivation and excretion,repair of DNA damage,tumor heterogeneity,or changes in tumor microenvironment,*** studies have shown that ferroptosis play a major role in therapies resistance by inducing phospholipid peroxidation and iron-dependent cell *** ferroptosis inducers in combination with clinical treatment techniques have been used to enhance the effect in tumor ***,versatile ferroptosis nanoinducers exhibit an extensive range of functions in reversing therapy resistance,including directly triggering ferroptosis and feedback ***,we provide a detailed description of the design,mechanism,and therapeutic application of ferroptosis-mediated synergistic tumor *** also discuss the prospect and challenge of nanomedicine in tumor therapy resistance by regulating ferroptosis and combination therapy.

关键词： ferroptosis cancer therapy therapy resistance nanoinducers

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Design of 10 MeV electron linear accelerator for space environment simulation

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NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-14页

作者： Zhang, Shu Meng, cai Zhou, Zu-Sheng He, Xiang Zhang, jing-Ru Iqbal, Munawar Zhang, Zhan-Dong Bai, Bo-Wen Chi, Yun-long Chinese Acad Sci Inst High Energy Phys Beijing 100049 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Harbin Inst Technol Inst Special Environm Phys Sci Shenzhen 518055 Peoples R China

A compact 10 MeV S-band irradiation electron linear accelerator (linac) was developed to simulate electronic radiation in outer space and perform electron irradiation effect tests on spacecraft materials and devices. According to the requirements of space environment simulation, the electron beam energy can be adjusted in the range from 3.5 to 10 MeV, and the average current can be adjusted in the range from 0.1 to 1 mA. The linac should be capable of providing beam irradiation over a large area of 1 m2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\hbox {m}2}$$\end{document} with a uniformity greater than 90% and a scanning rate of 100 Hz. A novel method was applied to achieve such a high beam scanning rate by combining a kicker and a scanning magnet. Based on this requirement, a design for the 10 MeV linac is proposed with an RF power pulse repetition rate of 500 Hz; it includes a thermal cathode electron gun, a bunching-accelerating section, and a scanning transport line. The detailed physical design and dynamic simulation results of the proposed 10 MeV electron linac are presented in this paper.

关键词： Electron linac Accelerating structure Beam scanning Beam homogenization Irradiation linac

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LLTH‑YOLOv5:A Real‑Time Traffic Sign Detection Algorithm for Low‑Light Scenes

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Automotive Innovation 2024年第1期7卷 121-137页

作者： Xiaoqiang Sun Kuankuan Liu long Chen Yingfeng cai Hai Wang Automotive Engineering Research Institute Jiangsu UniversityZhenjiang 212013China School of Automotive and Traffic Engineering Jiangsu UniversityZhenjiang 212013China

Traffic sign detection is a crucial task for autonomous driving ***,the performance of deep learning-based algorithms for traffic sign detection is highly affected by the illumination conditions of *** existing algo-rithms demonstrate high accuracy in well-lit environments,they suffer from low accuracy in low-light *** paper proposes an end-to-end framework,LLTH-YOLOv5,specifically tailored for traffic sign detection in low-light scenarios,which enhances the input images to improve the detection *** proposed framework comproses two stages:the low-light enhancement stage and the object detection *** the low-light enhancement stage,a lightweight low-light enhancement network is designed,which uses multiple non-reference loss functions for parameter learning,and enhances the image by pixel-level adjustment of the input image with high-order *** the object detection stage,BIFPN is introduced to replace the PANet of YOLOv5,while designing a transformer-based detection head to improve the accuracy of small target ***,GhostDarkNet53 is utilized based on Ghost module to replace the backbone network of YOLOv5,thereby improving the real-time performance of the *** experimental results show that the proposed method significantly improves the accuracy of traffic sign detection in low-light scenarios,while satisfying the real-time requirements of autonomous driving.

