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Computer-assisted three-dimensional individualized extreme liver resection for hepatoblastoma in proximity to the major liver vasculature

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1066-1077页

作者： Wen-li Xiu Jie liu jing-li zhang jing-Miao Wang Xue-Feng Wang Fei-Fei Wang Jie Mi Xi-Wei Hao NanXia Qian Dong Department of Pediatric Surgery The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Pediatric Surgery Yijishan Hospital of Wannan Medical CollegeWuhu 241000Anhui ProvinceChina Shandong Provincial Key Laboratory of Digital Medicine and Computer-assisted Surgery Shandong College Collaborative Innovation Center of Digital Medicine Clinical Treatment and Nutrition HealthQingdao UniversityQingdao 266003Shandong ProvinceChina

BACKGROUND The management of hepatoblastoma(HB)becomes challenging when the tumor remains in close proximity to the major liver vasculature(PMV)even after a full course of neoadjuvant chemotherapy(NAC).In such cases,extreme liver resection can be considered a potential *** To explore whether computer-assisted three-dimensional individualized extreme liver resection is safe and feasible for children with HB who still have PMV after a full course of *** We retrospectively collected data from children with HB who underwent surgical resection at our center from June 2013 to June *** then analyzed the detailed clinical and three-dimensional characteristics of children with HB who still had PMV after a full course of *** Sixty-seven children diagnosed with HB underwent surgical *** age at diagnosis was 21.4±18.8 months,and 40 boys and 27 girls were ***-nine(88.1%)patients had a single tumor,39(58.2%)of which was located in the right lobe of the liver.A total of 47 patients(70.1%)had PRE-TEXT III or ***-nine patients(58.2%)underwent delayed *** a full course of NAC,16 patients still had close PMV(within 1 cm in two patients,touching in 11 patients,compressing in four patients,and showing tumor thrombus in three patients).There were 6 patients of tumors in the middle lobe of the liver,and four of those patients exhibited liver anatomy *** 16 children underwent extreme liver resection after comprehensive preoperative *** procedures were performed according to the preoperative plan,and the operations were successfully ***,the 3-year event-free survival of 67 children with HB is 88%.Among the 16 children who underwent extreme liver resection,three experienced recurrence,and one died due to multiple *** Extreme liver resection for HB that is still in close PMV after a full course of NAC is both safe and *** approach not only reduces th

关键词： Children Hepatoblastoma Surgery Three-dimensional Computer-assisted

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Mechanical alloying behavior of Nb–Ti–Si-based alloy made from elemental powders by ball milling process

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Rare Metals 2017年第3期36卷 174-182页

作者： li-jing zhang Xi-Ping Guo State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an 710072China

Nb-Ti-Si-based alloy powders were prepared by mechanical alloying （MA） of elemental *** evolutions of morphology,size,phase constituents,crystallite size,lattice strain,composition and internal microstructure,etc.,of the alloy powders were analyzed by X-ray diffraction （XRD）,scanning electron microscopy （SEM）,energy-dispersive spectroscopy （EDS）,laser particle size analyzer and transmission electron microscope （TEM） *** alloy particles are gradually refined and their shapes become globular with the increase in milling *** diffraction peaks of Nb solid solution （Nbss） phase shift toward lower 2θ angles during ball milling from 2 to 5 h,and after that Nbss diffraction peaks shift toward higher 2θ angles with the increase in milling time from 5 to 70 h,which is mainly attributed to the alteration of the lattice parameter of Nbss powders due to the solution of the alloying element atoms into Nb lattice to form *** ball milling process,the decrease in crystallite size and increase in lattice strain of Nbss powders lead to continuous broadening of their diffraction peaks.A typical lamellar microstructure is formed inside the powder particles after ball milling for 5 h and becomes more refined and homogenized with the increase in milling *** 40-h-ball milling,the typical lamellar microstructure disappears and a very homogeneous microstructure is formed *** homogeneous microstmcture is proved to be composed of only supersaturated Nbss phase.

关键词： Mechanical alloying Nb-Ti-Si-based alloy Powder morphology Phase constituents MicrostructureSupersaturated Nb solid solution

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Hot deformation behavior and process parameter optimization of Ti22Al25Nb using processing map

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Rare Metals 2016年第1期35卷 118-126页

作者： jing-li zhang Hong-Zhen Guo Hou-Quan liang School of Materials Science and Engineering Northwestern Polytechnical University

The hot deformation behavior of Ti22A125 Nb was investigated by hot compression *** flow stressstrain curves can be divided into two types：conventional dynamic recrystallization（DRX） and discontinuous *** different softening mechanism and micro structure observation of conventional DRX and discontinuous DRX were *** processing map（PM） of Ti22A125 Nb was built to predict the safe deformation *** optimal low strain rate domain（DOM I） with high power dissipation efficiency indicates the complete ***,in the high strain rate and low-temperature domain（DOM Ⅲ）,the power dissipation efficiency is low and some adiabatic shear bands and glide bands are observed,which are unsafe and should be ***,the DRX map was *** DOM I,it reveals low dislocation density and high DRX content,which is in agreement with PM.

关键词： Ti22Al25Nb Intermetallic Processing map Hot deformation behavior Microstructure

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Natural Hybridization between Rhododendron delavayi and ***(Ericaceae),from Morphological,Molecular and Reproductive Evidence

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Journal of Integrative Plant Biology 2010年第9期52卷 844-851页

作者： Yong-Peng Ma Chang-Qin zhang jing-li zhang Jun-Bo Yang Kunming Botanic Garden Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China Key Laboratory of Resource Plants and Biotechnology Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China Graduate University of Chinese Academy of Sciences Chinese Academy of Sciences Beijing 100049 China Tunnan Agricultural University Kunming 650201 China Key Laboratory of Biodiversity and Biogeography Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China

The natural hybridization that occurs between two sympatric species of Rhododendron subgenus Hymenanthes in Yunnan, China, was investigated. In field observations, it was noted that the putative hybrids between R. delavayi Franch. and R. cyanocarpum （Franch.） Franch. ex W.W. Sm. had intermediate morphologies. On the basis of morphology, chloroplast DNA （trnL-rp132） and nuclear DNA （waxy）, hybrids and parental species were identified. Hybridization occurred in both directions, but was asymmetrical, with R. delavayi as the major maternal parent. Reciprocal hand pollination treatments showed that either species, as pollen donor or pollen receiver, could produce fruits. It was noted that fruit set varied among treatments. The same pollinators （bumblebees） were shared in both parental species. From these results, we conclude that individuals with intermediate morphologies are indeed of hybrid origin from natural hybridization between R. cyanocarpum and R. delavayi. Furthermore, we presume the hybridization at the study site could have been initiated by habitat disturbance in the 1950s, and we may hence witness the early stages of hybrid swarm formation.

关键词： Natural hybridization Hybridization Hybrids Species Fruits DNA Fruit Swarming Pollen Pollinators

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Experimental investigation on turbulence modification in a horizontal channel flow at relatively low mass loading

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Acta Mechanica Sinica 2006年第2期22卷 99-108页

作者： Yi Wu Hangfeng Wang Zhaohui liu jing li liqi zhang Chuguang Zheng State Key Lab. Coal Combustion Huazhong Univ. of Sci. & Tech.Wuhan 430074 China

Particle-laden flows in a horizontal channel were investigated by means of a two-phase particle image velocimetry （PIV） technique. Experiments were performed at a Reynolds number of 6826 and the flow is seeded with polythene beads of two sizes, 60μm and 110μm. One was slightly smaller than and the other was larger than the Kolmogorov length scale. The particle loadings were relatively low, with mass loading ratio ranging from 5 ×10^-4 to 4 × 10^-2 and volume fractions from 6×10×-7 to 4.8×10^-5, respectively. The results show that the presence of particles can dramatically modify the turbulence even under the lowest mass loading ratio of 5 × 10^-4. The mean flow is attenuated and de- creased with increasing particle size and mass loading. The turbulence intensities are enhanced in all the cases concerned. With the increase of the mass loading, the intensities vary in a complicated manner in the case of small particles, indicating complicated particle-turbulence interactions; whereas they increase monotonously in the case of large particles. The particle velocities and concentrations are also given. The particles lag behind the fluid in the center region but lead in the wall region, and this trend is more prominent for the large particles. The streamwise particle fluctuations are larger than the gas fluctuations for both sizes of particles, however their varying trend with the mass loadings is not so clear. The wallnormal fluctuations increase with increasing mass loadings. They are smaller in the 60μm particle case but larger in the 110μm particle case than those of the gas phase. It seems that the small particles follow the fluid motion to certain extent while the larger particles are more likely dominated by their own inertia. Finally, remarkable non-uniform distributions of particle concentration are observed, especially for the large particles. The inertia of particles is proved to be very important for the turbulence modification and particles behaviors and thus