关键词： Deep learning Traffic sign detection Low-light enhancement YOLOv5 Object detection

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Zn-air batteries for electric vehicles

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Tungsten 2024年第1期6卷 164-173页

作者： Nai-Qi Meng Yu-Xin Fan jing-Sheng cai State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China College of Energy Soochow Institute for Energy and Materials InnovationS(SIEMIS)Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province Soochow UniversitySuzhou 215006China Institute of New Energy for Vehicles School of Materials Science and EngineeringTongji UniversityShanghai 201804China

The increasingly serious environmental challenges have gradually aroused people's interest in electric *** the last decade,governments and automakers have collaborated on the manufacturing of electric vehicles with high ***-edge battery technologies are pivotal for the performance of electric ***-air batteries are considered as potential power batteries for electric vehicles due to their high ***-air battery researches can be classified into three categories:primary batteries,mechanically rechargeable batteries,and chemically rechargeable *** majority of current studies aim at developing and improving chemically rechargeable and mechanically rechargeable Zn-air *** have tried to use catalytic materials design and device design for Zn-air batteries to make it possible for their applications in electric *** review will highlight the state-of-the-art in primary batteries,mechanically rechargeable batteries,and chemically rechargeable batteries,revealing the prospects of Zn-air batteries for electric vehicles.

关键词： Energy storage Electric vehicles Bifunctional oxygen catalysts Mechanically rechargeable Zn-air batteries Chemically rechargeable Zn-air batteries

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Assembly of highly efficient aqueous light-harvesting system from sequence-defined peptoids for cytosolic microRNA detection

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Nano Research 2024年第2期17卷 788-796页

作者： Yang Song Xiaoli cai Mingming Wang Dan Du Yuehe Lin Chun-long Chen Department of Mechanical and Materials Engineering Washington State UniversityPullmanWA 99164USA Division of Physical Sciences Pacific Northwest National LaboratoryRichlandWA 99352USA Department of Chemical Engineering University of WashingtonSeattleWA 98195USA

Precisely controlled spatial distributions of artificial light-harvesting systems in aqueous media are of significant importance for mimicking natural light-harvesting systems;however,they are often restrained by the solubility and the aggregation-caused quenching effect of the hydrophobic ***,we report one highly efficient artificial light-harvesting system based on peptoid nanotubes that mimic the hierarchical cylindrical structure of natural *** high crystallinity of these nanotubes enabled the organization of arrays of donor chromophores with precisely controlled spatial distributions,favoring an efficient Förster resonance energy transfer(FRET)process in aqueous *** FRET system exhibits an extremely high efficiency of 98.6%with a fluorescence quantum yield of 40%and an antenna effect of *** further demonstrated the use of this artificial light-harvesting system for quantifying miR-210 within cancer *** fluorescence intensity ratio of donor to acceptor is linearly related to the concentration of intercellular miR-210 in the range of 3.3–156 copies/*** high sensitivity in intracellular detection of miR-210 using this artificial light-harvesting system offers a great opportunity and pathways for biological imaging and detection,and for the further creation of microRNA(miRNA)toolbox for quantitative epigenetics and personalized medicine.

关键词： light-harvesting peptoid nanotube Förster resonance energy transfer intracellular RNA detection

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Experimental Study of Fuel-Air Mixing and Dilution Jets on Outlet Temperature Distribution in a Small Gas Turbine Combustor

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Journal of Thermal Science 2024年第5期33卷 1883-1896页

作者： cai Wenzhe WU jing HU Yingqi YANG Zhiqiang XUE Xin LIN Yuzhen National Key Laboratory of Science and Technology on Aero-Engine Aero-thermodynamics Research Institute of Aero-EngineBeihang UniversityBeijing 100191China Beijing Institute of Power Machinery Beijing 100074China School of Energy and Power Engineering Beihang UniversityBeijing 100191China