关键词： Horizontal channel Particle-laden flow Turbulence modification PIV

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Analysis on the Dwarfing Genes in Zhepi 1 and Aizao 3:Two Dwarfing Gene Donors in Barley Breeding in China

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Agricultural Sciences in China 2006年第9期5卷 643-647页

作者： zhang jing li Zhen zhang Chi-hong Institute of Crop Science Chinese Academy of Agricultural Sciences Beijing 100081 P.R.China

Inheritance of plant height was studied in the two dwarfing gene donors, Zhepi 1 and Aizao 3, in barley breeding in China. Using direct cross and para-back-cross methods, allelic tests were carried out not only between the dwarfing genes in Zhepi 1 and Aizao 3, but also with br, uzu, denso, or sdwl and the six novel dwarfing genes that have been recently identified in barley in China. The results showed that the plant height was attributed to Mendelian inheritance of a recessive dwarfing gene both in Zhepi 1 and Aizao 3. The dwarfing genes carried by the two cultivars were the same, but different from the three known and the six novel dwarfing genes. On the basis of the present study, only two dwarfing genes have been used in barley breeding in China since 1950.

关键词： Hordeum vulgare dwarf source dwarfing gene

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Isolation and Expression Analysis of Two Cold-Inducible Genes Encoding Putative CBF Transcription Factors from Chinese Cabbage （Brassica pekinensis Rupr）

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Journal of Integrative Plant Biology 2006年第7期48卷 848-856页

作者： Yong zhang Tong-Wen Yang li-jing zhang Teng-Guo zhang Cui-Xia Di Shi-Jian Xu li-Zhe An Key Laboratory of Arid and Grassland Agroecology of Ministry of Education School of Life Sciences Lanzhou University Lanzhou 730000 China Cold and Arid Regions Environmental and Engineering Research Institute the Chinese Academy of Sciences Lanzhou 730000 China

Two homologous genes of the Arabidopsis C-repeat/dehydration-responsive element binding factors （CBF/ DREB1） transcriptional activator were isolated by RT-PCR from Chinese cabbage （Brassica pekinensis Rupr. cv. Qinbai 5） and were designated as BcCBF1 and BcCBF2. Each encodes a putative CBF/DREB1 protein with an AP2 （Apetal2） DNA-bindlng domain, a putative nuclear localization signal, and a possible acidic activation domain. Deduced amino acid sequences show that BcCBF1 is very similar to the Arabidopsis CBF1, whereas BcCBF2 Is different in that it contains two extra regions of 24 and 20 amino acids in the acidic domain. The mRNA accumulation profiles indicated that the expression of BcCBF1 and BcCBF2 is strongly induced by cold treatment, but does not respond similarly to dehydration or abscisic acid （ABA） treatment. However, the cold-induced accumulation of BcCBF2 mRNA was rapid but short-lived compared with that of BcCBFI. The mRNA levels of both BcCBF1 and BcCBF2 were higher in leaves than in roots when plants were exposed to cold, whereas, salt stress caused higher accumulation of BcCBF2 mRNA in roots than in leaves, suggesting that the organ specificity of the gene expression of the BcCBFs is probably stress dependent. In addition, the accumulation of BcCBF1 and BcCBF2 mRNAs was greatly enhanced by light compared with darkness when seedlings were exposed to cold. It is concluded that the two BcCBF proteins may be involved in the process of plant response to cold stress through an ABA-independent pathway and that there is also a cross-talk between the light signaling conduction pathway and the cold response pathway in B. pekinensis as in Arabidopsis.