Experimental analysis was conducted to study the impact of fuel-air mixing and dilution jet on the temperature distribution in a small gas turbine combustor using various optical diagnostic *** strength and velocity of the swirler at the venturi exit were adjusted to modify the fuel-air mixture,which is presumed to dominate the heat release of the main combustion ***,the dilution hole configuration,including the number and size of the holes,was varied to investigate the dilution effect on outlet temperature *** optical diagnostic techniques,such as particle image velocimetry,planar Mie scattering,and OH~*chemiluminescence,were used to measure the flow field,fuel spray distribution,and flame structure,respectively.A reduction in swirling strength led to a decrease in the average flow rate in the throat,which improved the structure and symmetry of the axial vortex system in the sleeve,enhanced the mixing of fuel and gas in the dome swirling air,and ultimately,improved the temperature uniformity of the heat release *** to larger and sparse dilution jets,smaller and dense dilution jets tended to generate hot spots shifted towards the radial middle area.

关键词： small gas turbine combustor fuel-air mixing outlet temperature distribution dilution jet laser diagnostics

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A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis

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Bone Research 2024年第1期12卷 227-239页

作者： Yong Li Zhengwen cai Wenjuan Ma long Bai En Luo Yunfeng Lin State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengduSichuan 610041PR China Department of Oral and Maxillofacial Surgery Affiliated Stomatological HospitalSouthwest Medical UniversityLuzhouSichuan 646000PR China Sichuan Provincial Engineering Research Center of Oral Biomaterials ChengduSichuan 610041China

Diabetic osteoporosis(DOP)is a significant complication that poses continuous threat to the bone health of patients with diabetes;however,currently,there are no effective treatment *** patients with diabetes,the increased levels of ferroptosis affect the osteogenic commitment and differentiation of bone mesenchymal stem cells(BMSCs),leading to significant skeletal *** address this issue,we aimed to target ferroptosis and propose a novel therapeutic approach for the treatment of *** synthesized ferroptosis-suppressing nanoparticles,which could deliver curcumin,a natural compound,to the bone marrow using tetrahedral framework nucleic acid(tFNA).This delivery system demonstrated excellent curcumin bioavailability and stability,as well as synergistic properties with *** in vitro and in vivo experiments revealed that nanoparticles could enhance mitochondrial function by activating the nuclear factor E2-related factor 2(NRF2)/glutathione peroxidase 4(GPX4)pathway,inhibiting ferroptosis,promoting the osteogenic differentiation of BMSCs in the diabetic microenvironment,reducing trabecular loss,and increasing bone *** findings suggest that curcumin-containing DNA tetrahedron-based ferroptosissuppressing nanoparticles have a promising potential for the treatment of DOP and other ferroptosis-related diseases.

关键词： curcumin osteoporosis diabetic

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An antistatic agent based on polyionic liquid applied to nylon 6

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Green Chemical Engineering 2024年第3期5卷 399-407页

作者： Shuangchan Fu Yinghao Yu Feng Wang jing Li Zhiqi cai School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou510641China SCUT-Zhuhai Institute of Modern Industrial Innovation Zhuhai519175China Yantai Xintelu New Material Technology Co.LTD. Shandong264006China

In order to improve the electrical conductivity of nylon 6(PA6)and avoid misfires and explosions caused by static charge accumulation,a quaternary ammonium salt polyionic liquid(PIL)antistatic agent was synthesized in this *** surface resistance of PA6 was reduced to 10~8Ωwith the addition of 2 wt%antistatic agent,and the mechanical properties and aging resistance of the substrate were ***,the morphology and crystallinity of PIL/PA6 composites were further characterized by scanning electron microscope(SEM),energy dispersion spectrometer(EDS)and X-ray diffraction(XRD).It is worth noting that the quaternary ammonium salt polyionic liquid antistatic agent synthesized in this paper has the advantages of excellent antistatic effect,durability,low cost,and simple reaction condition,so it has a broad application prospect in the antistatic aspect of PA6.

关键词： Polyionic liquid Nylon 6 Antistatic agent

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