关键词： Brassica pekinensis cold acclimation cold induced gene C-repeat/dehydration-responsive element binding factors (CBF/DREB1) expression pattern.

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Design optimization of a hexapod vibration isolation system for electro-optical payload

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Chinese Journal of Aeronautics 2024年第2期37卷 330-342页

作者： jing li Weipeng li Xiaoyan zhang Hai HUANG School of Astronautics Beihang UniversityBeijing 100191China

The electro-optical payloads on mobile platforms generally suffer undesirable vibrations generated by maneuvers and *** vibrations are in six degrees of freedom and cause line-of-sight jitters,resulting in image blurring and loss of tracking *** this paper,a Hexapod Vibration Isolation System(HVIS)is proposed and optimized to solve this *** optimization aims to centralize and minimize the natural frequencies of HVIS,for expanding the vibration isolation bandwidth and improving the vibration isolation in the higher frequency *** that the design space for HVIS is limited and interfered with the frames of the mobile platform,a non-collision algorithm is proposed and applied in the optimization to obtain the feasible optimal *** optimization result shows that the natural frequency bandwidth has been reduced by 42.9%,and the maximum natural frequency is reduced by 30.2%.The prototypes of initial and optimal designs are manufactured and *** simulated and experimental results demonstrate the validity of the optimization,and the optimal design provides a maximum of 15 dB more isolation in rotation direction than the initial design.

关键词： Electro-optical payload Vibrations Isolation system Hexapod Optimization Non-collision design

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Synthesis and in vitro cytotoxic activities of sorafenib derivatives

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Chinese Chemical Letters 2014年第5期25卷 702-704页

作者： Ke Wang Yan li li-jing zhang Xiao-Guang Chen Zhi-Qiang Feng Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation Institute of Materia MedicaChinese Academy of Medical Sciences &Peking Union Medical College State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences &Peking Union Medical College

A series of novel sorafenib derivatives have been designed and *** cytotoxic activities of these compounds were tested in three tumor cell *** of the compounds showed potent antiproliferative activity against the tested cell lines with IC50= 0–20 mmol/*** compounds demonstrated competitive antiproliferative activities to sorafenib against all three cancer cell *** them,compound 5g demonstrated significant inhibitory activity against A549,ACHN and MDAMB-231 cell lines with IC50values of 1.29,1.99,3.11 mmol/L,respectively.

关键词： Sorafenib Antiproliferative activity A549 ACHN MDA-MB-231

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Small non-coding RNAs transfer through mammalian placenta and directly regulate fetal gene expression

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Protein & Cell 2015年第6期6卷 391-396页

作者： jing li Yujing zhang Dameng li Yuchen liu Danping Chu Xiaohong Jiang Dongxia Hou Ke Zen Chen-Yu zhang State Key Laboratory of Pharmaceutical Biotechnology Nanjing Advanced Institute for Life Sciences (NAILS) Nanjing University School of Life Sciences Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnoiogy Nanjing University 22 Hankou Road Nanjing 210093 Jiangsu China

SMALL NON-CODING RNA CAN TRANSFER THROUGH THE PLACENTA AND REGULATE FETAL DEVELOPMENT Increasing evidence demonstrated that exogenous plant miRNAs in the diet can be absorbed and are found in mammalian tissues. These miRNAs influence the physio- logical and pathological progression of the recipient. In this issue, jing li and colleagues further reveal that exogenous/ endogenous small non-coding RNA in the maternal system can transfer through the placenta to the fetal side and influ- ence fetal development and health. These surprising finding demonstrate that maternal miRNAs profiling are very impor- tant to fetal development, which means maternal diet and the healthy status may influence fetal development and the postnatal morbidity via transplacental small non-coding RNAs. Furthermore, this finding also proposes a brand new potential strategy to treat fetal diseases in utero. Combining with gene therapy, maternal administrating represents a new trend for treating fetal diseases.

关键词： Amniotic Fluid Fetal liver Fetal Development Maternal Plasma Rubella Virus

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